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Mitigating growth-stress tradeoffs via elevated TOR signaling in rice

Molecular Plant 2024年第2期17卷 240-257页

作者： Wei Li Jiaqi Liu Zeqi Li Ruiqiang Ye Wenzhen Chen Yuqing Huang Yue Yuan yi Zhang Huayi Hu Peng Zheng Zhongming Fang Zeng Tao Shiyong Song Ronghui Pan Jian Zhang Jumim tu Jen Sheen Hao Du State Key Laboratory of Rice Biology College of Agriculture and BiotechnologyZhejiang UniversityYu-Hang-Tang Road No.866Hangzhou 310058China ZJU-Hangzhou Global Scientific and Technological Innovation Center Zhejiang UniversityHangzhou 311215China Hainan Institute of Zhejiang University Sanya 572025China National Key Laboratory of Plant Molecular Genetics CASCenter for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChineseAcademy of SciencesShanghai 200032China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Agricultural SciencesGuizhouUniversityGuiyang 550025China State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 311400China Department of Molecular Biology and Center for Computational and Integrative Biology Massachusetts General Hospitaland Department of GeneticsHarvard Medical SchoolBostonMA02114USA

Rice production accounts for approximately half of the freshwater resources utilized in agriculture,result-ing in greenhouse gas emissions such as methane(CH4)from flooded paddy *** address this chal-lenge,environmentally friendly and cost-effective water-saving techniques have become widely adopted in rice ***,the implementation of water-saving treatments(WsTs)in paddy-field rice has been associated with a substantial yield loss of up to 50%as well as a reduction in nitrogen use efficiency(NUE).In this study,we discovered that the target of rapamycin(TOR)signaling pathway is compromised in rice under *** profiling-coupled transcriptome sequencing(polysome-seq)analysis unveiled a substantial reduction in global translation in response to WST associated with the downregulation of TOR ***,biochemical,and genetic analyses revealed new insights into the impact of the positive TOR-S6K-RPS6 and negative TOR-MAF1 modules on translation repression under ***,ammonium exhibited a greater ability to alleviate growth constraints under WsT by enhancing TOR signaling,which simultaneously promoted uptake and utilization of ammonium and nitrogen *** further demonstrated that TOR modulates the ammonium transporter AMT1;1 as well as the amino acid permease APP1 and dipeptide transporter NPF7.3 at the translational level through the 5'untranslated ***,these findings reveal that enhancing TOR signaling could mitigate rice yield penalty due to WST by regulating the processes involved in protein synthesis and *** study will contribute to the breeding of new rice varieties with increased water and fertilizer utilization efficiency.

关键词： target of rapamycin TOR water-saving rice low-carbon agriculture drought nitrogen use efficiency NUE

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E-commerce,Pandemic Shock,and the Survival of Small and Medium Enterprises

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China & World Economy 2024年第5期32卷 113-139页

作者： Zengdong Cao Qin tu Nichola Latoya Williams Business School Beijing Normal UniversityChina Center for Innovation and Development Studies Beijing Normal UniversityChina Department of Finance and Economics Sheffield Hallam UniversityUnited Kingdom

This study examines the impact of e-commerce on the survival rate of small and medium enterprises(SMEs)during the COVID-19 pandemic using a combined dataset from the Enterprise Survey for Innovation and Entrepreneurship in China for the period from 2018 to *** conducted a difference-in-differences analysis by exploiting the variation in the adoption of e-commerce across SMEs before and after the outbreak of *** results show that e-commerce had a significantly positive effect on the survival rate of SMEs during the ***,it improved the survival rate of SMEs by 3.0 to 3.4 percentage points by expanding the scale of the enterprises'markets,mitigating declines in orders,shortening the repayment periods of accounts receivable,and improving cash flow during a *** analysis reveals that the impact of e-commerce was more pronounced for SMEs with a larger share of online sales and for labor-intensive SMEs,and third-party e-commerce platforms or Web sites played a bigger role than self-built Web sites and social *** study offers novel evidence highlighting the value of digitalization for firms during the crisis.

