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Regional green innovation system mode and its implication:Acase study in eastern China coastal areas

Ecological Economy 2020年第1期16卷 35-57页

作者： CI fu-yi LI Hong-fei SHI Jia-lu College of Geography and Environment Shandong Normal UniversityJi'nan 250300CHINA

Developing circular economy is the inevitable choice to realize regional sustainable *** innovation is the fundamental driving force for regional sustainable ***,the combination of circular economy and regional innovation systems is of great value in the study of regional circular innovation *** on the concepts and basic characteristics of the regional circular innovation system,the author takes Beijing,Shanghai,and Jiangsu as examples,which are the circular economy pilot provinces in developed region of eastern coastal *** outstanding circular economy and innovation achievements,Beijing Economic-Technological Development Area,Shanghai Caohejing Hi-Tech Park,and Suzhou Industrial Park(the National Eco-Industrial Demonstration Park),served to summarize the characteristics,formation mechanism and inspiration of the circular innovation system model in capital economic-technological development zones(characterized by innovation in the recycling of water and land resources and energy,and innovation in circular service industries supplemented with"Internet+Wisdom Park"),coastal new&hi-tech industrial development zones,(featured by innovation in the recycling of water and land resources and energy,in addition,the companies’management and export processing cooperate with government)and hi-tech industrial parks(marked by open innovation and Sino-foreign governments cooperate in construction and management).This paper mainly focuses on the concepts and characteristics,formation mechanisms,evaluations,structure laws,the optimizing strategies and the cases in China to study the progress of regional green innovation system.

关键词： regional circular innovation system model developed areas eastern coast of China

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力量速度法和力量平方法量测动力触探锤击能试验研究

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岩土力学 2022年第11期43卷 3127-3134页

作者：沈志平刘慧付君宜孙秀东贵州正业工程技术投资有限公司贵州贵阳550001

动力触探指标修正、试验稳定性、锤击数转化关系与有效锤击能密切相关。在探杆杆顶处和探头处安装应变片和加速度传感器,量测不同探杆长度下的重型、超重型动力触探锤击能。结果表明:当探杆中单个探杆较短、接头数多时,使用积分域为(0、... 详细信息

动力触探指标修正、试验稳定性、锤击数转化关系与有效锤击能密切相关。在探杆杆顶处和探头处安装应变片和加速度传感器,量测不同探杆长度下的重型、超重型动力触探锤击能。结果表明:当探杆中单个探杆较短、接头数多时,使用积分域为(0、2l/c)的力量平方法(F2法)计算所得探杆锤击能与实际锤击能相差较大(l为探杆长度,c为波的传播速度)。由于原位试验时干扰因素过多,力量速度法(FV法)选取首个极值和F2法选取锤击轴力首次穿过0点时作为锤击能量的积分结束时间计算锤击能更为合理。随着探杆长度的增大,达到探头处的锤击能量呈线性减小。3、5、8、11 m杆长下的重型和超重型锤击数转化系数分别为2.285、2.160、2.440、2.810,与超重型和重型的总势能比基本一致。

关键词：动力触探能量测试力量平方法力量速度法轴向冲击力

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Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer:a randomized phase Ⅲ ARTIST trial

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Chinese Journal of Cancer 2011年第10期30卷 682-689页

作者： Zhong-Zhen Guan Jian-Ming Xu Rong-Cheng Luo Feng-yi Feng Li-Wei Wang Lin shen Shi-ying Yu yi Ba Jun Liang Dong Wang Shu-Kui Qin Jie-Jun Wang Jing He Chuan Qi Rui-Hua Xu State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China 307 Hospital of PLA Beijing 100071 P. R. China Guangzhou Nanfang Hospital Guangzhou Guangdong 510515 P. R. China Cancer Institute ＆ Hospital Chinese Academy of Medical Sciences Beijing 100021 P. R China Shanghai First People＇s Hospital Shanghai 201620 P. R. China Beijing Cancer Hospital Beijing 100142 P. R. China Tongji Hospital Tongji Medical College of Huazhong University of Science ＆ Technology Wuhan Hubei 430030 P. R. China Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 P. R. China The Affiliated Hospital of Medical College Qingdao University Qingdao Shandong 266021 P. R. China Third Affiliated Hospital Third Military Medical University of People＇s Liberation Army Chongqing 400042 P. R. China The 81 Hospital of People＇s Liberation Army Nanjing Jiangsu 210002 P. R. China Shanghai Changzheng Hospital Shanghai 200003 P. R. China Roche Product Development in Asia Pacific Shanghai 201203 P. R. China.

The efficacy and safety of bevacizumab with modified irinotecan,leucovorin bolus,and 5-fluorouracil intravenous infusion(mIFL) in the first-line treatment of metastatic colorectal cancer(mCRC) has not been well evaluated in randomized clinical trials in Chinese *** conducted a phrase Ⅲ trial in which patients with previously untreated mCRC were randomized 2:1 to the mIFL [irinotecan(125 mg/m2),leucovorin(20 mg/m2) bolus,and 5-fluorouracil intravenous infusion(500 mg/m2) weekly for four weeks every six weeks] plus bevacizumab(5 mg/kg every two weeks) group and the mIFL group,***-primary objectives were progression-free survival(PFS) and 6-month PFS *** total,214 patients were *** results showed that addition of bevacizumab to mIFL significantly improved median PFS(4.2 months in the mIFL group vs.8.3 months in the bevacizumab plus mIFL group,P < 0.001),6-month PFS rate(25.0% vs.62.6%,P < 0.001),median overall survival(13.4 months vs.18.7 months,P = 0.014),and response rate(17% vs.35%,P = 0.013).Grades 3 and 4 adverse events included diarrhea(21% in the mIFL group and 26% in the bevacizumab plus mIFL group) and neutropenia(19% in the mIFL group and 33% in the bevacizumab plus mIFL group).No wound-healing complications or congestive heart failure *** results suggested that bevacizumab plus mIFL is effective and well tolerated as first-line treatment for Chinese patients with *** benefit and safety profiles were consistent with those observed in pivotal phase Ⅲ trials with mainly Caucasian patients.

关键词：结直肠癌转移性安全性 III 单抗患者随机中国

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A study on hydrolytic polymerization of lanthanide ions

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Chinese Journal of Chemistry 1990年第5期8卷 412-422页

作者： LUO,Qin-Hui shen,Meng-Chang BAO,Xin-Lu DING,yi DAI,An-Bang (An-Pang TAI) Coordination Chemistry Research Institute,Nanjing University,Nanjing,210008 Coordination Chemistry Research Institute Nanjing University Nanjing 210008

Experimental data of hydrolytic polymerization of lanthanide ions in aqueous solution were treated by graphic method,computer fitting and pq analysis,species present were ascertained and hydrolysis constants ***(OH)^(2+)and Ln_2(OH)_2^(4+)predominated in the species of all hydroly- sis *** the first and the second hydrolysis constants were plotted against radii and ef- fective nuclear charge of lanthanide ions,the curves obtained conformed with the“three-division groups”*** between hydrolysis constants of Ln_2(OH)_2^(4+)and other hydrolysis constants is linear. Using the above empirical correlations we calculated hydrolysis constants of all lanthanide ions and obtained satisfactory results which showed good regularity for hydrolysis of lanthanide ions and thus systematized all data of the reaction.

关键词： A study on hydrolytic polymerization of lanthanide ions La

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Delayed hepatocarcinogenesis through antiangiogenic intervention in the nuclear factor-kappa B activation pathway in rats

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 169-174页

作者： Dong, Zhi-Zhen Yao, Deng-fu Wu, Wei Yao, Min Yu, Hong-Bo shen, Jun-Jun Qiu, Li-Wei Yao, Ning-Hua Sai, Wen-Li Yang, Jun-Ling Nantong Univ Affiliated Hosp Res Ctr Clin Med Nantong 226001 Peoples R China Nantong Univ Affiliated Hosp Dept Diagnost Coll Med Nantong 226001 Peoples R China Nantong Univ Affiliated Hosp Dept Lab Med Nantong 226001 Peoples R China Nantong Univ Affiliated Hosp Dept Oncol Nantong 226001 Peoples R China Nantong Canc Hosp Dept Chemotherapy Nantong 226007 Peoples R China

BACKGROUND: The active form of nuclear factor-kappa B (NF-kappa B) is involved in the initiation, generation, and development of hepatocellular carcinoma (HCC), and is up-regulated in inflammation-associated malignancies. We investigated the dynamic expression of NF-kappa B and its influences on the occurrence of HCC through antiangiogenic (thalidomide) intervention in NF-kappa B activation. METHODS : Hepatoma models were induced with 2-fluorenylacetamide (2-FAA, 0.05%) in male Sprague-Dawley rats, and thalidomide (100 mg/kg body weight) was administered intragastrically to intervene in NF-kappa B activation. The pathological changes in the liver of sacrificed rats were assessed after hematoxylin and eosin staining. NF-kappa B mRNA was amplified by RT-nested PCR. The alterations of NF-kappa B and vascular endothelial growth factor (VEGF) expression were analyzed by enzyme-linked immunosorbent assay, immunohistochemistry, and Western blotting. RESULTS: Rat hepatocytes showed denatured, precancerous, and cancerous stages in hepatocarcinogenesis, with an increasing tendency of hepatic NF-kappa B, NF-kappa B mRNA, and VEGF expression, and their values in the HCC group were higher than those in controls (P<0.001). In the thalidomide-treated group, the morphologic changes generated only punctiform denaturation and necrosis at the early or middle stages, and nodular hyperplasia or a little atypical hyperplasia at the final stages, with the expression of NF-kappa B (chi(2)=9.93, P<0.001) and VEGF (chi(2)=8.024, P<0.001) lower than that in the 2-FAA group. CONCLUSION: NF-kappa B is overexpressed in hepatocarcinogenesis and antiangiogenic treatment down-regulates the expression of NF-kappa B and VEGF, and delays the occurrence of HCC. (Hepatobiliary Pancreat Dis Int 2010; 9: 169-174)

关键词： hepatocellular carcinoma nuclear factor-kappa B vascular endothelial growth factor intervention dynamic expression

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Increased expression of 70 kD heat shock protein in cultured primary human keratinocytes induced by human papillomavirus 16 E6/E7 gene

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Chinese Medical Journal 2005年第24期118卷 2058-2062页

作者： LIAO Wen-jun FAN Ping-shen fu Meng FAN Xue-li LIU Yu-feng Department of Dermatology Xijing Hospital Fourth MilitaryMedical University Xi＇ an 710032 China

Background Heat shock protein 70 （HSP70） is expressed highly in epithelial tumours associated closely with human papillomavirus 16 （HPV16） infections. However, evidence about the direct relationship between HSP70 expression and HPVs infections are still lacking. In the present study, we examined the expression of HSP70 in keratinocytes introduced with HPV16 E6/E7 oncogenes. Methods Stable transfected cells were established by transfection of the plasmids pLXSN16E6/E7 into cultured primary keratinocytes and subsequently selected by plasmid specific selection antibiotic （G418） at the required concentration. The expression of HSP70 in pLXSN16E6/E7 transfected keratinocytes was determined by Western blot. The correlation of HSP70 expression and E6/E7 transfeetion was further confirmed by doubly labelled immunofluorescent staining. Results Compared to non-transfected keratinocytes, there was a significant trend for higher levels of HSP70 in pLXSN16E6/E7 transfected keratinocytes. Doubly labelled immunofluorescent staining experiment showed that the co-localization of HPV16 E6/E7 and HSP70 in transfeeted keratinoeytes was observed and increased expression of HSP70 was strongly associated with the transfection of HPV16 E6/E7. Conclusions Our studies demonstrated increased levels of HSP70 proteins in keratinocytes stably transfected by HPV16 E6/E7 oncogenes. It suggests that the expression of HSP70 is modulated by HPV16 E6/E7 proteins, which may be involved in HPV16 E6/E7 induced immortalization.

关键词： heat shock protein 70 keratinocytes human papillomavirus 16 E6/E7

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New Discovery of the Devonian Orthoclase Granite of Nenjiang–Heihe Structural belt, China and its Zircon U-Pb Data

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Acta Geologica Sinica(English Edition) 2018年第2期92卷 874-875页

作者： YANG Fan NA fuchao ZHANG Guangyu WANG Yan fu Junyu SUN Wei CHEN Jingsheng LI Bin LIU Miao PANG Xuejiao SHI yi SHI Lu College of Earth Sciences Jilin University shenyang Geological Survey Center China Geological Survey Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Land and Resources of China

Objective The Nenjiang-Heihe structural belt is located in the eastern Xing＇anling Mongolian Orogenic Belt between the Songnen block and Xiang＇an block. This structural belt has long been the focus of geological scholars （Miao Laicheng et al., 2003; Liang Chenyue et al., 2011; Li Chao et al., 2017）, which has complex geological condition, strong metamorphism and deformation and serious vegetation cover. There is a great dispute about the time limit of collage of the structural belt. In order to solve the problem, this paper reports a newly discovered Devonian orthoclase granite near Hadayang in Molidawa banner in the middle of this structural belt, which will provide evidence for the tectonic evolution of Nenjiang-Heihe structural and Xing＇anling Mongolian Orogenic Belt.

