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The association between disruption of the circadian rhythm and aggravation of colitis in mice

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Gastroenterology Report 2022年第1期10卷 395-404页

作者： yi-dong chen Rui-Feng Zhao Gen Zheng Fang-Mei Ling Jun-Rong Li Ming-Yang Xu Di Guo Qiu-Lei Zhang Shuang Li Liang-Ru Zhu Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Delayed recovery from ulcerative colitis is mainly due to impaired healing of the intestinal epithelium after *** circadian rhythmcontrols cell proliferation and energy ***,the role of circadian genes in inflammatory bowel disease is largely *** purpose of this study was to investigate whether disrupting the circadian rhythm in mice can worsen colitis by altering mitochondrial energy *** in the experimental groups were under physiologic stress with an 8-h light shift jet-lag schedule every 3 days,whereas those in the control group were ***,half of the mice in the control and jet-lagged groups were given dextran sodium sulfate(DSS)to induce *** in each group were euthanized at zeitgeber time(ZT)0,ZT4,ZT8,ZT12,ZT16,and *** investigate the effects of jet lag on the mice,colon specimens were subjected to hematoxylin and eosin staining to analyse mRNA and protein expression of core circadian clock genes(Bmal1,Clock,Per1,Per2,Cry1,Cry2,and Nr1d1).We analysed the mitochondrial morphology,adenosine triphosphate(ATP)levels,and the expression of dynamin-related protein 1(Drp1)and ser637-phosphorylated(p)-Drp1,which are closely related to ATP *** further investigated the effect of PER2 knockdown in the colon epithelial cells(CCD 841 CoN)by measuring ATP and cell proliferation *** the circadian rhythm changed the oscillation of clock genes in the colon of mice,altered the mitochondrial morphology of the colon specimens,decreased the expression of p-Drp1,reduced ATP production,and exacerbated inflammatory responses in mice with DSS-induced ***,silencing of PER2 in the colon epithelial cells reduced ATP production and cell *** the circadian rhythm in mice decreases mitochondrial energy metabolism in the colon and exacerbates symptoms of colitis.

关键词： circadian rhythm mitochondrial energy metabolism PER2 colitis inflammatory bowel disease

STUDY ON OXYGEN ADSORPTION AND CATALYTIC PROPERTIES OF TiO2-BASED CATALYSTS

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Journal of Energy Chemistry 1992年第4期 328-340页

作者： QIN Dai-yi ZHANG Wei-dong chen Yu ZHOU Jian-Lue chen Yao-Qiang GONG Mao-Chu Analytic and Testing Center,Sichuan University,chengdu,Sichuan 610064

The active oxygen species and active sites for MOC（methane ox-idative coupling）over TiO-based catalysts are studied by ESR ***-gen chemisorption on TiO,La/TiOand Li/TiOwas measured by dynamicESR technique from 295 K to 105 *** process of oxygen adsorption onTiOis *** spectra show that Oions exist largely on TiObut lit-tle on Li/TiOdue to the decrease of surface density of electrons caused bythe substitution of Lifor lattice Tiin Li/*** not detected on *** Oand Oare not likely to be the active species in MOC *** triplet peaks in ESR spectra of Li/TiOare attributed to Ti（Ⅱ）and Ti（Ⅲ）of low coordination numbers,which are active in the presenceof *** of low coordinated Tior Tiare suggested to be responsi-ble for the formation of active oxygen species.

关键词： TiO STUDY ON OXYGEN ADSORPTION AND CATALYTIC PROPERTIES OF TiO2-BASED CATALYSTS

Systemic Therapy after Radiotherapy Significantly Reduces the Risk of Mortality of Patients with 1-3 Brain Metastases： A Retrospective Study of 250 Patients

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Chinese Medical Journal 2017年第24期130卷 2916-2921页

作者： Bo Li Zhao-Xia Dai yi-dong chen Yan-Wei Liu Shuai Liu Xue-Nan Gu Xiao-Guang Qiu Department of Radiation Oncology Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Medical Oncology The Second Hospital of Dalian Medical University Dalian Liaoning 116027 China Capital Medical University Cancer Center Beijing Shijitan Hospital Capital Medical University Beijing 100038 China

