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F：lole of Jaggedl-Heyl Signal in Angiotensin II-induced Impairment of Myocardial Angiogenesis

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Chinese Medical Journal 2017年第3期130卷 328-333页

作者： Ai-Li Guan Tao He yi-bing shao yi-Fan Chi Hong-Yan Dai Yan Wang Li Xu Xuan Yang Hua-Min Ding Shang-Lang Cai Department of Cardiology Heart Center Qingdao Municipal Hospital Qingdao University Qingdao Shandong 266071 China Department of Cardiology Affiliated Hospital of Qingdao University Qingdao Shandong 266005 China

Background： Angiotensin II （Ang ll） is a major contributor to the development of heart failure. However, the molecular and cellular mechanisms that underlie this process remain elusive. Inadequate angiogenesis in the myocardium leads to a transition from cardiac hypertrophy to dysfunction, and our previous study showed that Ang II significantly impaired the angiogenesis response. The current study was designed to examine the role of Jaggedl-Notch signaling in the effect of Ang II during impaired angiogenesis and cardiac hypertrophy. Methods： Ang II was subcutaneously infused into 8-week-old male C57BL/6 mice at a dose of 200 ng·kg^-1·min^-1 for 2 weeks using Alzet micro-osmotic pumps. N-[N-（3, 5-difluorophenacetyl）-L-alanyl]-S-phenylglycine tert-butyl ester （DAPT）, a y-secretase inhibitor, was injected subcutaneously during Ang II infusion at a dose of 10.0 ***^-1·d^-1. Forty mice were divided into four groups （n = 10 per group）： control group; Ang 11 group, treated with Ang I1; DAPT group, treated with DAPT; and Ang II ＋ DAPT group, treated with both Ang I1 and DAPT. At the end of experiments, myocardial （left ventricle [LV]） tissue from each experimental group was evaluated using immunohistochemistry, Western blotting, and real-time polymerase chain reaction, Data were analyzed using one-way analysis of variance test followed by the least significant difference method or independent samples t-test. Results： Ang II treatment significantly induced cardiac hypertrophy and impaired the angiogenesis response compared to controls, as shown by hematoxylin and eosin （HE） staining and immunohistochemistry fbr CD31, a vascular marker （P 〈 0.05 for both）. Meanwhile, Jaggedl protein was significantly increased, but gene expression for both Jagl and Heyl was decreased in the LV following Ang II treatment, compared to that in controls （relative ratio for Jag1 gene： 0.45 ± 0.13 vs. 0.84± 0.15; relative ratio for Heyl gene： 0.51 ± 0.08 vs. 0.91 ± 0.09; P 〈 0.05）. All these cell

关键词： y-secretase Angiotensin II Cardiac Angiogenesis Hey Jaggedl

Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome:a prospective multicenter single-arm interventional study

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Journal of Geriatric Cardiology 2023年第4期20卷 256-267页

作者： Xiao-Yun yiN Yun-Mei ZHANG Ai-Dong SHEN Jing-Ping WANG Zhe-Xun LIAN yi-bing shao Wen-Qi ZHANG Shu-ying ZHANG Yang ZHENG Kang CHENG Biao XU Cheng-Xing SHEN Rong-Chong HUANG Jin-Cheng GUO Guo-Sheng FU Dong-Kai SHAN Dan-Dan LI Yun-Dai CHEN Senior Department of Cardiology the Sixth Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese PLA BeijingChina Department of Cardiology Yunnan First People’s HospitalKunmingChina Department of Heart Center Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Cardiology Qingdao Municipal HospitalQingdaoChina Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchunChina Department of Cardiology the Affiliated Zhongshan Hospital of Dalian UniversityZhongshanChina Cardiovascular Center the First Hospital of Jilin UniversityChangchunChina Department of Cardiology the Affiliated Hospital of Northwest University&Xi’an No.3 HospitalXi’anChina Department of Cardiology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingChina Department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology School of MedicineSir Run Run Shaw HospitalZhejiang UniversityHangzhouChina

