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Chinese Physics B 2020年第8期29卷 133-136页

作者： Qi Hao Ji-Chao Qiao E V Goncharova G V Afonin Min-Na Liu yi-ting cheng V A Khonik School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Department of General Physics Voronezh State Pedagogical UniversityLenin Street 86Voronezh 394043Russia

A relationship between thermal effects and relaxation of the high-frequency shear modulus upon heat treatment of bulk Zr48(Cu5/6Ag1/6)44Al8 metallic glass is *** relationship is attributed to the relaxation of a interstitial-type defect system frozen-in from the melt upon glass *** data show that thermal effects occurring on heating include heat release below the glass transition temperature,heat absorption above it and heat release caused by *** equation derived within the Interstitialcy theory can be used to calculate the shear modulus relaxation using the calorimetric *** obtained results are used to trace the defect concentration as functions of temperature and thermal prehistory.

关键词： shear modulus metallic glass structural relaxation interstitialcy theory

Reduction of Plasma MicroRNA-21 is Associated with Chemotherapeutic Response in Patients with Non-small Cell Lung Cancer

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Chinese Journal of Cancer Research 2011年第2期23卷 123-128页

作者： Juan Wei Lian-ke Liu Wen Gao cheng-jun Zhu yi-qian Liu ting cheng Yong-qian Shu Department of Oncology the First Affiliated Hospital Nanjing Medical University Nanjing 210029 China

Objective： To examine plasma microRNA-21 （miR-21） level in patients with non-small cell lung cancer （NSCLC） and its potential correlation with chemotherapeutic response. Methods： 77 NSCLC patients and 36 age and sex-matched healthy controls were included. Plasma miR-21 concentration was examined using a quantitative real-time reverse transcription polymerase chain reaction assay （qRT-PCR）. Potential correlation between plasma mir-21 concentrations with chemotherapeutic responses was analyzed in 35 patients with advanced NSCLC （stages IIIB and IV）. Results： Plasma miR-21 was significantly higher in NSCLC patients relative to the healthy controls （P0.0001）. As a biomarker, plasma mir-21 had a receiver operating characteristic （ROC） curve area of 0.729 with 61.04% sensitivity and 83.33% specificity. Chemotherapeutic response in the 35 patients with advanced NSCLC （stages IIIB and IV） included partial response （PR）（n=11）, stable disease and progression disease （SD＋PD）（n=24）. The overall response rate （CR＋PR） was 31.4%. Plasma miR-21 in patients who achieved PR was significantly lower than those who did not respond （SD＋PD）（P=0.0487）, and comparable to that of the healthy controls （P=0.2744）. Conclusion： Plasma miR-21 is a good biomarker for NSCLC, and could be used to predict responses to chemotherapy.

关键词： NSCLC miR-21 Biomarker Plasma Chemotherapeutic response

Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer's disease:a meta-analysis

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 401-405页

作者： Xue-Fei He 1,yi-ting Liu 2,cheng Peng 1,Fan Zhang 1,Shi Zhuang 1,Jin-Song Zhang 1 1Key Laboratory of Lens Research Liaoning Province,Department of Ophthalmology,Eye Hospital of China Medical University,the Fourth Affiliated Hospital of China Medical University Shenyang 110005,Liaoning Province,China 2 Department of Clinical Epidemiology,the First Affiliated Hospital,China Medical University,Shenyang 110001,Liaoning Province,China Key Laboratory of Lens Research Liaoning Province Department of Ophthalmology Eye Hospital of China Medical University the Fourth Affiliated Hospital of China Medical University Shenyang 110005 Liaoning Province China Department of Clinical Epidemiology the First Affiliated Hospital China Medical University Shenyang 110001 Liaoning Province China

AIM:To investigate the difference of retinal nerve fiber layer(RNFL) thickness between Alzheimer's disease patients and normal people,so as to provide clue for the early diagnosis of Alzheimer's disease.· METHODS:The articles on the association of RNFL thickness and Alzheimer's disease were retrieved by searching international and national *** qualified articles were assessed by meta analysis with Stata11.0 *** results were pooled using weighted mean difference(WMD) with a corresponding 95% confidence interval(CI).· RESULTS:Totally 7 studies enrolled 324 eyes were included in the *** results of meta analysis showed that in AD patients,there was a significant average RNFL thickness reduction compared with the control group [WMD=-17.561,95%CI:(-23.971,-11.151)].There were significant differences in superior,inferior,nasal and temporal RNFL thickness between the two *** with a 95%CI were [-18.829,95%CI:(-25.915,-11.743);Pting that there was no publication bias existed.· CONCLUSION:There are significant differences in the RNFL thickness in all quadrants between the two *** thickness is reduced in AD patients compared with the control group.·

关键词： retinal nerve fiber layer thickness optical coherence tomography Alzheimer's disease meta analysis

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya cheng Duan-Rui Qiao yi-ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei Long Liyuan Han Qifeng Han yi‑Bing cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Fanlian Huazhuo formula:A promising therapeutic approach for metabolic associated steatotic liver disease

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World Journal of Gastroenterology 2025年第1期31卷 167-171页

作者： Chun-Han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article reviews the study,“Fanlian huazhuo formula alleviates high-fat-dietinduced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway”published in the World Journal of *** study explores the therapeutic potential of Fanlian Huazhuo formula(FLHZF)in treating metabolic-associated steatotic liver disease(MASLD),demonstrating that FLHZF reduces lipid accumulation,oxidative stress,and liver injury in MASLD models by modulating key signaling pathways involved in lipid metabolism and *** editorial emphasizes the potential of FLHZF as a treatment for MASLD and calls for further research to verify its clinical efficacy.

