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Identification of a four-miRNA signature predicts the prognosis of papillary thyroid cancer

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World Journal of Clinical Cases 2023年第1期11卷 92-103页

作者： Fan Yang yi-li zhou Department of Thyroid Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND In recently diagnosed patients with thyroid cancer,papillary thyroid cancer(PTC),as the most common histological subtype,accounts for 90%of all *** PTC is known as a relatively adolescent malignant disease,there still is a high possibility of recurrence in PTC patients with a poor ***,new biomarkers are necessary to guide more effective stratification of PTC patients and personalize therapy to avoid overtreatment or inadequate *** evidence demonstrates that microRNAs(miRNAs)have broad application prospects as diagnostic biomarkers in *** To explore novel markers consisting of miRNA-associated signatures for PTC *** We obtained and analyzed the data of 497 PTC patients from The Cancer Genome *** patients were randomly assigned to either a training or testing *** We discovered 237 differentially expressed miRNAs in tumorous thyroid tissues compared with normal tissues,which contained 172 up-regulated and 65 downregulated *** evaluation of differently expressed miRNAs was conducted using our risk score *** then successfully generated a fourmiRNA potential prognostic signature[risk score=(-0.001×hsa-miR-181a-2-3p)+(0.003×hsa-miR-138-5p)+(-0.018×hsa-miR-424-3p)+(0.284×hsa-miR-612)],which reliably distinguished patients from high and low risk with a significant difference in the overall survival(P<0.01)and was effective in predicting the five-year disease survival rate with the area under the receiver operating characteristic curve of 0.937 and 0.812 in the training and testing cohorts,***,there was a trend indicated that high-risk patients had shorter relapse-free survival,although statistical significance was not reached(P=0.082)in our sequencing *** Our results indicated a four-miRNA signature that has a robust predictive effect on the prognosis of ***,we would recommend more radical therapy and closer follow-u

关键词： Papillary thyroid cancer microRNA Prognosis Signature

Brassinosteroids Regulate the Differential Growth of Arabidopsis Hypocotyls through Auxin Signaling Components IAA19 and ARF7

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Molecular Plant 2013年第3期6卷 887-904页

作者： Xiao-yi zhou li Song Hong-Wei Xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road 200032 Shanghai China

Brassinosteroids （BRs） are an important class of phytohormones which regulates a wide range of physiological processes. Genetic and physiological studies have revealed that BR responses usually depend on an intact auxin signaling pathway. Here, we demonstrate that high BR concentration or enhanced BR signaling induce the differential growth of etiolated hypocotyls and result in the morphological changes, while auxin-resistant mutants, msg2 （dominant mutant of IAA19） and arf7, are insensitive to the BR effect and can partially suppress the phenotype of bzrl-D （dominant mutant of BZR1 with enhanced BR signaling）. Interestingly, BZR1 protein can directly bind to the promoter regions of both IAA19 and ARFT, indicating that IAA19 and ARF7 mediate the BR-induced differential growth by serving as direct targets of BZR1. Systemic microarray analysis revealed that a number of BR-responsive genes showed reduced BR response in msg2, confirming that BR employs auxin signaling components IAA19 and ARF7 to modulate the specific downstream processes. These results provide informative clues on the crosstalk of BR-auxin signaling and the mechanisms of BR-auxin effects in regulating differential growth.

关键词： brassinosteroids (BRs) auxin IAA19 ARF7 differential growth Arabidopsis.

An automatic Q-factor matching method for eliminating 77%of the ZRO of a MEMS vibratory gyroscope in rate mode

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Microsystems & Nanoengineering 2024年第3期10卷 35-48页

作者： Jingbo Ren Tong zhou yi zhou yixuan li Yan Su School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210000China

