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Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China

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World Journal of Gastroenterology 2020年第30期26卷 4465-4478页

作者： Dong-Xu Wang Xu Yang Jian-Zhen Lin yi Bai jun-Yu Long Xiao-Bo Yang Samuel Seery Hai-Tao Zhao Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Humanities Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

BACKGROUND Lenvatinib has become an indispensable part of treatment regimens for patients with advanced hepatocellular carcinoma(aHCC).Several recent real-world studies appear to have confirmed this;however,there are etiological *** necessitates further real-world studies of lenvatinib across diverse populations,such as in *** To investigate the efficacy and safety of lenvatinib in a Chinese HCC patient population under real-world *** This is a retrospective and multiregional study involving patients with aHCC receiving lenvatinib *** was assessed using the Response Evaluation Criteria in Solid Tumors version *** characteristics and adverse events(AEs)were recorded throughout the entire *** In total,54 HCC patients treated with lenvatinib monotherapy were included for final *** objective response rate was 22%(n=12)with a progressionfree survival(PFS)of 168 d;however,AEs occurred in 92.8%of *** analysis showed that the Barcelona Clinic Liver Cancer stage[hazard ratio(HR)0.465;95%CI:0.23-0.93;P=0.031],portal vein tumor thrombus(HR 0.38;95%CI:0.15-0.94;P=0.037)and Child-Pugh classifications(HR 0.468;95%CI:and specificity(83.3%)of decreasing serum biomarkers including alphafetoprotein were calculated in order to predict tumor size *** sequencing also provided insights into potential gene mutation signatures related to the effect of *** Our findings confirm previous evidence from the phase III REFLECT *** majority of patients in this Chinese sample were suffering from concomitant hepatitis B virus-related ***,further analysis suggested that baseline characteristics,changes in serum biomarkers and gene sequencing may hold the key for predicting lenvatinib *** large-scale prospective studies that incorporate more basic medical science measures should be conducted.

关键词： Lenvatinib Real-world study Hepatocellular carcinoma Efficacy Safety Treatment

煤矿区城市PM_(10)单颗粒微观形貌及粒径分布特征

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中国矿业大学学报 2011年第2期40卷 292-297页

作者：宋晓焱邵龙义宋建军乔玉霜中国矿业大学地球科学与测绘工程学院煤炭资源与安全开采国家重点实验室北京100083 华北水利水电学院资源与环境学院河南郑州450011 河南省煤田地质局资源环境调查中心河南郑州450003

利用高分辨率场发射扫描电镜(FESEM)和图像分析技术研究了可吸入颗粒物(PM10)的单颗粒微观形貌类型及粒度分布特征.研究表明,煤矿区城市夏季可吸入颗粒物的微观形貌类型主要有矿物、烟尘集合体、球形颗粒及未知细颗粒.前3种颗粒(未知细... 详细信息

利用高分辨率场发射扫描电镜(FESEM)和图像分析技术研究了可吸入颗粒物(PM10)的单颗粒微观形貌类型及粒度分布特征.研究表明,煤矿区城市夏季可吸入颗粒物的微观形貌类型主要有矿物、烟尘集合体、球形颗粒及未知细颗粒.前3种颗粒(未知细颗粒不做统计)的数量百分比分别为41.2%,28.0%和30.8%,体积百分比分别为71.5%,22.3%和6.3%.颗粒物的数量-粒度呈单峰分布,主要分布在0.1～0.4μm范围内;体积-粒度分布则以大于1μm的矿物颗粒为主.夏季空气中球形颗粒和规则柱状矿物较多,说明矿区SO2,NOx含量较高而引起的大气二次化学反应严重.强风天气PM10的质量浓度明显降低,颗粒物数量主要分布在0.1～0.4μm粒径范围内.轻微浮尘天气PM10的质量浓度增大,颗粒物数量主要分布在0.1～0.4和1～2.5μm范围内,粒径大于1μm的矿物颗粒占总体积(质量)80%.

