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Polyinosine-polycytidylic acid promotes excessive iodine intake induced thyroiditis in non-obese diabetic mice via Toll-like receptor 3 mediated inflammation

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Chinese Medical Journal 2013年第4期126卷 703-710页

作者： SHI Ya-nan liU Feng-hua YU Xiu-jie liU Ze-bing li Qing-xin YUAN Ji-hong ZANG xiao-yi li Lan-ying 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics Key Laboratory of Hormones and Development Metabolic Diseases Hospital & Tianjin Institute of Endocrinology Tianjin Medical University Tianjin 300070 China

Background Excessive iodine intake and viral infection are recognized as both critical factors associated with autoimmune thyroid diseases. Toll-like receptors （TLRs） have been reported to play an important role in autoimmune and inflammatory disorders. In this study, we aimed to clarify the possible mechanism of TLR3 involved in polyinosine- polycytidylic acid （poly（I：C）） promoting excessive iodine intake induced thyroiditis in non-obese diabetic （NOD） mice. Methods Both NOD and BALB/c mice were randomly assigned to four groups： control group （n=5）, high iodine intake （HI） group （n=7）, poly（I：C） group （n=7） and combination of excessive iodine and poly（l：C） injection （HIP） group （n=7）. After 8 weeks, mice were weighed and blood samples were collected. All the mice were sacrificed before dissection of spleen and thyroid gland. Then, thyroid histology, thyroid secreted hormone, expression of CD3＋ cells and TLR3 as well as inflammatory mRNA level were evaluated. Results Both NOD and BALB/c mice from HI and HIP group represented goiter and increasing thyroid relative weight. Thyroid histology evidence indicated that only HIP group of NOD mice showed severe thyroiditis with lymphocytes infiltration in majority of thyroid tissue, severe damage of follicles and general fibrosis. Immunofiuorescence staining results displayed a large number of CD3~ cells in HIP NOD mice. Real-time polymerase chain reaction （PCR） results suggested interferon （IFN）-a increased over 30 folds and IFN-y expression was doubled compared with control group, but interleukin （IL）-4 remained unchanged in HIP group of NOD mice thyroid. Meanwhile, over one third decrease of blood total thyroxine （TT4） and increased thyroid-stimulating hormone （TSH） was observed in HIP group of NOD mice. Only HIP group of NOD mice represented significantly elevation of TLR3 expression. Conclusion Poly（l：C） enhanced excessive dietary iodine induced thyroiditis in NOD mice through increasing TLR3 mediated inflammation.

关键词： polyinosine-polycytidylic acid excessive iodine thyroiditis Toll-like receptor 3

Correlation between the thrombospondin- 1 and the mucoepidermoid carcinoma expression of angiogenesis in

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中国口腔颌面外科杂志 2008年第B5期6卷 198-199页

作者： Sen Yang xiao yi Wang li Juan Guo Qing Hong Gao Ming Xuan Department of Head and Neck Tumor Surgery West ChinaCollege of Stomatology Sichuan University Chengdu 610041Sichuan Province China

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功能磁共振在神经外科中的应用

中国医学影像技术 2009年第2期25卷 319-321页

作者：仪晓立戴建平首都医科大学附属北京天坛医院神经影像中心北京100050

功能磁共振(fMRI)是一种被广泛接受的成像手段,近年来已用于多种临床实践中,特别是在指导神经外科手术方面有了很大的进展。本文就fMRI基本原理和技术及其在有效性评估、指导神经外科手术和术后患者随访方面的作用予以综述。

关键词：磁共振成像血氧水平依赖性神经外科

Application progress on Omaha system in total hip arthroplasty nursing

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TMR Integrative Nursing 2019年第1期3卷 7-12页

作者： xiao-yi li Meng-Ya Jing Yong-Hong Deng Xue-Yun Hao Guo-Min Song 1Graduate College Tianjin University of Traditional Chinese Medicine Tianjin China 2Department of Cardiovascular Surgery Union Hospital of Tongji Medical College Huazhong University of Science & Technology Wuhan China 3Department of Nursing Tianjin Hospital Tianjin China

This article analyzes the application of Omaha system in perioperative continuation nursing and discharge follow-up of patients undergoing total hip arthroplasty in China, and combine the Omaha system with mobile medical to design a mobile management platform APP suitable for patients with total hip arthroplasty, and strengthen professional training for nurses, with the cooperation of multi-disciplinary teams, will be widely applied and promoted in clinical, in order to better manage and improve the nursing outcomes of patients with total hip arthroplasty and enhance the quality of life of patients.

