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Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-Nian Wu Kai He yi-Bei Yu Bo Zheng Shao-Jun zhu Xiang-Qian Hong wen-Qun Xi Zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases:A prospective,blind clinical study

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World Journal of Gastroenterology 2024年第9期30卷 1121-1131页

作者： Yan-Ling Yang Huang-wen Qin Zhao-Yu Chen Hui-Ning Fan yi Yu Wei Da Jin-Shui zhu Jing Zhang Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Traditional esophagogastroduodenoscopy(EGD),an invasive examination method,can cause discomfort and pain in *** contrast,magnetically controlled capsule endoscopy(MCE),a noninvasive method,is being applied for the detection of stomach and small intestinal diseases,but its application in treating esophageal diseases is not *** To evaluate the safety and efficacy of detachable string MCE(ds-MCE)for the diagnosis of esophageal *** Fifty patients who had been diagnosed with esophageal diseases were pros-pectively recruited for this clinical study and underwent ds-MCE and conven-tional *** primary endpoints included the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for patients with esophageal *** secondary endpoints consisted of visualizing the esophageal and dentate lines,as well as the subjects'tolerance of the *** Using EGD as the gold standard,the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%,86.21%,81.82%,89.29%,and 86%,***-MCE was more comfortable and convenient than EGD was,with 80%of patients feeling that ds-MCE examination was very comfortable or comfortable and 50%of patients believing that detachable string v examination was very *** This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD,providing a novel noninvasive method for treating esophageal diseases.

关键词： Clinical trial Detachable string magnetically controlled capsule endoscopy Esophagogastroduodenoscopy Noninvasive diagnosis Esophageal diseases

Learning accurate template matching with differentiable coarseto-fine correspondence refinement

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Computational Visual Media 2024年第2期10卷 309-330页

作者： Zhirui Gao Renjiao yi Zheng Qin Yunfan Ye Chenyang zhu Kai Xu College of Computer National University of Defense TechnologyChangsha 410073China

Template matching is a fundamental task in computer vision and has been studied for *** plays an essential role in manufacturing industry for estimating the poses of different parts,facilitating downstream tasks such as robotic *** methods fail when the template and source images have different modalities,cluttered backgrounds,or weak *** also rarely consider geometric transformations via homographies,which commonly exist even for planar industrial *** tackle the challenges,we propose an accurate template matching method based on differentiable coarse-tofine correspondence *** use an edge-aware module to overcome the domain gap between the mask template and the grayscale image,allowing robust *** initial warp is estimated using coarse correspondences based on novel structure-aware information provided by *** initial alignment is passed to a refinement network using references and aligned images to obtain sub-pixel level correspondences which are used to give the final geometric *** evaluation shows that our method to be significantly better than state-of-the-art methods and baselines,providing good generalization ability and visually plausible results even on unseen real data.

关键词： template matching differentiable homography structure-awareness transformers

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儿童慢性肾脏病的营养管理

实用儿科临床杂志 2011年第5期26卷 311-313页

作者：易文中南大学湘雅二医院小儿肾脏病研究室长沙410011

对慢性肾脏病患儿的营养管理,重点在于定期进行营养状态评估及制定适当的营养配方。现简单介绍美国肾脏病杂志发表的最新肾脏病生存预后指南中的慢性肾脏病儿科营养临床实践指南内容,并结合指南简要介绍儿科肾病综合征、慢性肾小球肾炎... 详细信息

对慢性肾脏病患儿的营养管理,重点在于定期进行营养状态评估及制定适当的营养配方。现简单介绍美国肾脏病杂志发表的最新肾脏病生存预后指南中的慢性肾脏病儿科营养临床实践指南内容,并结合指南简要介绍儿科肾病综合征、慢性肾小球肾炎、慢性肾衰竭患儿的营养管理。

关键词：慢性肾脏病营养管理儿童

A Heuristic Radiomics Feature Selection Method Based on Frequency Iteration and Multi-Supervised Training Mode

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Computers, Materials & Continua 2024年第5期79卷 2277-2293页

作者： Zhigao Zeng Aoting Tang Shengqiu yi Xinpan Yuan Yanhui zhu School of Computer Hunan University of TechnologyZhuzhou412007China Hunan Key Laboratory of Intelligent Information Perception and Processing Technology Zhuzhou412007China

Radiomics is a non-invasive method for extracting quantitative and higher-dimensional features from medical images for *** has received great attention due to its huge application prospects in recent *** can know that the number of features selected by the existing radiomics feature selectionmethods is basically about *** this paper,a heuristic feature selection method based on frequency iteration and multiple supervised training mode is *** on the combination between features,it decomposes all features layer by layer to select the optimal features for each layer,then fuses the optimal features to form a local optimal group layer by layer and iterates to the global optimal combination *** with the currentmethod with the best prediction performance in the three data sets,thismethod proposed in this paper can reduce the number of features fromabout ten to about three without losing classification accuracy and even significantly improving classification *** proposed method has better interpretability and generalization ability,which gives it great potential in the feature selection of radiomics.

