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A boundary layer model for capture of inclusions by steel-slag interface in a turbulent flow

Journal of Iron and Steel Research International 2023年第6期30卷 1101-1108页

作者： yi-peng sun Hao-jian Duan Li-feng Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China

A boundary layer model was developed to predict the capture of inclusions by steel-slag interface in a turbulent fluid flow,which is based on the detailed analysis of inclusion *** effective boundary layer for inclusion removal was proposed by a statistical *** is noticed that the capture of inclusions by steel-slag interface is not only dependent on the diameter of inclusions but also related to the local turbulent *** high turbulent flow fields,the transport of inclusions is mainly dominated by the turbulent flow,and thus,the effective boundary layer thickness is mainly affected by the level of turbulent kinetic energy and is almost independent of the inclusion *** inertia of inclusions gradually takes over the stochastic effect of turbulent flow,and the effect of inclusion diameter on effective boundary layer thickness becomes more noticeable with the decrease in the level of turbulent kinetic ***,the effective boundary layer thickness is more susceptible to the inclusion diameter for larger inclusions due to its greater inertia under the same turbulent condition while it principally depends on the level of turbulent kinetic energy for smaller *** the characteristic velocity increases,the time for inclusions transport and interaction with steel-slag interface decreases,and thus,the effective boundary layer thickness ***,the graphical user interface was developed by using the cubic spline interpolation for ease of coupling the current boundary layer model with the macro-scale model of a turbulent fluid flow in the metallurgical vessel.

关键词： Boundary layer model Capture of inclusions steel–slag interface Turbulent flow

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin peng Yu Bai Hang Li Meixiu Qu Zhenhua Wang Kening sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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In situ polymerization of poly(3,4-ethylenedioxythiophene)protective layer towards stable zinc anode

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Nano Research 2025年第1期18卷 382-394页

作者： Debin Luo peng Zhou Xiaowei Lv Panpan sun Xiaohua sun Hewei Zhao College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Hubei Three Gorges Laboratory Yichang 443007China School of Chemistry Beihang UniversityBeijing 100191China

Aqueous zinc-ion devices are considered promising candidates for energy storage due to their high safety,low cost and relatively high energy ***,the dendrite growth,hydrogen evolution reaction(HER)and corrosion of the zinc anode significantly limit the development of Zn-ion ***,an inexpensive poly(3,4-ethylenedioxythiophene)(PEDOT)protective layer was constructed in situ on the Zn surface using electropolymerization to suppress dendrite growth and side reactions,thereby enhancing the reversibility of *** and theoretical calculations revealed that this hydrophilic protective layer promotes the desolvation process of hydrated Zn^(2+)and facilitates the transport of zinc ions,thus improving the thermodynamic and kinetic properties of Zn^(2+)deposition and inhibiting interfacial side ***,the optimized PEDOT@Zn symmetric battery exhibited a cycling stability exceeding 1250 h at 0.5 mA·cm^(-2)and 0.25 mAh·cm^(-2),with a significantly reduced overpotential(from 91.8 to 35 mV).With the assistance of the PEDOT protective layer,the PEDOT@Zn//Cu battery maintained approximately 99.5%Coulombic efficiency after 450 ***-situ scanning electron microscopy(SEM)and in situ optical microscopy characterizations further confirmed that the PEDOT protective layer can effectively suppress the growth of zinc ***,the Zn-ion capacitors assembled by the PEDOT@Zn and activated carbon also demonstrated outstanding cycling stability.

关键词： zinc-ion devices zinc anode poly(3 4-ethylenedioxythiophene)(PEDOT) dendrite desolvation process

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Increased carotid intima-media thickness(CIMT) levels in patients with type 1 diabetes mellitus(T1DM):a meta-analysis

Increased carotid intima-media thickness(CIMT) levels in pat...

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第九届全国免疫学学术大会

作者： yi-peng sun Yuan-Yuan Cai Hong-Miao Li Sen-Miao Deng Rui-Xue Leng Hai-Feng Pan Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical University Anhui provincial laboratory of population health & major disease screening and diagnosis Anhui Medical University

Background:Type 1 diabetes mellitus(T1DM)is associated with an increased cardiovascular(CV)morbidity and mortality as compared with the general *** disease is based on atherosclerosis(AS).And carotid inti-ma-media thickness(CIMT)level is the symbol of early atherosclerosis,it has been shown to be the marker of preclinical *** is widely used as a noninvasive method to detect the atherosclerosis and to forecast cardiovascular disease in patients with *** recent years,a great many of studies have been performed to compare the mean CIMT difference between patients with T1DM and healthy ***,these studies have shown inconsistent or even contradictory ***:To derive a more precise estimation of CIMT levels in patients with T1DM by ***:PubMed and Embase databases were searched to identify all available studies comparing CIMT levels between T1DM group and control ***-analysis was performed to compare the difference of overall mean CIMT levels between the two *** bias was evaluated by funnel plot,Begg’test and Egger’***-regression analysis was conducted to investigate the influential factors on CIMT *** meta-analysis was conducted by STATA 12.0 ***:738 articles were obtained after searching databases,47 studies were finally included in the *** heterogeneity was observed among these studies(Q=768.75,P<0.001,I2=94.0%).Compared with control group,T1DM group had significantly higher CIMT levels(standardized mean difference:1.01,95%CI:0.75-1.28;P<0.001).A likely source of heterogeneity was NOS scores and sample size ratio of patents and *** funnel plot did not show a skewed or asymmetrical shape,and the result of Begg’test and Egger’test was P=0.178 and P=***,it could be assumed that publication bias was not ***:T1DM patients have significantly increased CIMT levels compared

关键词： type 1 diabetes mellitus carotid intima-media thickness atherosclerosis meta-analysis

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Effect of microinjecting GABAA-receptor antagonist into the tuberomammillary nucleus on the sleep-wakefulness cycle after lesion of the ventrolateral preoptic area in rats

Effect of microinjecting GABAA-receptor antagonist into the ...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xin ZHANG,yi-Na sun,peng XIE,Xu-Guang YANG,yi-Ping HOU~* Department of Neuroscience and Anatomy,Histology and Embryology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000

Objective Recent evidences have demonstrated that the interaction between GABAergic neurons in the ventrolateral preoptic area(VLPO) and histaminergic(HA) neurons in the tuberomammillary nucleus(TMn) plays a key role for regulating sleep-wakefulness ***,GABAergic neurons in TMn have not received much attention for their role in sleep-wakefulness *** aim of this study is to investigate the effect of GABAergic neurons in the TMn on sleep-wakefulness *** Male SD rats(250-300 g,n=15) were randomized into 3 groups:before lesion group (n=5),VLPO lesion group(n=5) and VLPO lesion plus bicuculline treated group(n=5).The 4 EEG screw electrodes were implanted into the skull under anesthesia with pentobarbital(35 mg/Kg,ip),and three flexible EMG wire electrodes were placed into the nechal *** free ends of the leads were soldered into a *** cannular for microinjection were implanted into the adjacent of TMn(Aβ-4.2 mm,ML±1.3 mm,DV-7.4 mm).All implantations were affixed to the skull with dental cement,except the area(0.5 cm) around the bregma filling with bone wax that was *** week after surgery,the sockets were connected via flexible recording cables to EEG polygraph,signals were digitized by CED Micro 1401 and computer running the Spike 2 recording system.A 24 h basic wake-sleep states in before lesion group were recorded and analyzed by manually scored in 30 s epochs on the digitized EEG/*** the 8th day,a fine glass micropipette(10-20 mm tip diameter) containing ibotenic acid solution for specific cell damage(10 nM/0.5μ,Sigma) was injected into the VLPO on each side after bone wax removed under *** week after the second surgery,rats of VLPO lesion group were recorded for sleep-wakefulness *** the 10th day after lesion of VLPO,bicuculline(10 nM/0.5μ),a GABA-receptor antagonist,was microinjected into the TMn and recorded sleep-wakefulness states for 24 ***(1) The ratio during 24 h of wakefulness(

关键词： GABAergic neurons GABAA-receptor antagonist histaminergic neuron neurotoxic lesion tuberomammillary nucles ventrolateral preoptic area

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo sun Huijun Wang yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu yifei Yang yike Jing Zhen Zeng Xuesong yi Wei sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning sun Yuan Li Tifei Yuan Daihui peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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