关键词： Omaha system Total hip arthroplasty Review

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： ling-xiao yi Hui Ren Woon Genevieve Saw li Zeng Eng King Tan Zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

Clinicopathologic Features of Familial Nonmedullary Thyroic Carcinoma

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Chinese Medical Journal 2015年第8期128卷 1037-1041页

作者： Yu-Fang Fan Bo Zhang xiao Yang Zhong-Hua Shang Hong-Feng liu Yong Xie Yue-Wu liu Wei-Sheng Gao Qiong Wu xiao-yi li Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of General Surgery Second Clinical Hospital of Shanxi Medical University raiyuan Shanxi 030001 China

Background： Familial nonmedullary thyroid carcinoma （FNMTC） is a variant of nonmedullary thyroid carcinoma（NMTC） with particular clinicopathologic features. In recent years, a number of studies have shown that FNMTC is more invasive than sporadic NMTC（SNMTC）. The purpose of this study was to explore the differences in clinicopathologic features of FNMTC between different types of families and to determine in which of these families more invasive FNMTC occurred. Methods： We retrospectively reviewed all patients with thyroid carcinoma admitted to Peking Union Medical College Hospital from January 2009 to July 2013 in the database. Of all 2000 cases, 55 met the inclusive criteria for FNMTC and were studied. There are two different grouping methods. The first is that all samples were allocated to families with three or more first-degree relatives affected （FNMTC-3 group） and families with only two affected first-degree relatives （FNMTC-2 group）. The second is that all patients were divided into families with three or more affected first-degree relatives over two generations （FNMTC-3-2 group） and the other families. We compared the clinicopathologic features such as sex, age, tumor size, multifocality, location, complications by thyroiditis, complications by benign thyroid nodules, surgical procedure, capsule invasion, histological type, lymph node metastases, tumor node metastasis stage, and BRAF mutation between FNMTC-2 group and FNMTC-3 group. We also made the same comparison between FNMTC-3-2 group and other families. Results： No pronounced differences in clinicopathological features were present between FNMTC-2 group and FNMTC-3 group. The proportion of FNMTC-3-2 group aged 〈45 years was significantly higher than that in the other families （58.8% vs. 26.3%, P = 0.021）. A similar difference was found in the proportion of lymph node metastasis （64.7% vs. 34.2%, P = 0.035）. Conclusions： FNMTC-3-2 is more invasive than the other families. Early screening and positive tr

关键词： Clinical Pathology Familial Nonmedullary Thyroid Carcinoma

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氰化物定量检测方法应用研究进展

药物分析杂志 2016年第12期36卷 2075-2083页

作者：李悦李彦懿肖得力天津医学高等专科学校天津300222 中国药科大学南京211198

氰化物是一种剧毒物质,能够通过口服、吸入等方式引发中毒,因此关于氰化物检测的研究一直以来都受到了广泛重视。本文对氰化物的定性检测、半定量检测方法进行概述总结,并就氰化物定量检测方法的最新进展进行综述,主要归纳了光谱法、色... 详细信息

氰化物是一种剧毒物质,能够通过口服、吸入等方式引发中毒,因此关于氰化物检测的研究一直以来都受到了广泛重视。本文对氰化物的定性检测、半定量检测方法进行概述总结,并就氰化物定量检测方法的最新进展进行综述,主要归纳了光谱法、色谱法、电化学法等不同氰化物定量检测方法的原理、特点以及应用领域,重点在于对比不同方法的线性范围、检测限、回收率、RSD以及相关系数;同时进一步对不同方法的定量检测结果进行系统比较,包括方法的选择性、仪器的灵敏度、分离效果以及与其他检测技术的联用情况,最后对氰化物定量检测方法在药物分析中的发展趋势进行讨论和展望。

关键词：氰化物毒性化合物定量检测安全检测光谱法色谱法电化学法

Influence of high temperature treatment of activated carbon on performance of supercapacitors

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材料科学与工程（中英文版） 2008年第12期2卷 41-48页

作者： SUN Gang-wei WANG Can ZHAN liang QIAO Wen-ming liANG xiao-yi liNG li-cheng State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China

The Effect of Dictation Practice on listening Comprehension of Non-English Major Undergraduates

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海外英语 2017年第23期 253-254,256页

作者：陈晓宁易晓莉海南大学外语学院

This paper aims to explore the effectiveness of dictation practice in improving non-English major undergraduates listening comprehension.35 students were selected into the *** the comparison of the experimental data,we found that students'listening comprehension do improved after 12 weeks training while some other implications also were discussed for further study in order to promote listening teaching and learning.

关键词： Dictation practice listening comprehension non-English major undergraduates