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World Journal of Clinical Cases 2021年第35期9卷 11036-11042页

作者： Ka-Na Wang Qing-Qing Chen yi-lin zhu Chun-lin Wang Department of Pediatrics The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Androgen insensitivity syndrome is an X-linked recessive genetic disease caused by mutations in the androgen receptor gene(AR).However,the underlying molecular mechanisms for the majority of AR variants remain *** this study,we identified a point variant in three patients with complete androgen insensitivity syndrome(CAIS),summarized the correlation analysis,and performed a literature *** SUMMARY The proband was raised as a *** infancy,she was first referred to hospital with a right inguinal *** revealed the absence of a uterus and ovaries,and a testis-like structure located at the inguinal *** diagnostic workup detected a 46,XY karyotype,and fluorescence in situ hybridization analysis showed the presence of the SRY *** analysis revealed the excised tissue to be *** years later,she was admitted to our hospital with a lack of breast *** pubic hair and breasts were Tanner stage *** had normal female external *** hormone tests showed normal testosterone levels,low estradiol levels,and high gonadotropin *** two siblings underwent similar examinations,and all three had a rare hemizygous missense mutation in AR:c.2678C>*** vitro functional analyses revealed decreased nuclear translocation in AR-c.2678C>T mutation *** This case of CAIS was caused by an AR variant(c.2678C>T).Functional studies showed impaired nuclear translocation ability of the mutant protein.

关键词： Androgen insensitivity syndrome 46 XY disorders of sex development Variants Androgen receptor gene Ligand-binding domain Case report

Hepatic portal venous gas without definite clinical manifestations of necrotizing enterocolitis in a 3-day-old full-term neonate:A case report

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World Journal of Clinical Cases 2021年第30期9卷 9269-9275页

作者： Ke Yuan Qing-Qing Chen yi-lin zhu Fang Luo Department of Pediatrics The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Neonatal hepatic portal venous gas(HPVG)is associated with a high risk of necrotizing enterocolitis(NEC)and was previously believed to be associated with an increased risk of *** SUMMARY A 3-day-old full-term male infant was admitted to the pediatrics department after presenting with"low blood glucose for 10 min".Hypoglycemia was corrected by intravenous glucose administration and oral breast *** the 3rd d after admission,an ultrasound examination showed gas accumulation in the hepatic portal vein;this increased on the next *** vertical radiograph showed intestinal *** blood examination showed that the total number of white blood cells was normal,but neutrophilia was related to *** was a significant increase in C-reactive protein(CRP).The child was diagnosed with neonatal NEC(early-stage).With nil per os,rehydration,parenteral nutritional support,and anti-infection treatment with no sodium,his hepatic portal vein pneumatosis *** addition,routine blood examination and CRP examination showed significant improvement and his symptoms *** patient was given timely refeeding and gradually transitioned to full milk feeding and was subsequently ***-up examination after discharge showed that the general condition of the patient was *** The presence of HPVG in neonates indicates early *** active anti-infective treatment is effective in treating NEC,minimizes the risk of severe NEC,and reduces the need for *** findings of this study imply that early examination of the liver by ultrasound in a sick neonate can help with the early diagnosis of conditions such as NEC.

关键词： Hepatic portal venous gas Neonates Clinic Ultrasound Early diagnosis Case report

Discussion on Relationship Between Meridians and Viscera of Decreased Ovarian Reserve from the Perspective of"Preventive Treatment of Disease"by Acupuncture

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 111-122页

作者： Si-An Pan Zhi-Miao Murong yi-lin zhu Jia-Wei Song Xiao-Rong Chang Yu Liu Zeng-Hui Yue Department of Professional Acupuncture and Moxibustion College of AcupunctureMoxibustion and TuinaHunan University of Chinese MedicineChangshaHunanChina

Based on extensive historical data,clinical experience,and modern scientific research,we discuss the relationship between meridians and viscera of decreased ovarian reserve(OR)from the perspective of"preventive treatment of disease"by *** is believed that the endogenous protection mechanism of acupuncture in"preventive treatment of disease"lies in harmonizing yin and Yang and dredging meridians;stimulating righteousness and rejecting the evil outside;preventing disease;co-cultivating body and spirit,and regulating *** incidence ofOR dysfunction is closely related to the uterus-related meridians and *** mechanism of acupuncture treatment of OR dysfunction may be related to reproductive endocrine hormone levels,ovarian tissue morphology,immune system,granulosa cell apoptosis,and related signal transduction *** clinical effect of acupuncture treatment of diminished OR is reflected in improving menstruation and ovulation;improving OR function,promoting pregnancy;improving local ovarian microenvironment;improving negative emotions,improving quality of life,and thus affecting pregnancy *** article summarizes the mechanism of action and clinical effect of acupuncture in the treatment of decreased OR function based on recent findings,analyzes the advantages and disadvantages of acupuncture in the treatment of disease,and provides the rationale for the clinical application of acupuncture in the treatment of decreased OR function.

关键词： Acupuncture ovarian reserve dysfunction preventive treatment of disease theoretical discussion

Relationship between Maternal PBMC HBV cccDNA and HBV Serological Markers and its Effect on HBV Intrauterine Transmission

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Biomedical and Environmental Sciences 2019年第5期32卷 315-323页

作者： WANG Dan Dan yi lin zhu WU Li Na YANG Zhi Qing HAO Hai Yun SHI Xiao Hong WANG Bo FENG Shu ying FENG Yong Liang WANG Su Ping Department of Epidemiology Shanxi Medical UniversityTaiyuan 030001ShanxiChina Department of Obstetrics and Gynaecology the Third People’s Hospital of Taiyuan CityTaiyuan 030001ShanxiChina

Objective To investigate the relationship between maternal peripheral blood mononuclear cells (PBMC) hepatitis B virus(HBV) covalenty closed circular deoxyribonucleic acid(cccDNA) and other HBV serological markers and its effects on HBV intrauterine transmission. Methods We enrolled 290 newborns and their hepatitis B surface antigen(HBsAg) positive mothers. HBV cccDNA in PBMC and HBV DNA in serum were detected by a real‐time PCR‐TaqM an probe while HBV serological markers were detected with an electrochemiluminescence immunoassay. Results There was a positive correlation between the levels of PBMC HBV cccD NA and serum HBV DNA and HBeA g(r = 0.436 and 0.403, P < 0.001). The detection rate of pattern A [‘HBsA g(+), HBeA g(+), and anti‐HBc(+)’] was significantly higher in the PBMC HBV cccD NA positive group than in the control group(χ^2 = 48.48, P < 0.001). There was a significant association between HBV intrauterine transmission and PBMC HBV cccD NA(χ^2 = 9.28, P = 0.002). In the presence of serum HBV DNA, HBeA g, and PBMC HBV cccD NA, the risk of HBV intrauterine transmission was three times higher(OR = 3.69, 95% CI: 1.30‐10.42) than that observed in their absence. The risk of HBV intrauterine transmission was the greatest(OR = 5.89, 95% CI: 2.35‐14.72) when both PBMC HBV cccD NA and pattern A were present. A Bayesian network model showed that maternal PBMC HBV cccD NA was directly related to HBV intrauterine transmission. Conclusion PBMC HBV cccDNA may be a direct risk factor for HBV intrauterine transmission. Our study suggests that serological markers could be combined with PBMC‐related markers in prenatal testing.

关键词： Hepatitis B virus Intrauterine transmission Peripheral blood mononuclear cells Covalently closed circular deoxyribonucleic acid Serological markers

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青岛城镇大病医疗救助项目的政策分析

中国卫生资源 2015年第3期18卷 203-207页

作者：林苡竹陈文复旦大学公共卫生学院上海200032

依据药品风险共担方案的原理,分析青岛市城镇大病医疗救助特药特材项目的特点,总结其筹资、运作与管理机制,并通过与国际上类似项目进行比较,对青岛特药特材项目进行优势、劣势、机会和威胁(SWOT)分析与预期效果的理论分析,讨论其对药... 详细信息

依据药品风险共担方案的原理,分析青岛市城镇大病医疗救助特药特材项目的特点,总结其筹资、运作与管理机制,并通过与国际上类似项目进行比较,对青岛特药特材项目进行优势、劣势、机会和威胁(SWOT)分析与预期效果的理论分析,讨论其对药品保障模式、价格形成机制、流通模式以及医保谈判机制所带来的影响。

关键词：药品风险共担特药特材项目对比分析

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin Li Xue-Feng zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun zhu yifei Yang yike Jing Zhen Zeng Xuesong yi Wei Sun Fei Yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

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快速近似聚类算法及其在图像检索中的应用

上海交通大学学报 2011年第2期45卷 149-153页

作者：顾王一朱林杨杰上海交通大学图像处理与模式识别研究所系统控制与信息处理教育部重点实验室上海200240

为了解决传统K均值算法在处理大规模数据时的局限性,在近似K均值算法(AKM)基础之上,利用对聚类中心进行分类的思想,提出了快速近似K均值算法(FAKM).该算法舍去了在AKM聚类结果中只获得少数样本的聚类中心,并充分利用类内样本密集稳定的... 详细信息

为了解决传统K均值算法在处理大规模数据时的局限性,在近似K均值算法(AKM)基础之上,利用对聚类中心进行分类的思想,提出了快速近似K均值算法(FAKM).该算法舍去了在AKM聚类结果中只获得少数样本的聚类中心,并充分利用类内样本密集稳定的聚类中心,使得迭代过程中待聚类样本数和类别数逐步减少,达到了提高算法速度及精简聚类结果的目的.将FAKM算法运用于实际的图像检索系统中,实验结果表明,系统在检索准确率、检索时间和聚类时间方面都得到了很好的改善.

关键词：快速聚类近似最近邻图像检索大规模数据