关键词： Fanlian Huazhuo formula Metabolic associated steatotic liver disease Autophagy Lipid metabolism Oxidative stress

Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 252-255页

作者： Chun-Han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan City 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This study examines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard *** article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced ***,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.

关键词： Hepatic arterial infusion chemotherapy Advanced hepatocellular carcinoma Combination therapy Network meta-analysis Treatment efficacy

Elafibranor:A promising therapeutic approach for liver fibrosis and gut barrier dysfunction in alcohol-associated liver disease

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World Journal of Gastroenterology 2025年第3期31卷 123-126页

作者： Chun-Han cheng Wen-Rui Hao Tzu-Hurng cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This article discusses the recent study written by Koizumi et ***-associated liver disease(ALD)is a major cause of liver-related morbidity and mortality,which is driven by complex mechanisms,including lipid accumulation,apoptosis,and inflammatory responses exacerbated by gut barrier *** study explored the therapeutic potential of elafibranor,a dual peroxisome proliferatoractivated receptor alpha/delta *** clinical trials,elafibranor has shown promise for the treatment of other liver conditions;however,its effects on ALD remain *** authors’findings indicate that elafibranor significantly reduced liver fibrosis and enhanced gut barrier integrity in patients with *** positive effects of elafibranor are mediated through multiple *** promotes lipid metabolism,reduces oxidative stress,and inhibits inflammatory responses by restoring gut barrier ***,it improves hepatocyte function by enhancing autophagic and antioxidant capacity,and it mitigates inflammation by suppressing the lipopolysaccharide/toll-like receptor 4/nuclear factor kappa B signaling *** findings indicate that elafibranor has promising clinical *** addition,the study highlights elafibranor’s potential as a therapeutic agent for liver diseases,particularly *** article underscores the importance of understanding the mechanistic pathways underlying ALD and suggests directions for future research aimed at elucidating the benefits and limitations of elafibranor.

关键词： Elafibranor Liver fibrosis Gut barrier function Alcohol-associated liver disease Peroxisome proliferatoractivated receptor agonists

Damage detection of a thin plate using modal curvature via macrostrain measurement

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Earthquake Engineering and Engineering Vibration 2019年第2期18卷 409-424页

作者： ting Yu Hsu yi cheng Shih Quang-Vinh Pham Department of Civil and Construction Engineering Taiwan University of Science and Technology Chung-Shan Institute of Science and Technology

Plate structures are employed as important structural components in many engineering applications. Hence, assessing the structural conditions of in-service plate structures is critical to monitoring global structural health. Modal curvature-based damage detection techniques have recently garnered considerable attention from the research community, and have become a promising vibration-based structural health monitoring solution. However, computing errors arise when calculating modal curvatures from lateral mode shapes, which result from unavoidable measurement errors in the mode shapes as identified from lateral vibration signals; this makes curvature-based algorithms that use a lateral measurement only theoretically feasible, but practically infeasible. Therefore, in this study, long-gauge fiber Bragg grating strain sensors are employed to obtain a modal curvature without a numerical differentiation procedure in order to circumvent the computing errors. Several damage indices based on modal curvatures that were developed to locate beam damage are employed. Both numerical and experimental studies are performed to validate the proposed approach. However, although previous studies have reported relative success with the application of these damage indices on a simple beam, only one damage index demonstrated the capability to locate damage when the stiffness of the local region changed near the sensor.

关键词： macro strain long gauge modal curvature plate damage detection

Experimental Study of Overtopping on Sea Dikes and Coastal Flooding Under the Coupled Processes of Tides and Waves

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China Ocean Engineering 2022年第3期36卷 413-426页

作者： LI Yan-ting ZENG cheng-jie Zhao yi-han HU Po SUN Tian-ting HOU yi-jun MO Dong-xue WANG Deng-ting School of Civil Engineering Tianjin UniversityTianjin 300350China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Nanjing Hydraulic Research InstituteNanjing 210029China Water Resources Department of Jiangsu Province Nanjing 210029China Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Laboratory for Ocean and Climate Dynamics Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Storm surges are cataclysmic natural disasters that occur along the coasts and are usually accompanied by large *** effects of coupled storm surges and waves can pose a significant threat to coastal *** labo-ratory studies on the effects of storm surges and waves on coastal structures have typically utilized steady water levels and constant wave *** indoor simulation of the coupled processes of tides and waves is developed by adding a tide generation system to an existing laboratory wave basin to model continuous dynamic tide levels so that tide generation and wave-making occur synchronously in the *** experimental methods are given,which are applied to further study waves overtopping on artificial sea dikes and coastal flooding evolution under the coupled actions of tides and *** results of the overtopping discharge obtained by the test with a dynamic water level are compared with those obtained from steady water level tests and the existing empirical *** addition,the impacts of ecological coastal shelterbelts and structures on coastal flood processes and distributions are also *** proposed simulation methods provide a new approach for studying the effects of storm surges and waves on coastal *** study also aims to provide a reference for coastal protective engineering.

关键词： storm surge water level variation wave overtopping coastal flooding experimental technique