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国际感染病学（电子版） 2013年第1期2卷 1-5页

作者： yi-hai gu Xiao Zhu Jing-yun Li Jun Zhang Qing-yuan Zhou Yue Ma Chang-qin Hu Shao-hong Jin Sheng-hui Cui Department of Microbiology 3201 Hospital The National Center for Surveillance of Antimicrobial Resistance the State Food and Drug Administration

Objective To identify the risk factors for imipenem resistance development and transmission of clinical Pseudomonas aeruginosa *** Thirty-seven imipenem unsusceptible Pseudomonas aeruginosa isolates collected from patients in absence of carbapenem treatment were characterized by antimicrobial susceptibility test,pulsed field gel electrophoresis(PFGE)and carbapenem resistant mechanism *** Before the collection of imipenem unsusceptible Pseudomonas aeruginosa isolates,the average time of patients treated with more than one antimicrobial(20.0±9.5 days,n=16)was significantly longer than those treated with only one antimicrobial(12.6±4.4 days,n=21;t-test,Welch,t=-2.9004,P<0.01).And 32 isolates showed resistance to more than 3 classes of *** PFGE clusters were identified and 26 isolates were grouped into one dominant cluster(C2).An ISpa1328 sequence insertion in oprD was detected in 33 isolates and the function of efflux was observed in all 37 isolates in the presence of a wide spectrum efflux *** Our data demonstrated that exposure to non-carbapenem drug classes,especially fluoroquinolones andβ-lactams,may be important risk factors for the spread of carbapenem resistant Pseudomonas aeruginosa.

关键词： Pseudomonas aeruginosa Imipenem resistance Carbapenem

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun gu Wei Ma Yuying guan Mengyuan guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-yi Hsiao Chung-yi Nien Ruei-Feng Shiu Wei-Chun Chin Tzung-hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于大安全观的环境安全

江苏环境科技 2004年第3期17卷 44-46页

作者：李天昕宋存义林海谷为民北京科技大学环境工程系北京100083

在简单介绍了大安全观的基础上,详细分析了环境安全的由来、特点及内涵。最后提出了实现环境安全的具体措施,并对环境安全的发展进行了展望。

关键词：环境安全安全观由来内涵基础

A structural comparison of measurement-based admission control algorithms

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The Journal of China Universities of Posts and Telecommunications 2006年第3期13卷 81-86页

作者： gu yi-ran WANG Suo-ping WU hai-ya The College of Automation Nanjing University of Posts and TelecommunicationsNanjing 210003 China Ningbo Branch Co. Zhejiang Telecommunication Co. Ltd. Zhejiang ProvinceNingbo 315000 China

Measurement-based admission control （MBAC） algorithm is designed for the relaxed real-time service. In contrast to traditional connection admission control mechanisms, the most attractive feature of MBAC algorithm is that it does not require a prior traffic model and that is very difficult for the user to come up with a tight traffic model before establishing a flow. Other advantages of MBAC include that it can achieve higher network utilization and offer quality service to users. In this article, the study of the equations in the MBAC shows that they can all be expressed in the same form. Based on the same form, some MBAC algorithms can achieve same performance only if they satisfy some conditions.

关键词： connection admission control MBAC measurement process

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北师大版初中数学新教材的特色及变化分析

教学与管理 2025年第1期 44-48页

作者：常海斌宁依敏首都师范大学教育学院北京100048 华东师范大学数学科学学院上海200241

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着... 详细信息

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着重凸显课程内容的结构化和认知过程的进阶性;四个学习领域以“研究对象”的形式进行内容整合,具有重视代数推理、重构统计量的组合形式以及对综合与实践领域进行主题迭代和核心创变等变化。

关键词：初中数学新教材教材编写特色北师大版教材新教材变化分析

Clumpy metal concentrations in elliptical galaxies NGC 4374 and NGC 4636

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Research in Astronomy and Astrophysics 2010年第3期10卷 220-226页

作者： hai-guang Xu Jun-Hua gu Li-yi gu Zhong-Li Zhang Yu Wang Tao An Department of Physics Shanghai Jiao Tong University Shanghai 200240 China Max-Planck Institut fur Astrophysik D-85740 Garching Germany Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China

We present a high spatial resolution study of metal distributions in the nearby, gas-rich elliptical galaxies NGC 4374 and NGC 4636 with the Chandra ACIS archive data. We define the hardness ratio HRFeL as the ratio of the emission in 0.65- 1.4 keV to that in 0.3-0.6 keV and 1.4-3.5 keV （after the magnesium and silicon lines are excluded）, and HRcont as the ratio of the emission in 1.4-3.5keV to that in 0.3- 0.6 keV, so that the HRFeL and HRcont maps can be used to trace the iron abundance and gas temperature distributions, respectively. By applying the a Trous wavelet algorithm to the obtained emission hardness ratio maps, we reveal that the HRFeL distributions are highly irregular, exhibiting strong spatial variations on 0.1-1 Re scales, which do not follow the HRcont distributions. Since the effect of temperature variation is small, we conclude that most of the high-HRFeL regions are very likely to possess higher abundances than the ambient gas. We also find that these high-HRFeL substructures are not associated with either the LMXB or globular cluster populations, thus their origins should be related to AGN activity or mergers.

关键词： galaxies: elliptical and lenticular cD -- galaxies: individual (NGC 4374 NGC 4636) -- galaxies: ISM -- ISM: abundances -- X-rays: galaxies

Pseudomonas Cyclic Lipopeptide Medpeptin:Biosynthesis and Modulation of Plant Immunity

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Engineering 2023年第9期28卷 153-165页

作者： yi-Lin gu Jun-Zhou Li Yan Li Shen Cong Jing Wang yi-Nan Ma hai-Lei Wei State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China Key Laboratory of Microbial Resources Collection and PreservationMinistry of Agriculture and Rural AffairsInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

The multifunctional secondary metabolites known as cyclic lipopeptides(CLPs),which are produced by a large variety of bacteria,have become a key category of plant immunity ***-CLPs(PsCLPs)are extremely diverse in structure and biological ***,an understanding of CLP-plant structure–function interactions currently remains ***,we identify medpeptin,a novel CLP from Pseudomonas mediterranea that consists of 22 amino *** is synthesized by a non-ribosomal peptide synthase(NRPS)gene cluster and regulated by a quorum-sensing *** research indicates that medpeptin does not exhibit antimicrobial activity;instead,it induces plant cell death immunity and confers resistance to bacterial *** transcriptome analysis and virus-induced gene silencing(VIGS)reveal a set of immune signaling candidates involved in medpeptin *** of a cell-wall leucine-rich repeat extensin protein(NbLRX3)or a receptor-like protein kinase(NbRLK25)—but not BAK1 or SGT1—compromises medpeptin-triggered cell death and resistance to pathogen infection in Nicotiana *** findings point to a noncanonical mechanism of CLP sensing and suggest perspectives for the development of plant disease resistance.

关键词： Pseudomonas Cyclic lipopeptide Cell death Leucine-rich repeat extension(LRX) Medpeptin Receptor-like kinase(RLK)

Effects of pressure and plastic addition on sticking of fine iron ore particles in fluidized bed reduction

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Journal of Iron and Steel Research International 2021年第2期28卷 140-151页

作者： Qi-yan Xu Zhang-han gu Zhi-ping Li ying-yi Zhang hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

The adhesion of fine iron ore particles during fluidized bed reduction was studied using pressurized visible fluidized bed laboratory *** results showed that the optimal operating parameters for pure hydrogen reduction under high pressure were reduction temperature of 1073 K,particle size of 0.18-0.66 mm,pure H_(2) linear velocity of 0.8 m/s,reduction pressure of 200 kPa,and reduction time of 50 *** plastic particles were mixed into the fluidized bed,the optimal parameters were reduction temperature of 973 K,particle size of 0.18-0.66 mm,pure H_(2) linear velocity of 0.8 m/s,reduction pressure of 100 kPa,mass content of plastic particles of 8%,and reduction time of 65 *** chemical reaction resistance is much higher than the inner diffusion resistance at the initial stage of the reaction,whereas,in later stage,the inner diffusion resistance exceeds the chemical reaction *** contact area of iron atoms or iron whiskers gradually decreases with the increase in reduction pressure from 0.20 to 0.45 MPa,and the sticking trend gradually *** plastic particles in the fluidized reduction process of fine iron ore can effectively inhibit the adhesion among fine iron ore particles.

关键词： Fine iron ore Fluidized bed Reduction pressure Plastic particle Sticking Reduction