关键词： COVID-19 pandemic difference-in-differences e-commerce survival rate

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Ultrathin GaN Film Derived from Amorphous Ga_(2)O_(3) Film

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 814-818页

作者：王鹏 ZHANG Binbin LIU Xiaofei ZHANG Xin tu Rong ZHANG Song 李宝文 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Silicate Materials for Architectures School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China

It remains a big challenge to synthesize two-dimensional(2D)GaN material for applications in power *** synthetic methods require complex equipment and processes and time ***,we reported a two-step route to prepare polycrystalline 2D GaN *** amorphous ultrathin Ga_(2)O_(3)film was first exfoliated from the surface of liquid *** a vapor phase reaction,2D Ga_(2)O_(3)film was then converted into 2D GaN film while maintaining the 2D *** and high-resolution transmission electron microscope(HRTEM)analysis implies the successful synthesis of wurtzite-type GaN ultrathin *** simple strategy proposed in this work will provide more opportunities for applications of GaN ultrathin film in many devices.

关键词： GaN Ga_(2)O_(3) liquid gallium

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儒家教育主体间性思想及其当代启示

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江汉论坛 2024年第7期 85-90页

作者：涂一昂湖北省社会科学院马克思主义研究所湖北武汉430077

在儒家教育主体间性思想中,人作为主体从不孤立存在,而是借助“仁”的情感价值牵引,在“礼”的交往规则调适下,与其他主体或认知对象共同构成一个相互尊重、共生共存的道德认知关系网络,达到万物并育、和合统一。透过其中蕴含的交互伦... 详细信息

在儒家教育主体间性思想中,人作为主体从不孤立存在,而是借助“仁”的情感价值牵引,在“礼”的交往规则调适下,与其他主体或认知对象共同构成一个相互尊重、共生共存的道德认知关系网络,达到万物并育、和合统一。透过其中蕴含的交互伦理性和人文性,我们可以一窥中华民族独特深厚的精神气质和德性基质,在现实中可用以完善教育理念、重塑教育伦理和充盈教育生态。在“两个结合”的不断引领之下,这种主体间性思想亦能迸发更多的理论潜力,开拓更广阔的应用空间。

关键词：主体间性儒家思想教育主体马克思主义

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Fundamental Understanding on Selenium Electrochemistry:From Electrolytic Cell to Advanced Energy Storage

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Energy & Environmental Materials 2024年第3期7卷 236-256页

作者： Jiguo tu Cheng Chang Jingxiu Wang Haiping Lei R.Vasant Kumar Mingyong Wang Shuqiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Metallurgy University of CambridgeCambridge CB30FSUK

Selenium(Se),as an important quasi-metal element,has attracted much attention in the fields of thin-film solar cells,electrocatalysts and energy storage applications,due to its unique physical and chemical ***,the electrochemical behavior of Se in different systems from electrolytic cell to battery are complex and not fully *** this article,we focus on the electrochemical processes of Se in aqueous solutions,molten salts and ionic liquid electrolytes,as well as the application of Se-containing materials in energy ***,the electrochemical behaviors of Se-containing species in different systems are comprehensively summarized to understand the complexity of the kinetic processes and guide the Se ***,the relationship between the deposition conditions and resulting structure and morphology of electrodeposited Se is discussed,so as to regulate the morphology and composition of the ***,the advanced energy storage applications of Se in thin-film solar cells and secondary batteries are reviewed,and the electrochemical reaction processes of Se are systematically comprehended in monovalent and multivalent metal-ion *** on understanding the fundamental electrochemistry mechanism,the future development directions of Se-containing materials are considered in view of the in-depth review of reaction kinetics and energy storage applications.

关键词： electrochemical behaviors electrodeposition electrolytes energy storage selenium

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Enhanced ferroelectric and improved leakage of BFO-based thin films through increasing entropy strategy

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2263-2273页

作者： Dongfei Lu Guoqiang Xi Hangren Li Jie tu Xiuqiao Liu Xudong Liu Jianjun Tian Linxing Zhang Institute for Advanced Materials Technology University of Science and Technology BeijingBeijing 100083China

BiFeO_(3)(BFO)has received considerable attention as a lead-free ferroelectric film due to its large theoretical remnant ***,BFO suffers from a large leakage current,resulting in poor ferroelectric ***,the sol-gel method was used to deposit a series of BFO-based thin films on fluorine-doped tin oxide substrates,and the effects of the substitution of the elements Co,Cu,Mn(B-site)and Sm,Eu,La(A-site)on the crystal structure,ferroelectricity,and leakage current of the BFO-based thin films were *** confirmed that lattice distortion by X-ray diffraction can be attributed to the substitution of individual elements in the BFO-based *** and Eu substitutions contribute to the lattice distortion in a pseudo-cubic structure,while La is biased toward *** force microscopy confirmed that reversible switching of ferroelectric domains by nearly 180°can be realized through the prepared *** ferroelectric hysteresis loops showed that the order for the polarization contribution is as follows:Cu>Co>Mn(B-site),Sm>La>Eu(A-site).The current density voltage curves indicated that the order for leakage contribution is as follows:Mn

关键词： increasing entropy synergistic ferroelectric film remnant polarization leakage current

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The synergistic regulatory effect of PTP1B and PTK inhibitors on the development of Oedaleus decorus asiaticus Bei-Bienko

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Journal of Integrative Agriculture 2024年第8期23卷 2752-2763页

作者： Shuang Li Sibo Liu Chaomin Xu Shiqian Feng Xiongbing tu Zehua Zhang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Chongqing Academy of Agricultural Sciences Chongqing 401329China Institute of Grassland Research Chinese Academy of Agricultural SciencesHohhot 010010China Inner Mongolia University Hohhot 010019China Scientific Observation and Experimental Station of Pests in Xilin Gol Rangeland Institute of Plant ProtectionChinese Academy of Agricultural SciencesXilinhot 026000China

Tyrosine phosphorylation is crucial for controlling normal cell growth,survival,intercellular communication,gene transcription,immune responses,and other *** tyrosine phosphatase(PTP)and protein tyrosine kinases(PTK)can achieve this goal by regulating multiple signaling *** decorus asiaticus is an important pest that infests the Mongolian Plateau *** aimed to evaluate the survival rate,growth rate,overall performance,and ovarian developmental morphology of the 4th instar nymphs of *** asiaticus while inhibiting the activity of protein tyrosine phosphatase-1B(PTP1B)and *** addition,the expression and protein phosphorylation levels of key genes in the MAPK signaling pathway and antioxidant enzyme activity were *** results showed no significant differences in survival rate,growth rate,or overall performance between PTP1B inhibitor treatment and ***,after PTK inhibitor treatment,these indexes were significantly lower than those in the *** ovarian size of female larvae after 15 days of treatment with PTK inhibitors showed significantly slower development,while female larvae treated with PTP1B exhibited faster ovarian growth than the control *** comparison to controls and nymphs treated with PTK inhibitors,the expression and phosphorylation levels of key genes in the MAPK signaling pathway under PTP1B inhibitor treatments were significantly higher in 4th instar ***,reactiveoxygen(ROS)species levels and the activities of NADPH oxidase and other antioxidant enzymes were considerably reduced,although they were significantly greater in the PTK inhibitor *** results suggest that PTP1B and PTK feedback inhibition in the mitogen-activated-protein kinases(MAPK)signal transfer can regulate the physiological metabolism of the insect as well as its developmental *** findings can facilitate future uses of PTP1B and PTK inhibitors in controlling insect development to help contro

关键词： PTP1B PTK inhibitor MAPK pathway Oedaleus decorus asiaticus development

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A Fault Detection Method for Electric Vehicle Battery System Based on Bayesian Optimization SVDD Considering a Few Faulty Samples

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Energy Engineering 2024年第9期121卷 2543-2568页

作者： Miao Li Fanyong Cheng Jiong Yang Maxwell Mensah Duodu Hao tu School of Electronics and Electrical Engineering Anhui Polytechnic UniversityWuhu241000China

Accurate and reliable fault detection is essential for the safe operation of electric *** vector data description(SVDD)has been widely used in the field of fault ***,constructing the hypersphere boundary only describes the distribution of unlabeled samples,while the distribution of faulty samples cannot be effectively described and easilymisses detecting faulty data due to the imbalance of sample ***,selecting parameters is critical to the detection performance,and empirical parameterization is generally timeconsuming and laborious and may not result in finding the optimal ***,this paper proposes a semi-supervised data-driven method based on which the SVDD algorithm is improved and achieves excellent fault detection *** incorporating faulty samples into the underlying SVDD model,training deals better with the problem of missing detection of faulty samples caused by the imbalance in the distribution of abnormal samples,and the hypersphere boundary ismodified to classify the samplesmore *** Bayesian Optimization NSVDD(BO-NSVDD)model was constructed to quickly and accurately optimize hyperparameter *** the experiments,electric vehicle operation data with four common fault types are used to evaluate the performance with other five models,and the results show that the BO-NSVDD model presents superior detection performance for each type of fault data,especially in the imperceptible early and minor faults,which has seen very obvious ***,the strong robustness of the proposed method is verified by adding different intensities of noise in the dataset.

关键词： Fault detection vehicle battery system lithium batteries fault samples

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Large animal models for Huntington's disease research

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Zoological Research 2024年第2期45卷 275-283页

作者： Bofeng Han Weien Liang Xiao-Jiang Li Shihua Li Sen Yan Zhuchi tu Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan University Key Laboratory of CNS Regeneration(Jinan University)-Ministry of EducationGuangdong Key Laboratory of Non-Human Primate ResearchGuangzhouGuangdong 510632China Department of Pathophysiology School of MedicineJinan UniversityGuangzhouGuangdong 510632China

Huntington'sdisease(HD)isahereditary neurodegenerative disorder for which there is currently no ***,the development of appropriate disease models is critical to thoroughly investigate disease *** genetic basis of HD involves the abnormal expansion of CAG repeats in the huntingtin(HTT)gene,leading to the expansion of a polyglutamine repeat in the HTT *** HTT carrying the expanded polyglutamine repeat undergoes misfolding and forms aggregates in the brain,which precipitate selective neuronal loss in specific brain *** models play an important role in elucidating the pathogenesis of neurodegenerative disorders such as HD and in identifying potential therapeutic *** to the marked species differences between rodents and larger animals,substantial efforts have been directed toward establishing large animal models for HD *** models are pivotal for advancing the discovery of novel therapeutic targets,enhancing effective drug delivery methods,and improving treatment *** have explored the advantages of utilizing large animal models,particularly pigs,in previous *** then,however,significant progress has been made in developing more sophisticated animal models that faithfully replicate the typical pathology of *** the current review,we provide a comprehensive overview of large animal models of HD,incorporating recent findings regarding the establishment of HD knock-in(KI)pigs and their genetic *** also explore the utilization of large animal models in HD research,with a focus on sheep,non-human primates(NHPs),and *** objective is to provide valuable insights into the application of these large animal models for the investigation and treatment of neurodegenerative disorders.

关键词： Huntington's disease Large animal models Sheep Non-human primates Transgenic pigs

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双靶点经颅直流电刺激调控短时和持续性疼痛:一项双盲、随机对照研究

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心理学报 2024年第10期56卷 1313-1327,I0001-I0003页

作者：邱义常香玉涂毅恒中国科学院心理健康重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

当前经颅直流电刺激(transcranial direct current stimulation,tDCS)的镇痛效果不佳且存在较大的个体差异,可能与疼痛神经网络的复杂性及当前tDCS调控靶点单一有关。为提高tDCS缓解疼痛的效果,本研究使用双盲、随机对照的实验设计,采... 详细信息

当前经颅直流电刺激(transcranial direct current stimulation,tDCS)的镇痛效果不佳且存在较大的个体差异,可能与疼痛神经网络的复杂性及当前tDCS调控靶点单一有关。为提高tDCS缓解疼痛的效果,本研究使用双盲、随机对照的实验设计,采用双靶点tDCS技术,对背外侧前额叶皮层(dorsolateral prefrontal cortex,DLPFC)和初级运动皮层(primary motor cortex,M1)进行同步刺激,通过调节DLPFC和M1所属不同的疼痛传导通路,探究双靶点tDCS的镇痛效果及优势。结果表明,与假刺激对照组相比,双靶点tDCS组对中等强度短时热痛、辣椒素诱发的持续性疼痛以及压痛阈限具有显著的调控效应,且调控效应优于单靶点tDCS组。同时,双靶点tDCS的镇痛效应与被试的疼痛恐惧特质显著相关,即被试疼痛恐惧量表评分越高,镇痛效果越好。综上,本研究揭示了双靶点tDCS对短时热痛和持续性疼痛的稳定镇痛效果,支持了疼痛神经网络的并行处理理论,也为双靶点tDCS在疼痛治疗中的潜在应用提供了科学依据。

关键词：经颅直流电刺激双靶点tDCS 镇痛背外侧前额叶皮层初级运动皮层

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