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车用燃料电池电堆比功率提升的技术途径探讨

中国工程科学 2019年第3期21卷 84-91页

作者：侯明邵志刚衣宝廉中国科学院大连化学物理研究所

燃料电池车作为新能源汽车的一种,以其续驶里程长、动力性能高、燃料加注快、兼容可再生能源等特点,得到愈来愈广泛的重视。燃料电池堆是燃料电池汽车的核心,其比功率是反映燃料电池堆技术水平的重要指标,掌握高比功率燃料电池电堆技术... 详细信息

燃料电池车作为新能源汽车的一种,以其续驶里程长、动力性能高、燃料加注快、兼容可再生能源等特点,得到愈来愈广泛的重视。燃料电池堆是燃料电池汽车的核心,其比功率是反映燃料电池堆技术水平的重要指标,掌握高比功率燃料电池电堆技术可以降低电堆硬件数量,从而也会使电堆成本得到大幅降低。国际上先进的燃料电池堆由于具有高的比功率使其在车辆有限空间能提供较大功率,满足了车辆动力需求;然而,国内目前电堆比功率相比国际先进水平还有一定差距,针对这一问题,本文从高活性催化剂、增强复合质子交换膜、高扰动流场、导电耐腐蚀薄金属双极板、电堆组装与一致性等多方面,探讨了提高燃料电池电堆比功率的技术途径,基于理论与实践积累分析了燃料电池活化极化、欧姆极化及传质极化与材料、部件、组装的关联性,为进一步提高燃料电池堆性能与比功率提供方向性参考。

关键词：燃料电池车燃料电池电堆性能比功率

Percutaneous coronary intervention for chronic total occlusion in 1263 patients:a single-center report

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Chinese Medical Journal 2006年第14期119卷 1165-1170页

作者： HAN Ya-ling WANG Shou-li JING Quan-min LI yi ZHANG Jian MA ying-yan LUAN bo Department of Cardiology Shenyang General Hospital of PLA Shenyang 110016 China

Background Coronary chronic total occlusion （CTO） remains one of the most challenging lesion subsets in interventional cardiology, even with the development of medical device and operator expertise. This study was conducted to examine the relationship between lesion characteristics and procedural success and the incidence of in-hospital major adverse cardiac events （MACE） after percutaneous coronary intervention （PCI） for CTO. Methods Clinical and coronary angiographic data of 1263 patients with CTO who underwent PCI between June 1995 and December 2005 in Shenyang General Hospital of PLA were retrospectively analyzed. Results There were 1625 CTO lesions located in 1596 vessels with a mean occlusion time of 48.9 months. A total of 1647 coronary stents were implanted to the target lesions. The overall patient and lesion success rates were 90.8 % （1147/1263） and 88.9 % （1445/1625）, respectively. The success rate of PCI was declined with long duration of occlusion, abrupt missing stump, bridging collaterals ≥15 mm in occluded length, moderate to severe calcification or tortuosity and ostial or distal location of CTO lesions （P〈 0.05）. Procedural failure occurred in 116 patients, caused by impossibility of guide-wire （81.0%） or balloon （19.0%） to pass through the occlusion. There was no death during procedure, but 2 patients suffered from acute stent thrombosis and other 9 patients had acute or late pericardial perforation. Those complications were all successfully treated. After procedure, 3 patients died, 4 experienced urgent target vessel revascularization because of subacute stent thrombosis and 1 underwent coronary bypass graft surgery due to coronary ftstula during in-hospital period. The overall in-hospital MACE rate was 0.6% （8/1263）. Drug-eluting stents were used in 198 patients without in-hospital MACE. Conclusions In an experienced heart center, it is possible to obtain a relatively high success rate of PCI and favorable clinical outcomes for patients with

关键词： coronary heart disease chronic total occlusion angioplasty, transluminal percutaneous coronary

Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2^(-/-) acutemyeloid leukemia

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Cancer Communications 2021年第9期41卷 867-888页

