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Analgesic and Anti-inflammatory Effects of Ginger Oil

中华中医药学会中药化学分会2006年度学术研讨会

作者： Weidong Pan,~(a,b,d) Yongmin Zhang,~a Bixue Xu,~b Peixue Cao,~b and Guangyi liang,~(a,b,c) a Ecole Normale Superieur,Departement de Chimie,UMR CNRS 8642,24 rue Lhomond,75231 Paris Cedex 05,France. b The Key Laboratory of Chemistry for Natural Products of Guizhou Province and chinese Academy of Sciences,Guiyang 550002,China. c Guiyang College of traditional chinese Medicine,Guiyang 550002,China. d Guizhou University,the center for research and Development of Fine Chemicals,Guiyang,550025,China.

Four compounds were isolated from Torricellia angulata var intermedia(Harms.) Hu (Torricelliaceae) by column chromatography accompanied synthetic structure modification method and two new polyacetylene compounds with a chiral carbon center were included whose absolute configurations were determined by the recently developed expended Mosher’s method.

关键词： polyacetylene Torricellia angulata var intermedia separation Mosher’s method configuration

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chinese Herbal medicines 2011年第2期3卷 150-155页

作者： JIA Yong-liang1,ZHAO Jun-ming2,ZHANG Lin-hui1,SUN Bao-shan2,BAO Meng-jing1,LI Fen-fen1,SHEN Jian1,SHEN Hui-jun1,ZHAO Yu-qing3,4,XIE Qiang-min11.Department of Pharmacology,Medical College of Zhejiang University,Hangzhou 310031,China 2.Liaoning Xinzhong Modern Medicine Co.,Ltd.,Shenyang 110041,China 3.College of traditional chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China 4.Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China Department of Pharmacology Medical College of Zhejiang University Hangzhou 310031 China Liaoning Xinzhong Modern Medicine Co. Ltd. Shenyang 110041 China College of traditional chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China

Objective Ginger(Zingiber officinale) is widely used as a spice in cooking and as a medicinal herb in traditional herbal *** present study was to investigate the analgesic and anti-inflammatory activities of ginger oil in experimental animal *** The analgesic effect of the oils was evaluated by the 'acetic acid' and 'hot-plate' test models of pain in *** anti-inflammatory effect of the oil was investigated in rats,using rat paw edema induced by carrageenan,adjuvant arthritis,and vascular permeability induced by bradykinin,arachidonic acid,and ***(1 mg/kg),Aspirin(0.5 g/kg) and Dexamethasone(2.5 mg/kg) were used respectively as reference drugs for *** The ginger oil(0.25-1.0 g/kg) produced significant analgesic effect against chemically-and thermally-induced nociceptive pain stimuli in mice(P 1).And the ginger oil(0.25-1.0 g/kg) also significantly inhibited carrageenan-induced paw edema,adjuvant arthritis,and inflammatory mediators-induced vascular permeability in rats(P 1).Conclusion These findings confirm that the ginger oil can be used to treat pain and chronic inflammation such as rheumatic arthritis.

关键词： analgesic activity anti-inflammatory activity ginger oil Zingiber officinale Zingiberaceae

Three new phenanthrenes from Cremastra appendiculata (***) Makino

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chinese Chemical Letters 2013年第8期24卷 737-739页

作者： liang Liu Jun Li Ke-Wu zeng Ping Li Peng-Fei Tu State Key Laboratory of Natural medicines China Pharmaceutical University State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University Health Science Center Medical College Yangzhou University Modern research center for traditional chinese Medicine Beijing University of Chinese Medicine

Three new phenanthrenes,along with one known phenanthrene,were isolated from the ethanolic extract of the tubers of Cremastra appendiculata（***） *** structures were elucidated on the basis of extensive spectroscopic *** 1-4 were tested for in vitro cytotoxic activities against human lung（A549）,colon（HCT-116）,liver（HepG2）,and breast（MCF-7 and MDA-MB-231） cancer cell lines.

