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An improved formula for standard hypoxia tolerance time to evaluate hypoxic tolerance in mice

Military Medical Research 2019年第2期6卷 111-116页

作者： Gang Xu Yu-Qi gao yi-xing gao Gang Wu Jian-Yang Zhang Wen-Xiang gao Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineArmy Medical University(Third Military Medical University)Chongqing400038China Key Laboratory of High Altitude Medicine People’s Liberation ArmyChongqing400038China

Background: Hypoxia is a primary cause of mountain sickness and a common pathological condition in patients with heart failure, shock, stroke, and chronic obstructive pulmonary disease(COPD). Thus far, little advancement in countering hypoxic damage has been achieved, and one of the main reasons is the absence of an ideal algorithm or calculation method to normalize hypoxia tolerance scores when evaluating an animal model. In this study, we improved a traditional calculation formula for assessment of hypoxia ***: We used a sealed bottle model in which the oxygen is gradually consumed by a mouse inside. To evaluate the hypoxia tolerance of mice, the survival time(ST) of the mouse is recorded and was used to calculate standard hypoxia tolerance time(STT) and adjusted standard hypoxia tolerance time(ASTT). Mice administered with methazolamide and saline were used as positive and negative controls, ***: Since mice were grouped according to either body weight(BW) or bottle volume, we found a strongly negative correlation between STT and BW instead of between STT and bottle volume, suggesting that different BWs could cause false positive or negative errors in the STT results. Furthermore, both false positive and negative errors could be rectified when ASTT was used as the evaluation index. Screening for anti-hypoxic medicines by using mice as the experimental subjects would provide more credible results with the improved ASTT method than with the STT ***: ASTT could be a better index than STT for the evaluation of hypoxia tolerance abilities as it could eliminate the impact of animal BW.

关键词： Hypoxia Standard hypoxic tolerance time Mice model Body weight

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Microwave-assisted aqueous two-phase extraction of Rosa laevigata Michx polysaccharide:optimization,purification,characterization and antioxidant activities

Microwave-assisted aqueous two-phase extraction of Rosa laev...

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中国化学会第十一届全国天然有机化学学术会议

作者： yi-xing gao Ming-Yuan Huang Xiao-Dan Ding Hai-Feng Sun Zi-Wei Wang Xue-Gui Liu Pin-yi gao College of Pharmaceutical and Biotechnology Engineering Shenyang University of Chemical Technology

The extraction process of Rosa laevigata Michx(金樱子) Polysaccharides(RLMPs)were optimized using response surface methodology with microwave-assisted aqueous twophase *** operational conditions were optimized using a Box-Behnken design(BBD) of the response surface method(RSM).According to the analysis of experimental data from a Placket-Burman design(PBD) and a steepest ascent experiment,selected major factors(PEG2000 30-40%;(NH)SO 10-15%and extraction time 15-25 min) were *** analysis of the RSM data,a model proposed was able to predict an optimum value of 38.37%which was confirmed experimentally as 38.31%under the optimized *** the crude RLMPs was purified by DEAE-Cellulose 52 chromatography and Sephadex G-200 chromatography to afford two fractions,RLMP-1 and RLMP-2,which were characterized by *** composition was determined by acid hydrolysis and1-pheny1-3-5-pyrazolone(PMP) derivatization prior to ***-1 was mainly composed of mannose,glucose,galactose and arabinose in a molar ratio of 4.6:10.2:1.0:2.0,while RLMP-2 was only composed of *** RLMP-land RLMP-2 exhibited certain antioxidant *** the concentration of 50mg/mL,the DPPH radical scavenging effects of RLMP-1,RLMP-2 and ascorbic acid were 21.88,45.57 and 95.65%,*** the ABTS radical cation scavenging effects of RLMP-1,RLMP-2 and ascorbic acid were 22.26,45.96 and 95.30%,***,this study was proved as a green and efficient to extraction of polysaccharides from Rosa laevigata Michx and it was also a comprehensive and systematic approach for the further research of plant polysaccharides.

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Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2020年第1期41卷 3-19页

作者： Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng yi-xing gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi gao Wei yin Guo-Jie Zhang Guang-Mei Yan State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China BGI-Shenzhen ShenzhenGuangdong 518083China Section for Ecology and Evolution Department of BiologyUniversity of CopenhagenCopenhagen DK-2100Denmark Department of Pharmacology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Institute of Medicine and Hygienic Equipment for High Altitude Region College of High Altitude Military MedicineThird Military Medical UniversityChongqing 400038China Key Laboratory of High Altitude Medicine of People's Liberation Army Chongqing 400038China Key Laboratory of High Altitude Environmental Medicine Third Military Medical UniversityMinistry of EducationChongqing 400038China School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510006China Guangzhou Cellprotek Pharmaceutical Co.Ltd. GuangzhouGuangdong 510663China Institute of Medical Genetics School of MedicineCardiff UniversityCardiff CF144XNUK James D.Watson Institute of Genome Sciences HangzhouZhejiang 310058China Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouGuangdong 510080China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China China National Genebank BGI-ShenzhenShenzhenGuangdong 518120China

Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment.

关键词： Acute hypobaric hypoxia Cynomolgus monkeys Brain injury Neuroprotectant Gene regulatory networks

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Characteristics and related factors of brain function in the long staying soldiers at high altitude

Characteristics and related factors of brain function in the...

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中国神经科学学会第十届全国学术会议

作者： yi-xing gao Peng LI Chun-Hua JIANG Yu CHEN Chun LIU Yu-Qi gao Huai-Zhen RUAN Department of Neurobiology College of Basic Medical SciencesThird Military Medical UniversityChongqing Key Laboratory of Neurobiology College of High Altitude Military Medicine Third Military Medical UniversityKey Laboratory of High Altitude Medicine of Ministry of EducationKey Laboratory of High Altitude Medicine of PLA

Objective To investigate the features and related factors of brain function in the long staying soldiers at high *** Male soldiers living at the plain and soldiers living at 4500 m altitude for 1-15 years participated in this ***,heart rate,blood pressure and blood oxygen saturation(SpO) were collected in group of sea level and group of high *** brain tissue oxygenation index(TOI) was observed by near infrared oxygenation monitor(NIRO).S100B and BDNF were detected by using enzyme linked immunosorbent assay(ELISA).Use the PSQI to investigate the sleep quality,the neurobehavioral core tests battery(NCTB) to investigate the neurobehavioral,and the Raven’s standard progressive matrices(RSPM) to survey the cognitive *** The SpO decreased obviously in high-altitude group(P<0.01),the concentration of hemoglobin(Hb) and heart rate significantly increased in high-altitude group(P<0.01).The brain TOI of soldiers living at 4500m decreased significantly(P<0.01) and positively related to *** PSQI of high altitude group increased significantly(P<0.01) and negatively related to TOI.S100B significantly increased in high-altitude group(P<0.01),BDNF obviously decreased in high-altitude group(P<0.05).The five tests of NCTB(POMS,Simple Reaction Time,Digit-Symbol,the Benton visual retention,Pursuit Aiming)showed significantly decreased in high altitude group(P<0.05 or P<0.01).POMS were significantly correlated with TOI and PSQI(P<0.01).They were mate fallible on color discrimination(P<0.01) and slower on reaction to blue and yellow color stimulus(P<0.05),and motor stability(P<0.01).Except for a negative correlation between PSQI and brain TOI,no other decreasing brain function was associated with reduced brain oxygen *** RSPM increased in high-altitude group and negatively related to *** Chronic hypoxic exposure at high altitude has a profound effect on the basic indicator,TOI,*** the same time the SpO were negative cor

关键词： high altitude chronic hypoxic exposure brain function cognitive ability

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Author Correction: Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys

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Zoological Research 2021年第2期42卷 250-251页

Open Access This is an open-access article distributed under the terms of theCreative Commons Attribution Non-Commercial License(http:1/***/licenses/by-nc/4.0/).which permits unrestrictednon-commercial use,*** reprodu... 详细信息

关键词： Open Creative Access

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min xing Hai-Dong Qian Qiao gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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基于视觉导航的旋翼无人机自主降落系统

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传感器与微系统 2018年第9期37卷 77-80,83页

作者：张舸伊国兴高翔哈尔滨工业大学空间控制与惯性技术研究中心黑龙江哈尔滨150001

对视觉导航辅助下的无人机自主降落问题进行了研究:利用Harris角点检测和轮廓检测等图像识别方法,设计了基于针孔摄像机模型的无人机位姿估计算法;对无人机的自主降落控制算法进行了研究,采用比例—积分—微分(PID)控制方法,设计了无人... 详细信息

对视觉导航辅助下的无人机自主降落问题进行了研究:利用Harris角点检测和轮廓检测等图像识别方法,设计了基于针孔摄像机模型的无人机位姿估计算法;对无人机的自主降落控制算法进行了研究,采用比例—积分—微分(PID)控制方法,设计了无人机自主降落过程中的位姿控制器和云台控制器,在此基础上,创新性地提出了无人机的3种降落模式,并分别在各模式下进行了自主降落试验。试验结果表明:3种模式下无人机均能实现自主降落,但前2种模式由于视觉反馈次数低的原因,有较大降落误差,而第3种模式由于采用云台伺服追踪和速度控制,实现了高精度的无人机自主着陆。

关键词：旋翼无人机视觉导航自主降落位姿估计算法飞行控制器

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Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai Li Zhen Ma Jin-Hua gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng xing Yang Zheheng Song Yuhang Song Jingyu Chen yingcun Liu Chong gao Yong Du Zhe Sun Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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基于“教学、实践、科研”三位一体模式的《建筑力学》课程教学改革

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东华理工大学学报（社会科学版） 2017年第3期36卷 283-287页

作者：昌毅曹幸高金贺东华理工大学江西南昌330013

以东华理工大学工程管理专业《建筑力学》课程为研究对象,根据课程教学质量提升的要求,提出了基于"教学、实践、科研"三位一体模式的课程教学改革思路。全面分析了改革前《建筑力学》课程教学过程中发现的问题,并有针对性地制定了几项... 详细信息

以东华理工大学工程管理专业《建筑力学》课程为研究对象,根据课程教学质量提升的要求,提出了基于"教学、实践、科研"三位一体模式的课程教学改革思路。全面分析了改革前《建筑力学》课程教学过程中发现的问题,并有针对性地制定了几项改革措施。通过教学改革前后学生实际动手能力和理解能力的对比分析,该教学改革方案对教学质量的提升具有显著的促进作用。

关键词：建筑力学教学实践科研

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