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Ca_(1−x)Li_(x)Al_(1−x)Si_(1+x)N_(3):Eu^(2+) solid solutions as broadband,color-tunable and thermally robust red phosphors for superior color rendition white light-emitting diodes

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Light(Science & Applications) 2016年第1期5卷 465-473页

作者： Le Wang Rong-jun Xie Yuanqiang Li Xiaojun Wang Chong-Geng Ma Dong Luo Takashi Takeda yi-Ting Tsai Ru-Shi Liu Naoto Hirosaki College of Optics and Electronic Science and Technology China Jiliang UniversityHangzhouZhejiang 310018China College of Materials Xiamen UniversityXiamenFujian 361005China Sialon Group National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan Intematix Corporation FremontCA 94538USA College of Sciences Chongqing University of Posts and TelecommunicationsChongqing 400065China Department of Chemistry Taiwan University Department of Mechanical Engineering and Graduate Institute of Manufacturing Technology Taipei University of Technology

Color rendition,luminous efficacy and reliability are three key technical parameters for white light-emitting diodes(wLEDs)that are dominantly determined by down-conversion ***,there is usually an inevitable trade-off between color rendition and luminescence efficacy because the spectrum of red phosphor(that is,spectral broadness and position)cannot satisfy them *** this work,we report a very promising red phosphor that can minimize the aforementioned trade-off via structure and band-gap engineering,achieved by introducing isostructural LiSi_(2)N_(3) into CaAlSiN_(3):Eu^(2+).The solid solution phosphors show both substantial spectra broadening(88→117 nm)and blueshift(652→642 nm),along with a significant improvement in thermal quenching(only a 6%reduction at 150℃),which are strongly associated with electronic and crystal structure *** broadband and robust red phosphor thus enables fabrication of super-high color rendering wLEDs(Ra=95 and R9=96)concurrently with the maintenance of a high-luminous efficacy(101 lm W^(−1)),validating its superiority in highperformance solid state lightings over currently used red phosphors.

关键词： color rendering LEDs nitride phosphor structure disorder

Serum carbohydrate antigen (CA) 19-9 as a prognostic factorin cholangiocarcinoma: A meta-analysis

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Frontiers of Medicine 2010年第4期4卷 457-462页

作者： Shang-Long LIU Zi-Fang song Qing-Gang HU Duo SHAN Shao-Bo HU jun LI Qi-Chang ZHENG Department of Hepatobiliary Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China

This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen(CA)19-9 levels in the survival of patients with *** published up to june 1st,2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for *** required information for calculating indivi-dual relative risk(RR)was extracted from the studies,and a combined overall RR was *** eligible studies were *** study dealt with extra-hepatic cholangiocarcinoma,while the other eight studies analyzed intra-hepatic *** mean methodolo-gical quality score was 74.1%,ranging from 65.5%to 82.5%.The overall RR for the nine studies was 1.28(95%conﬁdence interval=1.10–1.46),and the Z-score for overall effect was 13.83(P<0.001).The association between serum CA19-9 level and lymph node involvement was also *** combined RR was 1.471(95%conﬁdence interval=0.411–5.264)and Z-score for overall effect was 0.59(P=0.553).CA19-9 levels were associated signiﬁcantly with the prognosis of patients with *** meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with ***,larger scale and randomized studies are needed to draw a more substantive conclusion.

关键词： cholangiocarcinoma prognostic factors serum carbohydrate antigen 19-9

光栅投影技术及逆向工程在重建和测量牙颌数字化模型中的应用

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华西口腔医学杂志 2015年第1期33卷 71-74页

作者：王珍珍逯宜宋君陈军周秦西安交通大学口腔医院修复科西安710004 西安交通大学机械工程学院西安710049

目的利用光栅投影技术采集数字化牙颌模型并用逆向工程分析测量模型特征,为建立正常牙列数字化模型数据库奠定基础。方法在计算机控制下将光栅投影在正常牙颌模型上,通过多角度拍摄模型获得三维数据外形轮廓,利用逆向工程重建数字化模... 详细信息

目的利用光栅投影技术采集数字化牙颌模型并用逆向工程分析测量模型特征,为建立正常牙列数字化模型数据库奠定基础。方法在计算机控制下将光栅投影在正常牙颌模型上,通过多角度拍摄模型获得三维数据外形轮廓,利用逆向工程重建数字化模型和测量分析牙列形态特征,并与石膏模型测量结果进行对比分析。结果重建的三维数字化模型结构清晰。数字化模型的两次测量结果无统计学差异(P>0.05);数字化模型与石膏模型的测量指标中,牙冠长度和牙弓宽度均无统计学差异(P>0.05),而牙冠宽度和牙弓长度均有统计学差异(P<0.05)。结论通过光栅投影技术以及逆向工程重建数字化模型,可用于临床、科研中的牙颌模型测量,为建立正常牙颌数字化模型数据库提供科学方法。