关键词： Phenanthrene Cremastra appendiculata Chemical constituent Cytotoxicity

Identification of species within Tetrastigma (Miq.) Planch.(Vitaceae) based on DNA barcoding techniques

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Journal of Systematics and Evolution 2011年第3期49卷 237-245页

作者： 1,2Yuan-Miao FU# 1,2Wei-Mei JIANG# 1,2Cheng-Xin FU* 1(The Key Laboratory of Conservation Biology for Endangered Wildlife of the Ministry of Education,College of Life Sciences,Zhejiang University,Hangzhou 310058,China) 2(Laboratory of Systematic and Evolutionary Botany and Biodiversity,Institute of Plant Sciences and Conservation center for Gene Resources of Endangered Wildlife,Zhejiang University,Hangzhou 310058,China) TheKeyLaboratoryofConservationBiologyforEndangeredWildlifeoftheMinistryofEducation CollegeofLifeSciencesZhejiangUniversityHangzhou310058

Many species of Tetrastigma(Miq.) Planch.(Vitaceae) have long been used as medicinal plants in China,and some are endangered due to *** adulterants are often added to traditional chinese medicines,there is no reliable or practical method for identifying *** this study,we used four markers(rbcL,matK,trnH-psbA,and internal transcribed spacer [ITS]) as DNA barcodes to test their ability to distinguish species of *** results indicated that the best barcode was ITS,which showed significant inter-specific genetic variability,and thus its potential as a DNA barcode for identifying *** loci provided a greater ability to distinguish species than single *** recommend using the combined rbcL+matK+ITS barcode for the *** trees from each barcode were *** using the unweighted pair group method with arithmetic mean discriminated an equal or greater percentage of resolvable species than did neighbor joining,maximum likelihood,or maximum parsimony ***,five medicinal species of Tetrastigma,especially ***,could be identified precisely using DNA barcoding.

关键词： DNA barcoding medicinal plants species identification Tetrastigma.

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我国儿童中成药现状分析及思考

中国中药杂志 2024年第7期49卷 1966-1973页

作者：刘晖陈宇静付乾芳赵书艺聂良卉马榕戎萍天津中医药大学第一附属医院天津300381 国家中医针灸临床医学研究中心天津300381

以《中国药典》(2020年版及第一增补本)、《国家基本医疗保险、工伤保险和生育保险目录》(2022年版)、《国家基本药物目录》(2018年版)收载的儿童中成药为研究对象,梳理分析儿童中成药(包括儿童专用药、儿童成人共用药、儿童酌减类药)... 详细信息

以《中国药典》(2020年版及第一增补本)、《国家基本医疗保险、工伤保险和生育保险目录》(2022年版)、《国家基本药物目录》(2018年版)收载的儿童中成药为研究对象,梳理分析儿童中成药(包括儿童专用药、儿童成人共用药、儿童酌减类药)分布现状、特点及可能存在的问题。经归纳统计,儿童中成药给药途径以口服为主,多为片剂、颗粒剂、胶囊剂、口服液等传统剂型,口感多为苦、甜,治疗病种主要分布在肺系疾病及脾胃疾病,安全用药信息缺失或“尚不明确”品种占比较大。我国儿童中成药存在专用品种较少、用药顺应性欠佳、用法用量欠细化、安全用药信息欠完善等问题,建议及时更新完善药品说明书,开发儿童中成药新品种,积极开展儿童中成药上市后评价及临床综合评价工作,为儿童中成药药品说明书补充完善、儿童中成药全面提升、儿童中成药目录制定及新药研发提供参考,保障用药。

关键词：儿童中成药合理用药

Studying the nature of ascending-descending-floating-sinking of chinese medicines based on gonadotropin-releasing hormone

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Journal of traditional chinese Medicine 2022年第4期42卷 546-555页

作者： FU Yang YUAN Peipei zeng Mengnan HOU ying GAO Liyuan WEI Yaxin ZHENG Xiaoke FENG Weisheng Department of Pharmacy Henan University of Chinese MedicineThe Engineering and Technology Center for Chinese Medicine Development of Henan ProvinceCo-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education MinistryZhengzhou 450046China

