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Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

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BIOCELL 2024年第7期48卷 1011-1022页

作者： JUN-FENG ZHAO yi-ran JIANG TIAN-LIN GUO YONG-QING JIAO XUN WANG Department of Neurointervention Center Dalian No.3 People’s HospitalDalian Medical UniversityDalianChina Department of Clinical Medicine China Medical UniversityShenyangChina

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the *** are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of *** the global population ages rapidly,increased people are being diagnosed with neurodegenerative *** has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neuroﬁbrillary tangles(NFTs),neuronal death as well as synaptic *** involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual *** instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inﬂammatory functions and act as a physical barrier after recognizing various ligands such as Aβand ***,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inﬂammatory *** can amplify the neuroinﬂammatory *** rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular *** can also increase the transformation of microglia from anti-inﬂammatory phenotype M2 to pro-inﬂammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of *** to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their speciﬁc roles and functions implicated in AD,and expect that there will be more in-depth research and scientiﬁc research results in the treatment of AD by targeted regulation of mi

关键词： Neurodegeneration Glial cell Receptor Alzheimer’s disease

Nitric oxide synthase-guided genome mining identifies a cytochrome P450 enzyme for olefin nitration in bacterial specialized metabolism

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Synthetic and Systems Biotechnology 2024年第1期9卷 127-133页

作者： Hu Li Wei Li Kaihui Song Yu Liu Guiyun Zhao yi-ling Du Polytechnic Institute Zhejiang UniversityHangzhou310022China Department of Microbiology Zhejiang University School of MedicineHangzhou310058China College of Life Sciences Zhejiang University310058HangzhouChina

The biological signaling molecule nitric oxide(NO)has recently emerged as a metabolic precursor for the creation of microbial natural products with diversified structures and biological *** the biosynthetic gene clusters(BGCs)of these compounds,genes associated with NO production pathways have been *** this study,we employ a nitric oxide synthase(NOS)-guided genome mining strategy for the targeted discovery of NO-derived bacterial natural products and NO-utilizing *** show that a conserved NOS-containing BGC,distributed across several actinobacterial genomes,is responsible for the biosynthesis of lajollamycin,a unique nitro-tetraene-containing antibiotic whose biosynthetic mechanism remains *** a combination of in vivo and in vitro studies,we unveil the first cytochrome P450 enzyme capable of catalyzing olefin nitration in natural product *** results not only expand the current knowledge about biosynthetic nitration processes but also offer an efficient way for targeted identification of NO-utilizing metabolic pathways and novel nitrating biocatalysts.

关键词： Nitric oxide Genome mining Biosynthesis Nitration Cytochrome P450

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-ling Xiao Yue Gong ying-Jia Qi Zhi-Ming Shao yi-Zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

In-situ analysis and genetic investigation of Li-bearing minerals in McDermitt clay-type lithium deposit,Nevada,USA

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Acta Geochimica 2024年第3期43卷 478-488页

作者： yi Cui Hanjie Wen Zhengbing Zhou Kunyue ling Lin Xu Shirong Liu Fei Xu School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth Sciences and Resources Chang’an UniversityXi’an 710054China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Clay-type Li deposits are poised to play a pivotal role in addressing the surging global demand for *** McDermitt clay-type Li deposit,located in Nevada,is the largest Li deposit in the United States,with Li hosted by a clay-rich sequence of smectite-dominated intervals and illite-dominated intervals,***,the occurrence of Li and the genesis of Li-bearing minerals within smectite-dominated intervals have not been thoroughly investigated in previous ***,we studied the mineralogy,the in-situ Li distribution,and the bonding environments of Li within the smectite intervals using a combination of instru-mental techniques including scanning electron microscope,transmission electron microscope,time-of-flight secondary ion mass spectrometry,and nuclear magnetic *** results indicate that the smectite exhibits low crystallinity characteristics of lacustrine clay authigenesis and is com-monly found tofill the interstices among volcanic minerals or envelop them;Li is mainly hosted by Mg-smectite rather than the volcanic *** the tuffaceous sediment samples,the volcanic glass has undergone a transformation,resulting in its complete disappearance and alteration into clay *** to the octahedral sites of Mg-smectite bounded in Li,it is referred to be *** interpret that the hectorite’s precipitation occurs in a high saline-alkaline water environment,a result of McDermitt *** conclusion can be supported by the coexistence of spherulitic calcite and ***,this study confirms hectorite as the main Li-bearing mineral and increases the understanding of the genetic model of hectorite formation in intracontinental caldera basins.

关键词： McDermitt caldera Lithium occurrence Tuffaceous sediments Mineralogy Hectorite neoformation

Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia

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Fundamental Research 2024年第4期4卷 829-840页

作者： Liang Zhou Qipeng ran Rulan yi Huanyao Tang Yu Zhang Tian Yu Key Laboratory of Brain Science Zunyi Medical UniversityZunyi 563003China Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003China Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical UniversityZunyi 563003China

Since their clinical application in the 1840s,the greatest mystery surrounding general anesthesia(GA)is how different kinds of general anesthetics cause reversible unconsciousness,and the precise neural mechanisms underlying the *** past years,although many studies revealed the roles of cortex,thalamus,brainstem,especially the sleep-wake circuits in GA-induced loss of consciousness(LOC),the full picture of the neural circuit mechanism of GA is still largely *** studies have focused on the importance of other brain ***,we report that the activity of glutamatergic(Glu)neurons in the piriform cortex(PC),a critical brain region for odor encoding,began to increase during the LOC of GA and gradually recovered after recovery of *** lesions of the anterior PC(APC)neurons accelerated the induction time of isoflurane *** and optogenetic activation of APcGlu neurons prolonged isoflurane and sevoflurane anesthesia induction,whereas APcclu neuron inhibition displayed the opposite ***,the modification of APcclu neurons did not affect the induction or emergence time of propofol *** addition,odor processing may be partially involved in the induction of isoflurane and sevofurane GA regulated by APCclu *** conclusion,our findings reveal a critical role of APCGlu neurons in inhalational GA induction.

关键词： Piriform cortex Inhalationalgeneral anesthesia Glutamatergic Induction time odor

Understanding the combustion behavior of electric bicycle batteries and unveiling its relationship with fire extinguishing

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Journal of Energy Chemistry 2024年第4期91卷 609-618页

作者： Zhanglong Yu Xueling Shen ran Xu Zheng Wang Zengming Wan Mingyang Chen yi Cui Yanyan Fang Xiaoli Ma China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Grinm Group Co. Ltd.Beijing 100088China Ministry of Industry and Information Technology Equipment Industry Development CenterBeijing 100846China Hefei Guoxuan High-tech Power energy Co. Ltd.Hefei 230000AnhuiChina

In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was *** research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat *** results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same *** on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different *** this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.

关键词： Combustion behavior Electric bicycle Lithium-ion battery Fire extinguishing Normalized total heat release

Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt_(1)/Ni and Pt_(1)/Co single-atom alloy catalysts

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Rare Metals 2024年第6期43卷 2859-2868页

作者： Huan-Shi Lan yi-Da Yang Qing-Di Sun Hao Zhang ying Zhang Qian He ran Chen Guo-yi Bai Xiao-Hui He Hong-Bing Ji School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education Fine Chemical Industry Research InstituteSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou510275China UBFC CNRSENSMMFEMTO-ST Institute25030 Besancon CEDEXFrance College of Chemistry and Materials Science Hebei UniversityBaoding 071002China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Selective hydrogenation of C=C and C=O bonds in cinnamaldehyde(CAL)to produce desired products is a challenging task due to the complex conjugate system of the two unsaturated functional *** this study,a simple ball milling method is presented for synthesizing Pt-based single-atom alloy catalysts(SAAs)that can function as a control switch for the selective hydrogenation of CAL into highly valuable products.

关键词： alloy hydrogenation conjugate

Pleomorphic rhabdomyosarcoma of the vagina: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2396-2403页

作者： Pan Xu Shan-Shan ling E Hu Bi-Xia yi Department of Gynecology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000Zhejiang ProvinceChina Zhejiang University School of Medicine Hangzhou 310006Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)of the vagina in postmenopausal women is an extre-mely rare malignant tumor that was originally described as a unique group of soft tissue sarcomas originating from primitive mesenchymal *** was first re-ported in postmenopausal women in 1970,and fewer than 50 postmenopausal patients have been reported to *** SUMMARY A 68-year-old multiparous female was admitted to the hospital on October 11,2023,with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 *** vaginal mass was approximately the size of a pigeon egg;after lying down,the vaginal mass *** resection was performed,and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining *** patient is currently undergoing *** present study also reviewed the clinical,histolo-gical,and immunohistochemical features and latest treatment recommendations for vaginal *** abnormal vaginal mass should be promptly investigated through pelvic examination and appropriate *** current initial treat-ment for vaginal RMS is biopsy and primary *** When surgery is planned for vaginal RMS,an organ-preserving approach should be considered.

关键词： Rhabdomyosarcoma Vagina Postmenopausal woman Pleomorphic Case report

Atmospheric Particulate Matter 2.5(PM_(2.5))Induces Cell Damage and Pruritus in Human Skin

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Biomedical and Environmental Sciences 2024年第2期37卷 216-220页

作者： HE Qiao XUE Wan Ting LI Li yi Fan ling Xiao GUO Miao Miao College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China China Light Industry Cosmetics Key Laboratory Beijing Technology and Business UniversityBeijing 100048China Beijing Lan Divine Technology Co.LTD Beijing 100872China

With the accelerated rate of urbanization in recent years,air pollution has become an environmental problem that requires urgent resolution,almost all of the world’s population exposed to pollution on a daily *** the... 详细信息

关键词： pollution Skin Human