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First Synthesis and Characterization of Stereoisomers of Choleretic Drug Dihydroxydibutylether

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Chinese Journal of Chemistry 2015年第10期33卷 1145-1152页

作者： Qiming Yue yi zhao Baohou Sun li Hai li Guo Yong Wu Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu Siehuan 610041 China

Dihydroxydibutylether （DHBE） is a choleretic drug used for the treatment of gallstone and hepatic disorders due to its choleretic activity and hepatoprotective action. The drug is a mixture of three regioisomers. The main re- gioisomer 3-（3-hydroxylbutoxy）-1-butanol （III） contains four stereoisomers, including （R）-3-（（R）-3-hydroxyl- butoxy）-1-butanol （IIIa）, （R）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIIh）, （S）-3-（（R）-3-hydroxylbutoxy）-1-butanol （Ille） and （S）-3-（（S）-3-hydroxylbutoxy）-1-butanol （IIId）. In this paper, the four stereoisomers are synthesized separately for the first time.

关键词： cholecystitis dihydroxydibutylether stereoisomer synthesis

Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

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Chinese Journal of Polymer Science 2016年第6期34卷 755-765页

作者： Zhang-yu Fan yi-li zhao 朱晓玥 Yu Luo Ming-wu Shen 史向阳 College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China Key Laboratory of Textile Science&Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai 201620China

Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid （FA） modified electrospun poly（vinyl alcohol）（PVA）/polyethyleneimine （PEI） nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA via a poly（ethylene glycol）（PEG） spacer, followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition, the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly, the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors, which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications.

关键词： Poly(vinyl alcohol) Polyethyleneimine Electrospun nanofibers Folic acid Cancer cell capture.

Direct Electrochemistry and Electrocatalysis of Hemoglobin at PAMAM Dendrimer-MWNTs-Au Nanoparticles Composite Film Modified Glassy Carbon Electrode

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Chemical Research in Chinese Universities 2010年第5期26卷 723-728页

作者： liU Xing-mei ZHANG Xue-yu zhao yi-li liU Wei-lu WANG Bao-jun ZHANG yi-hua ZHANG Zhi-quan College of Chemistry Alan G. MacDiarmid lnstitute Jilin University Changchun 130012 R R. China

The direct electron transfer of hemoglobin at the PAMAM-MWNTs-AuNPs composite film modified glassy carbon electrode was studied. In a phosphate buffer solution（PBS, pH=7.0）, the formal potential（E^0） of Hb was -0.105 V versus SCE, the electron transfer rate constant was 4.66 s-1. E^0＇ of Hb at the modified electrode was linearly varied in a pH range of 5.0-8.0 with a slope of-49.2 mV/pH. The Hb/PAMAM-MWNTs-AuNPs/GCE gave an excellent electrocatalytic response to the reduction of hydrogen peroxide. The catalytic current increased linearly with H2O2 concentration in a range of 1.0× 10^-6 to 2.2× 10^-3 mol/L. The detection limit was 2.0× 10^-7 mol/L at a signal to noise ratio of 3. The Michaelis-Menten constant（Km^app） was 2.95 mmol/L.

关键词： Direct electrochemistry Electrocatalysis Hemoglobin PAMAM dendrimer-MWNTs-Au nanoparticles composite Glassy carbon electrode

Study on method and mechanism for simultaneous desulfurization and denitrification of flue gas based on the TiO_2 photocatalysis

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Science China(Technological Sciences) 2008年第3期51卷 268-276页

作者： zhao yi, zhao li, HAN Jing, XU Yongyi & WANG ShuQin School of Environmental Science & Engineering, North China Electric Power University, Baoding 071003, China School of Environmental Science & Engineering North China Electric Power University Baoding China

Based on the TiO2 photocatalysis mechanism, a new method of simultaneous desulfurization and denitrification from flue gas was proposed. Preparation of TiO2 photocatalyst, design of photocatalysis reactor and influencing factors for simul- taneous removal of SO2 and NO, and removal mechanism of SO2 and NO were studied. After the optimal values of concentration of O2 in flue gas, the relative humidity of flue gas and the irradiation time in the photocatalysis reactor were used, the efficiencies of removal for SO2 and NO can be achieved above 98% and about 67%, respectively. According to the results of removal products analysis, the re- moval mechanism of SO2 and NO based on TiO2 photocatlysis can be put forward, namely, SO2 was oxidized to SO3 partly, the bulk of NO was oxidized to NO2, and both were removed by resorbing finally.

