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Advances in the differentiation of pluripotent stem cells into vascular cells

World Journal of Stem Cells 2024年第2期16卷 137-150页

作者： yi-chang jiao ying-Xin Wang Wen-Zhu Liu Jing-Wen Xu Yu-ying Zhao Chuan-Zhu Yan Fu-Chen Liu Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Research Institute of Neuromuscular and Neurodegenerative Diseases Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Mitochondrial Medicine Laboratory Qilu Hospital(Qingdao)of Shandong UniversityQingdao 266103Shandong ProvinceChina Brain Science Research Institute Shandong UniversityJinan 250012Shandong ProvinceChina

Blood vessels constitute a closed pipe system distributed throughout the body,transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and *** in blood vessels are related to many disorders like stroke,myocardial infarction,aneurysm,and diabetes,which are important causes of death *** research for new appro-aches to disease modeling and effective treatment is needed due to the huge socio-economic burden on healthcare *** mice or rats have been widely used,applying data from animal studies to human-specific vascular physiology and pathology is *** rise of induced pluripotent stem cells(iPSCs)provides a reliable in vitro resource for disease modeling,regenerative medicine,and drug discovery because they carry all human genetic information and have the ability to directionally differentiate into any type of human *** review summarizes the latest progress from the establishment of iPSCs,the strategies for differentiating iPSCs into vascular cells,and the in vivo trans-plantation of these vascular *** also introduces the application of these technologies in disease modeling,drug screening,and regenerative ***,the application of high-tech tools,such as omics analysis and high-throughput sequencing,in this field is reviewed.

关键词： Induced pluripotent stem cell Blood vessels Vascular organoids Endothelial cells Smooth muscle cells Pericytes Tissue engineering vascular graft

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Enhancing storage performance of P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2)cathode materials by Al_(2)O_(3)coating

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Transactions of Nonferrous Metals Society of China 2022年第1期32卷 262-272页

作者： yi-jiao chang Guang-hui XIE Yong-mao ZHOU Jie-xi WANG Zhi-xing WANG Hua-jun GUO Bian-zheng YOU Guo-chun YAN School of Metallurgy and Environment Central South UniversityChangsha 410083China

The P2-type Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2)materials were synthesized by an ultrasonic spray pyrolysis followed by solid-state sintering *** structures,morphologies and electrochemical performances of Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2)materials were characterized thoroughly by means of X-ray diffractometer,scanning electron microscope and electrochemical charge/discharge ***,a thin layer of Al_(2)O_(3),which was formed on the surface of Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2),can enhance the storage performance by preventing the formation of Na_(2)CO_(3)·H_(2)O,which is believed to enhance the electrochemical performances of Na_(2/3)Fe_(1/2)Mn_(1/2)O_(2)*** facile surface modification method may pave a way to synthesize advanced cathode materials for sodium-ion batteries.

关键词： Al_(2)O_(3)coating air-stability spray pyrolysis sodium-ion batteries iron-manganese oxide

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检测中晚期肺癌患者使用抗PD-1抗体药物前后外周血淋巴细胞刺激性和抑制性免疫检查点表达的变化及与病情进展的关系

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中国卫生检验杂志 2018年第4期28卷 400-404页

作者：杜无双胡毅焦顺昌柳俨哲解放军总医院肿瘤内科北京100832 解放军总医院肝胆外二科北京100832

目的探究抗PD-1单抗治疗前后免疫检查点的变化与疗效的关系。方法采集16例接受抗PD-1单抗治疗肺癌患者的外周血,分别于每次治疗前收集。通过流式细胞的方法检测PD-1、CTLA-4、TIM-3、LAG-3、BTLA、CD160、Ki-67、OX40和GITR在T淋巴细胞... 详细信息

目的探究抗PD-1单抗治疗前后免疫检查点的变化与疗效的关系。方法采集16例接受抗PD-1单抗治疗肺癌患者的外周血,分别于每次治疗前收集。通过流式细胞的方法检测PD-1、CTLA-4、TIM-3、LAG-3、BTLA、CD160、Ki-67、OX40和GITR在T淋巴细胞上的表达情况。结果通过两周期评价结果将患者分为有效和无效2组,组间比较发现PD-1、CTLA-4和Ki-67表达有统计学意义(P0.05),有效组PD-1、CTLA-4、LAG-3、BTLA、CD160和Ki-67表达在免疫治疗后有不同程度升高且有统计学意义。结论多个免疫检查点的表达与疗效有关,且可作为早期预测患者免疫治疗疗效的指标。

关键词： PD-1 免疫检查点免疫治疗 T淋巴细胞疗效预测

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Hydrothermal synthesis mechanism and electrochemical performance of LiMn_(0.6)Fe_(0.4)PO_4 cathode material

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Rare Metals 2019年第1期38卷 29-34页

作者： chang-chang Xu ying Wang Li Li yi-Jing Wang Li-Fang jiao Hua-Tang Yuan Institute of New Energy Material Chemistry Nankai University Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Nankai University Key Laboratory of Advanced Energy Materials Chemistry Nankai University Tianjin Key Laboratory on Metal and Molecule-based Material Chemistry Nankai University

Monocrystal LiMn_(0. 6)Fe_(0. 4)PO_4 cathode material was obtained via hydrothermal method at 180℃ for 10 h without any surfactant. The effects of hydrothermal time on the phase and morphology of the material were *** controlling the reaction solutions, the rodlike, flowerlike,and strawlike LiMn_(0.6)Fe_(0.4)PO_4 cathode materials were synthesized. Electrochemical performances show that the rodlike LiMn_(0. 6)Fe_(0. 4)PO_4 has the best electrochemical properties. The initial discharge capacity of the rodlike structure is 106.4 mAh·g^(-1), which is higher than those of flowerlike and strawlike materials.

关键词： LiMn0.6Fe0.4PO4 Hydrothermal method Cathode material Lithium-ion batteries Synthesis mechanism

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Machine learning-based direct solver for one-to-many problems on temporal shaping of relativistic electron beams

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Frontiers of physics 2022年第6期17卷 15-24页

作者： Jinyu Wan yi jiao Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China China Spallation Neutron Source Dongguan 523803China

To control the temporal profile of a relativistic electron beam to meet requirements of various advanced scientific applications like free-electronlaser and plasma wakefield acceleration,a widely-used technique is to manipulate the dispersion terms which turns out to be one-to-many *** to their intrinsic one-to-many property,current popular stochastic optimization approaches on temporal shaping may face the problems of long computing time or sometimes suggesting only one *** we propose a real-time solver for one-to-many problems of temporal shaping,with the aid of a semi-supervised machine learning method,the conditional generative adversarial network(CGAN).We demonstrate that the CGAN solver can learn the one-to-many dynamics and is able to accurately and quickly predict the required dispersion terms for different custom temporal *** machine learning-based solver is expected to have the potential for wide applications to one-to-many problems in other scientific fields.

关键词： beam shaping one-to-many problem machine learning

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Design study of APS-U-type hybrid-MBA lattice for mid-energy DLSR

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Nuclear Science and Techniques 2021年第7期32卷 46-54页

作者： Yu Zhao yi jiao Sheng Wang Institute of High Energy Physics(IHEP) Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Spallation Neutron Source Science Center(SNSSC) Dongguan 523803China

In recent years,a new generation of storage ring-based light sources,known as diffraction-limited storage rings(DLSRs),whose emittance approaches the diffraction limit for the range of X-ray wavelengths of interest to the scientific community,has garnered significant attention *** have begun to design and build *** various DLSR proposals,the hybrid multibend achromat(H-MBA)lattice enables sextupole strengths to be maintained at a reasonable level when minimizing the emittance;hence,it has been adopted in many DLSR *** on the H-7BA lattice,the design of the Advanced Photon Source Upgrade Project(APS-U)can effectively reduce emittance by replacing six quadrupoles with ***,we discuss the feasibility of designing an APS-U-type H-MBA lattice for the Southern Advanced Photon Source,a mid-energy DLSR light source with ultralow emittance that has been proposed to be built adjacent to the China Spallation Neutron *** linear and nonlinear dynamics are optimized to obtain a detailed design of this type of *** emittance is minimized,while a sufficiently large dynamic aperture(DA)and momentum acceptance(MA)are maintained.A design comprising 36 APS-U type H-7BAs,with an energy of 3 GeV and a circumference of 972 m,is *** horizontal natural emittance is 20 pm·rad,with a horizontal DA of 5.8 mm,a vertical DA of 4.5 mm,and an MA of 4%,as well as a long longitudinal damping time of 120 ***,a few modifications are performed based on the APS-U-type lattice to reduce the maximum value of damping time from 120 to 44 ms while maintaining other performance parameters at the same level.

关键词： Southern advanced photon source(SAPS) Diffraction-limited storage ring(DLSR) Hybrid multibend achromat(H-MBA) Advanced photon source upgrade project(APS-U) Lattice design

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Insight study of rare earth elements in PM_(2.5)during five years in a Chinese inland city:Composition

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Journal of Environmental Sciences 2024年第4期138卷 439-449页

作者： yi-Wen Shen chang-Xian Zhao Hao Zhao Shuo-Fei Dong Qi Guo jiao-jiao Xie Mei-Ling Lv Chun-Gang Yuan Hebei Key Lab of Power Plant Flue Gas Multi-Pollutants Control Department ofEnvironmental Science&EngineeringNorth China Electric Power UniversityBaoding 071000China MOE Key Laboratory of Resources and Environmental Systems Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Agilent Technologies Co.Ltd.(China) Beijing 100102China

The booming development of rare earth industry and the extensive utilization of its products accompanied by urban development have led to the accelerated accumulation of rare earth elements(REEs)as emerging pollutants in atmospheric *** this study,the variation of REEs in PM_(2.5)with urban(a non-mining city)transformation was investigated through five consecutive years of sample *** compositional variability and provenance contribution of REEs in PM_(2.5)were characterized,and the REEs exposure risks of children and adults via inhalation,ingestion and dermal absorption were also *** results showed an increase in the total REEs concentration from 46.46±35.16 mg/kg(2017)to 81.22±38.98 mg/kg(2021)over the five-year period,with Ce and La making the largest *** actual increment of industrial and traffic emission source among the three pollution sources was 1.34 ng/m^(3).Coal combustion source displayed a downward *** was the main exposure pathway for REEs in PM_(2.5)for both children and *** contributed the most to the total intake of REEs in PM_(2.5)among the population,followed by La and *** exposure risks of REEs in PM_(2.5)in the region were relatively low,but the trend of change was of great *** was strongly recommended to strengthen the concern about traffic-related non-exhaust emissions of particulate matter.

关键词： Rare earth elements Exposure risks Pollution sources Traffic-related non-exhaust emissions

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北师大版初中数学新教材的特色及变化分析

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教学与管理 2025年第1期 44-48页

作者：常海斌宁依敏首都师范大学教育学院北京100048 华东师范大学数学科学学院上海200241

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着... 详细信息

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着重凸显课程内容的结构化和认知过程的进阶性;四个学习领域以“研究对象”的形式进行内容整合,具有重视代数推理、重构统计量的组合形式以及对综合与实践领域进行主题迭代和核心创变等变化。

关键词：初中数学新教材教材编写特色北师大版教材新教材变化分析

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乙酰丙酮铱Ir(acac)_(3)电子结构及光学性质的理论研究

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原子与分子物理学报 2025年第1期42卷 1-7页

作者：樊依佳蔚娇娇郭家成陈扬尹杜恭贺西北工业大学伦敦玛丽女王大学工程学院西安710129 西安邮电大学理学院西安710121

乙酰丙酮铱是一种由过渡金属Ir与乙酰丙酮酸(acetylcaetonato)有机部分组成的过渡金属有机配合物,它是一种重要的绿光磷光材料,同时其也是多种铱系发光材料的组成部分.采用密度泛函理论(DFT)对Ir(acac)_(3)单体及其二聚物的基态几何结... 详细信息

乙酰丙酮铱是一种由过渡金属Ir与乙酰丙酮酸(acetylcaetonato)有机部分组成的过渡金属有机配合物,它是一种重要的绿光磷光材料,同时其也是多种铱系发光材料的组成部分.采用密度泛函理论(DFT)对Ir(acac)_(3)单体及其二聚物的基态几何结构进行了优化,在此基础上考察了它们的振动和红外光谱,并使用CIS方法对它们的激发态性质进行了理论研究.计算得到的单体和二聚物的吸收光谱均在紫外波段,单体的主要吸收峰有260 nm,350 nm,414 nm,二聚物的主要吸收峰有299 nm,353 nm,401 nm.计算得到了二者在乙腈CH_(3)CN溶液中的吸收光谱,与它们气相情况的结果相比,溶剂极性的影响使得电子吸收谱发生蓝移.计算结果表明Horst Kunkely和Arnd Vogler所得光谱中既含有单体的特征光谱,又含有二聚体的特征光谱,证明实验溶液中同时存在乙酰丙酮铱的低聚物,并且二者的组分比能被合理推算.最后,对多聚体的形成机理作了简单讨论.

关键词： Ir(acac)_(3) 密度泛函理论(DFT) CIS 电子吸收光谱溶液效应

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Starting flow in a rotating parallel plate channel

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Acta Mechanica Sinica 2012年第5期28卷 1271-1276页

作者： chang yi Wang Department of Mathematics Michigan State University

The starting flow due to a suddenly applied pressure gradient in a parallel plate channel which is rotating as a system is studied. Exact analytic series solutions to the unsteady Navier-Stokes equations are found by both the Laplace transform method and the separation of parameters method, the latter is shown to be superior. Rotation not only induces a secondary transverse flow but also alters the character of the transient flow rate and velocity profiles. Back flow and inertial oscillations occur, especially at higher rota- tion rates.

关键词： Rotating system Flow - Starting

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