OBJECTIVE:To explore the nature of ascendingdescending-floating-sinking of traditional chinese Medicine on normal rats using gonadotropin-releasing hormone(GnRh).METHODS:Normal male Sprague-Dawley rats were orally administered six floating chinese medicines and seven sinking chinese medicines for 14 ***,GnRh and relevant indicators were ***,the different effects of floating and sinking drugs on the body were *** verify the effects of floating and sinking drugs on the body,normal rats were orally administered Mahuang(Herba Ephedra Sinica)and Tinglizi(Semen Lepidii Apetali)for 14 ***,GnRh antagonists were *** observed the changes of relevant indicators and clarified the correlation between GnRh and the laws of floating and ***:Floating chinese medicines significantly increased the testicular coefficients;GnRh level in the serum;the protein level of GnRh receptor(GnRhR)in the testis;and the mRNA levels of androgen receptor(AR),small C-terminal domain phosphatase(SCP)3,SCP2,SYCE1,SMC1 B,SMC3,and Rec8(Pchinese medicines did not react similarly,while GnRh antagonists blocked the regulatory effect of Mahuang(Herba Ephedra Sinica)but did not affect Tinglizi(Semen Lepidii Apetali).CONCLUSIONS:GnRh may be closely related to the nature of ascending-descending-floating-sinking of chinese *** chinese medicines may promote their medicinal properties by regulating Gn RH level;however,sinking chinese medicines did not affect GnRh level.

关键词： gonadotropin-releasing hormone receptors,LHRH Mahuang(Herba Ephedra Sinica) Tinglizi(Semen Lepidii Apetali) testis ascending-descending-floating-sinking

SIMULTANEOUS QUANTITATION OF FIVE PANAX NOTOGINSENG SAPONINS IN EIGHT chinese PATENT medicines BY MULTI HEART-CUTTING TWODIMENSIONAL LIQUID CHROMATOGRAPHY

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World Journal of traditional chinese Medicine 2015年第4期1卷 69-69页

作者： Changliang Yao Wenzhi Yang Wanying Wu Jinjun Hou Jingxian Zhang Yanhai Zhang Dean Guo Shanghai research center for modernization of traditional chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Thermo Fisher Scientific

Current China Pharmacopoeia(ChP)standards employ diversified and case-dependent assay methods to evaluate the quality of different chinese patent medicines(CPM)that contain Panax notoginseng as the monarch *** study is aimed to develop a two-dimensional liquid chromatography(2D LC)based assay approach to unify and simplify the quality assessment of Notoginseng containing *** heart-cutting 2D LC(MHC-2D LC)was used to separate and quantify five major

关键词： MHC SIMULTANEOUS QUANTITATION OF FIVE PANAX NOTOGINSENG SAPONINS IN EIGHT chinese PATENT medicines BY MULTI HEART-CUTTING TWODIMENSIONAL LIQUID CHROMATOGRAPHY

整合毒理学:一种有效阐释中药之“毒”的解决方案

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Acupuncture and Herbal Medicine 2024年第2期4卷 167-170,I0003,I0004页

作者：徐焕华周维易剑锋张伯礼高月江西中医药大学现代中药制剂教育部重点实验室南昌330004 江西中医药大学经典名方现代中药创制全国重点实验室南昌330004 军事科学院军事医学研究院辐射医学研究所北京100850 江西中医药大学中医基础理论分化发展研究中心南昌330004 天津中医药大学天津301617

中药的安全性问题已经成为中医药行业发展的瓶颈,严重制约中医药的现代化和国际化。重新审视中药对“毒”的理解并进一步发展现代中药毒理学迫在眉睫。中药因其自身特性,其安全性研究与现代毒理学(西方毒理学)相比存在较大差异,且具备... 详细信息

中药的安全性问题已经成为中医药行业发展的瓶颈,严重制约中医药的现代化和国际化。重新审视中药对“毒”的理解并进一步发展现代中药毒理学迫在眉睫。中药因其自身特性,其安全性研究与现代毒理学(西方毒理学)相比存在较大差异,且具备如下特点:毒性发生的隐匿性、物质基础的不确定性、安全剂量的模糊性、毒-效机制的复杂性、个体差异的特殊性。由此也引申出中药安全性研究面临的一些关键科学问题,例如“有毒”中药与机体互作后如何产生毒性?配伍后如何减毒?针对上述关键科学问题,基于在中药安全性领域的多年实践,高月研究员团队率先在本文中提出中药整合毒理学研究理念。整合毒理学,即中药学、替代毒理学、药理学、计算科学、中药化学、分子生物学等多学科交叉融通,用以研究复杂体系与机体相互作用及其减毒配伍规律的一门交叉学科。以此理念为指导,研究团队在本文中展示了补骨脂毒性新机制发现及复方黄黛片减毒配伍新科学内涵阐释两项研究范例。整合毒理学研究理念的提出及应用,有利于克服中药的毒性孤岛评价,形成具有中药特色的毒理学评价体系和研究方法,是一种行之有效的、能阐释中药之“毒”内涵的解决方案。

关键词：中药安全性医药行业发展毒理学评价安全剂量中药化学配伍规律减毒中药学

Chemical and Biochemical Basis of the Anti-tumor Properties of Ganoderma lucidum

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Chemical and Biochemical Basis of the Anti-tumor Properties ...

