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CD133^+ gallbladder carcinoma cells exhibit self-renewal ability and tumorigenicity

World Journal of Gastroenterology 2011年第24期17卷 2965-2971页

作者： Cheng-Jian Shi Jun Gao Min wang Xin wang Rui Tian Feng Zhu Ming Shen Ren-yi Qin Department of Biliary-pancreatic Surgery Affiliated Tongji Hospital Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of General Surgery The Affiliated Hospital of Qingdao University Medical College Qingdao 266003 Shandong Province China

AIM： To identify cancer stern cells （CSCs） in human gallbladder carcinomas （GBCs）. METHODS： Primary GBC cells were cultured under serum-free conditions to produce floating spheres. The stem-cell properties of the sphere-forming cells, including self-renewal, differentiation potential, chemoresistance and tumorigenicity, were determined in vitro or in vivo. Cell surface expression of CD133 was investigated in primary tumors and in spheroid cells using flow cytometry. The sphere-colony-formation ability and tumorigenicity of CD133＋ cells were *** spheroids were generated from primary GBC cells, and these sphere-forming cells could generate new progeny spheroids in serum-free media. Spheroid cells were differentiated under serum-containing conditions with downregulation of the stem cell markers Oct-4, Nanog, and nestin （P 〈 0.05）. The differentiated cells showed lower spheroid-colony-formation ability than the original spheroid cells （P 〈 0.05）. Spheroid ceils were more resistant to chemotherapeutic reagents than the congenetic adherent cells （P 〈 0.05）. Flow cytometry showed enriched CD133＋ population in sphereforming cells （P 〈 0.05）. CD133＋ cells possessed high colony-formation ability than the CD133 population （P 〈 0.01）. CD133＋ cells injected into nude mice revealed higher tumorigenicity than their antigen-negative counterparts （P 〈 0.05）. CONCLUSION： CD133 may be a cell surface marker for CSCs in GBC.

关键词： Gallbladder carcinoma Cancer stem cell Non-adherent spheres CD133 protein Self-renewal Tumorigenicity

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A review of flexible perovskite oxide ferroelectric films and their application

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Journal of Materiomics 2020年第1期6卷 1-16页

作者： Wenxiu Gao yi Zhu yaojin wang Guoliang Yuan Jun-Ming Liu School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China Laboratory of Solid State Microstructure and Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China

Many perovskite oxide ferroelectrics(***_(1-x)Ti_(x)O_(3),BaTiO_(3),LiNbO_(3))are born with multitudinous robust performances and have been widely used in sensors,actuators,surface acoustic wave devices,and memories et ***,their hardness,brittleness and harsh synthesis conditions(*** temperature and oxygen ambience)restrain their application into flexible electronic devices which are significant components among the three pillars of modern society development,***,information and *** we review the preparation of flexible devices based on these oxide ferroelectrics,including transferring these freestanding films to flexible substrates after separating ferroelectric oxide films from the hard substrates,such as Si and SrTiO_(3) crystals,and also direct fabrication methods without transferring ***,we summarize three kinds of representative flexible devices,*** ferroelectric memories,sensors and *** inorganic electronics not only show excellent electric properties competitive with those corresponding electronics on hard substrates but also exhibit good flexibility similar to many organic flexible electronics.

关键词： Perovskite oxides Flexible devices Sensors Energy harvesters Memories

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Antifungal Activity of Chitosan on Fusarium sulphureum in Relation to Dry Rot of Potato Tuber

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Agricultural Sciences in China 2009年第5期8卷 597-604页

作者： LI Yong-cai SUN Xiao-juan BI yang GE Yong-hong wang yi College of Food Science and Engineering Gansu Agricultural University Lanzhou 730070 P.R.China

The antifungal activity of chitosan on Fusarium sulphureum in relation to the inhibitory effect on dry rot of potato tuber was investigated. The results showed spore germination and mycelial growth of F. sulphureum were inhibited by chitosan treatment and the inhibitory effect was highly correlated with chitosan concentration used in this study. Morphological changes such as intertwisting hyphal, distortion, and swelling with excessive branching were observed by scanning electron microscopy （SEM） observation. Transmission electron microscopy （TEM） observation further indicated the ultrastructural alterations of hyphae. These changes included abnormal distribution of cytoplasma, non-membraneous inclusion bodies assembling in cytoplasm, considerable thickening of the hyphal cellular walls, and very frequent septation with malformed septa. Application of chitosan at higher concentration caused serious damage to fungal hyphae, including cellular membrane disorganisation, cell wall disruption, and breaking of inner cytoplast. New hyphae （daughter hyphae） inside the collapsed hyphal cells was often detected in the cytoplasm of chitosan-treated hyphae. In vivo tests showed that chitosan treatment at 0.5 or 1% effectively controlled the dry rot of potato tuber inoculated with a spore suspension ofF. sulphureum. However, the chitosan treatment at 1% caused phytotoxicity to potato tuber. This study suggests that the use of chitosan could be a promising handling as a natural fungicide to partially substitute for the synthetic fungicides in potato tuber.

关键词： chitosan Fusarium sulphureum morphology and ultrastructure potato dry rot

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A Genetic-Algorithm-based Neural Network Approach for Radioactive Activity Prediction

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Nuclear Science and Techniques 2013年第6期24卷 12-16页

作者： wang Lei TUO Xianguo yaN Yucheng LIU Mingzhe CHENG yi LI Pingchuan State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology Southwest University of Science and Technology

In this paper,a genetic-algorithm-based artificial neural network(GAANN)model radioactivity prediction is proposed,which is verified by measuring results from Long Range Alpha Detector(LRAD).GAANN can integrate capabilities of approximation of Artificial Neural Networks(ANN)and of global optimization of Genetic Algorithms(GA)so that the hybrid model can enhance capability of generalization and prediction accuracy,*** this model,both the number of hidden nodes and connection weights matrix in ANN are optimized using genetic *** real data sets are applied to the introduced method and the results are discussed and compared with the traditional Back Propagation(BP)neural network,showing the feasibility and validity of the proposed approach.

关键词：神经网络方法遗传算法模型预测放射性人工神经网络活性逼近能力全局优化

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A Three-Dimensional Mn^Ⅱ-[Mo^Ⅲ(CN)7]^4-Ferrimagnet Containing Formate as a Second Bridging Ligand

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Chinese Journal of Chemistry 2019年第1期37卷 19-24页

作者： Le Shi Dong Shao Fu-ying Shen Xiao-qin Wei Xin-yi wang State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China

Summary of main observation and conclusion Serf-assembly of the [Mo(CN)7]^4-anion and the Mn^2+ ion in the aqueous solution containing ammonium formate results in a new coordination polymer,{(NH4)3[(H2O)Mn3(HCOO)][Mo(CN)7]2·4H2O}*** crystal X-ray analysis revealed a very complicated three-dimensional (3D)framework,where both the [Mo(CN)7]^4- and the formate anions act as bridges between the Mn^Ⅱ *** measurements revealed that this compound displays ferrimagnetic ordering below 70 *** antiferromagnetic interactions between the spin carriers might lead to spin frustration and non-linear alignment of the magnetic ***,this compound is the first mixed [Mo(CN)7]^4-/HCOO^- bridged molecule magnet.

关键词： Mn^2+ frustration spin X-ray act

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Asymptotic optimality for consensus-type stochastic approximation algorithms using iterate averaging

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控制理论与应用（英文版） 2013年第1期11卷 1-9页

作者： Gang yiN Le yi wang Yu SUN David CASBEER Raymond HOLSAPPLE Derek KINGSTON Department of Mathematics Wayne State University Department of Electrical and Computer Engineering Wayne State University Quantitative Business Analysis Department Siena College Control Science Center of Excellence Air Force Research Laboratory

This paper introduces a post-iteration averaging algorithm to achieve asymptotic optimality in convergence rates of stochastic approximation algorithms for consensus control with structural constraints. The algorithm involves two stages. The first stage is a coarse approximation obtained using a sequence of large stepsizes. Then, the second stage provides a refinement by averaging the iterates from the first stage. We show that the new algorithm is asymptotically efficient and gives the optimal convergence rates in the sense of the best scaling factor and ＇smallest＇ possible asymptotic variance.

