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Electroacupuncture improves myocardial fibrosis in heart failure rats by attenuating ECM collagen deposition through modulation of TGF-β1/Smads signaling pathway

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Traditional Medicine Research 2024年第8期9卷 1-10页

作者： Wen-Hui Wang Qian-lan zeng Jiao-Jiao Zhang Hao-Sheng Wu Sheng-Bing Wu Mei-Qi Zhou College of Acupuncture and Massage Anhui University of Chinese MedicineHefei 230038China Anhui Province Key Laboratory of Meridian Viscera Correlationship Anhui University of Chinese MedicineHefei 230038China

Background: To explore the effects of electroacupuncture on cardiac function and myocardial fibrosis in rat models of heart failure, and to elucidate the underlying mechanism of electroacupuncture in heart failure treatment. Methods: Healthy male Sprague-Dawley rats were allocated into three groups: Sham group, Model group, and electroacupuncture (Model + EA) group, with each group comprising 8 rats. The model underwent a procedure involving the ligation of the left anterior descending coronary artery to induce a model of heart failure. The Model + EA group was used for 7 consecutive days for electroacupuncture of bilateral Shenmen (HT7) and Tongli (HT5), once a day for 30 min each time. Left ventricular parameters in rats were assessed using a small-animal ultrasound machine to analyze changes in left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. Serum interleukin-1β (IL-1β), cardiac troponin (cTn), and N-terminal brain natriuretic peptide precursor levels were measured using ELISA. Histopathological changes in rat myocardium were observed through HE staining, while collagen deposition in rat myocardial tissue was assessed using the Masson staining method. Picro sirius red staining, immunohistochemical staining, and RT-qPCR were utilized to distinguish between the various types of collagen deposition. The expression level of TGF-β1 and SMAD2/3/4/7 mRNA in rat myocardial tissues was determined using RT-qPCR. Additionally, western blot analysis was conducted to assess the protein expression levels of TGF-β1, SMAD3/7, and p-SMAD3 in rat myocardial tissues. Results: Compared with the Sham group, the left ventricular ejection fraction and left ventricular fractional shortening values of the Model group were significantly decreased (P < 0.01);the left ventricular end-diastolic volume and left ventricular end-systolic volume values were remarkably increased (P < 0.01)

关键词： heart failure electroacupuncture heart meridian of Hand-Shaoyin collagen deposition TGF-β1/Smads signaling pathway myocardial fibrosis

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An accurate and efficient space-time Galerkin spectral method for the subdiffusion equation

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Science China Mathematics 2024年第10期67卷 2387-2408页

作者： Wei zeng Chuanju Xu School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High Performance Scientific Computing Xiamen UniversityXiamen 361005China

In this paper, we design and analyze a space-time spectral method for the subdiffusion ***, we are facing two difficulties. The first is that the solutions of this equation are usually singular near the initial time. Consequently, traditional high-order numerical methods in time are inefficient. The second obstacle is that the resulting system of the space-time spectral approach is usually large and time-consuming to solve. We aim at overcoming the first difficulty by proposing a novel approach in time, which is based on variable transformation techniques. Suitable ψ-fractional Sobolev spaces and a new variational framework are introduced to establish the well-posedness of the associated variational problem. This allows us to construct our space-time spectral method using a combination of temporal generalized Jacobi polynomials(GJPs) and spatial Legendre polynomials. For the second difficulty, we propose a fast algorithm to effectively solve the resulting linear system. The fast algorithm makes use of a matrix diagonalization in space and QZ decomposition in time. Our analysis and numerical experiments show that the proposed method is exponentially convergent with respect to the polynomial degrees in both space and time directions, even though the exact solution has very limited regularity.

关键词： subdiffusion equations variable transformation Ψ-Sobolev spaces well-posedness space-time Galerkin spectral method error estimate fast algorithm

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Basilic vein variation encountered during surgery for arm vein port:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2086-2091页

作者： Cheng-Da Hu Rui Lv Ya-Xin Zhao Ming-Hao Zhang Hong-Dou zeng yi-Wen Mao Department of Breast Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Venous variations are uncommon and usually hard to identify,and basilic vein variation is particularly *** vein variation usually presents without any clinical symptoms and is often regarded as a benign *** case was a patient with congenital basilic vein variation encountered during surgery for an infusion *** SUMMARY We documented and analyzed an uncommon anatomical variation in the basilic vein encountered during arm port *** peculiarity has hitherto remained undescribed in the *** offer remedial strategies for addressing this anomaly in the future and precautionary measures to circumvent its *** conducted a comprehensive review of analogous cases in the literature,offering pertinent therapeutic recommendations and solutions,with the aim of enhancing the efficacy and safety of future arm port *** Venous variation is rare and requires detailed intraoperative and postoperative examination to ensure accuracy,so as not to affect subsequent treatment.