关键词： PM10 形貌特征场发射扫描电镜(FESEM) 粒度分布

Metabolic dysfunction is associated with steatosis but no other histologic features in nonalcoholic fatty liver disease

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World Journal of Clinical Cases 2022年第13期10卷 4097-4109页

作者： yi-Ning Dai Cheng-Fu Xu Hong-ying Pan Hai-jun Huang Mei-Juan Chen You-Ming Li Chao-Hui Yu Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Center for General Practice Medicine Department of Infectious DiseasesZhejiang Provincial People's Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Recently,nonalcoholic fatty liver disease(NAFLD)has been renamed metabolicassociated fatty liver disease(MAFLD).Based on the definition for MAFLD,a group of non-obese and metabolically healthy individuals with fatty liver are excluded from the newly proposed *** To analyze the histologic features in the MAFLD and non-MAFLD subgroups of *** Eighty-three patients with biopsy-proven NAFLD were separated into MAFLD and non-MAFLD *** diagnosis of MAFLD was established as hepatic steatosis along with obesity/diabetes or evidence of metabolic *** histologic features were compared according to different metabolic disorders and liver enzyme *** MAFLD individuals had a higher NAFLD activity score(P=0.002)and higher severity of hepatic steatosis(42.6%Grade 1,42.6%Grade 2,and 14.8%Grade 3 in MAFLD;81.8%Grade 1,13.6%Grade 2,and 4.5%Grade 3 in non-MAFLD;P=0.007)than the non-MAFLD *** and portal inflammation,hepatic ballooning,fibrosis grade,and the presence of nonalcoholic steatohepatitis(NASH)and significant fibrosis were comparable between the two *** higher the liver enzyme levels,the more severe the grades of hepatic steatosis(75.0%Grade 1 and 25.0%Grade 2 in normal liver function;56.6%Grade 1,39.6%Grade 2,and 3.8%Grade 3 in increased liver enzyme levels;27.8%Grade 1,27.8%Grade 2,and 44.4%Grade 3 in liver injury;P3×upper limit of normal)presented a higher severity of hepatocellular ballooning(P=0.021).Moreover,the grade of steatosis correlated significantly with hepatocellular ballooning degree(r=0.338,P=0.002)and the presence of NASH(r=0.466,P<0.001).CONCLUSION Metabolic dysfunction is associated with hepatic steatosis but no other histologic features in *** research is needed to assess the dynamic histologic characteristics in NAFLD based on the presence or absence of metabolic disorders.

关键词： Nonalcoholic fatty liver disease Metabolic associated fatty liver disease Liver histology Hepatic steatosis Fibrosis

RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells

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World Journal of Gastroenterology 2007年第40期13卷 5312-5316页

作者： Tie-jun Li Jian-Ning song Kai Kang Shu-Sheng Tong Zan-Lan Hu Tong-Chuan He Bing-Qiang Zhang Cai-Quan Zhang The First Affiliated Hospital Chongqing University of MedicalSciences Chongqing 400016 China The Ninth Hospital of Chongqing Chongqing 400700 China Molecular Oncology Laboratory University of Chicago Medical Center IL 60637 United States

AIM： TO inhibit the expression of vascular endothelial growth factor （VEGF） in colon cancer cell line by RNA interference （RNAi）.METHODS： Followed the service of E-RNAi, we designed and constructed two kinds of shRNA expression vectors aiming at the VEGF gene, then transfected them into colon cancer HT29 cells by lipofectamineTM 2000. The level of VEGF mRNA was investigated by RT-PCR and Northern blotting. The protein expression of VEGF was observed by immunofluoresence staining and Western blotting.RESULTS： We got two kinds of VEGF specific shRNA expression vectors which could efficiently inhibit the expression of VEGF in HT29 cells. RT-PCR, Northern blotting, immunofluoresence staining and Western blotting showed that inhibition rate for VEGF expression was up to 42%, 89%, 73% and 82%, respectively.CONCLUSION： The expression of VEGF can be inhibited by RNA interference in HT29 cells.