关键词： TiO2 photocatalysis flue gas simultaneous desulfurization and denitrification reaction mechanism

The effects of Shuxuetong on the pathology of cerebral ischemia-reperfusion injury and GABA and TNF-α expression in gerbil models

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Neuroscience Bulletin 2006年第1期22卷 41-46页

作者： Dong-Jun ZHANG Guang-Run XU Zhi-Yuan li yi-zhao li Long-Xian XU Feng-Ya LU Qiu-ling ZHANG Department of Neurology Qilu HospitalShandong University Jinan 250012China Department of Neurology Heze Municipal Hospital Heze 274031 China Department of Physiology Taishan Medical CollegeTaian 271000 China

Objective To study the protective effect and mechanism of Shuxuetong on gerbil brain tissue from the area of ischemia-reperfusion. Methods Cerebral ischemia-reperfusion animal model by transient clipping bilateral common carotid arteries in gerbils. Pathological changes in the hippocampal tissue were observed at different reperfusion time （12 h, 3 d, 7 d）. The expression levels of GABA and TNF-α in the hippocampal CA1 subfield were observed using immunohistochemitry at 12 h, 3 d after reperfusion. The difference of above indices among false operation group, ischemia-reperfusion group and treatment group were compared. Results The injuries of pathology to hippocampal area in ischemia-reperfusion group were more serious than treatment group. The expression levels of GABA in treatment group were significantly increased compared with ischemia-reperfusion group, but the expression levels of TNF-α between the two groups have no difference. Conclusion Shuxuetong has protective effect on brain tissue of ischemia-reperfusion by enhancing the expression of GABA in the hippocampal tissue.

关键词： Shuxuetong ischemia-reperfusion GABA TNF-α

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

马克思两大部类模型与中国经济的宏观结构:一个经验研究

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中国人民大学学报 2017年第2期31卷 73-81页

作者：赵峰赵翌辰李帮喜中国人民大学经济学院中国特色社会主义经济建设协调创新中心清华大学社会科学学院

宏观经济结构的调整和优化是实现国民经济稳步持续增长的重要保证。马克思的两大部类再生产模型科学地界定了宏观经济结构及其与资本有机构成、剩余价值率和利润率等重要变量之间的动态关系,是马克思主义政治经济学分析宏观经济结构的... 详细信息

宏观经济结构的调整和优化是实现国民经济稳步持续增长的重要保证。马克思的两大部类再生产模型科学地界定了宏观经济结构及其与资本有机构成、剩余价值率和利润率等重要变量之间的动态关系,是马克思主义政治经济学分析宏观经济结构的重要工具之一。在探析从投入产出表到两大部类宏观模型的对应关系的基础上,我们利用中国2000年至2010年投入产出表的数据构建了一个中国宏观经济结构的两部类模型,并对其中的生产资料部类与消费资料部类的结构、收入分配结构和总需求结构及其与资本—工资率、利润—工资率、利润率的动态关系进行了经验分析。研究发现:中国宏观经济结构的经验数据及其变化趋势与马克思主义经济学理论所预期的基本一致,说明马克思的两大部类再生产模型对现实经济具有很好的解释和预测能力,可以为宏观经济分析和管理提供坚实的理论基础。

关键词：两大部类再生产模型投入产出表宏观经济结构经验分析

Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第3期16卷 191-197页

作者： Kai-fa TANG yi-li zhao Shang-shu DING Qi-fei WU Xing-yang WANG Jia-qi SHI Fa SUN Jun-ping XING Department of Urology Affiliated Hospital of Guiyang Medical College Department of Urology the First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization （WHO）, and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone un- decanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymor- phisms of CYP2D6＊10. A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D6＊10 genotype frequencies （P〉0.05）. The follicle-stimulation hormone （FSH）, luteinizing hormone （LH）, and testosterone （T） levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele （C/C） than in the heterozygous variant allele （C/T） or homozygous variant allele （T/T） subgroups （P〈0.05）. In addition, the percentage of normal morphology was raised at 6 months, and represented the highest percentage in the C/C subgroup （P〈0.05）. The incidence of spontaneous pregnancy in the C/C subgroup was higher than that in the C/T or T/T subgroups （P〈0.01）. This study showed that the CYP2D6＊10variant genotype demonstrated worse clinical effects in infertile men with idiopathic oligozoospermia.

关键词： Infertility Cytochrome P450 Oligozoospermia Tamoxifen Testosterone

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激光快速成型中激光扫描路径的快速生成算法

计算机辅助设计与图形学学报 1998年第3期10卷 260-265页

作者：赵毅李占利卢秉恒西安交通大学

在立体光固化（ＳＬ）快速成型中，零件是靠激光逐层扫描光敏树脂固化成型的．在由点到线、由线到面、由二维到三维的逐层累积过程中，扫描器要做大量的扫描．因而合理的扫描路径对提高成型效率无疑有重要意义；另外合理的扫描路径还能... 详细信息

在立体光固化（ＳＬ）快速成型中，零件是靠激光逐层扫描光敏树脂固化成型的．在由点到线、由线到面、由二维到三维的逐层累积过程中，扫描器要做大量的扫描．因而合理的扫描路径对提高成型效率无疑有重要意义；另外合理的扫描路径还能改善扫描器的工作状态，明显提高扫描器的使用寿命．本文提出了一种简捷有效的扫描路径生成算法，成功地应用于开发的快速成型机中．

关键词：快速成型激光扫描多边型路径生成激光