Mismatching quality factors(Q-factors)is one of the main factors causing zero-rate output(ZRO)in degenerate(DE)Micro-Electro-Mechanical Systems(MEMS)vibratory *** eliminate the ZRO of the DE MEMS gyroscope,this study introduces a method for real-time identification and automatic matching of Q-factors in rate *** leveraging the vibration characteristics of the DE MEMS vibratory gyroscope in rate mode,dedicated online test methods are designed to determine the Q-factors for both the drive and sense modes,enabling online identification of the Q-factor ***,an automatic Q-factor matching system is designed utilizing the mechanical-thermal dissipation mechanism of the resistive *** effectiveness of this proposed method is validated through simulations and experiments conducted on a MEMS disk resonator gyroscope(DRG).The results show a measurement error within 4%for Q-factor identification,and automatic Q-factor matching effectively reduces the ZRO by 77%.Employing this automatic Q-factor matching method successfully reduces the ZRO that is caused by the mismatching of Q-factors in the MEMS DRG from 0.11°/s to 0.025°/s and improves the bias instability(BI)from 0.40°/s to 0.19°/s.

关键词： matching mode method

Solidification pathways and hot tearing susceptibility of MgZn_xY_4Zr_(0.5) alloys

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China Foundry 2018年第2期15卷 124-131页

作者： Zhi Wang Sheng Yao Yu Feng Zheng liu yi-zhou li Feng Wang Ping-li Mao School of Materials Science and Engineering Shenyang University of Technology

Hot tearing is known as one of the most serious solidification defects commonly encountered during solidification. It is very important to study the solidification path of alloys. In the work, thermal analysis with cooling curve was used for the investigation of microstructure evolution with different Zn contents during solidification process of MgZn_xY_4Zr_(0.5) alloys. Thermal analysis results of MgY_4Zr_(0.5) alloys revealed one distinct phase precipitation: α-Mg. Three different phase peaks were detected in the Zn-containing alloys: α-Mg, Z-phase(Mg_(12)YZn) and W-phase(Mg_3 Y_2Zn_3). In addition, for the present MgZn_xY_4Zr_(0.5) alloys, the freezing ranges of these alloys from large to small were: MgZn_(1.5)Y_4Zr_(0.5)>MgZn)(3.0) Y)4Zr_(0.5)>MgZn0.5 Y4 Zr0.5>MgY_4Zr_(0.5). The effect of different contents of Zn(0, 0.5, 1.5, 3.0 wt.%) on hot tearing behavior of MgY_4Zr_(0.5) alloy was investigated using a constrained rod casting(CRC) apparatus equipped with a load cell and data acquisition system. The experimental results show that the addition of Zn element significantly increases hot tearing susceptibility(HTS) of the MgY_4Zr_(0.5) alloy due to its extended freezing range. Some free dendrite-like bumps and ruptured liquid films on the fracture surfaces were observed in all the fracture surfaces. These phenomena proved the fact that the hot tearing formation was caused by interdendritic separation due to lack of feeding at the end of solidification.

关键词： MgZnxY4Zr0.5 alloys microstructure thermal analysis hot tearing susceptibility

Prediction of Multicomponent Reaction yields Using Machine Learning

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Chinese Journal of Chemistry 2021年第12期39卷 3231-3237页

作者： Xing-Yong Zhu Chuan-Kun Ran Ming Wen Gui-ling Guo Yuan liu li-li liao yi-zhou li Meng-Long li Da-Gang Yu Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengduSichuan 610064China College of Cybersecurity Sichuan UniversityChengduSichuan 610064China Beijing National Laboratory for Molecular Sciences Beijing 100190China

Prediction of reaction yields using machine learning(ML)can help chemists select high-yielding reactions and provide prior experience before wet-lab experimenting to improve ***,the exploration of a multicomponent organic reaction features many complex variables and limited number of experimental data,which are challenging for the application of ***,we perform yield prediction for the synthesis of 2-oxazolidones via Cu-catalyzed radical-type oxy-alkylation of allylamines and herteroaryl-methylamines with CO_(2),which is a three-component *** physicochemical descriptors as features to launch ML modelling,we find that XGBoost shows significantly improved performance over linear models and these features are effective for the yield ***,out-of-sample prediction indicates the application potential of the *** study demonstrates great potential of regression-modelling-based ML in organic synthesis even with complex factors and a general small size of reaction data,which are generated from the classical research pattern of method for the inquiry of multicomponent reactions.

关键词： Machine,learning yield prediction Radical reactions Density functional calculations Multicomponent reactions

Rts: learning robustly from time series data with noisy label

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Frontiers of Computer Science 2024年第6期18卷 186332-186332页

作者： zhou Zhi JIN yi-Xuan li Yu-Feng National Key Laboratory for Novel Software Technology Nanjing University

Significant progress has been made in machine learning with large amounts of clean labels and static data. However, in many real-world applications, the data often changes with time and it is difficult to obtain massive clean annotations, that is, noisy labels and time series are faced simultaneously. For example, in product-buyer evaluation, each sample records the daily time behavior of users, but the long transaction period brings difficulties to analysis, and salespeople often erroneously annotate the user’s purchase behavior. Such a novel setting, to our best knowledge, has not been thoroughly studied yet, and there is still a lack of effective machine learning methods. In this paper, we present a systematic approach RTS both theoretically and empirically, consisting of two components, Noise-Tolerant Time Series Representation and Purified Oversampling Learning. Specifically, we propose reducing label noise’s destructive impact to obtain robust feature representations and potential clean samples. Then, a novel learning method based on the purified data and time series oversampling is adopted to train an unbiased model. Theoretical analysis proves that our proposal can improve the quality of the noisy data set. Empirical experiments on diverse tasks, such as the house-buyer evaluation task from real-world applications and various benchmark tasks, clearly demonstrate that our new algorithm robustly outperforms many competitive methods.

关键词： weakly-supervised learning time-series classification class-imbalanced learning

Iridoids modulate inflammation in diabetic kidney disease: A review

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Journal of Integrative Medicine 2024年第3期22卷 210-222页

作者： Tong-yi zhou Na Tian liu li Rong Yu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng Changsha 410208Hunan ProvinceChina

In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical *** has become a pervasive complication of type 2 *** the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic ***,primarily derived from the potent components of traditional herbs,have been the subject of long-standing *** data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of *** article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this ***,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic *** review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

关键词： Diabetic kidney disease Iridoids Gut-kidney axis Traditional Chinese medicine monomer Inflammation

Syngas production in a novel perovskite membrane reactor with co-feed of CO_2

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Chinese Chemical Letters 2011年第12期22卷 1492-1496页

作者： Yan ying Wei liu Huang Jun Tang ling yi zhou Zhong li Hai Hui Wang School of Chemistry ＆ Chemical Engineering South China University of Technology Guangzhou 510640 China

Partial oxidation of methane（POM） co-fed with CO_2 to syngas in a novel catalytic BaCo_（0.6）Fe_（0.2）Ta_（0.2）O_（3-δ） oxygen permeable membrane reactor was successfully *** CO_2 to the partial oxidation of methane reaction not only alters the ratio of CO/H_2,but also increases the oxygen permeation flux and CH_4 *** 96%CH_4 conversion with more than 93%CO_2 conversion and 100%CO selectivity is achieved,which shows an excellent reaction performance.A steady oxygen permeation flux of 15 mL/（cm^2 min） is obtained during the 100-h operation,which shows good stability as well.

关键词： POM Oxygen separation CO_2 Perovskite Membrane reactor

Enlightenment of German social health insurance system reform on China

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Chinese Medical Journal 2013年第14期126卷 2780-2785页

作者： zhou yi li Lan-juan State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

According to the latest Chinese Healthcare Reform .Plan, the medical insurance system is one ofthe four components of the healthcare sector. The Healthcare financing and payment in China are mainly based on medical insurance. So it is important to learn the experiences of the developed countries. This paper examines the key issues of the German Healthcare system and reforms, with a particular emphasis on basic social medical insurance, which has the broadest coverage in Germany. It reviews the evolution of the background of the German social medical insurance system, describes how the system functions, and analyzes the existing and emerging problems with the system which push the Germany government to adapt a series of reforms.

关键词： German health insurance system medical reform finance competition Chinese health insurance system