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Role of hsa_circ_0007482 in pterygium development: insights into proliferation, apoptosis, and clinical correlations

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1387-1395页

作者： Li-yun Zhang Xin Liu Shuo Zheng Wen-Qun Xi Xue-Ping Wu Dan-Yao Nie Hui-ling Hu Jian-Tao Wang Xin-Hua Liu Jing Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518000Guangdong ProvinceChina

AIM:To investigate the impact of hsa_circ_0007482 on the proliferation and apoptosis of human pterygium fibroblasts(HPFs)and its correlation with the severity grades of ***:Pterygium and normal conjunctival tissues were collected from the superior area of the same patient’s eye(n=33).The correlation between pterygium severity and hsa_circ_0007482 expression using quantitative reversetranscription polymerase chain reaction(RT-qPCR)were *** distinct siRNA sequences targeting hsa_circ_0007482,along with a negative control sequence,were transfected into *** proliferation was assessed using the cell counting *** levels of Ki67,proliferating cell nuclear antigen(PCNA),Cyclin D1,Bax,B-cell lymphoma-2(Bcl-2),and Caspase-3 were measured via *** staining was employed to detect Ki67 and vimentin *** was evaluated using flow ***:Hsa_circ_0007482 expression was significantly higher in pterygium tissues compared to normal conjunctival tissues(P<0.001).Positive correlations were observed between hsa_circ_0007482 expression and pterygium severity,thickness,and vascular *** of hsa_circ_0007482 inhibited cell proliferation,reducing the mRNA expression of Ki67,PCNA,and Cyclin D1 in ***_circ_0007482 knockdown induced apoptosis,increasing mRNA expression levels of Bax and Caspase-3,while decreasing Bcl-2 expression in ***,hsa_circ_0007482 knockdown attenuated vimentin expression in ***:The downregulation of hsa_circ_0007482 effectively hampers cell proliferation and triggers apoptosis in *** are discernible positive correlations detected between the expression of hsa_circ_0007482 and the severity of pterygium.

关键词： hsa_circ_0007482 circular RNA pterygium cell proliferation apoptosis

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng Jian Yang Xue-Mei Zhu Feng-ling Xiang Jing Tu Ming-Xue Huang yun Wang Jin-Hua Gan Wei-Hua Yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of Southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis

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Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou ling-Yu Zhang An-Ni Lin Yang Zhang Jing Jiang Xin Che yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

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Advancing Energy Systems with In-Situ and Operando Surface-Enhanced Raman Scattering Spectroscopy

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CCS Chemistry 2024年第6期6卷 1403-1421页

作者： Haoming Bao Shi Xuan Leong Jaslyn Ru Ting Chen Zhenhai Shi Suli Chen Yan Lv Tianxi Liu In Yee Phang Xing yi ling Key Laboratory of Synthetic and Biological Colloids Ministry of EducationInternational Joint Research Laboratory for Nano Energy CompositesSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122 School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371

Surface-enhanced Raman scattering spectroscopy(SERS)has emerged as a powerful analytical technique to enable nanoscale investigations of energy *** mini-review focuses on the applications of in-situ and operando SERS in energy-related research,highlighting its unique capabilities and significant contributions to understanding energy storage and conversion *** first introduce the fundamental principles of SERS,key SERS-derived techniques,and commonly employed ***,we delve into the diverse applications of in-situ and operando SERS across various energy systems,encompassing photocatalytic and electrocatalytic systems,fuel cells,solar cells,and ***,we conclude with our perspective on the current challenges and prospects in this *** hope thismini-review serves as an essential overview to guide the design and implementation of in-situ and operando SERS studies of energy systems.

关键词： surface-enhanced Raman scattering spectroscopy in-situ operando energy systems photocatalysis electrocatalysis fuel cells solar cells batteries

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SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA yun-ding ZOU Zhi-long LIU Gui-xian WU Yuan-ze ZHOU Cheng-xin LUO Xiang-tao HUANG Ming-ling XIE Shuang-nian XU Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

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含氮H13热作模具钢的热变形行为及热加工图

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材料热处理学报 2024年第1期45卷 185-192页

作者：原凌云山西太钢不锈钢股份有限公司技术中心山西太原030003

利用Gleeble-3800热模拟试验机,对含氮的H13热作模具钢开展了不同温度以及单道次的单向压缩试验,研究了其在应变速率为0.01~10 s^(-1)、变形温度为900~1250℃条件下的热变形行为,并根据高温应力-应变曲线,运用双曲正弦函数理论建立了该... 详细信息