关键词： Radiomics feature selection machine learning metaheuristic

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

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Science China(Life Sciences) 2024年第7期67卷 1427-1440页

作者： Hongfeng Guo Qihang Sun Xiaoli Huang Xiaohao Wang Feng Zhang wenzheng Qu Jinling Liu Xuejun Cheng Qiang zhu wen yi Qiang Shu Xuekun Li The Children’s Hospital National Clinical Research Center for Child HealthSchool of MedicineZhejiang UniversityHangzhou 310052China The Institute of Translational Medicine School of MedicineZhejiang UniversityHangzhou 310029China College of Life Sciences Zhejiang UniversityHangzhou 310058China Binjiang Institute of Zhejiang University Hangzhou 310053China Zhejiang University Cancer Center Zhejiang UniversityHangzhou 310029China

Fucosyltransferase 8(Fut8)and core fucosylation play critical roles in regulating various biological processes,including immune response,signal transduction,proteasomal degradation,and energy ***,the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains *** have shown that Fut8 and core fucosylation display dynamic features during the differentiation of adult neural stem/progenitor cells(aNSPCs)and postnatal brain ***8 depletion reduces the proliferation of a NSPCs and inhibits neuronal differentiation of aNSPCs in vitro and in vivo,***,Fut8 deficiency impairs learning and memory in ***,Fut8 directly interacts with integrinα6(Itga6),an upstream regulator of the PI3kAkt signaling pathway,and catalyzes core fucosylation of *** of Fut8 enhances the ubiquitination of Itga6 by promoting the binding of ubiquitin ligase Trim21 to *** levels of Itga6 inhibit the activity of the PI3K/Akt signaling ***,the Akt agonist SC79 can rescue neurogenic and behavioral deficits caused by Fut8 *** summary,our study uncovers an essential function of Fut8 and core fucosylation in regulating adult neurogenesis and sheds light on the underlying mechanisms.

关键词： Fut8 adult neural stem/progenitor cells neurogenesis Itga6 PI3K/Akt

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儿童系统性红斑狼疮的诊断

实用儿科临床杂志 2009年第21期24卷 1701-1704页

作者：易文中南大学湘雅二医院小儿肾脏病研究室长沙410011

系统性红斑狼疮(SLE)是自身免疫介导的,以免疫性炎性反应为突出表现的弥散性结缔组织病。血清中出现以抗核抗体为代表的多种自身抗体和多系统受累是SLE的2个主要临床特征。SLE临床表现多样,除发热、皮疹等共同表现外,因受累器官不同而... 详细信息

系统性红斑狼疮(SLE)是自身免疫介导的,以免疫性炎性反应为突出表现的弥散性结缔组织病。血清中出现以抗核抗体为代表的多种自身抗体和多系统受累是SLE的2个主要临床特征。SLE临床表现多样,除发热、皮疹等共同表现外,因受累器官不同而表现不同,常常先后或同时累及泌尿、神经、心血管、血液、呼吸、消化、关节等多个系统。目前仍推荐以美国风湿病学会1997年修订的SLE分类标准作为诊断标准。SLE分类标准的11项中,符合4项或4项以上者,在除外感染、肿瘤和其他结缔组织病后,可诊断儿童SLE。确定儿童SLE诊断后,还需评估病情活动性和病情轻重程度,SLE活动性和病情轻重程度的评估是治疗方案拟订的先决条件。

关键词：系统性红斑狼疮诊断儿童

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儿童急性肾损伤的概念与诊断

实用儿科临床杂志 2009年第5期24卷 321-323页

作者：易文中南大学湘雅二医院小儿肾脏病研究室长沙410011

急性肾损伤(AKI)的概念将逐渐取代传统急性肾衰竭(ARF)的概念。AKI的定义为病程在3个月以内,包括血、尿、组织学及影像学检查所见的肾脏结构与功能异常。2005年的阿姆斯特丹会议同时决定将48h内血肌酐(Scr)上升≥26.5μmol/L或原Scr值... 详细信息

急性肾损伤(AKI)的概念将逐渐取代传统急性肾衰竭(ARF)的概念。AKI的定义为病程在3个月以内,包括血、尿、组织学及影像学检查所见的肾脏结构与功能异常。2005年的阿姆斯特丹会议同时决定将48h内血肌酐(Scr)上升≥26.5μmol/L或原Scr值增长≥50%和(或)尿量<0.5mL/(kg.h)达6h定义为AKI的诊断标准,并制定了病情分期标准。但Scr在反映肾功能的速度和精度方面存在不足,故需要寻找敏感性和特异性更好,能够预测疾病预后并具有AKI病因特异性的生物学指标。

关键词：肾损伤,急性肾衰竭,急性概念诊断生物学标志物儿童

Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

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World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen yi-Jia zhu wen-wen Tang Yu-Ji Wang Ze-Peng Chen Lin-Hai He Yu-Gen Chen Wei Zhang Jiangsu Province Hospital of Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 Clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Collaborative Innovation Center of Chinese Medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites