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Interannual succession of phytoplankton community in a canyon-shaped drinking water reservoir during the initial impoundment period:Taxonomic versus functional groups

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Journal of Environmental Sciences 2025年第5期151卷 454-468页

作者： yi Hou Ya Cheng Kai Li Meng Yang Kangzhe huang Gang Ji Ruikang Xue Tinglin huang Gang Wen Shaanxi Provincial Field Scientific Observation and Research Station of Water Quality in Qinling Mountains Xi’an University of Architecture and TechnologyXi’an 710055China Key Laboratory of Northwest Water Resource Environment and EcologyMOEXi’an University of Architecture and TechnologyXi’an 710055China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

During the initial impoundment period of a canyon-shaped reservoir,the water body fluctuated violently regarding water level,hydrological condition,and thermal *** variations may alter the structure of phytoplankton community,resulting in algal blooms and seriously threatening the ecological security of the *** is of great significance to understand the continuous changes of phytoplankton in the initial impoundment period for the protection of reservoir water ***,a two-year in-situ monitoring study was conducted on water quality and phytoplankton in a representative canyonshaped reservoir named Sanhekou and the interannual changes of phytoplankton community and its response to environmental changes during the initial impoundment period were discussed at taxonomic versus functional classification *** results showed that the total nitrogen and permanganate index levels were relatively high in the first year due to rapid water storage and heavy rainfall input,and the more stable hydrological conditions in the second year promoted the increase of algae density and the transformation of community,and the proportion of cyanobacteria increased *** succession order of phytoplankton in the first year of the initial impoundment periodwas Chlorophyta-Bacillariophyta-Chlorophyta,or J/F/X1-P/MP/W1-A/X1/MP,*** the succession order in the second year was Cyanobacteria/Chlorophyta-Bacillariophyta-Chlorophyta,or L_(M)/G/P-P/A/X1-X1/J/*** temperature,relativewater column stability,mixing depth,and pHwere crucial factors affecting phytoplankton community *** study revealed the interannual succession law and driving factors of phytoplankton in the initial impoundment period and provided an important reference for the operation management and ecological protection of canyon-shaped reservoirs.

关键词： Canyon-shaped reservoir Functional groups Initial impoundment Interannual succession Water quality

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-yi Cen Shan-Jin Lu Rui-Sui huang Qiong Chen Li-Feng huang Jian-ning huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

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Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota

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World Journal of Gastroenterology 2025年第7期31卷 110-129页

作者： yi-Tong Qiu Xin-yi Luo Ya-Feng Deng Xue Zheng Jian-Guo Qiu Lin-Sheng Zhang Xiao-Qi huang Xue-Bao Zheng Hai-Yang huang School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 525000Guangdong ProvinceChina Druggability Research Team Dongguan Institute of Guangzhou University of Chinese MedicineDongguan 523808Guangdong ProvinceChina Institute of Traditional Chinese Medicine Dongguan Hospital of Traditional Chinese MedicineDongguan 523000Guangdong ProvinceChina

BACKGROUND Modified Pulsatilla decoction(PD),a PD with licorice and ejiao,is a classic Traditional Chinese Medicine formula with significant efficacy in treating intestinal mucositis(IM)induced by tumor ***,its specific molecular and biological mechanisms remain *** To investigate the therapeutic effect and mechanism of modified PD in *** This study used an IM mouse model established using 5-fluorouracil injections to investigate the effects of the modified PD(3,6,and 12 g/kg)in *** primary chemical components of the modified PD were identified using liquid chromatography-mass *** weight loss,diarrhea scores,intestinal length,histopathological scores,and inflammatory cytokine levels were measured to evaluate the effects of the modified PD in *** on the TLR4/MyD88/NF-κB pathway were evaluated using western blot *** intestinal microbiota was characterized using Illumina NovaSeq *** The results showed that modified PD significantly improved weight loss and diarrhea and shortened the intestines in IM ***,modified PD suppressed the TLR4/MyD88/NF-κB pathway and downregulated the expression of reactive oxygen species,lipopolysaccharides,and pro-inflammatory cytokines(IL-1β,TNF-α,IFN-γ,IL-6,IL-8,and IL-17),while increasing the expression of the anti-inflammatory cytokine ***,modified PD protected the intestinal mucosal barrier by increasing the expression of tight junction proteins(occludin-1,claudin-1,and ZO-1)and ***,16S rDNA sequencing revealed that modified PD improved intestinal *** Our research offers new insights into the potential mechanism of modified PD in alleviating IM and provides experimental evidence supporting its pharmaceutical application in clinical IM treatment.

关键词： Modified Pulsatilla decoction Intestinal mucositis Oxidative stress Gut microbiota,TLR4/MyD88/NF-κB pathway Inflammatory response

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Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

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Palindrome-mediated DNA nanotubes with cell-specific aptamers to improve targeted antitumor effects and reduce toxicity on non-small cell lung cancer

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Science China(Life Sciences) 2025年第2期68卷 454-466页

作者： Cheng Zheng Lanlan Song Chang Yu Lingye Zhu Jing Zhang ning Wang Mengchu Liu Shini Li Liangxing Wang Zhifa Shen Xiaoying huang Division of Pulmonary Medicine the First Affiliated Hospital of Wenzhou Medical UniversityKey Laboratory of Interdiscipline and Translational MedicineWenzhou 325000China Intervention Department the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of Laboratory Medicine Ministry of Education of Chinaand Zhejiang Provincial Key Laboratory of Medical GeneticsSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou 325035China

Chemotherapy is regarded as a widely used and effective treatment strategy for lung cancer,although most conventional chemotherapeutics cause severe toxic side-effects due to their indiscriminate attacks on both cancerous and normal *** nucleic acid nanomaterials are emerging as a promising drug delivery strategy,their clinical applications are limited by rapid degradation by nucleases and difficulties in targeting cancer *** this study,we have developed a Rhein-loaded aptamer-based DNA nanotube(DNT-S6@Rhein)for the targeted and efficient therapy of non-small cell lung *** the palindrome segments,two specified oligonucleotides were hybridized and folded into the well-defined nanotubes(DNT-S6),with the S6 aptamer distributed *** obtained nanotubes exhibited excellent serum stability and targeting ability towards A549 cells due to the firm structure and decoration of the S6 ***,as an antitumor drug and DNA intercalator,can be effectively inserted into the *** drug-loaded nanotubes rapidly disassembled in intracellular environment and then the released Rhein was found to activate cellular apoptotic process and significantly suppress proliferation,migration and invasion of A549 ***,DNT-S6@Rhein could efficiently accumulate in tumor regions,offering compelling therapeutic efficacy and biocompatibility under both in vitro and in vivo *** findings of this study provide a promising strategy for mitigating the inevitable systemic side-effects of chemotherapy and expand the potential application of DNA nanostructure on targeted drug delivery.

关键词： DNA nanotube self-assembly Rhein targeted drug delivery cancer therapy

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Metallized polymer current collector as “stress acceptor” for stable micron-sized silicon anodes

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Journal of Energy Chemistry 2025年第2期101卷 786-794页

作者： Ziyi Cao Haoteng Sun yi Zhang Lixia Yuan Yaqi Liao Haijin Ji Shuaipeng Hao Zhen Li Long Qie Yunhui huang State Key Laboratory of Material Processing and Die & Mold Technology School of Materials Science and Engineering Huazhong University of Science and Technology Department of Chemistry Brown University

Micron-sized silicon（μSi） is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant ***,the volume expansion that occurs during cycling leads to the accumulation of undesirable stresses,resulting in pulverization of silicon microparticles and shortened lifespan of the ***,a composite film of Cu-PET-Cu is proposed as the current collector（CC） for μSi anodes to replace the conventional Cu ***-PET-Cu CC is prepared by depositing Cu on both sides of a polyethylene terephthalate（PET） *** PET layer promises good ductility of the film,permitting the Cu-PET-Cu CC to accommodate the volumetric changes of silicon microparticles and facilitates the stress release through ductile *** a result,the μSi electrode with Cu-PET-Cu CC retains a high specific capacity of 2181 mA h g-1,whereas the μSi electrode with Cu CC（μSi/Cu） exhibits a specific capacity of 1285 mA h g-1after 80 *** stress relieving effect of CuPET-Cu was demonstrated by in-situ fiber optic stress monitoring and multi-physics *** work proposes an effective stress relief strategy at the electrode level for the practical implementation of μSi anodes.

关键词： Electrode design Metallized polymer current collector Micron-sized Si anodes Stress relieving

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Understanding and probing progression of localized corrosion on inner walls of steel pipelines:an overview

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Journal of Iron and Steel Research International 2025年第1期32卷 1-18页

作者： Ming-yu Wang Hai-yuan Yao Yong-fei Liu Ye-sen Zhu Wan-bin Chen Yun-ze Xu yi huang School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024LiaoningChina China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024LiaoningChina

Corrosion poses a major threat to the safety of transportation ***,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline *** research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis *** advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was *** on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical ***,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is ***,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.

关键词： Pipeline steel Localized corrosion Corrosion type Corrosion monitoring Corrosion mechanism

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Smoke and NO_(x)emission characteristics of in-use construction machinery base on substantial field measurement:A case study in Beijing,China

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Journal of Environmental Sciences 2025年第3期149卷 386-393页

作者： Huawei yi Yangyang Cui Lijun Zhu Yan Shen Han Li Guanghan huang Linzhen Qu Dongdong Guo Lei Nie yifeng Xue National Engineering Research Center of Urban Environmental Pollution Control Beijing Municipal Research Institute of Eco-Environmental ProtectionBeijing 100037China Beijing Vehicle Emission Management Affairs Centre Beijing 100176China

To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission level of smoke and NO_(x).The exhaust smoke level and excessive emission situation of different machinery types were identified,and their NO_(x)emission levels were monitored according to the free acceleration *** investigated the correlation of NO_(x)and smoke emission,and proposed suggestions for controlling pollution discharge from construction machinery in the *** results show that the exhaust smoke level was 0–2.62 m^(−1),followed a log-normal distribution(μ=-1.73,δ=1.09,R^(2)=0.99),with a 5.64%exceedance *** observed amongmachinery types,with low-power engine forklifts showing higher smoke *** NO_(x)emission range was 71–1516 ppm,followed a normal distribution(μ=565.54,δ=309.51,R^(2)=0.83).Differences among machinery types were relatively *** rated net power had the most significant impact on NO_(x)***,NO_(x)emissions from construction machinery need further ***,we found a weak negative correlation(p<0.05)between the emission level of smoke and NO_(x),that is the synergic emission reduction effect is poor,emphasizing the need for NO_(x)emission *** the future,the oversight in Beijing should prioritize phasing out ChinaⅠand ChinaⅡmachinery,and monitor emissions from highpower engine ChinaⅢmachinery.

关键词： Fuel-oil construction machinery Smoke NO_(x) Emission level Regulatory suggestion

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Dark energy effects on surface gravitational redshift and Keplerian frequency of neutron stars

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Communications in Theoretical Physics 2025年第1期77卷 122-129页

作者： Jia-Jing He Yan Xu yi-Bo Wang Xiu-Lin huang Xing-Xing Hu Yu-Fu Shen Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

Research on the properties of neutron stars with dark energy is a particularly interesting yet unresolved problem in *** analyze the influence of dark energy on the equation of state,the maximum mass,the surface gravitational redshift and the Keplerian frequency for the traditional neutron star and the hyperon star matter within the relativistic mean field theory,using the GM1 and TM1 parameter sets by considering the two flavor symmetries of SU(6)and SU(3)combined with the observations of PSR J1614-2230,PSR J0348+0432,PSR J0030+0451,RX J0720.4-3125,and 1E *** is found that the existence of dark energy leads to the softened equations of the state of the traditional neutron star and the hyperon *** radius of a fixed-mass traditional neutron star(or hyperon star)with dark energy becomes smaller,which leads to increased *** existence of dark energy can also enhance the surface gravitational redshift and the Keplerian frequency of traditional neutron stars and hyperon *** growth of the Keplerian frequency may cause the spin rate to speed up,which may provide a possible way to understand and explain the pulsar glitch ***,we infer that the mass and the surface gravitational redshift of PSR J1748-2446ad without dark energy for the GM1(TM1)parameter set are 1.141 M_(☉)(1.309 M_(☉))and 0.095(0.105),*** corresponding values for the GM1(TM1)parameter set are 0.901 M_(☉)(1.072M_(☉))and 0.079(0.091)if PSR J1748-2446ad contains dark energy withα=*** J1748-2446ad may be a low-mass pulsar with a lower surface gravitational redshift under our selected models.

关键词： dark energy neutron stars gravitational redshift Keplerian frequency

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Dual-functional additive of cesium ion for achieving ultrahigh efficiency of persistent phosphorescence in existing polymer-based materials

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Science China Chemistry 2025年第2期68卷 754-762页

作者： Yao Liu Jinzheng Chen yiling Miao Kaimin Zhang Faxu Lin Huahua huang Lina Zhang Zhan Yang yi Zhang Zhenguo Chi Zhiyong Yang Key Laboratory for Polymeric Composite&Functional Materials of Ministry of Education Guangdong Engineering Technology Research Center for High-performance Organic and Polymer Photoelectric Functional FilmsGuangdong Basic Research Center of Excellence(GBRCE)for Functional Molecular EngineeringSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China College of Materials Science and Engineering Hebei University of EngineeringHandan 056038China School of Environmental and Chemical Engineering Wuyi UniversityJiangmen 529020China

Despite great achievements obtained for polymer-based room-temperature phosphorescence(RTP)materials,the limited efficiencies of persistent RTP still hinder their ***,a simple and universal strategy of using the dual-functional additive of Cs+was presented,which could simultaneously enhance the efficiency(Φp)and maintain the long lifetime(τp)of RTP in existing polymer-based systems with various phosphors and *** them,the commercial emitter(TpB)-doped polyvinyl alcohol(PVA)/Cs_(2)CO_(3) system possessed an extremely high Φp up to 75.5% and still maintained a longτp of 2.13 s,by introducing the heavy-atom effect and an extra network of ionic bonding through the Cs+***,the temperature resistance of RTP in TpB@PVA/Cs+film could also be improved to 85℃.More satisfactorily,the efficiency of Förster resonance energy transfer(FRET)from RTP to near-infrared(NIR)was also remarkably enhanced in the multi-component *** work provides a simple and universal strategy for developing polymer systems with high RTP performance.

关键词： persistent phosphorescence cesium carbonate efficiency heavy-atom effect ionic interaction

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