关键词： Totally implantable venous access ports Arm ports Venous variation Postoperative breast cancer Systematic review Case report

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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1479-1499页

作者： Xuan-zeng Pei Min Cai Da-Wei Jiang Song-Hai Chen Qing-Qing Wang Hui-Min Lu yi-Fan Lu Department of Hepatological Surgery The First Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Department of General Surgery West China Hospital of Sichuan UniversityChengdu 610044Sichuan ProvinceChina

BACKGROUND Our study investigated the role of FAM53B in regulating macrophage M2 polarization and its potential mechanisms in promoting pancreatic ductal adenocarcinoma(PDAC)*** To further investigate the role of FAM53B in regulating macrophage M2 polarization and its potential mechanism in promoting PDAC *** goal is to determine how FAM53B affects macrophage M2 polarization and to define its underlying mechanism in PDAC *** Cell culture and various experiments,including protein analysis,immunohisto-chemistry,and animal model experiments,were *** compared FAM53B expression between PDAC tissues and healthy tissues and assessed the correlation of FAM53B expression with clinical *** study analyzed the role of FAM53B in macrophage M2 polarization in vitro by examining the expression of relevant ***,we used a murine model to study the role of FAM53B in PDAC metastasis and analyzed the potential underlying *** Our research showed that there was a significant increase in FAM53B levels in PDAC tissues,which was linked to adverse tumor *** findings indicated that FAM53B can enhance macrophage M2 polarization,leading to increased anti-inflammatory factor *** results from the mouse model further supported the role of FAM53B in PDAC metastasis,as blocking FAM53B prevented tumor cell invasion and *** FAM53B promotes PDAC metastasis by regulating macrophage M2 *** discovery could lead to the development of new strategies for treating *** example,interfering with the FAM53B signaling pathway may prevent cancer *** research findings also provide important information for expanding our understanding of PDAC pathogenesis.

关键词： FAM53B Pancreatic ductal adenocarcinoma Tumor metastasis Macrophage polarization

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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang yi-Fu Wang Jie Zheng yi-Ming Lei Zhong-Yuan Chen yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Topologically engineering of π-conjugated macrocycles: Tunable emission and photochemical reaction toward multi-cyclic polymers

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Chinese Chemical Letters 2024年第10期35卷 259-266页

作者： yi Liu Peng Lei Yang Feng Shiwei Fu Xiaoqing Liu Siqi Zhang Bin Tu Chen Chen yifan Li Lei Wang Qing-Dao zeng Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST) Institute of Critical Materials for Integrated Circuits Shenzhen Polytechnic University

The topology of conjugated macrocycles had significant impacts on their photo-physical and photochemical properties. Herein, a series of π-conjugated macrocycles with diverse topology were synthesized via intramolecular McMurry coupling. Their chemical structure and macrocyclic topology were unambiguously confirmed via NMR, MALDI-TOF mass spectra, crystal analysis and scanning tunneling microscopy(STM). Depending on the structural topology and structural rigidity, these cyclic compounds display obviously distinctive emission behavior and photochemical reactions in the solution and in the solid *** phenylene vinylene macrocycle(denoted as MST) exhibiting aggregation-induced emission behavior, was more vulnerable to photo-cyclization in solution and triplet sensitizer promoted photodimerization due to lower strain and more flourishing intramolecular motions. After UV light irradiation,relatively more flexible MST could yield the anti-dimer via triplet excimer on the HOPG surface confirmed by STM investigation. By contrast, highly constrained bicyclic analogue(named as DMTPE) with central tetraphenylethene core, displayed high emission quantum yields of 68% both in solution and in the solid state, and was relatively inert to photochemical reactions and yield syn-dimer on the surface via singlet excimer involved [2 + 2] photo-dimerization. Based on the solution-mediated photo-polymerization of MST moiety, multicyclic porous carbon-rich ribbon connected with four-membered ring was successfully constructed and validated via STM imaging.

关键词： Aggregation-induced emission Conjugated macrocycle Multicyclic ribbon Photochemistry Scanning tunneling microscopy

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Structural integration of solar desalination system

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Science China Materials 2024年第6期67卷 2039-2041页

作者： Diling Yang Hao Zhang Hongbo zeng School of Materials and Environmental Engineering Hunan University of HumanitiesScience and TechnologyLoudi 417000China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada

As population grow and climate change place significant water stress on numerous regions,the demand for efficient and environmentally friendly water resource solutions becomes increasingly *** address this challenge,desalination technology has received much attention and is widely employed,with a recent emphasis on solar-powered solutions driven by the global push for carbon neutrality.

关键词： neutral system integration

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2-O-β-D-Glucopyranosyl-L-ascorbic acid,an ascorbic acid derivative isolated from the fruits of Lycium barbarum L.,ameliorates high fructose-induced neuroinflammation in mice:involvement of gut microbiota and leaky gut

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Food Science and Human Wellness 2024年第1期13卷 241-253页

作者： Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou Jia Mi Lu Lu yi Sun Xiaoxiong zeng Youlong Cao Yamei Yan College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Institute of Wolfberry Engineering Technology National Wolfberry Engineering Research CenterNingxia Academy of Agriculture and Forestry SciencesYinchuan 750002China

Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function *** and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain ***,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in *** was found that AA-2βG prevented HFr D-induced cognitive ***-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory *** beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed ***,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal *** present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky *** a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.

关键词： Neuroinfl ammation Gut microbiota Leaky gut Lipopolysaccharide Fecal microbiome transplantation 2-O-β-D-Glucopyranosyl-L-ascorbic acid

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Achieving structurally stable O3-type layered oxide cathodes through site-specific cation-anion co-substitution for sodium-ion batteries

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Journal of Energy Chemistry 2024年第6期93卷 411-418,I0011页

作者： yihao Shen Chen Cheng Xiao Xia Lei Wang Xi Zhou Pan zeng Jianrong zeng Liang Zhang Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123JiangsuChina Institute for Advanced Study School of Mechanical EngineeringChengdu UniversityChengdu 610106SichuanChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhou 215123JiangsuChina

O3-type layered oxides have garnered great attention as cathode materials for sodium-ion batteries because of their abundant reserves and high theoretical ***,challenges persist in the form of uncontrollable phase transitions and intricate Na^(+)diffusion pathways during cycling,resulting in compromised structural stability and reduced capacity over *** study introduces a special approach employing site-specific Ca/F co-substitution within the layered structure of O_(3)-NaNi_(0.5)Mn_(0.5)O_(2) to effectively address these ***,the strategically site-specific doping of Ca into Na sites and F into O sites not only expands the Na^(+)diffusion pathways but also orchestrates a mild phase transition by suppressing the Na^(+)/vacancy ordering and providing strong metal-oxygen bonding strength,*** as-synthesized Na_(0.95)Ca_(0.05)Ni_(0.5)Mn_(0.5)O_(1.95)F_(0.05)(NNMO-CaF)exhibits a mild O3→O3+O'3→P3 phase transition with minimized interlayer distance variation,leading to enhanced structural integrity and stability over extended *** a result,NNMO-CaF delivers a high specific capacity of 119.5 mA h g^(-1)at a current density of 120 mA g^(-1)with a capacity retention of 87.1%after 100 *** study presents a promising strategy to mitigate the challenges posed by multiple phase transitions and augment Na^(+)diffusion kinetics,thus paving the way for high-performance layered cathode materials in sodium-ion batteries.

关键词： Sodium-ion batteries O3-type layered oxides Site-specific co-doping Phase transition

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Locally Self-Injective Property of FI^(m)

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Algebra Colloquium 2024年第1期31卷 97-110页

作者： Duo zeng LCSM(Ministry of Education) School of Mathematics and Statistics Hunan Normal UniversityChangsha 410081China

We consider the locally self-injective property of the product FI^(m) of category FI of finite sets and ***,we prove that the external tensor product commutes with the coinduction functor,and hence preserves injective *** corollaries,every projective FI^(m)-module over a field of characteristic O is injective,and the Serre quotient of the category of finitely generated FI^(m)-modules by the category of finitely generated torsion FI^(m)-modules is equivalent to the category of finite-dimensional FI^(m)-modules.

关键词： self-injective property Serre quotient FI^(m)-modules

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