脑出血后血肿周围神经元Cyt-c与Caspase-3的表达及不同中医治法的干预

2002国际灵芝专题研讨会

作者： Hin Wing Yeung Qing-yi Lu Qi-Feng Zhang Vay liang W. Go UCLA center for Human Nutrition , Los Angeles , California , USA

The fruiting bodies of Ganoderma lucidum are edible, medicinal mushrooms known as Ling Zhi in China. Ling Zhi has been used in traditional chinese medicine (TCM) for over 2000 years with a reputation rivaling that of ginseng. In addition to the fruiting bodies, the spores and cultivated mycelia have recently been used as health foods and herbal medicines. As a superior herbal medicine, it has been used in TCM for promotion of vitality and longevity. In modern chinese medicine, Ganoderma lucidum is used in the treatment of debility and weakness, hepatitis, diabetes, altitude sickness, cardiovascular diseases, AIDS and cancer. Scientific studies on extracts and substances from Ganoderma lucidum have demonstrated their anti-aging, cardiovascular, hepato-protective, hypoglycemic, immuno-modulatory, anti-viral and anti-tumor effects. This evidence provides a pharmacological basis for their ancient and contemporary medical *** investigations on the fruiting bodies, spores and mycelia of Ganoderma lucidum have shown that these mushrooms contain various hioactive substances. Active constituents of Ganoderma lucidum include polysaccharides, proteins, nucleosides, fatty acids, terpenoids and sterols. Water or alcohol extracts have been used for investigation of its biological activities. Water extract contains biological compounds that are responsible for its immunological and anti-inflammatory properties. In contrast, alcohol extract contains biological compounds that lower blood cholesterol levels, blood glucose levels, and platelet aggregation. While the anti-tumor effects can be attributed both to the water soluble polysaccharide and alcohol soluble triterpenes. Recent clinical and pharmacological research substantiating the benefits and effects of Ganoderma lucidum has focused on tumor activities. This presentation attempts to review and analyze our current knowledge on the anti-tumor properties and mechanism of Ganoderma lucidum *** teipenoid

关键词： Ganoderma lucidum ,anti-tumor, polysaccharides, triterpenoids

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实用预防医学 2007年第5期14卷 1357-1360页

作者：熊新贵梁清华陈疆谢映王娟蒋勇前刘晓春中南大学湘雅医院中西结合研究所湖南长沙410008 中南大学湘雅医院远程医学中心

目的观察大鼠脑出血后血肿周围神经元Cyt-c与活化Caspase-3的表达情况及不同中医治法的干预作用。方法用Ⅶ胶原酶脑内立体定位注射诱导大鼠脑出血模型,免疫组化检测血肿周围神经元Cyt-c的释放情况与活化Caspase-3的表达,同时用直尺测量... 详细信息

目的观察大鼠脑出血后血肿周围神经元Cyt-c与活化Caspase-3的表达情况及不同中医治法的干预作用。方法用Ⅶ胶原酶脑内立体定位注射诱导大鼠脑出血模型,免疫组化检测血肿周围神经元Cyt-c的释放情况与活化Caspase-3的表达,同时用直尺测量不同时间点血肿的最大直径。结果大鼠脑出血后血肿周围神经元于6h即有Cyt-c释放;1d后阳性细胞表达最多;3d后阳性细胞数减少;5d后阳性细胞继续减少,与假手术组比较差异明显(P1);血肿周围于6h出现Caspase-3阳性表达细胞,1d阳性细胞计数达高峰,3d出现轻度下降,5d明显下降,与假手术组比较差异明显(P1);采取不同中医治法治疗后Cyt-c与Caspase-3均有所下降,与其他各组比较,平肝熄风汤组治疗后下降最明显(P1)。结论脑出血后血肿周围神经元Cyt-c与活化Caspase-3表达明显上调,采取熄风、泻火、祛痰、化瘀以及风火痰瘀同治等治法均能抑制Cyt-c与Caspase-3的表达,阻止神经元的凋亡,以平肝熄风汤组最为明显。

关键词：脑出血中医治法 Caspase Cyt-c Rat