关键词： Stochastic approximation algorithm Consensus Iterate averaging Asymptotic optimality

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eμ Production in R-Parity Violating Supersymmetric Model at Hadron Colliders

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Communications in Theoretical Physics 2007年第3X期48卷 491-501页

作者： wang Shao-Ming HAN Liang MA Wen-Gan ZHANG Ren-You JIANG yi Department of Modern Physics University of Science and Technology of China Hefei 230026 China

We investigate the lepton flavor violating productions pp/pp→eμ ＋ X in the framework of the R-parity violating （RPV） supersymmetric model at the Tevatron and the CERN large hadron collider （LHC）. We present the total cross sections including the next-to-leading order （NLO） QCD corrections and the contribution from gluon-gluon fusion subprocess. Our numerical results show that the one-loop QCD corrections significantly increase the tree-level cross sections, and the variation of K factor is in the range between 1.28 （1.32） and 1.79 （1.58） at the Tevatron （LHC）. We find that the QCD correction from the one-loop gluon-gluon fusion subprocess is remarkable at the LHC and should be taken into account.

关键词： R-parity violating supersymmetric model QCD corrections

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Non-Halogenated Solvent-Processed High-Efficiency Polymer Solar Cells:the Role of Diphenyl Ether in Morphology,Light-Trapping,Transport Properties

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Transactions of Tianjin University 2022年第5期28卷 423-432页

作者： yi Chen Xiangxu Ding Ge wang Songwen Xiao Xin Liu Zihan Zhu Chen wang Shanpeng Wen State Key Laboratory On Integrated Optoelectronics and College of Electronic Science and Engineering Jilin UniversityChangchun 130012China

There is an urgent need to use green non-halogenated solvents to prepare polymer solar cells(PSCs) for *** is time-consuming but necessary to find a suitable non-halogenated solvent/additive combination for a given donor:acceptor materials *** this research,we report a non-halogenated binary solvent system toluene/diphenyl ether(DPE) for the PBDTT-DTffBT:PC_(71)BM and PM6:Y6 blending systems that exhibit comparable power conversion efficiency(PCE) to that of devices prepared with halogenated *** nano scale morphology indicates that blending film processed solely with toluene has poor phase segregation and a rough surface,which hinders charge separation and interfacial ***,the total absorption spectra revealed significant light-trapping losses in the toluene-processed solar cells,resulting in low photocurrent *** incorporation addresses these issues and significantly improves the short-circuit current density and fill ***,non-halogen solvent-processed devices exhibit high hole mobility and low transporting impedance *** present study enriches the families of eco-friendly,high-efficiency PSCs fabricated using nonhalogenated solvents.

关键词： Green solvents Diphenyl ether Morphology Charge extraction Polymer solar cells

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Entering the duodenal diverticulum:A method for cannulation of the intradiverticular papilla

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World Journal of Gastroenterology 2012年第48期18卷 7394-7396页

作者： Bao-Can wang Wei-Bin Shi Wen-Jie Zhang Jun Gu yi-Jing Tao Yu-Qin wang Xue-Feng wang Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of Medicine Department of General Surgery Xinhua HospitalShanghai Jiaotong University School of Medicine

Successful cannulation of the common bile duct may be difficult in patients in whom the papilla is located entirely within a *** this study,we report successful biliary cannulation in three patients following intubation of the distal tip of the duodenoscope into the duodenal diverticulum and locating the major *** complications occurred during the operation or during the postoperative *** method didn't need second incubation an endoscope and might lower the burden of *** this skill is useful to deal with the papilla hidden inside the large diverticulum because of its safety and convenience.

关键词： Endoscopic retrograde cholangiopancrea-tography Intradiverticular papilla Duodenoscope

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Improved FRACS parameterizations for cross sections of isotopes near the proton drip line in projectile fragmentation reactions

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Nuclear Science and Techniques 2018年第7期29卷 133-137页

作者： yi-Dan Song Hui-Ling Wei Chun-wang Ma Jian-Hua Chen Institute of Particle and Nuclear Physics Henan Normal University Shanghai Institute of Applied Physics Chinese Academy of Sciences College of Information and Electronic Engineering Shangqiu Institute of Technology

The FRACS parameterizations,labeled as FRACS-C,have been improved in order to predict the presence of isotopes near the proton drip line produced in projectile fragmentation *** investigating the cross sections for proton-rich isotopes in a series of reactions with energies ranging from intermediate to relativistic,it is shown that the FRACS-C parameterizations can predict isotopes near the proton drip line considerably *** FRACS-C parameterizations are suggested to serve as an effective tool for predicting the presence of proton-rich isotopes with large asymmetry in a projectile fragmentation *** reactions have been investigated to check these results.

关键词：同位素质子反应破碎射弹滴线不对称现象有效工具

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