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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.ence core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for english language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-english language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization

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Sc.ence china chemistry 2025年第1期 308-316页

作者： Sili Wang Jianc.eng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian wen Liu State Key Laboratory of chemical Biology Shanghai Institute of Organic Chemistry University of Chinese Academy of SciencesChinese Academy of Sciences State Key Laboratory of Microbial Technology Shandong University National Health commission (NHc) Key Laboratory of Biotechnology for Microbial Drugs Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College

cobalamin(cbl)-dependent radical S-adenosyl-L-methionine(SAM) proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members. Many of these proteins are involved in the biosynthesis of pharmaceutically important natural products to catalyze chemically demanding reactions. In the biosynthetic pathway of chuangxinmycin(cXM), a unique indole alkaloid antibiotic with potent anti-infective activity, functionalization of the characteristic thiopyrano[4,3,2-cd]indole scaffold by regio-and stereoselective c3-methylation is believed to rely on a cbl-dependent radical process, which, however, remained to be reconstituted biochemically. We here report the dissection of this enzymatic process, which requires the incorporation of cxm8, a cbl-dependent radical SAM protein, with cxm9, a DUF5825family protein that shares no homology to any proteins of known functions. cxm8 and cxm9 function together by forming an unexpected heterodimeric complex that selectively catalyzes c3-methylation of the tricyclic indole-S-hetero ring system in a successive manner, achieving cXM and a recently identified, c3-dimethylated congener. Detailed biochemical characterization,isotope labeling, structural simulation and bioinformatics analysis rationalized the catalysis of the cxm8/cxm9 complex and particularly the necessity of the DUF5825 protein for c3-methylase activity. This is the first example that a cbl-dependent protein acts with a partner to exhibit radical SAM activity.

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黑磷/黑砷异质结纳米器件热电性质应力调控研究

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原子与分子物理学报 2025年第1期42卷 69-74页

作者：戎杙邱乙峰张蓓新疆大学物理科学与技术学院乌鲁木齐830046

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形... 详细信息

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形,能够更有效抑制声子输运行为;与此同时,拉伸应变对于器件的电子输运的调控效果并不明显.在费米能附近,黑磷/黑砷异质结纳米器件在6%拉伸应变调控下热电优值达到最大值2.31.

关键词：黑磷黑砷异质结应力热电性质

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Large-area, Flexible Polymer Solar cell Based on Silver Nanowires as Transparent Electrode by Roll-to-Roll Printing

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chinese Journal of Polymer Sc.ence 2017年第2期35卷 261-268页

作者： yi-fan Zhao wen-jun Zou Huan Li 吕琨延卫魏志祥 chinese Academy of Sc.ences Key Laboratory of Nanosystem and Hierarchical Fabrication Chinese Academy of Sciences Center for Excellence in Nanoscienee National Center for Nanoscience and Technology Beijing 100190 China Department of environmental Sc.ence and engineering Xi ＇an Jiaotong University Xi ＇an 700049 China

conventional organic solar cell＇s （OSc） architectures, including rigid transparent substrate （Glass）, conductive electrode （Indium tin oxide, ITO） and small working areas, are widely utilized in organic photovoltaic fields. However, such a structure as well as conventional spin-coating method obviously restrict their industrial application. In this article, we report the deposition of silver nanowires （AgNWs） on the flexible substrate by slot-die printing. The obtained AgNWs films exhibited a high transmittance and a low resistance, and were further used as the transparent conductive electrode ofOScs. A typical conjugated polymer, poly[（2-5-bis（2-hexyldecyloxy）phenylene）-alt-（5,6-difluoro-4,7-di（thiophen-2-yl）benzo[c] [1,2,5]thiadiazole）] （PPDT2FBT）, was used as the active material to fabricate large-area （7 cm2） solar cells by a slot-die coating process. The power conversion effic.ency （PcE） could reach 1.87% initially and further increased to 3.04% by thermal annealing. compared to the performance of reference cell on ITO substrate, the result indicated that the AgNWs could be developed as an alternative substitute of conductive electrode to fabricate the large-area flexible OScs by roll-to-roll printing.

关键词： Polymer solar cell Silver nanowires Slot-die Large area Flexible substrate

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Visible to ultraviolet up-conversion in a novel rare earth-free up-converting phosphor

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chinese chemical Letters 2012年第1期23卷 117-120页

作者： en Zhou Liu Jun Fan Xiao Yun Hu wen Qian Hou Hong Zhe Dai School of chemical engineering Northwest UniversityXi'an 710069China Department of Physics Northwest UniversityXi'an 710069China

A novel up-converting phosphor,Na_xAl_yF_（x＋3y）/caF2（0.3 〈 x 〈 0.5,0 〈 y 〈 0.1） composite,is prepared by a hydrothermal process at 180°c and an annealing treatment at 500℃.X-ray diffraction（XRD） pattern indicates that Na_xAl_yF_（x＋3y）/caF_2 is a composite consisting of NaF,Na_3 AlF_6,and caF_*** up-conversion luminescence properties of this phosphor are investigated by fluorescence *** show that Na_xAl_yF_（x＋3y）/caF_2 exhibits visible-to-ultraviolet up-conversion luminescence *** emission peaks at 316 and 336 nm are observed when excited by 610 nm,the luminescence lifetime of the emissions is great than 18 ms,and the internal fluorescence quantum yield is 4.2%.Additionally,the luminescent mechanism of this phosphor is also mentioned.

关键词： Up-converting phosphor Luminescence properties Fluorides caF_2

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The energy Sources and the Explosion Mechanism of ca-rich Supernova PTF 10iuv

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Research in Astronomy and Astrophysics 2024年第9期24卷 106-118页

作者： Qiu-Ping Huang Shan-Qin Wang Tao Wang wen-Pei Gan Deng-Wang Shi Liu-yi Wang en-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Department of Astronomy Beijing Normal UniversityBeijing 100875China Nanjing Hopes Technology co. Ltd.Nanjing 210000China

In this paper,we perform the detailed modeling for the light curves(Lcs)of PTF 10iuv which is a calcium-rich(ca-rich)supernova(SN)to constrain the physical properties of its ejecta and the energy sources,as well as the explosion *** find that the^(56)Ni model and the56Ni plus circumstellar interaction model fail to explain the Lcs,while the four-element(^(56)Ni,^(48)cr,^(52)Fe,and^(44)Ti)model can account for the *** ejecta mass of PTF10iuv derived by the model(1.52_(-0.25)^(+0.34)M_(⊙))is consistent with that of the merger of a sub-chandrasekhar mass white *** early-time Lcs were mainly powered by^(56)Ni whose mass is~0.03 M_(⊙),while the contributions of^(48)cr and^(52)Fe can be *** derived^(44)Ti mass(~0.25 M_(⊙))is~1.8 times the upper limit of the derived^(44)Ti mass of ca-rich SN *** suggest that subtracting the contributions of the host-galaxy,which are unknown,and including the flux from other long-lived elements(e.g.,^(57)co,^(55)Fe,^(60)co)can reduce the amount of^(44)Ti,and that this value can be regarded as an upper limit.

关键词： (stars:)supernovae:general (stars:)supernovae:individual(PTF 10iuv) (stars:)novae cataclysmic variables

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enhancing strength of an ultra-low-carbon weathering steel to 700 MPa by adjusting Ti content

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Journal of Iron and Steel Research International 2023年第12期30卷 2494-2504页

作者： Tian-en Peng Zhi-wei Lian Yuan-yang Zhang Bo He Xue-wen Hu Tao Zhu Bo Jiang School of Materials Sc.ence and engineering University of Science and Technology BeijingBeijing100083China Technical center Ma’anshan Iron&Steel Co.Ltd.Ma’anshan243041AnhuiChina

The microstructure and mechanical properties of a traditional Ti-microalloyed weathering steel were analyzed,and the strength was improved by proposing an optimized Ti *** yield strength and elongation of the steel were 640 MPa and 25.5%,*** microstructure was ferrite and pearlite,and the average grain size was 5.4μ*** precipitates were mainly Tic with the size below 20 nm,and the average diameter was 18.2 *** yield strength of the newly proposed weathering steel with Ti content of 0.018%higher than that of the traditional steel reached up to 709 MPa,and the elongation was 23.5%.The ferrite grain was refined to 3.8μm,the fraction of Tic under 10 nm was obviously increased,and the average diameter of particles was 9.8 *** increase in Ti also promoted the recrystallization process,thus leading to the reduction in dislocation *** yield strength of the newly proposed weathering steel was increased to higher than 700 MPa by adjusting the Ti content mainly resulting from three aspects:grain refinement,precipitation and dislocation *** contributed values were 45,64 and–40 MPa,respectively.

关键词： Ti microalloying Weathering steel Microstructure Strength Plasticity

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characteristics and roles of cytochrome b5 in cytochrome P450-mediated oxidative reactions in Locusta migratoria

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Journal of Integrative Agriculture 2020年第6期19卷 1512-1521页

作者： LIU Jiao ZHANG Xue-yao WU Hai-hua MA wen ZHU wen-ya Kun-Yan ZHU MA en-bo ZHANG Jian-zhen Institute of Applied Biology Shanxi UniversityTaiyuan 030006P.R.China college of Life Sc.ence Shanxi UniversityTaiyuan 030006P.R.China Modern Research center for Traditional chinese Medicine Shanxi UniversityTaiyuan 030006P.R.China Institute of Plant Protection Shanxi Academy of Agricultural SciencesTaiyuan 030031P.R.China Department of entomology Kansas State UniversityManhattanKS 66506USA

cytochrome b5(cyt-b5)is a small heme protein and known to be involved in a wide range of biochemical transformations,in eluding cytochrome P450 monooxyge nase(cYP)-mediated metabolism of endoge nous and exogenous compo un *** on cyt-b5 are more con centrated in mammals,but are relatively rare in in *** characteristics and functi on of cyt-b5 from Locusta migratoria have not been described *** sequeneed the full-length cDNA sequenee of cyt-b5 from ***(Lmcyt-b5)by reverse transcription-PcR(RT-PcR)based on locust transcriptome *** phylogenetic analysis showed that Lmcyt-b5 was closely related to the cyt-b5 from ***-b5 was highly expressed in ovary,Malpighian tubules,midgut,gastric caeca,and fat *** of Lmcyt-b5 had no effect on the susceptibility of *** to four different *** of Lmcyt-b5 or silencing of both Lmcyt-b5 and LmcPR did not significantly change the total cYP activity toward the substrate 7-ethoxycoumarin(7-Ec).However,coexpression of LmcYP6FD1 with LmcPR and Lmcyt-b5 together in Sf9 cells by using Bac-to-Bac baculovirus expression system significantly increased the catalytic activity of LmcYP6FD1 toward 7-Ec as compared with the coexpression of ***6FD1 with cytochrome P450 reductase(LmcPR)or Lmcyt-b5 *** results suggest that Lmcyt-b5 plays an important role in the catalytic reaction of LmcYP6FD1 toward 7-Ec in our in vitro *** study is needed to clarify the role of Lmcyt-b5 in cYP-mediated catalytic reactions in ***.

