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Neural Regeneration Research 2012年第30期7卷 2370-2376页

作者： Liang peng Mi Liu Xiaorong Chang Zhou yang Shouxiang yi Jie yan yan peng College of Acupuncture and Tuina Hunan University of Chinese Medicine Changsha 410007 Hunan Province China

Studies have shown that pre-moxibustion protects the gastric mucosa by up-regulating the expression of heat shock protein 70. However, the signaling pathway underlying this effect remains unclear. Rats were intragastrically administered absolute alcohol, causing obvious lesion of the gastric mucosa. Following pre-moxibustion at Zusanfi （ST36） for 8 days, the ulcer index decreased to different degrees. The results of an enzyme linked immunosorbent assay and western blotting showed significant upregulation of heat shock protein 70 expression in the gastric mucosa and serum. None out of transection of the spinal cord, damage to the nucleus of the solitary tract, neurotomy of the vagal nerve and neurotomy of the common peroneal nerve affected the decrease in ulcer index or the increase in heat shock protein 70 expression in serum after pre-moxibustion at Zusanfi, and heat shock protein 70 expression was obviously decreased in the gastric mucosa. These findings suggest that pre-moxibustion at Zusanfi can protect the gastric mucosa against lesioning, and that the mechanism underlying this effect involves its induction of heat shock protein 70 expression. Neural pathways participate in the regulatory effects of moxibustion on heat shock protein 70 expression in the gastric mucosa.

关键词： pre-moxibustion transection of neural pathway Zusanli (ST36) gastric mucosal lesion heat shockproteins-70 ulcer index traditional Chinese medicine neural regeneration

Effect of pre-moxibustion on apoptosis and proliferation of gastric mucosa cells

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World Journal of Gastroenterology 2007年第15期13卷 2174-2178页

作者： Shou-Xiang yi yan peng Xiao-Rong Chang Na peng Jie yan Yap-Ping Lin The Institute of Acupuncture Moxibustion and Massage Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

AIM： TO observe the effects of pre-moxibustion on apoptosis and proliferation of gastric mucosal cell in rats with stress-induced ulcer, and to analyze the relationship between those effects and the expression of heat-shock protein 70 （HSP70）. METHODS： Sixty healthy Sprague Dawley rats were randomly assigned into four groups, namely group A, B, C and D. The animal model of stress ulcer was established by water immersion and restraint stress. The rats in group A, B, and D served as the restraint, model, and non-acupoint controls, respectively, while those in group C received moxibustion at Zusanli and Uangmen points. Immunohistochemical methodology was used to detect the expression of HSP70, apoptosis index （AI, × 10^-6/μm^2） and proliferation index （PCNA-LI, × 10^-6/μm^2）. The mucosal expression of transforming growth factor α （TGF-α） was detected by radioimmunoassay. RESULTS： IVloxibustion at Zusanli and Liangmen points significantly decreased the gastric injury and the apoptosis of gastric mucosal cells, while markedly increased the mucosal expression of TGF-α and HSP70 as well as the proliferation of gastric mucosal cells. Compared with group A, ulcer index （UI）（26.8 ± 9.8 vs 12.0 ± 5.9, P 〈 0.01）, AI （9.6 ± 4.2 vs 4.4 ± 2.6, P 〈 0.05） and expression of HSP70 （9.6 ± 4.2 vs 4.4 ± 2.6, P 〈 0.05） were significantly increased, but the content of TGF-α （104.7 ± 51.2 pg/mL vs 254.0 ± 86.9 pg/mL, P 〈 0.01） and PCNA-LI （6.9 ± 4.7 vs 14.9 ± 4.6, P 〈 0.05） were significantly decreased in group B. However, ulcer index values （UI） and AI were obviously lower in group C compared to groups B and D （14.1 ± 5.4 vs 26.8 ± 9.8 and 26.2 ± 7.7, P 〈 0.01, 3.0 ± 1.6 vs 9.6 ± 4.2 and 8.2 ± 5.2, P 〈0.05, respectively）, but content of TGF-α （237.0 ± 72.6 pg/mL vs 104.7 ± 51.2 pg/mL and 154.1 ± 61.3 pg/mL, P 〈0.01） and expression of HSP70 （0.13 ± 0.03 vs 0.08 ± 0.06 and 0.06 ± 0.04, P 〈 0.05） were higher in group C. Furthermore, the PCNA-LI was significantly higher in group C than in

关键词： Moxibustion Stress ulcer HSP70 Proliferating cell nuclear antigen Apoptosis

Fabrication of Highly Porous Interconnected Three-dimensional Scaffolds with Micro-channels

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Chinese Journal of Polymer Science 2014年第7期32卷 864-870页

作者： Zhi-xiang Cui Hai-bin Zhao yi-yan peng Yottha Srithep Lih-Sheng Turng 申长雨 Fujian University of Technology Shandong University University of Wisconsin-Madison Zhengzhou University

A novel highly porous 3-D poly（e-caprolactone）（PCL） scaffold with micro-channels was fabricated by injection molding and diluent acetic acids leaching technologies. In this study, the chitosan fiber was employed to form the microchannel in PCL matrix. The morphology, porosity and mechanical properties of the scaffolds were studied and calculated. It was found that the larger the content of chitosan fiber is, the higher the porosity would be, due to the volumetric expansion of chitosan fiber in PCL matrix during it being leached. In addition, the less the content of chitosan fiber is, the higher the compressive modulus would be.

关键词： Injection molding Micro-channel Chitosan fiber Poly(ε-caprolactone) scaffold.

Fabrication of shish-kebab-structured carbon nanotube/poly(ε-caprolactone) composite nanofibers for potential tissue engineering applications

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Rare Metals 2019年第1期38卷 64-72页

作者： Tong Wu Xin Chen Jin Sha yi-yan peng Yu-Lu Ma Lin-Sheng Xie Lih-Sheng Turng Engineering Center of Efficient Green Process Equipment and Energy Conservation Ministry of Education East China University of Science and Technology School of Mechanical and Power Engineering East China University of Science and Technology Wisconsin Institute for Discovery University of Wisconsin-Madison

The electrospinning process was applied to fabricate the nanofibers of biodegradable poly(ε-caprolactone)(PCL) in which different contents of multiwalled carbon nanotubes(MWCNTs) were embedded. Afterward,the electrospun nanofibers were successfully decorated with shish-kebab structure via a self-induced crystallization technique. The topographical features and the mechanical properties of the composite scaffolds were characterized,and the biocompatibility of the material was assessed by using human osteogenic sarcoma osteoblasts(MG-63 cells). The carbon nanotube(CNT) concentration is found to affect the fiber diameter and mechanical properties of electrospun nanofibers and the periodic distance of the shish-kebab architecture. Cellular attachment and proliferation assays reveal that 0.5 wt% CNT-embedded PCL scaffold shows enhanced biocompatibility with MG-63 cells than their counterparts made of neat PCL, and the collagen-like nanotopology provided by the shish-kebab structure further facilitates the cell adhesion and proliferation. The superior interactions between cells and scaffolds demonstrate that the shish-kebab-structured CNTs/PCL nanofibers may be promising candidate for tissue engineering scaffold application.

关键词： Carbon nanotubes Poly(ε-caprolactone) Electrospinning Shish-kebab structure Tissue engineering

Kinetic studies of the decomposition reaction of adducts of dinuclear Fe(Ⅱ)/O_2

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Chinese Science Bulletin 2002年第6期47卷 461-463页

作者： peng yi, yan Shiping, CHENG peng,LIAO Daizheng, JIANG Zonghui & WANG GenglinDepartment of Chemistry, Nankai University, Tianjin 300071, China Department of Chemistry Nankai University Tianjin China

Kinetic studies of the decomposition reaction of dinuclear Fe(Ⅱ) adducts [Fe2(N-Et-HPTB){O2P(OPh)2}](Cl-O4)2(1) and [Fe2(N-Et-HPTB) {O2P(Ph)2}] (C1O4)2 (2) with O2 have been carried out at low temperature using UV-vis spectra. The decomposition reaction of Fe(Ⅱ)/O2 adducts was first-order in the experimental conditions, and the activation parameters were obtained. △H≠ = 85.62kJ·mol-1, △S≠ =19.43 J·mol-1·K-1 for compound (1) and △H≠=97.97 kJ·mol-1, △S≠ = 55.68 J·mol-1·K-1 for compound (2). These results are similar to those of dioxygen adducts of other metals complexes and natural enzymes such as methane mono-oxygenase (MMOH).

关键词： dinuclear iron complex activation of O2 kinetics mo-deling system.

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退火对注射成型PC制品力学性能的影响

化工学报 2010年第6期61卷 1555-1559页

作者：王鑫 yi-yan peng 李海梅申长雨郑州大学橡塑模具国家工程研究中心河南郑州450002 Engineering Polymer Center University of Wisconsin-Madison WI 53706 USA

注射成型的塑料光学制品应用日益广泛,但注射成型加工的聚碳酸酯制品通常有较大的残余应力,会对制品的光学性能、力学性能有负面的影响,而退火可减少/消除制品的残余应力。本文考察了退火对不同工艺条件下注射制品残余应力和力学性能的... 详细信息

注射成型的塑料光学制品应用日益广泛,但注射成型加工的聚碳酸酯制品通常有较大的残余应力,会对制品的光学性能、力学性能有负面的影响,而退火可减少/消除制品的残余应力。本文考察了退火对不同工艺条件下注射制品残余应力和力学性能的影响。研究的工艺条件包括三水平的变化的模具温度、熔体温度、保压压力、冷却时间等;残余应力的变化通过光弹实验的应力干涉条纹表示,力学性能的变化以拉伸强度、延伸率的变化表示。实验发现,退火前后,不同工艺条件下注塑PC制品拉伸强度平均提高4.5%,最大达9.0%;同时,断裂延伸率平均降低3%,最多减少14%。

关键词：退火注射成型拉伸强度延伸率

Channel pruning on frequency response

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Science China(Information Sciences) 2025年第1期68卷 159-170页

作者： Hang LIN yifan peng Lin BIE Chenggang yan Xibin ZHAO Yue GAO School of Software Tsinghua University School of Automation Hangzhou Dianzi University

Network pruning has a significant role in reducing network parameters and accelerating the inference time of the network. Some existing methods prune the network based on the frequency of the data, and finally obtain a sub-network with high accuracy. However, according to our experimental analysis, different frequencies of information in the data contribute differently to the accuracy of the model, and using this information directly for pruning without making a selection will lead to incorrect results. We believe that pruning should retain the convolutional kernels in the network that process important information, while those kernels that process unimportant information should be removed. In this paper, we first investigate the meaning of each frequency band information in the spectrum and their contribution to the prediction accuracy of the network,and according to these results, we propose a new pruning method based on frequency response(PFR). Our PFR finds and removes the convolutional kernels in the network that specialize in processing unimportant information, resulting in a compact neural network model. PFR obtains significant experimental results on different datasets, for example, a 56.0% raduction of float points operations(FLOPs) on Res Net-50 and only 0.37% of Top-1 accuracy degradation on the Image Net dataset.

关键词： deep learning model compression filter pruning channel pruning frequency response

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin