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Dry environment on the expression of lacrimal gland S100A9,Anxa1,and Clu in rats via proteomics

International Journal of Ophthalmology(English edition) 2024年第3期17卷 435-443页

作者： yi-lin sun A-Yuan Cui Li-Xin Wang Wang-Wang Zhang Hong Shi College of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Research on High Incidence of Diseases in Xinjiang Region Key Laboratory of the Ministry of Education(Xinjiang Medical University)Urumqi 830011Xinjiang Uygur Autonomous RegionChina

●AIM:To investigate the underlying mechanism of dry environment(autumn dryness)affecting the lacrimal glands in rats.●METHODS:Twenty Sprague-Dawley rats were randomly divided into two *** rats were fed in specific pathogen free environment as the control group(n=10),and the rats fed in dry environment as the dryness group(n=10).After 24d,lacrimal glands were collected from the *** tissues morphology was observed by hematoxylineosin(HE)*** mass tags(TMT)quantitative proteomics analysis technology was used to screen the differential expressed proteins of lacrimal glands between the two groups,then bioinformatics analysis was ***,the immunohistochemical(IHC)method was used to verify the target proteins.●RESULTS:In dryness group,the lacrimal glands lobule atrophied,the glandular cavities enlarged,the sparse nuclear distribution and scattered inflammatory infiltration between the acinus were *** proteomics exhibited that a total of 195 up-regulated and 236 downregulated differential expressed proteins screened from the lacrimal glands of *** was indicated that the biological processes(BP)of differential expressed proteins mainly included cell processes and single *** cellular compositions of differential expressed proteins mainly located in cells,*** molecular functions of differential expressed proteins mainly included binding,catalytic ***,the Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that the differential expressed proteins mainly involved lysosome,complement and coagulation cascade,and ribosome *** IHC result verified that the up-regulated expression proteins of Protein S100A9(S100A9),Annexin A1(Anxa1),and Clusterin(Clu)in lacrimal glands of rats in dryness group were higher than control group.●CONCLUSION:The up-regulated expression proteins of S100A9,Anxa1,and Clu may be the potential mechanisms of dry eye symptoms caused by dry *** study pr

关键词： dry eye lacrimal gland S100A9 Clu Anxa1 environment rats

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多元化的多样性:连续6周交通日志的购物出行分析(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第3期18卷 234-244页

作者： yi-lin sun Ari TARIGAN Owen WAYGOOD Dian-hai WANG School of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China Cofely Fabricom GDF Suez Kanalsletta 3 Stavanger 4033 Norway Ecole supérieure d'aménagement du terroire et de development regional (ESAD) University Laval Quebec QC GIV 0A6 Canada)

目的:探究个人的购物出行模式随时间的变化差异性。探讨个人在星期中的天变化,量化多样化的特征和识别个体间的异质性。创新点:1.使用连续6周的数据进行动态交通行为分析;2.建立二元逻辑回归模型,识别个体间购物出行模式的异质性。方法... 详细信息

目的:探究个人的购物出行模式随时间的变化差异性。探讨个人在星期中的天变化,量化多样化的特征和识别个体间的异质性。创新点:1.使用连续6周的数据进行动态交通行为分析;2.建立二元逻辑回归模型,识别个体间购物出行模式的异质性。方法:1.通过描述性统计分析,解析不同群体之间的购物行为的差异、每周购物天数的分布以及每周每人购物天数的标准偏差(表1、图1和2);2.通过回归模型分析,得出解释变量对购物地点和频率的影响结论(表2和3);3.构建二元逻辑回归模型,识别个体间购物出行模式的异质性,找出具有常规购物行为的群体(表4)。结论:1.低收入和卡尔斯鲁厄居住地对日常购物目的地的多样性呈正影响关系,而全职工作和男性对日常购物目的地的多样性呈负影响关系;2.连续6周的日常购物出行次数受到35~44岁的年龄范围、2500~2999德国马克的家庭月收入以及市中心居住地区的积极影响;3.购物地点和频率的多样性是随着个人属性和居住地点以系统的方式变化。

关键词：购物行为日常购物购物地点和频率购物出行模式购物出行

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日本大阪都市圈居民的年龄、居住位置与家庭生命周期对小汽车使用与保有的影响（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第7期15卷 517-528页

作者： yi-lin sun Yusak O.SUSILO E.Owen D.WAYGOOD Dian-hai WANG Department of Civil Engineering and Architecture Zhejiang University Department of Transport Science KTH Royal Institute of Technology Teknikringen 10Stockholm 100 44Sweden école Supérieure D’Aménagement du Territoire et de Development Regional University Laval

研究目的:探究城市居民小汽车交通行为变化的原因有多少来自人口统计特性的变化,有多少来自城市结构的改变。创新要点:考虑家庭成员的生活任务分工以及家庭资源的分配等对每个家庭成员出行方式的影响,构建基于家庭生命周期的小汽车出行... 详细信息

研究目的:探究城市居民小汽车交通行为变化的原因有多少来自人口统计特性的变化,有多少来自城市结构的改变。创新要点:考虑家庭成员的生活任务分工以及家庭资源的分配等对每个家庭成员出行方式的影响,构建基于家庭生命周期的小汽车出行行为模型,为控制小汽车出行对策的研究提供准确依据。研究方法:采用调查与统计理论,掌握居民的出行行为特征;基于经济计量学建模方法,构建居民小汽车出行行为联立方程模型。重要结论:城市结构关系的改变在抵消了人口统计特性的变化对小汽车交通产生的负面影响之后,小汽车交通总体呈上升趋势。

关键词：城市小汽车交通家庭生命周期城市结构变化联立方程模型

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Malicious Document Detection Based on GGE Visualization

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Computers, Materials & Continua 2025年第1期82卷 1233-1254页

作者： Youhe Wang yi sun Yujie Li Chuanqi Zhou Henan Province Key Laboratory of Information Security Information Engineering UniversityZhengzhou450000China

With the development of anti-virus technology,malicious documents have gradually become the main pathway of Advanced Persistent Threat(APT)attacks,therefore,the development of effective malicious document classifiers has become particularly ***,detection methods based on document structure and behavioral features encounter challenges in feature engineering,these methods not only have limited accuracy,but also consume large resources,and usually can only detect documents in specific formats,which lacks versatility and *** address such problems,this paper proposes a novel malicious document detection method-visualizing documents as GGE images(Grayscale,Grayscale matrix,Entropy).The GGE method visualizes the original byte sequence of the malicious document as a grayscale image,the information entropy sequence of the document as an entropy image,and at the same time,the grayscale level co-occurrence matrix and the texture and spatial information stored in it are converted into grayscale matrix image,and fuses the three types of images to get the GGE color *** Convolutional Block Attention Module-EfficientNet-B0(CBAM-EfficientNet-B0)model is then used for classification,combining transfer learning and applying the pre-trained model on the ImageNet dataset to the feature extraction process of GGE *** shown in the experimental results,the GGE method has superior performance compared with other methods,which is suitable for detecting malicious documents in different formats,and achieves an accuracy of 99.44%and 97.39%on Portable Document Format(PDF)and office datasets,respectively,and consumes less time during the detection process,which can be effectively applied to the task of detecting malicious documents in real-time.

关键词： Malicious document visualization EfficientNet-B0 convolutional block attention module GGE image

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RF Optimizer Model for Predicting Compressive Strength of Recycled Concrete

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 215-223页

作者： LIU lin WANG Liuyan WANG Hui sun Huayue School of Civil Engineering and Architecture Shenyang UniversityShenyang 110000China

Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed *** address this issue,we introduce two optimized hybrid models:the Bayesian optimization model(B-RF)and the optimal model(Stacking model).These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed ***,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression(SVR),decision tree(DT),and random forest(RF).The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional ***,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by ***,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.

关键词： machine learning recycled concrete compressive strength

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Short-term Preoperative Octreotide for Thyrotropin-secreting Pituitary Adenoma

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Chinese Medical Journal 2017年第8期130卷 936-942页

作者： Hong-Juan Fang Yu Fu Huan-Wen Wu yi-lin sun Yang-Fang Li Ya-Zhuo Zhang Li-Yong Zhong Department of Endocrinology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Pathology Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China Department of Ultropathology Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China Beijing Neurosurgical Institute Beijing Institute for Brain Disorders Brain Tumor Center Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background： Thyrotropin-secreting pituitary adenomas （TSHomas） are a rare cause of hyperthyroidism. Somatostatin （SST） analogs work by interacting with somatostatin receptors （SSTRs）. This study aimed to evaluate short-term preoperative octreotide （OCT） use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue. Methods： We reviewed records and samples from eight TSHoma patients treated between July 2012 and July 2015. We tested immunohistochemically for SSTR2/5 expression and examined TSHoma cells for morphological changes. Signed rank sum test was used to compare the efficacy of short-term preoperative OCT treatment. Results： OCT treatment （median time： 7.9 days, range： 3-16 days; median total dose： 1.8 mg, range： 0.94.2 mg） led to significant decrease in all patients＇ thyroid hormone levels （FT3 [nmol/L]： 8.33 [7.02, 12.29] to 4.67 [3.52, 5.37] [P = 0.008]; FT4 [pmol/L]： 25.36 [21.34, 28.99] to 16.66 [14.88, 21.49] [P = 0.016]; and TSH [gU/ml]： 5.80 [4.37, 6.78] to 0.57 [0.19, 1.24] [P = 0.008]）. All the eight tumor specimens expressed high SSTR2 protein levels; 5/8 expressed high SSTRS, but 3/8 that expressed low SSTR5 presented a significantly higher TS H suppression rate （P = 0.036）. Electron microscopy showed subcellular level impairments, including clumped nuclear chromatin and reduced cytoplasmic volume. Golgi complexes were observed in the OCT-treated TSHoma specimens. Conclusions： OCT can control hormone levels and damage the ultrastructure of tumor cells and organelles. Short-term response to OCT may be related to SSTR5 expression. Preoperative SST analog treatment for TSHoma could be considered as a combination therapy.

关键词： Electron Microscopy Somatostatin Analogs Somatostatin Receptor Therapy Thyrotropin-secreting Pituitary Adenoma

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Diagnostic Significance of Intraoperative Ultrasound Contrast in Evaluating the Resection Degree of Brain Glioma By Transmission Electron Microscopic Examination

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Chinese Medical Journal 2015年第2期128卷 186-190页

作者： Shu-Qing Yu Ji-Sheng Wang Si-Yuan Chen Xiang-Ming Liu Yan Li yi-Ming Ding Xiao-Ya Li yi-lin sun Hui Chen Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Electronic Microscopy Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Statistics Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background：Contrast-enhanced ultrasound is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and *** order to evaluate the diagnostic significance of intraoperative contrast-enhanced ultrasound in assessing the resection degree of brain glioma by transmission electron microscopic （TEM） examination,it is important to have specific knowledge about contrast-enhanced ***：Ultrasound contrast was applied in operations of 120 cases of brain glioma,to evaluate the degree of tumor *** tissues were obtained the suspicious residual tumors surrounding the tumor *** sensitivity and specificity of the residual tumors were determined by the intraoperative ultrasound contrast according to TEM examination ***：There were 44 cases of low-grade gliomas and 76 cases of high-grade *** hundred and sixty biopsy tissues were *** sensitivity of intraoperative ultrasound contrast in diagnosing the residual tumor was 62.2%,while the specificity degree of it was 92.8%.The consistency coefficient of the ultrasound contrast diagnosis and TEM examination results was 0.584 （Kappa =0.584）,which was between 0.4 and 0.6,therefore it was of medium ***：Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of *** consistency of the residual tumor rate detected,respectively,by ultrasound contrast and TEM examination was of medium *** application of intraoperative ultrasound contrast can improve the resection rate of brain glioma.

关键词： Brain Gliona Intra-sutgery Transmissionelectron Microscopic Resection Degree: UltrasoundContrast

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多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物的合成及性能研究

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高分子学报 2016年第11期26卷 1529-1537页

作者：刘新孙仪琳李坚任强汪称意江苏省光伏科学与工程协同创新中心常州大学材料科学与工程学院常州213164

采用电子转移再生催化剂原子转移自由基聚合(ARGET ATRP)制备了端羟基聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物(HO-PBA-b-PMMA),在此基础上,与六亚甲基二异氰酸酯三聚体(N3390)反应,合成了多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段... 详细信息

采用电子转移再生催化剂原子转移自由基聚合(ARGET ATRP)制备了端羟基聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物(HO-PBA-b-PMMA),在此基础上,与六亚甲基二异氰酸酯三聚体(N3390)反应,合成了多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物.通过凝胶渗透色谱(GPC)、核磁共振仪(1H-NMR)、傅里叶变换红外光谱计(FTIR)对聚合物的结构进行了表征,利用原子力显微镜(AFM)观察了其形貌,采用动态热机械分析仪(DMA)和万能拉伸机研究了聚合物的热性能、力学性能及多臂嵌段共聚物对PMMA的增韧性能.结果表明:成功制备了端羟基聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯,以及多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物.在异氰酸酯基/羟基(NCO/OH)摩尔比为1.2/1时,制得的多臂嵌段共聚物相对分子质量最大,Mark-Houwink参数α值最小,表明此时三臂嵌段共聚物最多.多臂嵌段聚合物的拉伸强度和断裂伸长率比线型聚合物均有明显提高,且在NCO/OH摩尔比为1.2/1时达到最大,分别为7.6 MPa和73%.多臂嵌段聚合物具有更高的玻璃化转变温度(Tg).通过原子力显微镜(AFM)表明,多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物形成了以聚丙烯酸丁酯链段为核,聚甲基丙烯酸甲酯为壳的核壳结构.具有核壳结构的多臂聚丙烯酸丁酯-b-聚甲基丙烯酸甲酯嵌段共聚物对聚甲基丙烯酸甲酯有明显的增韧作用.

关键词：多臂嵌段丙烯酸酯增韧

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng Yu Bai Hang Li Meixiu Qu Zhenhua Wang Kening sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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Recent advances of metal vacancies in energy and environmental catalysis:Synthesis,characterization,and roles

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Green Energy & Environment 2025年第1期10卷 84-108页

作者： Long sun Shunzheng Zhao Sirui Gao Ronghui Zhu yiran Tan Xiaolong Tang Honghong yi School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing100083China

With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective ***,being one of the hallmarks of modern industry,offers a promising avenue for ***,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of *** engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent *** vacancies have received extensive attention due to their simple ***,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this ***,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic ***,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.

关键词： Metal vacancies Catalysis Construction strategies Characterization techniques Roles

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