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Acta Geologica Sinica(English Edition) 2018年第4期92卷 1651-1652页

作者： cao jun Fundamental Science on Radioactive Geology and Exploration Technology Laboratory East China University of Technology School of Earth Sciences East China University of Technology

Objective During the Permian, at least four mafic continental large igneous provinces （LIPs） were tbrmed in eastern Asia, i.e., the Siberian traps （-251 Ma）, Emeishan LIP （-260 Ma）, Tarim LIP （-290-270 Ma） and Panjal traps （-290 Ma）（Shellnutt et al., 2015）. The Emeishan and Tarim LIPs in China are both known for the presence of several magmatic Fe-Ti-V oxide deposits hosted in layered mafic- ultramafic intrusions. The origin of such magmatic Fe-Ti- V oxide deposits is enigmatic. One of the long-lasting debates is the mechanism by which large amounts of Fe-Ti oxides accumulated in the layered intrusions. Regardless of mechanism, there is still considerable debate regarding the mantle source compositions of the Fe-Ti-V oxide ore- bearing intrusions, in the Tarim LIP, a giant Fe-Ti-V oxide deposit is hosted by the Piqiang layered intrusion at the northern margin of the Tarim block. This intrusion consists mainly of gabbro and minor plagioclase-bearing clinopyroxenite and anorthosite （Fig. l a）. For this study we present new SHRIMP zircon U-Pb age and whole-rock geochemical data for the Piqiang layered gabbroic intrusion to evaluate the nature of its possible source compositions, which in turn aids in understanding the formation of the giant Fe-Ti-V oxide deposit in the plume- related LIPs.

关键词： SHRIMP Zircon U-Pb Age of the Piqiang Layered Intrusion in the Tarim Large Igneous Province and Subducted Slab-Plume Interaction In Ta Pb

A novel protease-activated receptor 1 inhibitor from the leech Whitmania pigra

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Chinese Journal of Natural Medicines 2019年第8期17卷 591-599页

作者： REN Shen-Hong LIU Zhao-jun cao Yuan HUA yi CHEN Cong GUO Wei KONG yi School of Life Science & Technology China Pharmaceutical University Nanjing 210009 China School of Life Science China Pharmaceutical University Nanjing 210009 China Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029 China

Whitmania pigra has been used as a traditional Chinese medicine(TCM) for promoting blood circulation, alleviating blood coagulation, activating meridians and relieving stasis for several hundred years. However, the therapeutic components of this species, especially proteins and peptides were poorly exploited. Until now only a few of them were obtained by using chromatographic isolation and purification. In recent decade, transcriptome techniques were rapidly developed, and have been used to fully reveal the functional components of many animal venoms. In the present study, the c DNA of the salivary gland of Whitmania pigra was sequenced by illumina and the transcriptome was assembled by using Trinity. The proteome were analysed by LC-MS/MS. Based on the data of the transcriptome and the proteome, a potential antiplatelet protein named pigrin was found. Pigrin was cloned and expressed using P. pastoris GS115. The antiplatelet and antithrombotic bioactivities of pigrin were tested by using aggregometer and the rat arterio-venous shunt thrombosis model, respectively. The bleeding time of pigrin was measured by a mice tail cutting method. The docking of pigrin and protease-activated receptor 1(PAR1) or collagen were conducted using the ZDOCK Server. Pigrin was able to selectively inhibit platelet aggregation stimulated by PAR1 agonist and collagen. Pigrin attenuated thrombotic formation in vivo in rat, while did not prolong bleeding time at its effective dosage. There are significant differences in the key residues participating in binding of Pigrin-Collagen complex from Pigrin-PAR1 complex. In conclusion, a novel PAR1 inhibitor pigrin was found from the leech Whitmania pigra. This study helped to elucidate the mechanism of the leech for the treatment of cardiovascular disorder.

