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Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke

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Neural Regeneration Research 2019年第2期14卷 280-288页

作者： Hong-Yun He Lu Ren Tao Guo yi-hao deng Department of Basic Medicine Medical School Kunming University of Science and Technology

Ischemic stroke often induces excessive neuronal autophagy, resulting in brain damage; meanwhile, inflammatory responses stimulated by ischemia exacerbate neural injury. However, interactions between neuronal autophagy and microglial inflammation following ischemic stroke are poorly understood. CX3CL1/fractalkine, a membrane-bound chemokine expressed on neurons, can suppress microglial inflammation by binding to its receptor CX3CR1 on microglia. In the present study, to investigate whether autophagy could alter CX3CL1 expression on neurons and consequently change microglial inflammatory activity, middle cerebral artery occlusion(MCAO) was established in Sprague-Dawley rats to model ischemic stroke, and tissues from the ischemic penumbra were obtained to evaluate autophagy level and microglial inflammatory activity. MCAO rats were administered 3-methyladenine(autophagy inhibitor) or Tat-Beclin 1(autophagy inducer). Western blot assays were conducted to quantify expression of Beclin-1, nuclear factor kappa Bp65(NF-κB), light chain 3B(LC3B), and CX3CL1 in ischemic penumbra. Moreover, immunofluorescence staining was performed to quantify numbers of LC3B-, CX3CL1-, and Iba-1-positive cells in ischemic penumbra. In addition, enzyme linked immunosorbent assays were utilized to analyze concentrations of tumor necrosis factor alpha(TNF-α), interleukin 6(IL-6), interleukin 1 beta(IL-1β), and prostaglandin E2(PGE2). A dry/wet weight method was used to detect brain water content, while 2,3,5,-triphenyltetrazolium chloride staining was utilized to measure infarct volume. The results demonstrated that autophagy signaling(Beclin-1 and LC3B expression) in penumbra was prominently activated by MCAO, while CX3CL1 expression on autophagic neurons was significantly reduced and microglial inflammation was markedly activated. However, after inhibition of autophagy signaling with 3-methyladenine, CX3CL1 expression on neurons was obviously increased, whereas Iba-1 and NF-κB expression was

关键词： nerve regeneration ischemic stroke neuronal autophagy microglial inflammation CX3CL1 autophagic neurons autophagy induction autophagy inhibition neural regeneration

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Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy

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Neural Regeneration Research 2021年第5期16卷 813-819页

作者： yi-hao deng Ling-Ling Dong Yong-Jie Zhang Xiao-Ming Zhao Hong-Yun He Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunmingYunnan ProvinceChina

Autophagy is crucial for maintaining cellular homeostasis,and can be activated after ischemic *** also participates in nerve injury and *** purpose of this study was to investigate whether an enriched environment has neuroprotective effects through affecting autophagy.A Sprague-Dawley rat model of transient ischemic stroke was prepared by occlusion of the middle cerebral artery followed by *** week after surgery,these rats were raised in either a standard environment or an enriched environment for 4 successive *** enriched environment increased Beclin-1 expression and the LC3-II/LC3-I ratio in the autophagy/lysosomal pathway in the penumbra of middle cerebral artery-occluded *** environment-induced elevations in autophagic activity were mainly observed in *** environment treatment also promoted the fusion of autophagosomes with lysosomes,enhanced the lysosomal activities of lysosomal-associated membrane protein 1,cathepsin B,and cathepsin D,and reduced the expression of ubiquitin and *** 4 weeks of enriched environment treatment,neurological deficits and neuronal death caused by middle cerebral artery occlusion/reperfusion were significantly alleviated,and infarct volume was significantly *** findings suggest that neuronal autophagy is likely the neuroprotective mechanism by which an enriched environment promotes recovery from ischemic *** study was approved by the Animal Ethics Committee of the Kunming University of Science and Technology,China(approval No.5301002013855)on March 1,2019.

关键词： autophagy brain central nervous system factor injury pathways protection regeneration repair stroke

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Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke

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Neural Regeneration Research 2016年第7期11卷 1108-1114页

作者： yi-hao deng Hong-yun He Li-qiang Yang Peng-yue Zhang Department of Human Anatomy and Histoembryology Medical SchoolKunming University of Science and Technology

The temporal dynamics of neuronal autophagy and apoptosis in the ischemic penumbra following stroke remains ***,in this study,we investigated the dynamic changes in autophagy and apoptosis in the penumbra to provide insight into potential therapeutic targets for *** adult Sprague-Dawley rat model of permanent ischemic stroke was prepared by middle cerebral artery *** autophagy and apoptosis in the penumbra post-ischemia were evaluated by western blot assay and immunofluorescence staining with antibodies against LC3-Ⅱ and cleaved caspase-3,*** of both LC3-Ⅱ and cleaved caspase-3 in the penumbra gradually increased within 5 hours ***,levels of both proteins declined,especially LC3-Ⅱ.The cerebral infarct volume increased slowly 1–4 hours after ischemia,but subsequently increased rapidly until 5 hours after *** severity of the neurological deficit was positively correlated with infarct ***3-Ⅱ and cleaved caspase-3 levels were high in the penumbra within 5 hours after ischemia,and after that,levels of these proteins decreased at different ***3-Ⅱ levels were reduced to a very low level,but cleaved caspase-3 levels remained high 72 hours after *** results indicate that there are temporal differences in the activation status of the autophagic and apoptotic *** suggests that therapeutic targeting of these pathways should take into consideration their unique temporal dynamics.

关键词： neuronal autophagy permanent infarct deficit caspase neurological targeting occlusion unclear

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Autophagy Elicits Neuroprotection at the Subacute Phase of Transient Cerebral Ischaemia but Has Few Effects on Neurological Outcomes After Permanent Ischaemic Stroke in Rats

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Current Medical Science 2021年第4期41卷 803-814页

作者： Tao GUO yi-hao deng Ling-ling DONG Lu REN Hong-yun HE Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunming 650500China

Objective Autophagy was prominently activated by cerebral *** study was to investigate the exact role of autophagy in ischaemic *** Two rat models of transient middle cerebral artery occlusion(tMCAO)and permanent MCAO(pMCAO)were *** brain tissues in the penumbra were obtained to observe the dynamic variations of autophagy activity with Beclin1 and LC3 antibodies by Western *** the characteristic time points,when autophagy activity was markedly elevated or reduced,the autophagy activation signaling was intervened with rapamycin and 3-methyladenine,***,key proteins in the autopahgic/lysosomal pathway were detected with the antibodies of LC3,p62,ubiquitin,LAMP-1 and cathepsin ***,TTC staining,neurological score and immunofluorescence were performed to evaluate brain infarct volume,neurological deficit and neuron survival,*** Both Beclin1 and LC3 expression levels were remarkably altered at 6 h,12 h,2 days and 7 days after ***,the dynamic changes of autophagy activity following pMCAO were identical to those after *** autophagy induction nor autophagy inhibition was able to ameliorate the pMCAO-induced neurological injury due to lysosomal dysfunction,as indicated by low levels of LAMP-1 and cathepsin B,accompanied with the accumulation of LC3-II,ubiquitin and insoluble ***,autophagy induction elicited overt neuroprotection at 2 and 7 days after tMCAO,and this neuroprotection might be elicited by the enhancement of autophagy *** Our study suggests that autophagy confers neuroprotection at the subacute phase of tMCAO but has few effects on neurological outcomes after pMCAO.

关键词： permanent cerebral stroke transient cerebral ischaemia autophagy induction autophagy inhibition neuroprotection

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Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu hao-Yu Jiang Dan-Dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-Chang hao yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

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Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： yingjie Zhao yicheng Sun Chaoxin Pei Xing yin Xinyi Li yi hao Mengru Zhang Meng Yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

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Dissipation-free approach for realizing non-Hermitian dynamics in a superconducting circuit

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： yi-hao Kang Yang Xiao Yu Wang Qi-Ping Su Chui-Ping Yang School of Physics Hangzhou Normal University Fujian Key Laboratory of Quantum Information and Quantum Optics Fuzhou University Department of Physics Fuzhou University

Non-Hermitian dynamics exhibits a wealth of surprising and potentially useful phenomena. However, it is typically realized by coupling a system with thermal reservoirs, which makes the system suffer from thermal fluctuations associated with the dissipation. Here, we propose a dissipation-free approach to realize non-Hermitian dynamics using a superconducting circuit composed of two resonators and a superconducting qutrit. The non-Hermiticity arises in the dynamical matrix for the evolution of the two resonators in the Heisenberg picture, via a photon-number non-conserved dynamics. The energy spectrum of the non-Hermitian dynamical matrix can be retrieved by measuring the state of the two resonators, and a phase transition of the energy spectrum can be observed by varying the control parameters. In the realization of the non-Hermitian dynamics, the dissipation of the system and the post-selection are not required. Thus, the approach is implemented in a deterministic way, and the reservoir-induced noise is suppressed. Numerical simulations indicate that the energy spectrum of the non-Hermitian dynamical matrix obtained via the measurement of the resonators is in accordance with the theoretical prediction. Moreover, we demonstrate the parity discrimination for the state of two four-level qudits as an application, exhibiting the potential of the non-Hermitian dynamics in the field of quantum measurement. This work opens a new avenue for the realization of non-Hermitian dynamics and may have a significant implication in exploring the non-Hermitian phenomena.

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-yi Wang Yao hao Zi-Jian Wang Xiu-Liang Xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Hunting the Datable Garnet using the LA-ICP-MS U-Pb Method:Predicting Garnet U Concentration,based on Major and Minor Elements

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 2148-2157页

作者： deng yi ZHONG Richen LI dengfeng LI Yanxia CUI hao School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China School of Marine Sciences Sun Yat-sen UniversityZhuhaiGuangdong 519082China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering ZhuhaiGuangdong 519082China

Garnet occurs in a wide range of rock types,from mantle peridotites to granites,from eclogites to *** recent years,garnet LA-ICP-MS(Laser Ablation Inductively Coupled Plasma Mass Spectrometry)U-Pb dating has provided a powerful solution for retrieving the ages of rock formations,but successful dating is often prohibited by the low concentration of ***,the concentration of U,a trace element of garnet,is unknown prior to the LA-ICP-MS *** this study,we propose that the U concentration in garnet can be predicted by the contents of major and minor elements,which can be quantitatively obtained by EPMA(electron probe microanalysis).Using a supervised machine learning method(neural network),a model is trained to discriminate U-rich(>2 ppm)and U-poor(<2 ppm)garnets,based on EPMA *** of cross validation shows that the model has an average accuracy of~92%and is a powerful tool in detecting datable U-rich *** facilitate the use of the discriminator,it is programmed as a stand-alone Microsoft Excel spreadsheet(HighUGarnet)and users directly paste the molar proportions of garnet end members into it and obtain the discrimination result.

关键词： garnet U-Pb LA-ICP-MS machine learning

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