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Mutations of voltage-gated sodium channel contribute to pyrethroid resistance in Panonychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng Pan Qiu-Juan Luo Andrias O.O'Reilly Guo-Rui Yuan Jin-Jun Wang Wei dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in Panonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to pyrethroids has evolved in some ***,the resistance to the pyrethroid fenpropathrin was investigated and 7 out of 8 field-collected populations of P citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the susceptible(SS)comparison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested populations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field populations.L1031V and F1751I were present in all populations at frequencies of 11.6%-82.1%and 0.5%-31.8%,respectively,whereas the F1747L mutation was only present in 12 populations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenpropathrin and these flies also exhibited reduced mortality after exposure to the pyrethroids permethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with pyrethroids,which are lost with mutation,whereas L1031 mutation may diminish pyrethroid effects through an allosteric ***,the results provide molecular markers for monitoring pest resistance to pyrethroids and offer new insights into the basis of pyrethroid actions on sodium channels.

关键词： amplicon sequencing kdr mutation molecular docking Panonychus citri pyrethroid resistance transgenic flies

A justice and innovative way ahead of consumption-based emission accounting approach

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Science China Earth Sciences 2024年第9期67卷 2999-3010页

作者： Qun SHEN Hongbo DUAN Yun TANG Linbing TANG Li SHANG Xinyu dou Wei WEI Weiqiang CHEN Zhu LIU State Key Laboratory of Low Carbon Catalysis and Carbon Dioxide Utilization CAS Key Laboratory of Low-Carbon Conversion Science &EngineeringShanghai Advanced Research InstituteChinese Academy of Sciences School of Economics & Management University of Chinese Academy of Sciences Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of Sciences Department of Earth System Science Tsinghua Univesity

Carbon emission accounting is an important basis for global climate governance. Based on the consumption-based accounting(CBA) method, the characteristics of carbon flow between national, regional, and product processes could be more clearly reflected. Therefore, CBA is more conducive to clarifying the attribution of responsibilities between producers and consumers, with the principles of fairness and justice. By accounting for carbon emissions in typical countries from 1990 to 2019, we found that the CBA emissions are higher than the production-based accounting(PBA) emissions in major developed countries, while the results are reversed for developing countries. In the past 30 years, the CBA emissions in targeted developed countries generally have shown a downward trend, while in developing countries, they have shown an upward trend. CBA emissions in China have shown a continuous growth trend from 1990 to 2019, but the pace has slowed down significantly over the last decade. Meanwhile, the embodied carbon intensity of China's exports continues to decline, indicating that China is providing more green and low-carbon products to the world. Taking the PV industry as an example, this study further reveals the contribution of specific product industries to the country's carbon transfer through product carbon footprint analysis. In order to provide a scientific basis for global mitigation and climate governance, it is urgent to innovate a scientific, practical, and standardized CBA technology system.

关键词： Consumption-based accounting Production-based accounting Carbon transfer Carbon footprint

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Research on Intelligent Vehicle Following Technology Based on UWB

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Research on Intelligent Vehicle Following Technology Based o...

以人的现代化为核心的人才强国战略及其政策创新

第三十九届中国控制会议

作者： Jing-run Pan yi-geng dou Xu-dong Huang Jian-hua Xu Jia-bin Chen Ling Xie School of Automation Beijing Institute of Technology

Considering the communication interference and occlusion for close following, this paper proposes an intelligent vehicle following method based on Ultra-Wideband（UWB）. Based on the characteristics of UWB ranging, we proposed four ranging schemes by combining different base station placement methods and positioning algorithms. We obtained the best method by collecting a large number of distance data from vehicle to beacon and angle data away from the front of the vehicle. Taking the characteristics of vehicle following into account, the deviation between the distance from the vehicle to the beacon and the safety distance is used to control the linear velocity, the angle away from the front of the vehicle is used to control the angular velocity. Finally, in order to test the following method, we carried out tracking experiment, and it is verified that it has good tracing effect under linear, V-shaped and S-shaped tracks.

关键词： UWB Positioning ROS Fuzzy control

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东南学术 2024年第4期 22-30+247页

作者：任保平豆渊博南京大学数字经济与管理学院

人的现代化是衡量中国式现代化进入新阶段的重要标志，新时代人才强国战略要充分体现人的现代化。新科技革命背景下，人的现代化的内涵表现在人的思维方式、人的行为方式、人的生活方式以及人的价值观念的现代化。推进以人的现代化为核... 详细信息

人的现代化是衡量中国式现代化进入新阶段的重要标志，新时代人才强国战略要充分体现人的现代化。新科技革命背景下，人的现代化的内涵表现在人的思维方式、人的行为方式、人的生活方式以及人的价值观念的现代化。推进以人的现代化为核心的新时代人才强国战略，重点在于以人才强国建设为目标，推动人才链优化；以科技创新为引领，培养适应高质量发展的创新人才；以高质量发展为导向，打造高水平科技人才发展高地；以产学研一体化发展为着力点，形成新型协同育人新模式。深入实施以人的现代化为核心的新时代人才强国战略的政策创新，应着眼于制定高端人才发展战略，提高科技、教育和产业发展的适配度；加大普惠性人力资本投入力度，增强人力资本集聚；加快建设高质量教育体系，实现教育、科技、人才一体化推进；持续优化人才发展的体制机制，建立多元化人才评价体系。

关键词：新科技革命高质量发展人的现代化人才强国战略

数据、算力和算法结合反映新质生产力的数字化发展水准

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浙江工商大学学报 2024年第3期 91-100页

作者：任保平豆渊博南京大学数字经济与管理学院

数字经济的发展促进新的劳动主体、新的生产工具和新的生产要素不断涌现，为人们认识世界和改造世界创造了新模式，新质生产力的数字化发展是新质生产力在数字经济领域的表现。数字经济时代，数据作为新质生产力数字化发展的新要素，算... 详细信息

数字经济的发展促进新的劳动主体、新的生产工具和新的生产要素不断涌现，为人们认识世界和改造世界创造了新模式，新质生产力的数字化发展是新质生产力在数字经济领域的表现。数字经济时代，数据作为新质生产力数字化发展的新要素，算力体现新质生产力数字化发展的新动能，算法反映新质生产力数字化发展的新优势，数据、算力和算法的结合反映了新质生产力的数字化发展水准，形成数字时代的新质生产力。新发展阶段，数据、算力和算法的结合首先引起生产力的决策革命，其次引起生产力的工具革命、劳动力革命、生产要素革命和技术—经济范式革命，进一步推动新质生产力的数字化发展。在全球经济新周期的背景下，提高新质生产力的数字化发展水平已经成为推动经济社会高质量发展的关键力量。

关键词：新质生产力数据+算力+算法数字技术智能化工具

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A Simple yet Effective Framework for Active Learning to Rank

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Machine Intelligence Research 2024年第1期21卷 169-183页

作者： Qingzhong Wang Haifang Li Haoyi Xiong Wen Wang Jiang Bian Yu Lu Shuaiqiang Wang Zhicong Cheng Dejing dou Dawei yin Baidu Incorporated Beijing 100085China

While China has become the largest online market in the world with approximately 1 billion internet users,Baidu runs the world's largest Chinese search engine serving more than hundreds of millions of daily active users and responding to billions of queries per *** handle the diverse query requests from users at the web-scale,Baidu has made tremendous efforts in understanding users'queries,retrieving relevant content from a pool of trillions of webpages,and ranking the most relevant webpages on the top of the *** the components used in Baidu search,learning to rank(LTR)plays a critical role and we need to timely label an extremely large number of queries together with relevant webpages to train and update the online LTR *** reduce the costs and time con-sumption of query/webpage labelling,we study the problem of active learning to rank(active LTR)that selects unlabeled queries for an-notation and training in this ***,we first investigate the criterion-Ranking entropy(RE)characterizing the entropy of relevant webpages under a query produced by a sequence of online LTR models updated by different checkpoints,using a query-by-com-mittee(QBC)***,we explore a new criterion namely prediction variances(PV)that measures the variance of prediction res-ults for all relevant webpages under a *** empirical studies find that RE may favor low-frequency queries from the pool for la-belling while PV prioritizes high-frequency queries ***,we combine these two complementary criteria as the sample selection strategies for active *** experiments with comparisons to baseline algorithms show that the proposed approach could train LTR models to achieve higher discounted cumulative gain(i.e.,the relative improvement DCG4=1.38%)with the same budgeted labellingefforts.

关键词： Search information retrieval learning to rank active learning query by committee

Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury

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Neural Regeneration Research 2024年第7期19卷 1608-1617页

作者： Yanan dou Xiaowei Fei Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou Fei Xia Li Fei Fei Department of Neurosurgery Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology Xijing HospitalAir Force Military Medical UniversityXi’anShaanxi ProvinceChina

Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual *** is repo rted to play a protective role in neuroinflammation in the ***,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain *** our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion *** in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller *** found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion ***,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte *** opposite results we re observed with Homerla ove ***,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion *** together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.

关键词： caspase-8 Homer1a interleukin-18 interleukin-1β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 retina

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Synergistic coupling among Mg_(2)B_(2)O_(5),polycarbonate and N,Ndimethylformamide enhances the electrochemical performance of PVDF-HFP-based solid electrolyte

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Journal of Energy Chemistry 2024年第7期94卷 158-168页

作者： Yutong Jing Qiang Lv Yujia Chen Bo Wang Bochen Wu Cheng Li Shengbo Yang Zhipeng He Dianlong Wang Huakun Liu Shixue dou MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Institute of Energy Material Science University of Shanghai for Science and TechnologyShanghai 200093China Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW 2500Australia

Polymer solid electrolytes(SPEs)based on the[solvate-Li+]complex structure have promising prospects in lithium metal batteries(LMBs)due to their unique ion transport ***,the solvation structure may compromise the mechanical performance and safety,hindering practical application of *** this work,a composite solid electrolyte(CSE)is designed through the organic-inorganic syner-gistic interaction among N,N-dimethylformamide(DMF),polycarbonate(PC),and Mg_(2)B_(2)O_(5) in poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP).Flame-retardant Mg_(2)B_(2)O_(5) nanowires provide non-flammability to the prepared CSEs,and the addition of PC improves the dispersion of Mg_(2)B_(2)O_(5) ***,the organic-inorganic synergistic action of PC plasticizer and Mg_(2)B_(2)O_(5) nanowires pro-motes the dissociation degree of LiTFSI and reduces the crystallinity of PVDF-HFP,enabling rapid Li ion ***,Raman spectroscopy and DFT calculations confirm the coordination between Mg atoms in Mg_(2)B_(2)O_(5) and N atoms in DMF,which exhibits Lewis base-like behavior attacking adjacent C-F and C-H bonds in PVDF-HFP while inducing dehydrofluorination of *** on the syner-gistic coupling of Mg_(2)B_(2)O_(5),PC,and DMF in the PVDF-HFP matrix,the prepared CSE exhibits superior ion conductivity(9.78×10^(-4) s cm^(-1)).The assembled Li symmetric cells cycle stably for 3900 h at a current density of 0.1 mA cm^(-2) without short *** LFP||Li cells assembled with PDL-Mg_(2)B_(2)O_(5)/PC CSEs show excellent rate capability and cycling performance,with a capacity retention of 83.3%after 1000 cycles at 0.5 *** work provides a novel approach for the practical application of organic-inorganic Synergistic CSEs in LMBs.

关键词： Composite solid electrolytes Safe Li metal batteries Synergistic coupling effect Poly(vinylidene fluoride-co-hexafluoropro pylene)

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Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： TAO Lei dou Renjie CHEN Xueming CAO Yu DAI Zhen HU Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis