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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 33-40页

作者： xin-yi guo yi-Lin Xia Zhi-Yang Li Ran Li Yang Fan Wen-Mo Yao Fei Liu West China School of Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Liver Surgery&Liver Transplantation Center West China HospitalSichuan UniversityChengdu 610041China

Background:Apoptosis,also called programmed cell death,is a genetically controlled process against hyperproliferation and *** Fas-Fas ligand(FasL)system is considered a major pathway for apoptosis in cells and ***,this study aimed to investigate whether single nucleotide polymor-phisms(SNPs)in Fas and FasL gene may have effects on the recurrence and survival of patients with hepatocellular carcinoma(HCC)after curative ***:We investigated the relationship between Fas rs1800682,rs2234767 and FasL rs763110 poly-morphisms and recurrence-free survival(RFS)as well as overall survival(OS)in 117 Chinese Han patients with HCC who underwent ***:In Kaplan-Meier survival analysis,only Fas rs1800682(-670 A/G)was associated with RFS and *** with AA genotype,the AG/GG genotype was significantly associated with better RFS(P=0.008)and OS(P=0.020).Moreover,multivariate Cox regression analysis showed that Fas rs1800682 remained as a significant independent predictor of RFS for HCC patients with hepatectomy[AG/GG ***:adjusted hazard ratio=0.464,95%confidence interval:0.275-0.782,P=0.004],but was not an independent predictor of OS(P=0.395).Conclusions:This study demonstrated that Fas-670 G allele may play a protective role in the recurrence and survival of HCC patients with ***,Fas rs1800682 polymorphism might be a promising biomarker for HCC patients after hepatectomy.

关键词： Hepatocellular carcinoma Single nucleotide polymorphism Cell apoptosis Prognosis Resection

Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol

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World Journal of Gastroenterology 2022年第23期28卷 2569-2581页

作者： yi-xin guo Bing Han Ting Yang Yu-Si Chen yi Yang Jia-Yao Li Qin Yang Ru-Jia Xie Department of Pathophysiology Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic DiseasesGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Pathophysiology College of Basic Medical SciencesGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina

BACKGROUND Endoplasmic reticulum(ER)stress-related hepatocyte apoptosis is responsible for multiple hepatic *** studies have revealed that endoplasmic reticulophagy(ER-phagy)promotes the selective clearance of damaged ER fragments during ER stress,playing a crucial role in maintaining ER homeostasis and inhibiting *** with sequence similarity 134 member B(FAM134B)is a receptor involved in ER-phagy that can form a complex with calnexin(CNX)and microtubule-associated protein 1 light chain 3(LC3).The complex can mediate the selective isolation of ER fragments to attenuate hepatocyte ***,the precise regulatory mechanisms remain *** To elucidate the effect of FAM134B-mediated ER-phagy on ER stress-induced apoptosis in buffalo rat liver 3A(BRL-3A)rat hepatocytes and the potential regulatory *** ER stress-related hepatocyte apoptosis was induced using dithiothreitol(DTT).Proteins related to ER stress and autophagy were measured with western *** complex interactions with FAM134B were isolated by ***-phagy was evaluated in immunofluorescence *** cycle distribution and apoptosis were measured by flow *** Ca^(2+) levels were evaluated by the co-localization of intracellular Ca^(2+)-tracker and *** small interfering RNA against FAM134B was used to knockdown FAM134B in BRL-3A *** ER stress-related and autophagy-related proteins in BRL-3A cells were elevated by both short and long-term DTT ***,co-immunoprecipitation confirmed an interaction between FAM134B,CNX,FAM134B,and LC3 in BRL-3A *** assays revealed that autolysosomes significantly decreased following short-term DTT treatment,but increased after long-term *** Ca2+levels and apoptotic rates were dramatically elevated,and more cells were arrested in the G1 stage after short-term DTT treatment;however,these decreased

关键词： Hepatocytes Reticulophagy Family with sequence similarity 134 member B Apoptosis Endoplasmic reticulum stress Endoplasmic reticulum homeostasis

Stereoselective Synthesis of α-Aminonitril on Glucose Templates

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有机化学 2003年第Z1期23卷 90-92页

作者： ZHANG Peng-Fei GU yi-xin guo Jun-Li CHEN Min Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036 Department of Chemistry Hangzhou Teachers College Zhejiang 310036

　　Both proteinogenic and non proteinogenic α-amino acids are of particular interest as constituents of peptide factors, peptidomimetics and antibiotics for the construction of modern selective drugs. [1] Furthemore, α-amino acid derivatives are interesting building units for chiral-pool syntheses of enantiomerically pure natural products. [2] Numerous efforts in modern organic synthesis are centered on the synthesis of enantiomerically pure α-amino acids. [3] During the past three decades efficient methods of asymmetric synthesis of α-amino acids have been developed; most of them are based on electrophilic transformations of organometallic intermediates. [4] Using the concept that the chirality of the carbohydrates can be exploited for diastereoselective reactions, Kunz and his cooperator had developed a Strecker synthesis with glycosyl amines as chiral auxiliaries. [5] ……

关键词： asymmetric synthesis organic synthesis natural products methods of

Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer

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World Journal of Gastroenterology 2024年第39期30卷 4281-4294页

作者： Jing-Zhao Zhang Zhi-Wei Zhang xin-yi guo Deng-Sheng Zhu Xiao-Rui Huang Ming Cai Tong guo Ya-Hong Yu Department of Biliopancreatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND Ampullary cancer is a relatively rare malignant tumor in the digestive *** incidence has increased in recent *** for now,its biological characteristics have not been fully *** studies have primarily focused on the histological classification and genetic changes,but there are fewer investigations into the differences among site-specific *** clinicopathological charac-teristics of ampullary cancer occurring in different positions have not been ***,the role of adjuvant therapy in the treatment of patients with ampullary cancer remains *** cancer and explore the factors affecting *** A total of 356 patients who met the inclusion and exclusion criteria were *** were divided into ampulla of Vater cancer(AVC)and duodenal papilla cancer(DPC)based on the gross and microscopic *** data,admission examination results,and perioperative outcomes were collected and *** Kaplan-Meier curve was used for survival *** and multivariate analysis was performed to explore the independent risk factors affecting the overall survival(OS)of both *** The preoperative total bilirubin level in patients with AVC was significantly higher than those with DPC(P=0.04).The OS for patients with DPC was 58.90±38.74 months,significantly longer than 44.31±35.90 months for patients with AVC(P<0.01).The independent risk factors affecting the OS of AVC included:Preoperative albumin level(P=0.009),total bilirubin level(P=0.017),and number of positive lymph nodes(P=0.005).For DPC,risk factors included:Age(P=0.004),tumor size(P=0.023),number of positive lymph nodes(P=0.010)and adjuvant treatment(P=0.020).Adjuvant therapy significantly improved the OS rate of patients with DPC,but not for those with *** Patients with AVC had a shorter OS compared to those with *** prognosis factors and the role of adjuvant therapy of two groups were diffe

关键词： Ampullary cancer Prognosis Risk factors Overall survival Adjuvant therapy

Suberoylanilide hydroxamic acid upregulates reticulophagy receptor expression and promotes cell death in hepatocellular carcinoma cells

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World Journal of Gastroenterology 2023年第34期29卷 5038-5053页