关键词： Whitmania pigra Transcriptome and proteome PAR1 inhibitor Thrombosis

Numerical simulation of ice accretion in supercooled large droplet conditions

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Science China(Technological Sciences) 2019年第7期62卷 1191-1201页

作者： cao yi Hua XIN Miao School of Aeronautic Science and Engineering Beihang University

The simulated methods for ice accretion on two-dimensional airfoil surface are established completely under the Eulerian framework in supercooled large droplet(SLD) conditions. The two-dimensional code to solve the partial differential equations(PDEs) of droplet phase is derived to simulate the impingement characteristic of SLD. Also, several semi-empirical models which explain the droplet-wall interaction are compared and discussed to show respective features when simulating the splashing phenomenon. In particular, a new boundary condition for wall called penetrable wall for splashing droplet(PWSD) is proposed to deal with the impingement of SLD on solid surface, which efficiently improves the accuracy of simulation. Then the improved impingement characteristic of SLD is input into the extended mass and heat transfer model to simulate the ice growth on airfoil surface. The multistep advanced method is carried out to better match the physical phenomenon of ice growth. At last, the simulated results of critical parameters: local droplet collection efficiency and the height of ice growth are compared with the experimental data which verify the applicability of proposed models.

关键词： numerical simulation supercooled large droplet ice accretion penetrable wall for splashing droplet

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

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Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei Jiang Ping cao yi-Ming Wu Xian-Ke Liu Zhu-jun Fang Zhi-Yong Zhang Bin Shi jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution

Genomic Analysis of Mitochondrial Carrier Genes in the Bombyx mori

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Journal of Integrative Agriculture 2012年第10期11卷 1707-1713页

作者： cao jun SHI Feng Institute of Life Science Jiangsu University Shandong Lvdu Bio-Technique Industry

This study is performed to investigate the mitochondrial carrier gene family in silkworm genome. In total, 30 genes are identified and claded into eight well-conserved groups. Gene duplication contributes to the expansion and complexity of this family. Diverse expression patterns suggest their functional differentiation. Analyses of the sitespecific profiles reveal critical amino acid residues for functional divergence. This study highlights the molecular evolution of the mitochondrial carrier gene family in silkworm and may provide a starting point for further experimental verification.

关键词： mitochondrial carrier gene phylogenetic analysis evolution silkworm

Conductive phthalocyanine-based metal-organic framework as a highly efficient electrocatalyst for carbon dioxide reduction reaction

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Science China Chemistry 2021年第8期64卷 1332-1339页

作者： Meng-Di Zhang Duan-Hui Si jun-Dong yi Qi yin Yuan-Biao Huang Rong cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of Chinese Academy of Sciences Beijing100049China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou350007China Fujian College University of Chinese Academy of SciencesFuzhou350002China

Porous crystalline metal-organic frameworks(MOFs)are one class of promising electrode materials for CO_(2)electroreduction reaction(CO_(2)RR)by virtue of their large CO_(2)adsorption capacities and abundant tunable active sites,but their insulating nature usually leads to low current ***,a two-dimensional(2D)Ni-phthalocyanine-based MOF(NiPc-Ni(NH)4)constructed by 2,3,9,10,16,17,23,24-octaaminophthalocyaninato nickel(II)(NiPc-(NH_(2))_(8))and nickel(II)ions attained high electrical conductivity due to the high overlap of d-πconjugation orbitals between the nickel node and the Ni-phthalocyanine-substituted *** CO_(2)RR,the NiPc-Ni(NH)4 nanosheets achieved a high CO Faradaic efficiency of 96.4%at−0.7 V and a large CO partial current density of 24.8 mA cm^(−2)at−1.1 V,which surpassed all the reported two-dimensional MOF electrocatalysts evaluated in an *** control experiments and density functional theory(DFT)calculations suggested that the Ni-N_(4)units of the phthalocyanine ring are the catalytic active *** work provides a new route to the design of highly efficient porous framework materials for the enhanced electrocatalysis via improving electrical conductivity.

关键词： metal-organic frameworks electroreduction conductive CO_(2) CO

Spontaneous multivessel coronary artery spasm diagnosed with intravascular ultrasound imaging:A case report

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World Journal of Clinical Cases 2020年第16期8卷 3601-3607页

作者： Hao-Yu Wu yi-Wei cao Feng-jun Chang Lei Liang Department of Cardiology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Coronary artery spasm is a major cause of myocardial *** coronary artery spasm has been known for a long time,its mechanism has not yet been *** clinicians,especially young clinicians pay less attention to coronary artery spasm,which may lead to some patients not being appropriately diagnosed and treated in *** report a patient with spontaneous multivessel coronary artery spasm for more than 30 years diagnosed with intravascular ultrasound(IVUS)*** SUMMARY A 66-year-old Chinese male patient had chest squeezing at rest for more than 30 *** had a history of cigarette smoking for more than 40 years and hypertension for 10 *** presenting at our institution,the patient had undergone coronary angiography 4 times and percutaneous transluminal coronary angioplasty procedures twice at other hospitals without a diagnosis of coronary artery ***,his chest symptoms *** multivessel coronary artery spasm occurred during IVUS without provocation testing,and the IVUS image was ***,the diagnosis of multifocal spontaneous coronary artery spasm was *** patient was placed on oral diltiazem,isosorbide mononitrate,and nicorandil to suppress coronary artery *** medications were given at the maximum dosages tolerated by the *** was discharged after 5 d without *** the six-month follow-up period,the patient was *** Coronary artery spasm is still prevalent in Eastern *** is essential for clinicians to be aware of coronary artery spasm,which may be hard to detect and can be lethal,in order to diagnose and treat patients appropriately.

关键词： Coronary artery spasm Multivessel coronary Spontaneous Intravascular ultrasound Case report

Final size of network epidemic models: properties and connections

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Science China(Information Sciences) 2021年第7期64卷 244-246页

作者： yi WANG Jinde cao School of Mathematics Southeast University School of Mathematics and Physics China University of Geosciences Jiangsu Provincial Key Laboratory of Networked Collective Intelligence Southeast University

Dear editor,The classical final size relation of the standard susceptible-infected-recovered (SIR) epidemic model is based on homogeneous-mixing population [1, 2]. Recent results have demonstrated the generality of th... 详细信息

关键词： Information Systems and Communication Service

A fuzzy quantification approach of uncertainties in an extreme wave height modeling

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Acta Oceanologica Sinica 2015年第3期34卷 90-98页

作者： ZHANG yi cao yingyi Division of Infrastructure Systems and Maritime Studies School of Civil and Environmental EngineeringNanyang Technological University College of Preschool Education Zibo Normal College

A non-traditional fuzzy quantification method is presented in the modeling of an extreme significant wave height. First, a set of parametric models are selected to fit time series data for the significant wave height and the extrapolation for extremes are obtained based on high quantile estimations. The quality of these results is compared and discussed. Then, the proposed fuzzy model, which combines Poisson process and gener-alized Pareto distribution （GPD） model, is applied to characterizing the wave extremes in the time series data. The estimations for a long-term return value are considered as time-varying as a threshold is regarded as non-stationary. The estimated intervals coupled with the fuzzy theory are then introduced to construct the probability bounds for the return values. This nontraditional model is analyzed in comparison with the traditional model in the degree of conservatism for the long-term estimate. The impact on the fuzzy bounds of extreme estimations from the non stationary effect in the proposed model is also investigated.

关键词： offshore engineering extreme value distribution wave height peak over threshold fuzzy set Pareto distribution

ON THE COMPLEX OSCILLATION OF HIGHER ORDER LINEAR DIFFERENTIAL EQUATIONS WITH MEROMORPHIC COEFFICIENTS

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Journal of Systems Science & Complexity 2007年第1期20卷 135-148页

作者： Tingbin cao Hongxun yi Department of Mathematics Shandong University Jinan 250100 China

In this paper, we investigate the complex oscillation of higher order homogenous and non- homogeneous linear differential equations with meromorphic coefficients of iterated order, and obtain some results which improv... 详细信息

关键词： Exponent iterated convergence iterated order linear differential equation meromorphic function.