利用Gleeble-3800热模拟试验机,对含氮的H13热作模具钢开展了不同温度以及单道次的单向压缩试验,研究了其在应变速率为0.01~10 s^(-1)、变形温度为900~1250℃条件下的热变形行为,并根据高温应力-应变曲线,运用双曲正弦函数理论建立了该钢的本构模型,并根据动态材料模型确定了其在不同应变下的热加工图。结果表明:高温热压缩变形状态下,含氮H13热作模具钢的流变应力随变形温度的升高而降低,随应变速率的降低而减小,当变形温度高于1100℃,应变速率小于0.1 s^(-1)时,含氮H13热作模具钢的流变应力曲线表现为动态再结晶特征;含氮H13热作模具钢的热变形激活能为610.23 kJ/mol,适合的热加工工艺范围为1100~1250℃,应变速率0.8~10 s^(-1)。

关键词：含氮H13钢热压缩变形本构方程热加工图

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Application of three-dimensional electron diffraction in structure determination of zeolites

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Chinese Journal of Structural Chemistry 2024年第4期43卷 39-47页

作者： Yuhang Li Yang ling Yanhang Ma School of Physical Science and Technology&Shanghai Key Laboratory of High-resolution Electron Microscopy ShanghaiTech UniversityShanghai201210China

Zeolites have received great attention due to their wide applications in various fields such as catalysis,adsorp-tion/separation,ion exchange,*** the atomic crystal structure of zeolites is crucial to understanding their functions and exploring their *** to the difficulty of synthesizing large single crystals,the structures of many zeolites cannot be solved using conventional single-crystal X-ray diffraction(SCXRD)***-dimensional electron diffraction(3D ED)has witnessed rapid development during the past decade and has shown its powerful ability in the structure determination of *** this review,we will briefly introduce the history of 3D ED and summarize recent advances in the application of 3D ED for the analysis of zeolite structures,along with several typical examples in this research field.

关键词： Electron diffraction Three-dimensional electron diffraction Zeolite Structure solution Electron crystallography

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带有摩擦耗能组件的可更换钢梁柱拼接节点抗震性能试验

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吉林大学学报（工学版） 2024年第6期54卷 1643-1656页

作者：刁延松任义建杨元强赵凌云刘秀丽刘芸青岛理工大学土木工程学院山东青岛266525

基于可恢复功能的抗震设计理念,提出了一种带有摩擦耗能组件的可更换钢梁柱拼接节点。该节点同时利用屈服和摩擦两种机制进行耗能,具有延性好、损伤可控及损伤后可更换等优点。设计制作了缩尺比为1∶1.5的2个可更换钢梁柱拼接节点和1个... 详细信息

基于可恢复功能的抗震设计理念,提出了一种带有摩擦耗能组件的可更换钢梁柱拼接节点。该节点同时利用屈服和摩擦两种机制进行耗能,具有延性好、损伤可控及损伤后可更换等优点。设计制作了缩尺比为1∶1.5的2个可更换钢梁柱拼接节点和1个悬臂段螺栓连接钢梁柱节点试验模型,分别对其进行拟静力试验。对破坏后的2个可更换钢梁柱拼接节点试件进行修复,并进行二次加载,得到了节点试件在低周往复荷载作用下的滞回曲线、骨架曲线、刚度退化曲线、应变和位移曲线、延性及耗能等抗震性能指标。结果表明:提出的可更换钢梁柱拼接节点的延性及耗能能力均优于悬臂段螺栓连接钢梁柱节点;可更换钢梁柱拼接节点的塑性损伤主要集中在可更换构件上,而主体构件基本保持在弹性工作范围内;修复后的节点几乎完全恢复了抗震性能,满足可更换性的要求。

关键词：结构工程可恢复功能可更换钢梁柱拼接节点抗震性能摩擦耗能拟静力试验

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Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei yi Xu ling Wang yi Xia Xu Qi Huanping Mei Xueqiang Xu Huijuan Mao Changying Xing Ningning Wang Department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China Department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China Department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the *** present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in *** early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of *** one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal *** diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the *** changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and ***,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary *** the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal *** focal infection ultimately resolved during the subsequent three ***-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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