作者： Jiachun Song Longting Du Ping Liu Fuhui Wang bo Zhang yinyin Xie Jing Lu yi Jin Yan Zhou Gang Lv Jianmin Zhang Saijuan Chen Zhu Chen Xiaojian Sun Yuanliang Zhang Qiuhua Huang Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Novel Bioinformatics Co. LtdShanghai 201114P.R.China Central Laboratory Renji Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127P.R.China

Background:Heterogeneity of leukemia-initiating cells(LICs)is a major obstacle in acute myeloid leukemia(AML)*** evidence indicates that the coexistence of multiple types of LICs with different pathogenicity in the same individual is a common feature in ***,the functional heterogeneity including the drug response of coexistent LICs remains ***,this study aimed to clarify the intra-heterogeneity in LICs that can help predict leukemia behavior and develop more effective ***:Spleen cells from the primary Setd2^(-/-)-AML mouse were transplanted into C57BL/6 recipient mice to generate a transplantable *** cytometry was used to analyze the immunophenotype of the leukemic ***-genome sequencing was conducted to detect secondary hits responsible for leukemia transformation.A serial transplantation assay was used to determine the self-renewal potential of Setd2^(-/-)-AML cells.A limiting-dilution assay was performed to identify the LIC frequency in different subsets of leukemia *** and single-cell RNA sequencing were performed to analyze the transcriptional heterogeneity of *** molecular inhibitor screening and in vivo drug treatment were employed to clarify the difference in drug response between the different subsets of ***:In this study,we observed an aged Setd2^(-/-)mouse developing AML with co-mutation of Nras^(G12S) and Braf^(K520E).Further investigation identified two types of LICs residing in the c-Kit^(+)B220^(+)Mac-1^(-)and c-Kit^(+)B220^(+)Mac-1^(+)subsets,*** vivo transplantation assay disclosed the heterogeneity in differentiation between the coexistent ***,an intrinsic doxorubicinresistant transcriptional signature was uncovered in c-Kit^(+)B220^(+)Mac-1^(+)***,doxorubicin plus cytarabine(DA),the standard chemotherapeutic regimen used in AML treatment,could specifically kill c-Kit^(+)B220^(+)Mac-1^(−)cells,but it hardly affected c-Kit^(+)B220^(

关键词： heterogeneity leukemia-initiating cell Setd2−/−acute myeloid leukemia single-cell RNA sequencing drug response

辽宁新品系绒山羊血液蛋白多态性及其与经济性状的关系

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遗传 2006年第5期28卷 529-532页

作者：金梅崔义厚傅忠扬高文波王薇辽宁师范大学生命科学学院大连116029

利用聚丙烯酰胺凝胶电泳法对120只辽宁新品系绒山羊的6种血液蛋白进行多态性检测,并分析了蛋白标记座位与体重、绒产量和绒细度等经济性状的相关性。采用SAS统计软件处理,统计各经济性状的最小二乘均值(LSM),并进行方差分析和多重比较... 详细信息

利用聚丙烯酰胺凝胶电泳法对120只辽宁新品系绒山羊的6种血液蛋白进行多态性检测,并分析了蛋白标记座位与体重、绒产量和绒细度等经济性状的相关性。采用SAS统计软件处理,统计各经济性状的最小二乘均值(LSM),并进行方差分析和多重比较。结果表明:EsBB型可作为体重性状的优势基因型。TfBB和Amy1-2型位点可作为绒产量的优势基因型,可望作为遗传标记用于标记辅助选择。

关键词：绒山羊经济性状血液蛋白

Positive end expiratory pressure titrated by transpulmonary pressure improved oxygenation and respiratory mechanics in acute respiratory distress syndrome patients with intra-abdominal hypertension

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Chinese Medical Journal 2013年第17期126卷 3234-3239页

作者： YANG yi LI Yang LIU Song-qiao LIU Ling HUANG ying-zi GUO Feng-mei QIU Hai-bo Department of Critical Care Medicine Nanjing Zhongda Hospital Southeast University Nanjing Jiangsu 210009 China