OBJECTIVE To evaluate the feasibility and tolerability of metoprolol standard dosing pathway(MSDP)in Chinese patients with acute coronary syndrome(ACS).METHODS In this multicenter,prospective,open label,single-arm and interventional study that was conducted from February 2018 to April 2019 in fifteen Chinese hospitals.A total of 998 hospitalized patients aged≥18 years and diagnosed with ACS were *** MSDP was applied to all eligible ACS patients based on the standard treatment recommended by international *** primary endpoint was the percentage of patients achieving the target dose at discharge(V2).The secondary endpoints included the heart rate and blood pressure at V2 and four weeks after discharge(V4),and percentage of patients experiencing bradycardia(heart rate<50 beats/min),hypotension(blood pressure<90/60 mmHg)and transient cardiac dysfunction at V2 and *** Of the 998 patients,29.46%of patients achieved the target dose(≥95 mg/d)at *** total population was divided into two groups:target group(patients achieving the target dose at V2)and non-target group(patients not achieving the target dose at V2).There was significant difference in the reduction of heart rate from baseline to discharge in the two groups(-4.97±11.90beats/min vs.-2.70±9.47 beats/min,P=0.034).There was no significant difference in the proportion of bradycardia that occurred in the two groups at V2(0 vs.0,P=1.000)and V4(0.81%vs.0.33%,P=0.715).There was no significant difference in the proportion of hypotension between the two groups at V2(0.004%vs.0.004%,P=1.000)and V4(0 vs.0.005%,P=0.560).No transient cardiac dysfunction occurred in two groups during the study.A total of five adverse events(1.70%)and one serious adverse event(0.34%)were related to the pathway in target *** In Chinese ACS patients,the feasibility and tolerability of the MSDP have been proved to be acceptable.

关键词： patients prospective coronary

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各向异性磁介质中的静磁交换模

物理学报 1989年第7期38卷 1177-1181页

作者：李义兵李少平华中理工大学固体电子学系

继作者对Damon和Easbach(简称DE)理论在长波部分的修正,本文探讨了DE理论在短波部分的适应性,研究了具有单轴各向异性和弱交换作用的偶极自旋模式,给出了临界角的表达式,并分析了频率-波矢空间的实际图象。所得结果与铁磁共振的频谱实... 详细信息

继作者对Damon和Easbach(简称DE)理论在长波部分的修正,本文探讨了DE理论在短波部分的适应性,研究了具有单轴各向异性和弱交换作用的偶极自旋模式,给出了临界角的表达式,并分析了频率-波矢空间的实际图象。所得结果与铁磁共振的频谱实验结果较好地符合。

关键词：磁介质各向异性静磁交换模

Anatomical characteristics of patients with symptomatic severe aortic stenosis in China

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Chinese Medical Journal 2021年第22期134卷 2738-2740页

作者： Tian-Yuan Xiong yi-Ming Li yi-Jun Yao Yu-Heng Jia Kai Xu Zhen-Fei Fang Jun Jin Guo-Sheng Fu yi-Ning Yang Lei Jiang Wei-Dong Li Yan-Qing Wu Yan-Song Guo Ran Guo Yun-Dai Chen yi Li yi-bing shao yi Zhang Bo-Sen Yang yi-Ke Zhang Jing-Jing He Kai-Yu Jia Sheng-Hu He Fa-Xin Ren Jian-Cheng Xiu Xing-Hua Gu Liang-Long Chen Ke Han Yuan Feng Mao Chen Department of Cardiology West China HospitalSichuan UniversityChengduSichuan 610041China State Key Lab of Hydraulics and Mountain River Engineering Sichuan UniversityChengduSichuan 610044China Department of Cardiology General Hospital of Northern Theater CommandShenyangLiaoning 110015China Department of Cardiology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Cardiology Xinqiao Hospital of Third Military Medical UniversityChongqing 400037China Department of Cardiology Sir Run Run Shaw Hospital of Zhejiang UniversityHangzhouZhejiang 310016China Department of Cardiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Cardiology The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Cardiovascular Surgery The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang 310009China Department of Cardiology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Department of Cardiology Fujian Provincial HospitalFuzhouFujian 350013China Department of Cardiology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Department of Cardiology Chinese People’s Liberation Army General Hospital(301 Hospital)Beijing 100853China Department of Cardiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Cardiology Qingdao Municipal HospitalQingdaoShandong 266071China Department of Cardiology Subei People’s HospitalYangzhouJiangsu 225001China Department of Cardiology Yantai Yuhuangding HospitalYantaiShandong 264000China Department of Cardiology Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong 510515China Department of Cardiovascular Surgery Qilu Hospital of Shandong UniversityJinanShandong 250063China Department of Cardiology Fujian Medical University Union HospitalFuzhouFujian 350001China Department of Cardiology

With accumulating evidence of transcatheter aortic valve replacement(TAVR)worldwide,it is gradually realized that patients being treated are different across different coun-tries,including but not limited to their age,habitus,disease etiology,aortic valve morphology,and sizes of structures.[1]In China,the average age of TAVR patients is around 5 years younger than industrialized countries,[2]making Chinese patients a good predictive sample of what the industrialized countries might see in TAVR screening in the near future due to the expansion of this technique to younger patients,but anatomical features appreciated from multi-slice computed tomography(MSCT)in the Chinese patient population have not been well demonstrated.