关键词： cytochrome b5 cytochrome P450 cytochrome P450 reductase Locusta migratoria RNA interference

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Optimization of Hot Workability in Superaustenitic Stainless Steel 654SMO

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Journal of Iron and Steel Research International 2014年第10期21卷 975-982页

作者： en-xiang PU wen-jie ZHenG Zhi-gang SONG Jin-zhong XIANG Xian-ping WEI School of Physics Sc.ence and Technology Yunnan University central Iron and Steel Research Institute

Hot compression tests were conducted on a Gleeble-3800 machine in a temperature range of 950 to 1200 ℃ and a strain rate range of 0. 001 to 10 s-1 in order to study the hot deformation behaviour of superaustenitic stainless steel 654SMO. The results show that peak stress increases with decreasing temperature and increasing strain rate, and the apparent activation energy of this alloy was determined to be about 494 kJ/mol. The constitutive equation which can be used to relate the peak stress to the absolute temperature and strain rate was obtained. The processing maps for hot working developed on the basis of flow stress data and the dynamic materials model were adopted to op- timize the hot workability. It is found that the features of the maps obtained in the strain range of 0.2 to 1.0 are fun- damentally similar, indicating that the strain does not have a substantial influence on processing map. The combina- tion of processing map and mierostructural observations indicates that the favorable hot deformation conditions are located in two domains of processing map. The first domain occurs in the temperature range of 980 to 1035 ℃ and strain rate range of 0. 001 to 0.01 s-1 with a peak effic.ency of 55%. The second domain appears in the temperature range of 1 120 to 1 180 ℃ and strain rate range of 0.3 to 3 s-1 with peak effic.ency of 35%. compared to other stable domains, the specimens deformed in these two domains exhibit full dynamic recrystallization grains with finer and more uniform sizes. An instability domain occurs at temperatures below 1 100 ℃ and strain rate above 0.1 s-1 , and flow instability is manifested in the form of flow localization.

关键词： 654SMO steel superaustenitic stainless steell processing mapl hot deformationl dynamic recrystallization

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后交叉韧带胫骨附着点撕脱骨折:关节镜治疗中的材料、植入物及内固定技术

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中国组织工程研究 2025年第4期29卷 872-880页

作者：余铭王文贵州医科大学贵州省贵阳市550004 暨南大学附属广州市红十字会医院广东省广州市510220

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不... 详细信息

背景:治疗后交叉韧带胫骨附着点撕脱骨折的最佳手术技术仍值得商榷。随着关节镜手术的应用与成熟,它在后交叉韧带胫骨附着点撕脱骨折的诊疗中有很大前景。目的:综述关节镜技术在后交叉韧带胫骨附着点撕脱骨折治疗中的应用与进展,包括不同关节镜治疗方法、手术入路、胫骨隧道设计、缝合材料选择以及内固定植入物选择等。方法:通过计算机对中国知网、PubMed、Web of Sc.ence及Sc.enceDirect等数据库中的相关文献进行检索,检索时间为2003年1月至2023年11月,中文检索词为“后交叉韧带,后十字韧带,撕脱骨折,关节镜”;英文检索词为“posterior cruciate ligament,avulsion,fracture,tibia,arthroscopic,operation,fixation,treatment”。共纳入97篇文献进行综述。结果与结论:关节镜技术提供了一种可靠的治疗方式来治疗后交叉韧带胫骨附着点撕脱骨折。根据入路、缝合材料类型以及用于缝合的入路和胫骨隧道数量等不同,关节镜技术可以分为关节镜下缝线固定结合自体移植物增强重建、关节镜下多交叉带缝合桥固定、关节镜下高强度缝线固定以及关节镜下直接前后缝合悬吊固定等几类。在各种研究中,常用的临床结果评估指标包括关节活动度、Lysholm评分、国际膝关节文献委员会评分及KT-2000关节测量仪差等,研究显示关节镜手术后末次随访时上述指标检测结果较术前显著改善,影像学随访结果显示关节镜手术都取得了令人满意的结果。在随访过程中,接受关节镜技术治疗后的各类交叉韧带胫骨附着点撕脱骨折患者都未出现严重并发症,例如创伤性关节炎、神经血管损伤、围手术期伤口感染、血栓形成以及骨折不愈合等。

关键词：后交叉韧带胫骨撕脱骨折关节镜手术缝合材料内固定治疗

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