作者： Jia-Yao Li Tian Tian Bing Han Ting Yang yi-xin guo Jia-Yu Wu Yu-Si Chen Qin Yang Ru-Jia Xie Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases College of Basic Medical SciencesGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Pathophysiology College of Basic Medical SciencesGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Eugenic Genetics Guiyang Maternal and Child Health Care HospitalGuiyang 550003Guizhou ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a common clinical condition with a poor prognosis and few effective treatment *** anticancer agents for treating HCC must be *** plays an essential role in HCC *** hydroxamic acid(SAHA),the most common histone deacetylase inhibitor agent,triggers many forms of cell death in ***,the underlying mechanism of action remains *** with sequence similarity 134 member B(FAM134B)-induced reticulophagy,a selective autophagic pathway,participates in the decision of cell fate and exhibits anticancer *** study focused on the relationship between FAM134B-induced reticulophagy and SAHA-mediated cell *** To elucidate potential roles and underlying molecular mechanisms of reticulophagy in SAHA-induced HCC cell *** The viability,apoptosis,cell cycle,migration,and invasion of SAHA-treated Huh7 and MHCC97L cells were *** related to the reticulophagy pathway,mitochondria-endoplasmic reticulum(ER)contact sites,intrinsic mitochondrial apoptosis,and histone acetylation were quantified using western *** and lysosome colocalization,and mitochondrial Ca^(2+)levels were characterized via confocal *** level of cell death was evaluated through Hoechst 33342 staining and propidium iodide *** immunoprecipitation was used to verify histone H4 lysine-16 acetylation in the FAM134B promoter *** After SAHA treatment,the proliferation of Huh7 and MHCC97L cells was significantly inhibited,and the migration and invasion abilities were greatly blocked in *** promoted apoptosis and caused G1 phase cells to increase in a concentration-dependent *** treatment with SAHA,ER-phagy was activated,thereby triggering autophagy-mediated cell death of HCC cells in *** blotting and chromatin immunoprecipitation assays confirmed that SAHA regulated FAM134B expression by enhancing the hi

关键词： Suberoylanilide hydroxamic acid Histone H4 lysine-16 Reticulophagy Apoptosis Autophagic cell death Hepatocellular carcinoma

Influence of the femoral head size on early postoperative gait restoration after total hip arthroplasty

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Chinese Medical Journal 2009年第13期122卷 1513-1516页

作者： ZHOU yi-xin guo Sheng-jie LIU Qing TANG Jing LI Yu-jun Department of Orthopaedic Surgery Beijing Jishuitan Hospital Fourth Clinical College of Peking University Beijing 100035 China

Background We investigated the effects of using large-diameter femoral heads in total hip prostheses on early postoperative gait restoration in patients undergoing total hip arthroplasty （THA）. Methods We collected data for 19 primary THAs using 28-mm metal-on-polyethylene heads （conventional group） and for 12 THAs （BHR group） using metal-on-metal femoral heads with an average size of 45 mm （range, 40-49mm）. All patients had unilateral femoral head avascular necrosis. All patients underwent Harris Hip Scores evaluation and gait analysis with the IDEEA device at the same 3 time points which were before surgery and then at 1 month and again at 3 months after surgery, and the parameters measured were walking speed, stride length （SL）, single limb support （SLS）, cycle duration （CD）, and swing power （SP）. Harris Hip Scores and gait analysis parameters for both groups were compared. Results Intraclass comparison indicated that Harris Hip Scores, speed scores, and gait parameter measures in both groups improved significantly with the passage of time; Interclass comparison showed no significance between Harristm postop - HarriSpreop and Harris3m postop- HarriSpreop in both groups. The speed in the BHR group at 1 month and at 3 months after surgery was significantly higher than that of conventional group. At 1 month after surgery, each mean for SLnormal - SLaffected, （SLSnormal - SLSaffected）/CD, and SPnormal - SPaffected in the BHR group was significantly lower than that for the conventional group. At 3 months after surgery, the differences between means for both groups for SLnormal - SLaffected, （SLSnormal- SLSaffected）/CD, and SPnormal - SPaffected were not significant, but the mean of SPnorrnal - SPaffected in the BHR group was significantly lower than that in the conventional group. Conclusions Our data suggest that large-diameter femoral heads in THA provide better early gait restoration than conventional-size femoral heads.

关键词： total hip arthroplasty femoral head size Harris Hip Score gait analysis

Association factors of target organ damage： analysis of 17 682 elderly hypertensive patients in China

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Chinese Medical Journal 2011年第22期124卷 3676-3681页

作者： CUI Hua WANG Fan FAN Li HU yi-xin HU guo-liang LIU Lin HONG Chang-ming Chinese People＇s Liberation Army General Hospital （Fan L） Beijing 100853 China

Background Hypertensive target organ damage （TOD） is the main reason for mortality or disability in elderly hypertensive patients. The studies on TOD of hypertension in Asia, especially in Chinese elderly hypertensive patients, are very limited. The aim of this study was to evaluate the prevalence and correlative factors of TOD in older Chinese hypertensive inpatients. Methods This is a retrospective survey and data were collected from the computerized medical files of hypertensive inpatients from January of 1993 to December of 2008. The analysis was done on 17 682 inpatients, aged 60 years or older, with a diagnosis of essential hypertension （EH）. The evidence of hypertensive TOD and associated factors with TOD were collected. Results The prevalence of any hypertensive target organ involvement among these subjects was high. In multivariable Logistic regressions adjusted for potentially confounding factors, older age, male gender, diabetes, EH grade 3, systolic blood pressure （SBP）, and low-density lipoprotein cholesterol （LDL-C）, were independently associated with coronary artery disease. Age, duration of EH, EH grade 3, SBP, pulse pressure （PP）, and homocysteine （Hcy） were independently associated with cerebrovascular disease. Age, diabetes, duration of EH, EH grade 3, SBP, PP and estimated glomerular filtration rate （eGFR） were independently associated with chronic kidney disease. Male gender, EH grade 3 and SBP were independently associated with aortic dissection. Conclusions The prevalence of hypertensive TOD is high in older Chinese hypertensive inpatients. Various cardiovascular risk factors are associated with hypertensive TOD. The level of SBP and severe hypertension （grade 3 hypertension） are common independent risk factors of TOD.

关键词： hypertension target organ damage risk factors elderly inpatients

Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

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Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou xin-yi guo ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke Yamanishi Hiromichi Yamanishi Hideaki Higashino Haruki Okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine Hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42 prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

Small-Scale Duplications Play a Significant Role in Rice Genome Evolution

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Rice science 2005年第3期12卷 173-178页

作者： guo xin-yi Xu guo-hua ZHANG Yang Hu Wei-min FAN Long-jiang Institute of Crop Science/Institute of Bioinformatics Zhejiang University Hangzhou 310029 China

Genes are continually being created by the processes of genome duplication （ohnolog） and gene duplication （paralog）. Whole-genome duplications have been found to be widespread in plant species and play an important role in plant evolution. Clearly un-overlapping duplicated blocks of whole-genome duplications can be detected in the genome of sequenced rice （Oryza sativa）. Syntenic ohnolog pairs （ohnologues） of the whole-genome duplications in rice were identified based on their syntenic duplicate lines. The paralogs of ohnologues were further scanned using multi-round reciprocal BLAST best-hit searching （E〈e^-14）. The results indicated that an average of 0.55 sister paralogs could be found for every ohnologue in rice. These results suggest that small-scale duplications, as well as whole-genome duplications, play a significant role in the two duplicated rice genomes.

关键词： small-scale duplication ohnologue genome evolution Oryza sativa Arabidopsis

Pituitary apoplexy complicated with subarachnoid hemorrhage caused by incidentaloma following a head injury:case report

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Chinese Medical Journal 2007年第24期120卷 2341-2343页

作者： BAO yi-jun LI xin-guo JING Zhi-tao OU Shao-wu WU An-hua WANG Yun-jie Department of Neurosurgery First Hospital of China Medical University Shenyang 110001 China

Plituitary apoplexy is a rare clinical syndrome caused by acute enlargement of pituitary adenomas, which may be secreting or nonfunctioning, and symptomatic or asymptomatic, resulted from hemorrhage or infarction. Subarachnoid hemorrhage （SAH） is an unusual presentation in patients with pituitary apoplexy, and that following a head injury is more infrequently reported. Here, we report a case of pituitary apoplexy complicated with subarachnoid hemorrhage caused by an incidentaloma after head trauma in an aged man, who experienced a spontaneous regression of the tumor.

关键词： incidentaloma pituitary apoplexy subarachnoid hemorrhage