Background：For patients with a brain metastasis （BM）,systemic therapy is usually administered after the completion of radiotherapy,especially in cases of multiple ***,the role of systemic therapy in patients with a limited number of BMs is not ***,we conducted a retrospective study to explore this ***：Consecutive patients with a pathologically confirmed malignancy and 1-3 intracranial lesions that had been documented within the last decade were selected from the databases of three hospitals in ***：A total of 250 patients were enrolled;of them,135 received radiotherapy alone and 115 received radiotherapy plus systemic *** patients receiving whole-brain radiation therapy （WBRT） as radiotherapy,28 received WBRT alone and 35 patients received WBRT plus systemic *** the patients treated with stereotactic radiosurgery （SRS）,107 received SRS alone and 80 received SRS plus systemic *** analysis revealed that systemic therapy significantly reduced the risk of mortality compared with radiotherapy alone （hazard ratio [HR] =0.294,95% confidence interval [CI] =0.158-0.548）.Further,when the analysis was conducted in subgroups ofWBRT （HR =0.230,95% CI =0.081-0.653） or SRS （HR=0.305,95% CI=0.127-0.731）,systemic therapy still showed the ability to reduce the risk of mortality in patients with ***：Systemic therapy after either SRS or WBRT radiotherapy may significantly reduce the risk of mortality of patients with 1-3 BMs.

关键词： Brain Metastasis Stereotactic Radiosurgery Systemic Therapy Whole-brain Radiation Therapy

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei Zhang Wenhao Li Yangfei chen Yang Jiang Xiaofei Guo Han dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

土壤水分对异株荨麻(Urtica dioica)保护酶和渗透调节物质的影响及其与叶片光合和生物量的相关性

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生态学报 2009年第6期29卷 2845-2851页

作者：董伊晨刘悦秋北京农学院园林系北京102206 中国科学院生态环境研究中心城市与生态国家重点实验室北京100085

通过对不同土壤水分处理下异株荨麻保护酶系(SOD、POD)活性、渗透调节物质(可溶性蛋白、可溶性糖和游离脯氨酸)和细胞膜脂过氧化产物(MDA)含量以及最大光合速率、生物量的测定,各项生理指标间线性相关性的分析,探讨异株荨麻对水分变化... 详细信息

通过对不同土壤水分处理下异株荨麻保护酶系(SOD、POD)活性、渗透调节物质(可溶性蛋白、可溶性糖和游离脯氨酸)和细胞膜脂过氧化产物(MDA)含量以及最大光合速率、生物量的测定,各项生理指标间线性相关性的分析,探讨异株荨麻对水分变化的响应特性和耐干旱适应能力。实验采用盆栽水分梯度法将异株荨麻扦插苗按土壤相对含水量93.58%、80.74%、67.90%、55.06%和42.22%分组,以充足水分93.58%为CK对照组,实验组水分由高到低为T1、T2、T3和T4共5组。结果表明,(1)异株荨麻体内SOD活性随水分含量下降而呈先上升后下降的变化趋势,POD活性与之成相似互补的变化趋势;可溶性蛋白、可溶性糖、游离脯氨酸和MDA含量随水分含量的下降而升高;(2)各保护酶系和渗透调节物质与土壤水分呈显著线性负相关,保护酶系、渗透调节物质与过氧化产物MDA线性正相关;(3)比较光合速率、生物量和各种酶系、渗透调节物质的关系发现,光合速率与各生理指标无明显相关性,渗透调节物质对生物量积累有显著负相关性。

关键词：异株荨麻土壤水分含量保护酶系渗透调节物质膜脂过氧化产物

异株荨麻(Urtica dioica)生长及光合特性对不同土壤水分含量的响应

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生态学报 2008年第10期28卷 4685-4691页

作者：董伊晨刘悦秋北京农学院园林系北京102206 中国科学院生态环境研究中心城市与区域生态国家重点实验室北京100085

异株荨麻是我国一种重要中药植物，如何对其进行人工定向培植具有重要意义。以异株荨麻扦插苗为实验材料，采用盆栽水分梯度法，按土壤相对含水量93．58％、80．74％、67．90％、55．06％和42．22％分为对照组CK，实验处理组T1，T2，T3... 详细信息