关键词： patients aortic younger

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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大口径空调立管固定支架设计及安装施工技术

机电工程技术 2015年第5期44卷 100-103,127页

作者：易少兵高文李生兵李黎武汉建工集团股份有限公司湖北武汉430023

大口径空调立管固定支架设计及安装施工技术，是为了改善大型公共建筑空调系统大口径空调立管安装质量和效益而发展、创新而成的一种新型施工技术。它通过设计、科学选材，并结合现场的实际情况，将横担式固定支架作为大口径空调立管与... 详细信息

大口径空调立管固定支架设计及安装施工技术，是为了改善大型公共建筑空调系统大口径空调立管安装质量和效益而发展、创新而成的一种新型施工技术。它通过设计、科学选材，并结合现场的实际情况，将横担式固定支架作为大口径空调立管与建筑结构连接的载体，将大口径空调立管固定在建筑结构上。武汉国际博览中心洲际酒店空调系统安装工程成功运用该技术，与传统空调系统立管安装技术相比，施工效率更高、安装质量更好、系统运行效果提高了5%-10%，成本降低了10%。

关键词：大口径空调立管横担式固定支架弧形钢板同步安装

VRV多联机空调系统管道托架安装施工工艺与方法

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机电工程技术 2015年第5期44卷 124-127页

作者：高文易少兵李生兵陈忠武汉建工集团股份有限公司湖北武汉430023

VRV多联机空调系统管道托架安装施工技术是为了提高公共建筑VRV多联机空调系统管道安装质量、观感质量和成品保护效果而在传统的VRV多联机空调管道安装技术的基础上发展而形成的新型施工技术。它将空调气管、液管、凝结水管及控制线敷... 详细信息

VRV多联机空调系统管道托架安装施工技术是为了提高公共建筑VRV多联机空调系统管道安装质量、观感质量和成品保护效果而在传统的VRV多联机空调管道安装技术的基础上发展而形成的新型施工技术。它将空调气管、液管、凝结水管及控制线敷设在托架内，通过凝结水管下敷设橡塑衬垫以调节排水坡度，利用尼龙塑胶布将管线缠绕固定。武汉市民行政服务中心工程VRV多联机空调系统管道安装工程成功运用该新型施工技术，与传统VRV多联机空调系统管道安装技术相比，施工质量更高，观感效果更好，成品保护效果更好，有效地减少了交叉作业对管线破坏，延长了系统使用寿命，系统运行效果提高了20%-30%，施工成本节约了10%。

关键词： VRV空调系统托架橡塑衬垫观感质量使用寿命

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避雷带焊接施工工艺与方法

机电工程技术 2015年第8期44卷 49-51页

作者：李生兵高文易少兵陈忠武汉建工集团股份有限公司湖北武汉430023

避雷带焊接技术是为了提高建筑物屋面避雷带焊接的施工质量、观感质量和施工效率而在传统的避雷带焊接技术的基础上发展的一种新型的施工技术。根据避雷带的实际长度、镀锌圆钢每根长度计算出圆钢与圆钢的焊接有几处进行材料下料,避雷... 详细信息

避雷带焊接技术是为了提高建筑物屋面避雷带焊接的施工质量、观感质量和施工效率而在传统的避雷带焊接技术的基础上发展的一种新型的施工技术。根据避雷带的实际长度、镀锌圆钢每根长度计算出圆钢与圆钢的焊接有几处进行材料下料,避雷带圆钢与圆钢对接,再用同等型号长度为14D的圆钢两侧倒45°圆弧作为连接件,将连接件分别与两个对接的圆钢进行双面焊接。某工程避雷带焊接成功运用该新型施工技术,与传统避雷带焊接施工技术相比,施工质量高,观感效果好,施工效率高,有效地减小了劳动强度,施工操作方便,施工成本节约了20%。

关键词：避雷带镀锌圆钢焊接施工