Background Intra-abdominal hypertension （IAH） is common in acute respiratory distress syndrome （ARDS） patients and when resulting in decrease of chest wall compliance will weaken the effect of positive end expiratory pressure （PEEP）. We investigated the effect of PEEP titrated by transpulmonary pressure （Ptp） on oxygenation and respiratory mechanics in ARDS patients with IAH compared with PEEP titrated by ARDSnet protocol. Methods ARDS patients admitted to the intensive care unit （ICU） of the Zhongda Hospital were enrolled. Patients were ventilated with volume control mode with tidal volume of 6 ml/kg under two different PEEP levels titrated by Ptp method and ARDSnet protocol. Respiratory mechanics, gas exchange and haemodynamics were measured after 30 minutes of ventilation in each round. IAH was defined as intra-abdominal pressure of 12 mmHg or more, Results Seven ARDS patients with IAH and 8 ARDS patients without IAH were enrolled. PEEP titrated by Ptp were significant higher than PEEP titrated by ARDSnet protocol in both ARDS patients with IAH （（17.3±2.6）cmH20 vs. （6.3±1.6） cmH2O and without IAH （（9.5±2.1） cmH2O vs. （7.8±1.9） cmH2O）. Arterial pressure of O2/fraction of inspired oxygen （PaO2/ FiO2） was much higher under PEEP titrated by Ptp when compared with PEEP titrated by ARDSnet protocol in ARDS patients with IAH （（27.2±4.0） cmHg vs. （20.9± 5.0） cmHg. But no significant difference of PaO2/FiO2 between the two methods was found in ARDS patients without IAH. In ARDS patients with IAH, static compliance of lung and respiratory system were higher under PEEP titrated by Ptp than by ARDSnet protocol. In ARDS patients with IAH, central venous pressure （CVP） was higher during PEEP titrated by Ptp than by ARDSnet protocol. Conclusion Positive end expiratory pressure titrated by transpulmonary pressure was higher than PEEP titrated by ARDSnet protocol and improved oxygenation and respiratory mechanics in ARDS patients with IAH.

关键词： acute respiratory distress syndrome transpulmonary pressure intra-abdominal hypertension chest wall compliance

铜镉胁迫对2种菌根真菌生长和细胞壁离子交换量的影响

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环境科学 2006年第8期27卷 1654-1658页

作者：黄志基黄艺彭博北京大学环境学院北京100871

在离体培养条件下，研究了铜镉胁迫对2种外生菌根真菌美味牛肝菌（boletus edulis）和铆钉菇（Gomphidius viscidus）生长状况，培养环境pH值和细胞壁离子交换量的影响．结果表明，以对照相比，铜镉处理抑制了菌根真菌的生物量积累．通... 详细信息

在离体培养条件下，研究了铜镉胁迫对2种外生菌根真菌美味牛肝菌（boletus edulis）和铆钉菇（Gomphidius viscidus）生长状况，培养环境pH值和细胞壁离子交换量的影响．结果表明，以对照相比，铜镉处理抑制了菌根真菌的生物量积累．通过半致死浓度评价2种菌根真菌耐受性发现，铆钉菇的Cu耐受性强于美味牛肝菌，而Cd耐受性弱于美味牛肝菌．菌根真菌培养后，基质pH降低与真菌生物量有关．铜镉处理下菌根真菌单位生物量下降的pH单位大于对照，说明菌根真菌在重金属胁迫下能通过调节自身pH环境缓解压力．铆钉菇的离子交换量在780～1800μmol·g^-1之间，并随重金属处理浓度的增加而增加；美味牛肝菌的离子交换量在500～750μmol·g^-1之间，并随重金属处理浓度的增加而减少.

关键词：外生菌根真菌铜镉 pH 离子交换量

Prognostic impact of the red cell distribution width in esophageal cancer patients: A systematic review and meta-analysis

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World Journal of Gastroenterology 2018年第19期24卷 2120-2129页

作者： Wei-Yu Xu Xiao-bo Yang Wen-Qin Wang yi Bai Jun-Yu Long Jian-Zhen Lin Jian-Ping Xiong Yong-Chang Zheng Xiao-Dong He Hai-Tao Zhao Xin-Ting Sang Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

AIM To clarify the previous discrepant conclusions, we performed a meta-analysis to evaluate the prognostic value of red cell distribution width(RDW) in esophageal cancer(EC). METHODS We searched the PubM ed, EMBASE, Web of Science and Cochrane Library databases to identify clinical studies, followed by using STATA version 12.0 for statistical analysis. Studies that met the following criteria were considered eligible:(1) Studies including EC patients who underwent radical esophagectomy;(2) studies including patients with localized disease without distant metastasis;(3) studies including patients without preoperative neoadjuvant therapy;(4) studies including patients without previous antiinflammatory therapies and with available preoperative laboratory outcomes;(5) studies reporting association between the preoperative RDW and overall survival(OS)/disease-free survival(DFS)/cancer-specific survival(CSS); and(6) studies published in *** A total of six articles, published between 2015 and 2017, fulfilled the selection criteria in the end. Statistical analysis showed that RDW was not associated with the prognosis of EC patients, irrespective of OS/CSS [hazard ratio(HR) = 1.27, 95% confidence interval(CI): 0.97-1.57, P = 0.000] or DFS(HR = 1.42, 95%CI: 0.96-1.88, P = 0.000). Subgroup analysis indicated that elevated RDW was significantly associated with worse OS/CSS of EC patients when RDW > 13%(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000), when the patient number ≤ 400(HR = 1.45, 95%CI: 1.13-1.76, P = 0.000) and when the study type was retrospective(HR = 1.42, 95%CI : 1.16-1.69, P = 0.000).CONCLUSION Contrary to our general understanding, this meta-analysis revealed that RDW cannot serve as an indicator of poor prognosis in patients with EC. However, it may still be a useful predictor of unfavorable prognosis using an appropriate cut-off value.

关键词： Red cell distribution width Prognostic impact Systematic review Meta-analysis

电动汽车和可再生能源经济环保协同并网调度的优化模型

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可再生能源 2017年第11期35卷 1655-1663页

作者：侯建朝侯鹏旺孙波上海电力学院经济与管理学院上海200090

文章在考虑等效负荷均方差最小的基础上,以火电机组的运营成本和污染物排放量最低为目标函数,考虑到风力发电、光伏发电和火电机组的约束条件,建立了一种含电动汽车、风光发电参与下的经济环保调度优化模型。采用动态改变学习因子的粒... 详细信息

文章在考虑等效负荷均方差最小的基础上,以火电机组的运营成本和污染物排放量最低为目标函数,考虑到风力发电、光伏发电和火电机组的约束条件,建立了一种含电动汽车、风光发电参与下的经济环保调度优化模型。采用动态改变学习因子的粒子群算法,以某地区电力系统为实例,验证了文章所提模型的有效性;并通过4种不同的运行模式的对比分析发现,风力发电、光伏发电和电动汽车协同并网调度,不但能够最大限度地利用光能和消纳风电来平滑负荷的波动,而且有利于削峰填谷和降低火电机组运营成本和污染物排放量。

关键词：风力发电光伏发电经济环保调度削峰填谷

Characteristics and Degradation Mechanism of Fomesafen

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Journal of Northeast Agricultural University(English Edition) 2018年第1期25卷 9-15页

作者： Tao bo Qiao Yu-xin Ma Cheng-yi Shao Bai-hui Jie Bai College of Agricultural Northeast Agricultural University

High performance liquid chromatography(HPLC) was used to determine the degradation efficiency of bacteria 2 strain(B2 S) under different conditions, the optimum cultivation conditions for fomesafen degradation bacterium B2 S were as the followings: temperature 35℃; inoculation quantity 5%; p H 5.0; glucose content 0.5% and fomesafen concentration 10 mg · L-1. Under optimal conditions, B2 S degraded fomesafen within 72 h of fomesafen application, with a degradation rate of nearly 100%. High performance liquid chromatography-mass spectrometry(HPLC-MS) was used to analyze fomesafen degradation into microbial products. A more thorough understanding of microbial fomesafen degradation mechanisms was discussed. The pathway of fomesafen degradation by B2 S was also inferred herein.

关键词： fomesafen bacteria 2 strain(B2S) degradation rate degradation product