关键词： Pb ICP MS China and its Zircon U-Pb Data

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ON THE MEAN VALUE AND VARIANCE OF DISTANCE DISTRIBUTION OF NON-LINEAR CODES IN GF(q)

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Journal of Electronics(China) 1998年第1期15卷 58-62页

作者： fu Fangwei shen Shiyi(Department of Mathematics, Nankai University, Tianjin 300071)

This paper presents the lower bounds and upper bounds for the mean value and variance of distance distribution of non-linear codes in GF(q). By presenting several examples, it is shown that these bounds could be achie... 详细信息

关键词： Coding theory Distance distribution Althofer-Sillke inequality MacWilliams-Delsarte identity

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眼科非计划再次手术质控监管系统构建与应用研究

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医院管理论坛 2024年第3期41卷 46-49,40页

作者：王静陈晓蒙宋梓菱沈媛媛姚鑫周奕博黄小琼温州医科大学眼视光学院/生物医学工程学院温州医科大学附属眼视光医院/国家眼耳鼻喉疾病(眼部疾病)临床医学研究中心温州肯恩大学

本研究通过建立眼科非计划再次手术质控监管系统,实现了对眼科手术质量的实时监管,显著降低了非计划再次手术率和漏报率。系统具有上报审核、自动实时监管、数据收集、预警提醒、流程闭环监管等特点,能够全面收集患者基本信息、手术情... 详细信息

本研究通过建立眼科非计划再次手术质控监管系统,实现了对眼科手术质量的实时监管,显著降低了非计划再次手术率和漏报率。系统具有上报审核、自动实时监管、数据收集、预警提醒、流程闭环监管等特点,能够全面收集患者基本信息、手术情况、再次手术原因及整改措施等信息,为医院管理提供了有力支持。通过制定非计划再次手术质控监管流程,确保了监管工作的标准化和规范化。研究结果表明,系统运行后非计划再次手术率由0.25%降至0.14%,漏报率从25%下降为5%,差异均具有统计学意义。建立眼科非计划再次手术质控监管系统是提高手术质量、保障患者安全的有效措施,有助于医院实现手术质量安全的持续改进。

关键词：眼科非计划再次手术监管系统医疗质量

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四环素类抗性基因在黑土农田和蔬菜中的分布特征

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生态学杂志 2024年第3期43卷 758-765页

作者：武轶张珣王宝玉高程程黎馨月安婧沈阳大学环境学院沈阳110044 中国科学院沈阳应用生态研究所污染生态与环境工程重点实验室沈阳110016 中国科学院大学北京100049

抗生素及其抗性基因可随动物粪肥施用进入农田土壤中,进而给土壤-蔬菜系统带来潜在的生态风险。为分析抗生素抗性基因在土壤及蔬菜系统中的分布特征,本研究以四环素类抗性基因(TRGs)为对象,通过温室盆栽试验研究了典型TRGs在3种可生食蔬... 详细信息

抗生素及其抗性基因可随动物粪肥施用进入农田土壤中,进而给土壤-蔬菜系统带来潜在的生态风险。为分析抗生素抗性基因在土壤及蔬菜系统中的分布特征,本研究以四环素类抗性基因(TRGs)为对象,通过温室盆栽试验研究了典型TRGs在3种可生食蔬菜(小白菜、生菜和樱桃萝卜)中的分布特征,探讨了蔬菜根系扰动对其根际土壤中TRGs多样性和丰度的影响,并分析了TRGs在蔬菜和土壤中分布特征的相关性。结果表明,受试蔬菜体内及根际土壤中均检测到TRGs和可移动元件(MGEs),检出种类和丰度依次为根际土壤>蔬菜根部>茎叶部。蔬菜根部检出的TRGs与MGEs种类和丰度高于茎叶内,其中tetD-01、tetG-01、tetT、tet(32)、IS613、tnpA-04、intI-1(clinic)检出率和丰度尤为突出。樱桃萝卜根际土壤的TRGs及MGEs比生菜、小白菜富集量大,且土壤和蔬菜系统中部分TRGs的分布与MGEs呈显著正相关。研究结果可为揭示TRGs在土壤-蔬菜系统中存在的安全风险提供数据支持。

关键词：农田土壤生食蔬菜四环素抗生素抗性基因可移动元件

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