异株荨麻是我国一种重要中药植物，如何对其进行人工定向培植具有重要意义。以异株荨麻扦插苗为实验材料，采用盆栽水分梯度法，按土壤相对含水量93．58％、80．74％、67．90％、55．06％和42．22％分为对照组CK，实验处理组T1，T2，T3和T4五个处理组，通过观测不同水分条件下，异株荨麻生长量、生物量变化和光合特征变化，试图探讨异株荨麻的水分适应性，寻找出适合其生长的水分范围及对生物量分配的影响，为北方地区种植栽培此类植物提供科学依据。结果发现：随土壤水分含量的降低，异株荨麻生长量和生物量积累呈先上升后下降趋势，在土壤相对含水量80．74％生长达到高峰，土壤相对含水量67．90％～80．74％为异株荨麻生长的适宜范围。净光合速率、蒸腾速率、气孔导度、气孔限制值及叶绿体色素含量的变化趋势与之相近似。在上述水分范围以外其光合功能下降、同化作用减弱，使异株荨麻生长衰退和干物质积累的减少。此外，土壤水分直接调控光合产物在地上和地下的分配以及植株个体形状，生产实践中，通过控水可以达到控制株形和根冠比的作用，用以诱导植株朝种植的预期方向生长，以达到获取植株不同部位产量的实际应用需求。

关键词：异株荨麻土壤水分含量生长量光合作用

数控机床热误差时间序列模型预测稳健性的提升

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光学精密工程 2016年第10期24卷 2480-2489页

作者：苗恩铭刘义董云飞陈维康合肥工业大学仪器科学与光电工程学院安徽合肥230009

针对数控机床热误差建模应用的时间序列算法受严重多重共线性的影响存在预测稳健性不足的问题,提出一种提升时间序列预测稳健性的方法。该方法将时间序列算法与能够抑制多重共线性的建模算法相结合,从而既可通过在模型中加入温度滞后值... 详细信息

针对数控机床热误差建模应用的时间序列算法受严重多重共线性的影响存在预测稳健性不足的问题,提出一种提升时间序列预测稳健性的方法。该方法将时间序列算法与能够抑制多重共线性的建模算法相结合,从而既可通过在模型中加入温度滞后值来提供更全面的温度信息,又可对温度滞后值引入的更为严重的多重共线性进行处理。文中以时间序列算法中的分布滞后(DL)算法、共线性抑制算法中的主成分回归(PCR)算法为例,采用主成分分布滞后(PCDL)算法建立了机床热误差补偿模型,并将其与DL算法的预测精度和稳健性进行了比较。结果显示,PCDL算法因为抑制了多重共线性的影响,其模型预测精度和稳健性远优于DL模型,预测精度提升了约9μm。本文所述方法可为时间序列数据建模在不同领域内的应用提供参考。

关键词：数控机床热误差时间序列模型预测稳健性主成分分布滞后算法

Low-temperature chlorination roasting technology for the simultaneous recovery of valuable metals from spent LiCoO_(2)cathode material

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 80-91页

作者： Junjie Shi Changle Hou Jingjing dong dong chen Jianzhong Li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

With the continuous increase in the disposal volume of spent lithium-ion batteries(LIBs),properly recycling spent LIBs has become essential for the advancement of the circular *** study presents a systematic analysis of the chlorination roasting kinetics and proposes a new two-step chlorination roasting process that integrates thermodynamics for the recycling of LIB cathode *** activation energy for the chloride reaction was 88.41 kJ/mol according to thermogravimetric analysis–derivative thermogravimetry data obtained by using model-free,model-fitting,and Z(α)function(αis conversion rate).Results indicated that the reaction was dominated by the first-order(F1)model when the conversion rate was less than or equal to 0.5 and shifted to the second-order(F2)model when the conversion rate exceeded *** conditions were determined by thoroughly investigating the effects of roasting temperature,roasting time,and the mass ratio of NH_(4)Cl to LiCoO_(2).Under the optimal conditions,namely 400℃,20 min,and NH_(4)Cl/LiCoO_(2)mass ratio of 3:1,the leaching efficiency of Li and Co reached 99.43% and 99.05%,*** of the roasted products revealed that valuable metals in LiCoO_(2)transformed into CoCl_(2) and ***,the reaction mechanism was elucidated,providing insights for the establishment of a novel low-temperature chlorination roasting technology based on a crystal structure *** technology can guide the development of LIB recycling processes with low energy consumption,low secondary pollution,high recovery efficiency,and high added value.

关键词： spent lithium-ion battery thermodynamics chlorination roasting kinetics circular economy

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying chen Bowen Liu Xuliang Lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling