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乳腺癌术后行自体脂肪移植的研究进展及安全评估

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中国美容医学 2018年第7期27卷 151-154页

作者：夏逸君曹东升安徽医科大学第二附属医院整形外科安徽合肥230601

自体脂肪移植(AFG)在改善乳腺癌术后的不对称性方面取得了令人满意的临床结果,为常见的整形手术。然而,对这种术式的肿瘤安全性仍然是争论的一个热点话题,多项实验研究表明脂肪细胞通过内分泌、旁分泌、自分泌途径释放调控因子,刺激乳... 详细信息

自体脂肪移植(AFG)在改善乳腺癌术后的不对称性方面取得了令人满意的临床结果,为常见的整形手术。然而,对这种术式的肿瘤安全性仍然是争论的一个热点话题,多项实验研究表明脂肪细胞通过内分泌、旁分泌、自分泌途径释放调控因子,刺激乳腺癌细胞生长,但现有的临床证据并没有明确AFG和癌症复发之间的关系。本文通过系统性回顾实验研究和临床数据,对自体脂肪移植的肿瘤学安全性进行讨论,并为有移植意愿的患者提出建议。

关键词：自体脂肪移植肿瘤学安全性乳腺癌

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罗氏沼虾苗肌肉白浊病病原的初步研究

水生生物学报 2002年第5期26卷 472-476页

作者：钱冬杨国梁刘问王军毅曹铮浙江省淡水水产研究所湖州市313001

收集罗氏沼虾肌肉白浊病典型病虾苗 ,进行细菌分离、除菌组织悬液制备及人工感染试验、超薄切片、病毒粗提取 ,结果表明 :从白浊病病虾的肌肉、肝胰腺中分离到的细菌以5× 1 0 8CFU/mL浓度浸泡感染正常沼虾苗不能复制疾病 ;病虾除菌组... 详细信息

收集罗氏沼虾肌肉白浊病典型病虾苗 ,进行细菌分离、除菌组织悬液制备及人工感染试验、超薄切片、病毒粗提取 ,结果表明 :从白浊病病虾的肌肉、肝胰腺中分离到的细菌以5× 1 0 8CFU/mL浓度浸泡感染正常沼虾苗不能复制疾病 ;病虾除菌组织过滤液以 1∶5 0、1∶2 5 0浓度浸泡感染正常虾苗 ,7d后可发病 ,并出现典型的肌肉白浊病症状 ,氯仿处理不能破坏病毒的感染力 ;病虾超薄切片电镜观察发现肌肉间隙组织中存在 2 1— 2 3nm大小的球状病毒 ,病虾组织浆经氯仿处理、PEG沉淀、磷钨酸负染后可见到大量 2 2— 2 4nm大小的球状病毒颗粒。上述结果表明罗氏沼虾肌肉白浊病是一种由病毒引起的疾病。

关键词：罗氏沼虾苗肌肉白浊病病原

EB病毒潜伏膜蛋白1通过TRAF/TRADD激活JNK信号途径

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生物化学与生物物理进展 2002年第4期29卷 562-566页

作者：胡智曾亮陶永光唐发清王海罗非君易薇曹亚中南大学湘雅医学院肿瘤研究所长沙410078

为了探讨在鼻咽癌细胞中EB病毒编码的潜伏膜蛋白 1(LMP1)激活c jun氨基端激酶 (JNK)信号途径的分子机制 ,利用可调控表达LMP1的鼻咽癌细胞系L7,蛋白质印迹检测 ,发现LMP1能够促进JNK的活化 ;利用稳定表达LMP1的鼻咽癌细胞系HNE2 LMP1... 详细信息

为了探讨在鼻咽癌细胞中EB病毒编码的潜伏膜蛋白 1(LMP1)激活c jun氨基端激酶 (JNK)信号途径的分子机制 ,利用可调控表达LMP1的鼻咽癌细胞系L7,蛋白质印迹检测 ,发现LMP1能够促进JNK的活化 ;利用稳定表达LMP1的鼻咽癌细胞系HNE2 LMP1及其三种突变体HNE2 LMP1ΔCTAR 1、HNE2 LMP1ΔCTAR2、HNE2 LMP1ΔCTAR 1,2及LMP1阴性的HNE2 为材料 ,采用蛋白质印迹和报告基因法分析JNK和活化蛋白 1(AP1)活化情况 ,结果显示HNE2 LMP1和HNE2 LMP1ΔCTAR1中磷酸化JNK蛋白表达量和AP1活性都无显著差异 ,而与HNE2 LMP1ΔCTAR2、HNE2 LMP1ΔCTAR1,2、阴性对照HNE2及空白载体转染细胞的JNK蛋白表达和AP1活性具有显著差异 ;进一步比较转染TRAF、TRADD显性负性突变体鼻咽癌细胞系HNE2 LMP1中磷酸化的JNK量和AP1活性 ,结果显示 :TRAF DN和TRADD DN的导入使活化的JNK蛋白和AP 1活性显著降低 ,二者间无显著差异 ,提示TRAF和TRADD可能参与了LMP1对JNK和AP 1的活化 .以上结果提示在鼻咽癌细胞系中LMP1功能结构域CTAR2通过结合TRAF/TRADD激活JNK从而活化重要的转录因子AP1.

关键词： EB病毒潜伏膜蛋白1 TRAF/TRADD 激活 JNK信号途径鼻咽癌

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving cao bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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玉米根际土壤中铜形态的动态变化

生态学报 2002年第10期22卷 1666-1671页

作者：陈有[钅监] 黄艺曹军徐福留李本纲陶澍北京大学城市与环境学系地表过程分析与模拟教育部重点实验室北京100871

采用根垫法研究玉米根际土壤铜形态动态变化。结果表明 :玉米生长过程中根际土壤铜形态发生显著变化。植物生长前期交换态和碳酸盐结合态铜含量逐渐增加 ,随后增加量减少。植物生长后期根际交换态和碳酸盐结合态铜含量低于非根际土壤。... 详细信息

采用根垫法研究玉米根际土壤铜形态动态变化。结果表明 :玉米生长过程中根际土壤铜形态发生显著变化。植物生长前期交换态和碳酸盐结合态铜含量逐渐增加 ,随后增加量减少。植物生长后期根际交换态和碳酸盐结合态铜含量低于非根际土壤。这种变化主要由根际环境变化与植物吸收引起。与根际土壤中铜形态变化 ,特别是交换态铜含量变化关系密切的因素包括土壤溶解性有机碳、p H和土壤微生物。随着植物生物量的增加 ,对铜的吸收速率不断增加。

关键词：玉米根际土壤铜形态动态变化重金属吸收

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang jun-Zhao Xiao yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Optimal Time-consistent Investment and Reinsurance Strategy for Mean-variance Insurers Under the Inside Information

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 1087-1100页

作者： Jing cao Xing-chun PENG yi-jun HU School of Mathematics and Statistics Wuhan University School of Mathematics and Statistics South-Central University for Nationalities School of Science Wuhan University of Technology

In this paper, we consider the problem of the optimal time-consistent investment and proportional reinsurance strategy under the mean-variance criterion, in which the insurer has some inside information at her disposal concerning the future realizations of her claims process. It is assumed that the surplus of the insurer is governed by a Brownian motion with drift, and the insurer has the possibility to reduce the risk by purchasing proportional reinsurance and investing in financial markets. We first formulate the problem and provide a verification theorem on the extended Hamilton-Jacobi-Bellman equations. Then, the closed-form expression is obtained for the optimal strategy of the optimization problem.

关键词： reinsurance portfolio inside information time-consistency mean-variance criterion

Reaction mechanism and metal ion transformation in photocatalytic ozonation of phenol and oxalic acid with Ag^+/TiO_2

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Journal of Environmental Sciences 2014年第3期26卷 662-672页

作者： yingying Chen Yongbing Xie jun Yang Hongbin cao yi Zhang National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences

Photocatalytic ozonation of phenol and oxalic acid （OA） was conducted with a Ag^＋/TiO2 catalyst and different pathways were found for the degradation of different compounds. Ag^＋ greatly promoted the photocatalytic degradation of contaminants due to its role as an electron scavenger. It also accelerated the removal rate of OA in ozonation and the simultaneous process for its complex reaction with oxalate. Phenol could be degraded both in direct ozonation and photolysis, but the TOC removal rates were much higher in the simultaneous processes due to the oxidation of hydroxyl radicals resulting from synergetic effects. The sequence of photo-illumination and ozone exposure in the combined process showed quite different effects in phenol degradation and TOC removal. The synergetic effects in different combined processes were found to be highly related to the properties of the target pollutants. The color change of the solution and TEM result confirmed that Ag＋ was easily reduced and deposited on the surface of Tit2 under photo-illumination, and dissolved again into solution in the presence of ozone. This simple cycle of enrichment and distribution of Ag^＋ can greatly benefit the design of advanced oxidation processes, in which the sequences of ozone and photo-illumination can be varied according to the needs for catalyst recycling and the different properties of pollutants.

关键词： photocatalytic ozonation phenoloxalic acid Ag+/TiO2

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China Life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing Song He Li Maomao cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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