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Success of susceptibility-guided eradication of Helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates

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World Journal of Gastroenterology 2024年第2期30卷 184-195页

作者： Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han yi-ling li Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in liaoning Education Department The First Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(***)is increasing in severity,and successful eradication is ***,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment *** To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided *** We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April *** underwent a string test after an overnight *** gastric juice was obtained and transferred to vials containing storage ***,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the *** on these results,the participants were administered susceptibility-guided *** was compared with that of the empiric treatment *** A total of 132 individuals tested positive for the *** ureA gene by qPCR *** resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,*** antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,*** eradication rates of these two treatment strategies were significantly

关键词： Helicobacter pylori Antibiotic resistance Clarithromycin Levofloxacin String-test Susceptibility-guided therapy Eradication rate

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A New Dimeric Phthalide from Angelica sinensis

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Chinese Chemical Letters 2006年第12期17卷 1579-1581页

作者： ling yi Ping li Zhi Ming BI Key Laboratory of Modem Chinese Medicines Ministry of Education and Department of Pharmacognosy China Pharmaceutical University Nanjing 210009

A new dimeric phthalide named Z, Z＇-3.3＇a, 7.7＇a-diligustilide was isolated from the roots of Angelica sinensis. Its structure was determined using spectroscopic methods and X-ray crystallographic diffraction analy... 详细信息

关键词： Angelica sinensis dimeric phthalide X-ray diffraction.

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Pituitary stalk interruption syndrome and liver changes:From clinical features to mechanisms

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World Journal of Gastroenterology 2020年第44期26卷 6909-6922页

作者： Ze-Yu Wu yi-ling li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Pituitary stalk interruption syndrome(PSIS)is a rare congenital abnormality characterized by thinning or disappearance of the pituitary stalk,hypoplasia of the anterior pituitary and an ectopic posterior *** the etiology of PSIS is still unclear,gene changes and perinatal adverse events such as breech delivery may play important roles in the pathogenesis of *** can cause multiple hormone deficiencies,such as growth hormone,which then cause a series of changes in the human *** the one hand,hormone changes affect growth and development,and on the other hand,they could affect human metabolism and subsequently the liver resulting in nonalcoholic fatty liver disease(NAFLD).Under the synergistic effect of multiple mechanisms,the progression of NAFLD caused by PSIS is faster than that due to other ***,in addition to early identification of PSIS,timely hormone replacement therapy and monitoring of relevant hormone levels,clinicians should routinely assess the liver function while managing PSIS.

关键词： Pituitary stalk interruption syndrome Hormone deficiency Etiology liver change Clinical characteristics Mechanisms

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Lunate dislocation with avulsed triquetral fracture: A case report

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World Journal of Clinical Cases 2022年第1期10卷 331-337页

作者： ling-yi li Cheng-Jyh lin Chih-Yuan Ko Department of Orthopedic Surgery China Medical University HospitalTaichung City 40402Taiwan

BACKGROUND Lunate dislocation is an uncommon traumatic wrist injury that require prompt surgical *** or delayed treatment often leads to a poor *** reduction and surgical repair of disrupted ligaments are done in most cases to prevent long-term joint ***,this method has certain limitations that include partial functional improvement,which poses a high risk for degenerative arthritis and wrist *** SUMMARY A 37-year-old man presented to the Emergency Department of our hospital following a motorcycle *** examination revealed swelling and tenderness of the right hand and *** patient was initially misdiagnosed with a wrist contusion by an emergency physician,but was eventually diagnosed with lunate dislocation associated with a triquetral avulsed fracture,indicated for open reduction and ligament *** performed closed reduction and two Kirschner wire fixations following Tavernier’s *** injured hand was protected with a standard short-arm orthosis for one *** patient returned to normal daily work without discomfort at five months ***,there was no lunate necrosis or arthritis in the latest radiologic *** This case provides evidence that the closed reduction technique for addressing such cases can reduce soft tissue destruction.

关键词： Hand trauma Carpal injury Lunate dislocation Triquetral fracture Closed reduction Case report

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Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection

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World Journal of Clinical Cases 2021年第23期9卷 6639-6653页

作者： Xin-He Zhang Die Huang yi-ling li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Clonorchis sinensis infection is still a major public health *** is estimated that more than 15 million people worldwide are infected,especially in Northeast China,Taiwan,South Korea,and North *** detection of Clonorchis sinensis eggs in feces and bile is still the only gold standard for the diagnosis of Clonorchis sinensis infection,and new detection methods are needed to improve the detection *** Clonorchis sinensis invades the human body,it mainly parasitizes the hepatobiliary ***,it is closely related to hepatobiliary diseases such as cholangitis,bile duct stones,liver fibrosis,and *** increase in immunoglobulin G4(IgG4)caused by Clonorchis sinensis infection is rare and there are few reports about the relevant *** may be related to the inflammatory factors interleukin(IL)-4,IL-10,and IL-13 produced by human phagocytes,T cells,B cells,and other immune cells in the process of resisting the invasion of Clonorchis ***,this finding still needs further clarification and *** article reviews the epidemiology,clinical manifestations,serology,imaging,pathogenic mechanism,and control measures of Clonorchis sinensis infection to help establish the diagnostic process for Clonorchis *** report novel mechanisms of IgG4 elevation due to Clonorchis sinensis infection to provide more experience and a theoretical basis for clinical diagnosis and treatment of this infection.

关键词： liver damage Bile duct damage Hepatobiliary system destruction Clonorchis sinensis infection Immunoglobulin G4 Clinical manifestations

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Mathematical Model,Numerical Simulation and Convergence Analysis of a Semiconductor Device Problem with Heat and Magnetic Influences

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 302-319页

作者： Chang-feng li yi-rang YUAN Huai-ling SONG School of Economics Shandong UniversityJinan 250100China Institute of Mathematics Shandong UniversityJinan 250100China College of Mathematics and Econometrics Hunan UniversityChangsha 410082China

In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical *** important factors,heat and magnetic influences are *** mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical *** influences of magnetic fields are supposed to be weak,and the strength is parallel to the *** elliptic equation is treated by a block-centered method,and the law of conservation is *** computational accuracy is improved one *** equations are convection-dominated,thus are approximated by upwind block-centered *** difference can eliminate numerical dispersion and nonphysical *** diffusion is approximated by the block-centered difference,while the convection term is treated by upwind ***,the unknowns and adjoint functions are computed at the same *** characters play important roles in numerical computations of conductor device *** the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is *** a composite numerical method is shown for solving this problem.

关键词： three-dimensional conductor device problem with heat and magnetic influences upwind blockcentered differences elemental conservation of mass numerical analysis

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Eosinophilic pancreatitis:a review of the pathophysiology,diagnosis,and treatment

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Gastroenterology Report 2021年第2期9卷 115-124,I0001页

作者： Yue Sun Dan Pan Kai Kang Ming-Jun Sun yi-ling li li-Xuan Sang Bing Chang Department of Gastroenterology First Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China Department of Geriatrics First Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China

Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the *** is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical harm to the *** report three cases of EP that were cured by steroids without relapse from 2017 to *** clinical data of the three patients,including clinical manifestations,serological manifestations,imaging(ultrasound,computed tomography,and MRI),pathological diagnosis and treatment,and telephone follow-up of all patients,were retrospectively *** addition,a literature search was conducted on the Web of Science and PubMed databases using key terms related to EP,considering case reports with no restrictions on the date of publication or *** conclusion,we analysed 19 cases and determined the diagnostic criteria for *** diagnostic algorithm for EP can be used to diagnose EP *** hope that our standards and algorithm can reduce the rate of misdiagnosis and contribute to clinical diagnosis and *** addition,we expect to evaluate more EP cases to test our diagnostic criteria and design a systematic diagnostic flow chart.

关键词： eosinophilic pancreatitis rare disease diagnostic criteria mechanism diagram systematic diagnostic flowchart

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Enhancement of low-temperature toughness of Fe-Mn-C-Al alloy by rare earth Ce-modified inclusions

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Journal of Iron and Steel Research International 2024年第1期31卷 157-173页

作者： Guang-kai Yang Chang-ling Zhuang yi-zhuang li Chen Hu Shao-bo li College of Materials and Metallurgy Guizhou UniversityGuiyang550025GuizhouChina Department of Mechanical Engineering University of Hong KongHong Kong999077China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025GuizhouChina

Fe-Mn-C-Al alloys have been recognized as promising materials for certain low-temperature applications due to their exceptional mechanical properties and ***,their limited low-temperature toughness restricts their large-scale applications in specific *** influence of trace amounts of rare earth cerium(Ce)on the low-temperature toughness of Fe-18Mn-0.6C-1.8Al alloys was *** addition of Ce effectively alters the inclu-sions in the alloy,transforming large-sized irregular inclusions into fine ellipsoidal rare earth *** leads to a significant reduction in both the proportion and average size of the inclusions,resulting in their effective dispersion throughout the matrix and improved cryogenic *** presence of Ce-containing inclusions within the matrix reduces stress concentration,thereby inhibiting microcrack formation and improving impact absorption ***-cally,the addition of rare earth Ce alters the fracture behavior of the material at room temperature and low temperature,changing from brittle cleavage fracture to a more ductile failure *** impact toughness of the Fe-Mn-C-Al alloy is significantly improved by the addition of 0.0048 wt.%Ce,particularly at-196℃where the impact toughness reaches 103.6 J/cm^(2),representing an impressive improvement of 87.3%.

关键词： Fe-Mn-C-Al alloy Rare earth Low-temperature toughness Inclusion Fracture

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Two triterpene glycosides from the sea cucumber Bohadschia marmorata Jaeger

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Chinese Chemical Letters 2008年第4期19卷 457-460页

作者： Wei Hua Yuan Yang Hua yi ling li Bao Shu liu Hong Wei Zhang Peng Sun Research Center for Marine Drugs School of PharmacySecond Military.Medical UniversityShanghai 200433PR China

Further studies on the sea cucumber Bohadschia marmorata Jaeger led to the isolation of a new holostan-type triterpene glycoside,Marmoroside C（1）together with a known triterpene glycoside（2）.On the basis of spectroscopic analyses,including two- dimensional NMR techniques,and chemical reactions,the structure of the new triterpene glycoside was elucidated as 3-O-[3-O- methyl-β-D-glucopyranosyl-（1→3）-β-D-glucopyranosyl-（1→4）-β-D-quinovopyranosyl-（1→2）-4-O-sodium-sulfato-β-D-xylo- pyranosyl]-25-acetoxy-22-oxo-9（11）-holostene-3β,12α,17α-triol.

关键词： Sea cucumber Bohadschia marmorata Triterpene glycoside

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FSS: algorithm and neural network accelerator for style transfer

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Science China(Information Sciences) 2024年第2期67卷 253-266页

作者： yi ling Yujie HUANG Yujie CAI Zhaojie li Mingyu WANG Wenhong li Xiaoyang ZENG State Key Laboratory of ASIC & System Fudan University Shanghai Explore X Technology Co. Ltd.

Neural networks(NNs), owing to their impressive performance, have gradually begun to dominate multimedia processing. For resource-constrained and energy-sensitive mobile devices, an efficient NN accelerator is necessary. Style transfer is an important multimedia application. However, existing arbitrary style transfer networks are complex and not well supported by current NN accelerators, limiting their application on mobile devices. Moreover, the quality of style transfer needs improvement. Thus, we design the Fast Style system(FSS), where a novel algorithm and an NN accelerator are proposed for style transfer. In FSS, we first propose a novel arbitrary style transfer algorithm, Fast Style. We propose a light network that contributes to high quality and low computational complexity and a prior mechanism to avoid retraining when the style changes. Then, we redesign an NN accelerator for Fast Style by applying two improvements to the basic NVIDIA deep learning accelerator(NVDLA) architecture. First, a flexible dat FSM and wt FSM are redesigned to enable the original data path to perform other operations(including the GRAM operation)by software programming. Moreover, statistics and judgment logic are designed to utilize the continuity of a video stream and remove the data dependency in the instance normalization, which improves the accelerator performance by 18.6%. The experimental results demonstrate that the proposed Fast Style can achieve higher quality with a lower computational cost, making it more suitable for mobile devices. The proposed NN accelerator is implemented on the Xilinx VCU118 FPGA under a 180-MHz clock. Experimental results show that the accelerator can stylize 512×512-pixel video with 20 FPS, and the measured performance reaches up to 306.07 GOPS. The ASIC implementation in TSMC 28 nm achieves about 22 FPS in the case of a 720-p video.

关键词： neural network accelerator style transfer neural network deep learning

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