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南昌市2017-2022年鼠类种群密度与季节消长监测分析

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中国媒介生物学及控制杂志 2024年第1期35卷 32-35页

作者：付仁龙陈飞刘仰青陶卉英马红梅范义兵杨树传染病预防控制国家重点实验室研究基地江西省卫生健康新发传染病病原学诊断及基因组学重点实验室南昌市疾病预防控制中心江西南昌330038

目的了解南昌市鼠种构成、鼠密度、不同生境鼠密度变化及季节消长情况,为南昌市科学制定鼠类防控方案提供依据。方法 2017-2022年设置城镇居民区、农村自然村和特殊行业3种监测生境,采用夹夜法进行鼠密度监测,采用描述性统计方法分析... 详细信息

目的了解南昌市鼠种构成、鼠密度、不同生境鼠密度变化及季节消长情况,为南昌市科学制定鼠类防控方案提供依据。方法 2017-2022年设置城镇居民区、农村自然村和特殊行业3种监测生境,采用夹夜法进行鼠密度监测,采用描述性统计方法分析南昌市3类不同生境的鼠种构成及鼠密度季节消长等。采用Excel 2021软件整理数据,SPSS 26.0软件用于分析南昌市3类不同生境的鼠种构成及鼠密度季节消长等。描述性方法对监测数据进行统计分析,不同年份和不同生境的鼠密度比较采用χ^(2)检验。结果 2017-2022年南昌市共布放有效鼠夹104 121夹次,捕获鼠类548只,平均鼠密度为0.53%,6年间鼠密度差异有统计学意义(χ^(2)=34.857,P特殊行业(0.45%)>城镇居民区(0.30%)(χ^(2)=304.340,P<0.001)。城镇居民区和农村自然村的优势鼠种为褐家鼠和黄胸鼠,小家鼠在特殊行业占优势(47.47%)。褐家鼠在特殊行业和农村自然村的构成比呈下降趋势,黄胸鼠在城镇居民区的构成比先升后降,而在特殊行业和农村自然村则总体呈上升趋势;小家鼠在3类不同生境的构成比总体均呈上升趋势。结论2017-2022年南昌市不同年份间鼠密度差异较大,鼠密度随季节变化呈双峰分布,农村自然村鼠密度较高,应针对不同生境鼠种的变化采取针对性的防制措施以降低鼠密度及鼠源疾病风险。

关键词：鼠类密度鼠种构成季节消长监测

A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues

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Cellular & Molecular Immunology 2022年第5期19卷 647-649页

作者： Chunyan yi Zhiyang Ling Xiao Lu Yadong fu Zhuo Yang Sonam Wangmo Shuangfeng Chen Yaguang Zhang Liyan Ma Wangpeng Gu Hongzhou Lu Xiaoyu Sun Bing Sun State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai200031China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China National Clinical Center for Infectious Disease The Third People’s Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518112Guangdong ProvinceChina Shanghai Public Health Clinical Center Shanghai Medical CollegeFudan UniversityShanghai201508China

The newly emerged Omicron(B.1.1.529)variant of SARS-CoV-2 is quickly overtaking the Delta variant and becoming the dominant strain around the world due to its enhanced transmissibility and high immune escape potential[1,2].Compared to the Wuhan strain,the Omicron variant carries 37 spike mutations,of which 15 are within the receptor-binding domain(RBD)(Fig.1A).A high mutation rate is associated with remarkable resistance to current vaccines and RBD-specific antibody therapeutics[2,3,4].

关键词： residues becoming Omi

functionalizing MOF with Redox-Active Tetrazine Moiety for Improving the Performance as Cathode of Li-O_(2)Batteries

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CCS Chemistry 2021年第3期3卷 1297-1305页

作者： Na Li Ze Chang Ming Zhong Zi-Xuan fu Jun Luo yi-Fang Zhao Guo-Bao Li Xian-He Bu School of Materials Science and Engineering Tianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350 Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071 Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871

A redox-active tetrazine moiety is immobilized within a metal-organic framework(MOF)aiming at targeted construction of a cathode with improved performance for lithium–oxygen batteries.A 1,2,4,5-tetrazine(Tz)functionalized ligand is used to construct a nanoporous MOF,Tz-Mg-MOF-74,in which the redox activity of the Tz moiety is *** the redox activity of Tz with the porous nature of a MOF produced a Tz-Mg-MOF-74-based cathode with significantly improved electrochemical ***,the material has improved sustainable capacity with a lower overpotential compared with otherwise similar batteries without Tz and other reported MOF-based *** present approach productively integrates electrochemical activity derived from redox-active moieties and MOFs,and this combination opens a new avenue for the design of effective materials for energy storage and conversion.

关键词： redox-active tetrazine functionalized MOF cathode material lithium–oxygen battery

Short-term efficacy assessment of transarterial chemoembolization combined with radioactive iodine therapy in primary hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 105-113页

作者： Lei Wang Kun Huang Yu Zhang yi-Fan Wu Zhen-Dong Yue Zhen-Hua Fan fu-Quan Liu Yong-Wu Li Jian Dong Department of Interventional Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Radiology Chinese Medical University Affiliated First HospitalShenyang 110001Liaoning ProvinceChina Department of Nuclear Medicine The Fifth Center of People’s Liberation Army General HospitalBeijing 100071China Department of Radiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Transarterial chemoembolization(TACE)is an effective treatment for primary hepatocellular carcinoma(PHC).Radioactive iodine therapy has been used in the treatment of advanced PHC,especially in patients with portal vein tumor ***,data on the therapeutic effect of TACE combined with radioactive iodine therapy in PHC are *** To investigate the clinical efficacy of TACE combined with radioactive iodine implantation therapy in advanced PHC via perfusion computed tomography(CT).METHODS For this study,98 advanced PHC patients were recruited and divided randomly into the study and control *** in the study group were treated with TACE combined radioactive iodine implantation *** in the control group were treated with only *** tumor lesion length,clinical effect,serum alpha-fetoprotein(AFP)and CT perfusion parameters were compared before and after therapy,and statistical analysis was *** There was no significant difference in tumor length and serum AFP between the study and control groups(P>0.05)before ***,the tumor length and serum AFP in the study group were lower than those in the control group 1 mo and 3 mo after *** 3 mo of treatment,the complete and partial remission rate of the study group was 93.88%,which was significantly higher than the control group(77.55%)(Pfusion CT variables,including the lesion blood volume,permeability surface,blood flow,hepatic artery flow and mean transit time(P>0.05).After 3 mo of treatment,all perfusion CT variables were lower in the study group compared to the control group(P<0.05).The survival time of patients in the study group was 22 mo compared to 18 mo in the control group,which was significantly different[log rank(Mantel-Cox)=4.318,P=0.038].CONCLUSION TACE combined with radioactive iodine implantation in the treatment of advanced PHC can in

关键词： Transarterial chemoembolization Radioactive iodine Primary hepatocellular carcinoma Perfusion Computed tomography

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基于滑动窗口的自适应拉伸系数超声弹性成像

仪器仪表学报 2014年第9期35卷 2087-2093页

作者：金晶张家皖沈毅哈尔滨工业大学控制科学与工程系哈尔滨150001

组织弹性的改变与病变常有着非常密切的联系,因此弹性成像技术能给医生的诊断带来很大帮助.自适应拉伸系数超声弹性成像算法,通过迭代反复拉伸组织压缩后的射频数据,寻找能使拉伸后数据与组织压缩前数据的互相关系数达到最大的拉伸系数... 详细信息

组织弹性的改变与病变常有着非常密切的联系,因此弹性成像技术能给医生的诊断带来很大帮助.自适应拉伸系数超声弹性成像算法,通过迭代反复拉伸组织压缩后的射频数据,寻找能使拉伸后数据与组织压缩前数据的互相关系数达到最大的拉伸系数,从而得到组织的应变量图像.该算法生成的图像噪声小,但成像效率低.通过加入窗口滑动,简化了原算法的互相关函数计算,提出了基于滑动窗口的自适应拉伸系数超声弹性成像算法.新算法只计算延迟时间为0时的互相关系数以提高算法效率.用超声仿真数据对提出的算法进行实验表明,算法在组织总应变量为2％～ 5％时生成的弹性图像能够定性地显示直径大于等于4 mm的硬物的弹性特征,成像效果良好,图像没有严重噪声污染.此外对程序运行时间进行的统计表明,改进后算法的效率明显提高.

关键词：弹性成像超声拉伸系数滑动窗口

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射频联合外用药物在增生性瘢痕治疗中的应用

中国美容医学 2024年第6期33卷 185-188页

作者：张杉杨亦付秋悦陈浩熊楚楚张天琦胡国强(综述) 陈刚(审校) 南京中医药大学附属医院(江苏省中医院)整形外科江苏南京210029 中国人民解放军东部战区空军医院烧伤整形外科江苏南京210002

瘢痕是人体创伤修复的必然产物,其治疗方式有多种,包括药物、光电、手术治疗等。常见的外用抗瘢痕药物包括硅酮凝胶、植物提取物等,但局部外用抗瘢痕药物受到皮肤屏障的限制,渗透效率低。射频是由电磁辐射产生的电流,当射频作用于皮肤... 详细信息

瘢痕是人体创伤修复的必然产物,其治疗方式有多种,包括药物、光电、手术治疗等。常见的外用抗瘢痕药物包括硅酮凝胶、植物提取物等,但局部外用抗瘢痕药物受到皮肤屏障的限制,渗透效率低。射频是由电磁辐射产生的电流,当射频作用于皮肤时产生热效应可刺激胶原蛋白合成和重塑,从而有效防治增生性瘢痕。射频也是一种物理促透方法,通过产生皮下微通道输送药物,提高了药物的经皮吸收。该文对常见的外用抗瘢痕药物及其机制、射频技术的发展及射频联合药物在增生性瘢痕治疗中的应用进行了分析和总结,有助于进一步扩展增生性瘢痕的临床治疗思路,提高其治疗效果。

关键词：射频增生性瘢痕硅酮积雪苷洋葱提取物

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星载粒子探测器中的偏转磁铁设计研究

地球物理学报 2007年第3期50卷 684-690页

作者：张珅毅王世金中国科学院空间科学与应用研究中心

在对空间带电粒子进行探测时,大量电子的混入会减少半导体探测器的寿命和工作效率,同时电子的噪声本底也是影响测量精度的重要因素.为了减少电子的影响,需要在离子探测器的探头中加上合适的偏转磁铁用来屏蔽电子的干扰.本文中,磁铁的结... 详细信息

在对空间带电粒子进行探测时,大量电子的混入会减少半导体探测器的寿命和工作效率,同时电子的噪声本底也是影响测量精度的重要因素.为了减少电子的影响,需要在离子探测器的探头中加上合适的偏转磁铁用来屏蔽电子的干扰.本文中,磁铁的结构设计借鉴了国外的成功经验,并通过有限元的方法来计算磁场的强度,选择合适的方案消除漏磁的影响以及模拟电子在磁场的轨迹来估计磁场对电子的偏转能力.并用理论计算的数据与实验结果进行了比对,得到了比较好的结果.最后针对空间粒子探测中的偏转磁铁设计提出了一些建议.加偏转磁场的技术也是我国在星载粒子探测器中的首次应用.

关键词：空间粒子探测偏转磁铁永磁魔环有限元分析磁屏蔽

Applications of circulating tumor cells for prostate cancer

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Asian Journal of Urology 2016年第4期3卷 254-259页

作者： Shirley Cheng Jie-fu Chen yi-Tsung Lu Leland W.K.Chung Hsian-Rong Tseng Edwin M.Posadas Urologic Oncology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Division of Hematology/Oncology Department of MedicineCedars-Sinai Medical CenterLos AngelesCAUSA Department of Internal Medicine John H Stroger HospitalChicagoILUSA Cancer Biology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA California Nanosystems Institute University of CaliforniaLos AngelesCAUSA Department of Molecular Pharmacology University of CaliforniaLos AngelesCAUSA Translational Oncology Program Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA

One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease *** cancer is among these diseases and greatly affects the health of men *** tumor cells(CTCs)are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral *** until recently,clinical applications of CTCs have been limited to using enumeration as a prognostic tool in ***,advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate *** is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes,biochemical analyses,and genomic *** advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic *** recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men.

关键词： Prostate cancer Circulating tumor cell Biomarker Liquid biopsy Molecular oncology

microRNA在结核分枝杆菌抗细胞自噬作用中的研究进展

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生物化学与生物物理进展 2019年第1期46卷 43-50页

作者：张益源伊正君付玉荣潍坊医学院临床医学院潍坊261053 潍坊医学院医学检验学系潍坊261053

结核分枝杆菌(Mycobacteria tuberculosis,MTB)是结核病的致病菌,其感染机体后能在细胞内长期生存并在合适的条件下引发疾病.非氧依赖性杀伤是巨噬细胞清除MTB的重要途径,主要表现为细胞内吞体和溶酶体融合,利用细胞自噬作用清除内部细... 详细信息

结核分枝杆菌(Mycobacteria tuberculosis,MTB)是结核病的致病菌,其感染机体后能在细胞内长期生存并在合适的条件下引发疾病.非氧依赖性杀伤是巨噬细胞清除MTB的重要途径,主要表现为细胞内吞体和溶酶体融合,利用细胞自噬作用清除内部细菌.相应的,MTB可利用多种方式顽强抵抗细胞自噬作用,与细胞共存从而逃避宿主免疫杀伤作用. MicroRNA(miRNA)是一种内源性非编码单链小RNA分子,其能在转录后水平沉默相关基因表达,是介导MTB与炎性细胞许多反应的重要分子.近期研究发现,MTB能够通过诱导巨噬细胞特异表达一些miRNA分子并靶向自噬相关基因,阻碍自噬发生、发展,从而实现MTB的抗细胞自噬作用.本文就miRNA在MTB抗细胞自噬中的作用及机制的研究进展作一综述.

关键词：结核分枝杆菌巨噬细胞自噬 microRNA