关键词： RNA interference Vascular endothelialgrowth factor Colon cancer Northern blotting Western blotting

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硼泥中硼的形态分析

冶金分析 2007年第10期27卷 65-68页

作者：顾佳丽邓桂春张俊姚琳宋俊俊张逸馨孙静怡辽宁锦州121000 渤海大学化学化工学院辽宁大学化学科学与工程学院辽宁大学化学科学与工程学院辽宁沈阳110036

硼与变色酸可形成强荧光络合物,采用分子荧光法对硼泥中硼的总量进行测定。在此基础上,选用不同的溶剂,通过连续浸取方法对硼泥中硼的分布及形态进行分析。结果表明:在λex\λem=313/380 nm,硼量在10~250 ng/25 mL范围内呈良好线性关系... 详细信息

硼与变色酸可形成强荧光络合物,采用分子荧光法对硼泥中硼的总量进行测定。在此基础上,选用不同的溶剂,通过连续浸取方法对硼泥中硼的分布及形态进行分析。结果表明:在λex\λem=313/380 nm,硼量在10~250 ng/25 mL范围内呈良好线性关系。硼泥中总硼含量为4.01 g/kg;各形态硼含量(w/%)依次为:水溶态(49.13)>醋酸溶解态(16.46)>螯合态(14.96)>盐溶态(3.34)>盐酸羟胺溶解态(1.00)>残渣态(0.50),测定结果对硼泥的综合治理及资源再生有一定指导意义。

关键词：硼分子荧光法连续浸取形态分析

Effect evaluation of interleukin-1 receptor antagonist nanoparticles for mesenchymal stem cell transplantation

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World Journal of Gastroenterology 2013年第12期19卷 1984-1991页

作者： Xiao-Lei Shi Wei Zhu Jia-jun Tan Jiang-Qiang Xiao Lin Zhang Qian Xu Zheng-Liang Ma yi-Tao Ding Department of Hepatobiliary Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical School Key Medical Center of Jiangsu Province for Hepatobiliary Diseases Gulou Clinical Medical College of Combined TCM and Western Medicine Nanjing University of Chinese Medicine Department of Anesthesiology the Affiliated Drum Tower Hospital of Nanjing University Medical School School of Public Health Southeast University

AIM: To study the efficacy of marrow mesenchymal stem cells (MSCs) transplantation combined with interleukin-1 receptor antagonist (IL-1Ra) for acute liver failure (ALF). METHODS: Chinese experimental miniature swine were randomly divided into four groups (n = 7), and all animals were given D-galactosamine (D-gal) to induce ALF. Group A animals were then injected with 40 mL saline via the portal vein 24 h after D-gal induction;Group B animals were injected with 2 mg/kg IL-1Ra via the ear vein 18 h, 2 d and 4 d after D-gal induction; Group C received approximately 1 × 108 green fluorescence protein (GFP)-labeled MSCs (GFP-MSCs) suspended in 40 mL normal saline via the portal vein 24 h after D-gal induction; Group D animals were injected with 2 mg/kg IL-1Ra via the ear vein 18 h after D-gal induction, MSCs transplantation was then carried out at 24 h after D-gal induction, and finally 2 mg/kg IL-1Ra was injected via the ear vein 1 d and 3 d after surgery as before. Liver function, serum inflammatory parameters and pathological changes were measured and the fate of MSCs was ***: The optimal efficiency of transfection (97%) was achieved at an multiplicity of infection of 80, as observed by fluorescence microscopy and flow cytometry (FCM). Over 90% of GFP-MSCs were identified as CD44+ CD90+ CD45-MSCs by FCM, which indicated that most GFP-MSCs retained MSCs characteristics. Biochemical assays, the levels of serum inflammatory parameters and histological results in Group D all showed a significant improvement in liver injury compared with the other groups (P < 0.05). The number of GFP-MSCs in Group D was also greater than that in Group B, and the long-term cell proliferation rate was also better in Group D than in the other ***: MSCs transplantation is useful in ALF, IL-1Ra plays an important role in alleviating the inflammatory condition, and combination therapy with MSCs transplantation and IL-1Ra is a promising treatment for ALF.

关键词： Interleukin-1 receptor antagonist Mesenchymal stem cells Cell transplantation Acute liver failure Inflammatory environment

A pilot study of single-use endoscopy in screening acute gastrointestinal bleeding

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World Journal of Gastroenterology 2013年第1期19卷 103-107页

作者： Jae Hee Cho Hee Man Kim Sangheun Lee Yu Jin Kim Ki jun Han Hyeon Geun Cho Si Young song Division of Gastroenterology Department of Internal MedicineMyongji HospitalKwandong University College of MedicineGoyang 412-270South Korea Department of Internal Medicine Graduate SchoolYonsei University College of MedicineSeoul 120-752South Korea Division of Gastroenterology Department of Internal MedicineBrain Korea 21 Project for Medical ScienceSeverance Biomedical Science InstituteYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate the feasibility of a single-use endoscopy as an alternative procedure to nasogastric lavage in patients with acute gastrointestinal(GI) ***:Patients who presented with hematemesis,melena or hematochezia were enrolled in this *** scan and conventional esophagogastroduodenoscopy(EGD) were subsequently *** bleeding was defined as blood in the stomach,and inactive bleeding was defined as coffee ground clots and clear fluid in the *** findings were recorded and ***:Between January and March,2011,13 patients that presented with hematemesis(n = 4),melena(n = 6),or bleeding from a previous nasogastric feeding tube(n = 3),were enrolled in this *** 12 patients with upper GI bleeding,the EG scan device revealed that 7 patients had active bleeding and 5 patients had inactive bleeding,whereas conventional EGD revealed that 8 patients had active bleeding and 4 patients had inactive *** sensitivity and specificity of the EG scan device was 87.5% and 100% for active bleeding,with conventional EGD serving as a *** complication were reported during the EG scan ***:The EG scan is a feasible device for screening acute upper GI *** may replace nasogastric lavage for the evaluation of acute upper GI bleeding.

关键词： Gastrointestinal hemorrhage Bleeding Endoscopy Nasogastric tube Lavage

Research Progress of Cold Resistance Mechanism of Cassava

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Agricultural Science & Technology 2017年第9期18卷 1607-1614页

作者： Wei ZHANG Tuo yi Yong WU Yong song Horticulture & Landscape College Hunan Agricultural University Hunan Provincial Engineering Research Center for Potato

Cassava is vulnerable to frost and snow, so it is suitable for planting in tropical and subtropical region. Low temperature is an important environment factor affecting the growth and development and production of cassava, and the region with annual average temperature below 15 ℃ is not conducive to its normal growth and development. The improvement of cold resistance of cassava can increase the planting area and improve the yield and quality of cassava. In this study, morphological,physiological and biochemical and molecular researches on cold resistance of cassava, as well as the latest research progress,were reviewed in this paper. At the same time, some potential difficulties in the research on cold resistance of cassava were put forward, and the future work focus was also discussed.

关键词： Cassava Low temperature Cold resistance Physiology and Biochemistry Research progress

CGX巡洋舰多学科设计优化模型的再分析(英文)

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船舶力学 2009年第6期13卷 895-904页

作者：刘军易宏上海交通大学船舶海洋与建筑工程学院水下工程研究所上海200030

传统的设计螺旋方法由于割裂了学科间耦合,得到的设计往往是满足设计要求的设计而不是最优的设计。多学科设计优化(MDO)方法正是一种能得到最优设计的新设计方法,MDO目前被广泛应用于复杂工程系统的设计中。文中对多学科设计优化的理论... 详细信息

传统的设计螺旋方法由于割裂了学科间耦合,得到的设计往往是满足设计要求的设计而不是最优的设计。多学科设计优化(MDO)方法正是一种能得到最优设计的新设计方法,MDO目前被广泛应用于复杂工程系统的设计中。文中对多学科设计优化的理论进行了简要综述,在此基础上为了演示MDO方法应用于舰船设计,采用iSIGHT对国外的CGX巡洋舰概念设计的13个模块进行了集成,建立了MDO模型并优化,得到了较好的优化解。在此基础上采用神经网络重新建立了该MDO模型,将优化结果和原MDO模型优化结果进行了比较。

关键词：船舶设计多学科设计优化神经网络