关键词：光栅投影技术逆向工程牙颌模型三维重建三维测量

Rapid Identification of Legionella Pathogenicity by Surface-Enhanced Raman Spectroscopy

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Biomedical and Environmental Sciences 2015年第6期28卷 437-444页

作者： LI Jing QIN Tian JIA Xiao Xiao DENG Ai Hua ZHANG Xu FAN Wen Hui HUO Shuai Dong WEN Ting yi LIU Wen jun CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences National Institute for Communicable Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control Chinese Centre for Disease Control and Prevention Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases University of Chinese Academy of Sciences CAS Key Laboratory of Microbial Physiological and Metabolic Engineering Institute of MicrobiologyChinese Academy of Sciences National Center for Nanoscience and Technology Chinese Academy of Sciences

Objective To establish Surface-enhanced Raman Spectroscopy（SERS） can be used as a rapid and reliable method to distinguish virulent strain and mild strain of L. pneumophila. Methods We isolated and characterized of bacterial strains from ATCC and water samples strains, while we analyzed data from SERS technology using gold nanoparticles as a base and cell infections were employed to rapidly detect L. pneumophila strains. Origin 8.0 was used to collect Raman spectra, smooth and homogenize data, and to contrast spectra. Principal component analysis（PCA） was conducted to discriminate differences between groups using the multivariate analysis package Py Chem 3.0.5. Results Our results indicated that the peaks of high virulence strains reached ≥4000. This criterion was verified by subsequent cell experiments. In addition, we also conducted SERS rapid identification on the virulence of several collected clinical strains and obtained accurate results. Conclusion The present study indicates that the established SERS protocol can be used as a rapid and reliable method to distinguish virulent and mildly virulent strains of L. pneumophila, which can be further used in clinical samples.

关键词： Legionella pneumophila Surface-enhanced Raman Spectroscopy Pathogenicity Gold nanoparticles

Hereditary hemorrhagic telangiectasia involving portal venous system:A case report and review of the literature

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2367-2375页

作者： jun-Ling Wu Zhi-Zhuang Zhao jun Chen Han-Wen Zhang Zhe Luan Cong-Yong Li yi-Ming Zhao Yu-Jia Jing Shu-Fang Wang Gang Sun Medical School of Chinese PLA Department of Gastroenterology and HepatologyThe First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Geriatrics Hainan Hospital of PLA General HospitalSanya 572013Hainan ProvinceChina Department of Sixth Health Care Second Medical Center of PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology Hainan Hospital of PLA General HospitalSanya 572013Hainan ProvinceChina Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Hereditary hemorrhagic telangiectasia(HHT)is an autosomal dominant genetic disorder with an incidence of approximately 1 in 5000 in the general *** is characterized by vasodilation,which affects specific organs,such as the skin,mucous membranes,brain,lungs,gastrointestinal tract,liver,and ***,HHT rarely involves the portal venous system to cause serious clinical *** SUMMARY A 68-year-old woman was admitted to the emergency department due to four consecutive days of abdominal pain and bloody stool and was subsequently diagnosed with *** tomography angiography confirmed the presence of an arteriovenous fistula(AVFs).Considering this specific manifestation,whole exome sequencing was *** a comprehensive evaluation,a selective superior mesenteric artery embolization was prioritized to avoid intestinal *** postoperative symptoms of the patient were quickly ***,two months post-procedure the patient died from intestinal necrosis and abdominal infection related to remaining *** For patients with diffuse superior mesenteric AVFs,selective mesenteric arterial embolization may lead to positive short-term outcomes.

关键词： Hereditary hemorrhagic telangiectasia Portal system Arteriovenous fistula Arteriovenous malformation Selective artery embolization Case report

Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer

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World Journal of Gastroenterology 2002年第4期8卷 591-595页

作者： Zheng-jun song Ping Gong Yu-E Wu Department of Gastroenterology,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,ShaanXi Province,China Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061 ShaanXi ProvinceChina. gongp828@***

AIM：To in vestigate the relationship between the expression of inducible nitric oxide synthase(iNOS),vascular endothelial growth factor(VEGF),the microvascular density(MVD)and the pathological features and clinical staging of gastric ***:Immunohistochemical staining was used for detecting the expression of iNOS and VEGFin46resected specimens of gastric carcinoma;the monoclonal antibody against CD34 was used for displaying vascular endothelial cells,and MVD was detected by counting of CD34-positive vascular endothelial ***:Of 46resected specimens of gastric carcinoma,the rates of expressions of iNOS and VEGF were 58.70%and76.09%,respectively,and MVDaveraged55.59±19.39,Judged by the standard TNM criteria,the rate of expression of iNOS in stageⅣ（84.46%)was higher than those in stageⅠ，Ⅱ，Ⅲ（Fish exact probabilities test,P=0.019,0.023and 0.033,respectively);the rates of expression of VEGFin stage Ⅲ，Ⅳ（76.0%,92.31%,respectively)were higher than those in stageⅠ，Ⅱ（Fis exact probabilities test,P=0.031,0.017,0.022and0.019).MVDs in stageⅢ，Ⅳ（64.72±14.96,67.09±18.29,respectively)were higher than those in stageⅠ，Ⅱ(t\2.378,4.015,2.503and2.450,P<0.05,P<0.001,P<0.001,P<0.05,respectively),In37gastric carcinoma specimens with lymph node metastasis,MVD(68.69±18.07)and the rates of expression of iNOS and VEGF(70.27%,83.78%,respectively)were higher than those in the specimens with absence of metastasis(t=2.205,X^2=6.3587,X^2=6.2584,P<0.01,P<0.05,P<0.05,respectively),MVD and the expressions of iNOS and EGF were not correlated to the location,size or grade of tumor,nor with the depth of invasion of tumor;MVDs in the positive iNOS and VEGF specimens(59.88±18.02,58.39±17.73,repectively)were higher than those in the negative iNOS and VEGF specimens(X^2=6.3587and 6.1574,P<0.05,P<0.05,respectively);thus the expressions of iNOS and VEGF was correlated to MVD,but the expression of iNOS was not correlated to that of VEGF,In *** the 46 surviving patients,the 5-year surviva

关键词：胃癌血管内皮生长因子一氧化氮合酶血管生成

An Improved Barcoded Oligonucleotide Primers-based Next-generation Sequencing Approach for Direct Identification of Viral Pathogens in Clinical Specimens

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Biomedical and Environmental Sciences 2017年第1期30卷 22-34页

作者： WANG Churl Hua NIE Kai ZHANG yi WANG Ji ZHOU Shuai Feng LI Xin Na ZHOU Hang Yu QI Shun Xiang MA Xue jun Key Laboratory for Medical Virology National Health and Family Planning Commission National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Center for Disease Prevention and Control of Hunan Province Changsha 410005 Hunan China Institute for Viral Disease Control and Prevention Center for Disease Control and Prevention of Hebei Shijiazhuang 050000Hebei China

Objective To provide a feasible and cost-effective next-generation sequencing （NGS） method for accurate identification of viral pathogens in clinical specimens, because enormous limitations impede the clinical use of common NGS, such as high cost, complicated procedures, tremendous data analysis, and high background noise in clinical samples. Methods Viruses from cell culture materials or clinical specimens were identified following an improved NGS procedure： reduction of background noise by sample preprocessing, viral enrichment by barcoded oligonucleotide （random hexamer or non-ribosomal hexanucleotide） primer-based amplification, fragmentation-free library construction and sequencing of one-tube mixtures, as well as rapid data analysis using an in-house pipeline. Results NGS data demonstrated that both barcoded primer sets were useful to simultaneously capture multiple viral pathogens in cell culture materials or clinical specimens and verified that hexanucleotide primers captured as many viral sequences as hexamers did. Moreover, direct testing of clinical specimens using this improved hexanucleotide primer-based NGS approach provided further detailed genotypes of enteroviruses causing hand, foot, and mouth disease （HFMD） and identified other potential viruses or differentiated misdiagnosis events. Conclusion The improved barcoded oligonucleotide primer-based NGS approach is simplified, time saving, cost effective, and appropriate for direct identification of viral pathogens in clinical practice.

关键词： NGS Barcoded oligonucleotide primers Virus identification Clinical specimen

Fluorinated 1,3-dicarbonyl Compounds:Magical Building-Block for Organic and Medicinal Chemistry

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Fluorinated 1,3-dicarbonyl Compounds:Magical Building-Block ...

Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

中国化学会第十四届全国氟化学会议

作者： Zhidong song Wenbin yi School of Chemical Engineering Nanjing University of Science and Technology

Organofluorine chemistry is an active research topic because introduction of fluorine atom（s） could have a significant effect on parent molecules’ chemical, physical, and biological properties. Nucleophilic fluoroalkylation reaction is one of the important methods to introduce fluorinated group into organic molecules. However, the introduction of fluorine poses a negative effect on the thermal stability of many α-fluoro carbon anion and corresponding nucleophilic fluoroalkylation reactions. Our group investigated the fluorinated1,3-dicarbonyl compounds, a new type of fluorine-containing building-block, which participate in some of the fluoroalkylation reactions and applicate in some highly stereoselective and multicomponent reaction systems to obtain some structure which is unable or difficult to obtain directly fluoroalkylation raction. The success on organic and medicinal chemistry of this fluorinated building-block is summarized in an apple tree with many red apples（published work） and green apples（unpublished work）.

关键词： α-fluoro-1,3-dicarbonyl compound fluorinated building-block asymmetric synthesis aromatization

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： Yun-Dai CHEN Wei-yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-ying QIAN Ya-jun SHI Zhu-jun SHEN Jing WANG yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI Chinese PLA General Hospital Beijing China Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital Zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guangxi Medical University Nanning China The First Affiliated Hospital of Shanxi Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of Jilin University Changchun China University of Pennsylvania United States

1 Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 2013 ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities