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Reconstruction algorithm for cross-waveband optical computing imaging

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Chinese Physics B 2024年第10期33卷 233-239页

作者： Jin-Tao xie Shu-Hang Bie Ming-Fei Li Yuan-Jin Yu yi-Fei Li Jin-Guang Wang Bao-Gang Quan Ling-An Wu Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Automation Beijing Institute of TechnologyBeijing 100081China

In a single-pixel fast imaging setup,the data collected by the single-pixel detector needs to be processed by a computer,but the speed of the latter will affect the image reconstruction *** we propose two kinds of setups which are able to transform non-visible into visible light imaging,wherein their computing process is replaced by a camera integration *** image captured by the camera has a low contrast,so here we present an algorithm that can realize a high quality image in near-infrared to visible cross-waveband *** scheme is verified both by simulation and in actual *** setups demonstrate the great potential for single-pixel imaging and high-speed cross-waveband imaging for future practical applications.

关键词： optical computing imaging single-pixel imaging

Prognostic value of time-varying dead space estimates in mechanically ventilated patients with acute respiratory distress syndrome

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Journal of Intensive Medicine 2024年第2期4卷 187-193页

作者： Lianlian Jiang Hui Chen Jianfeng xie Ling Liu yi Yang Jiangsu Provincial Key Laboratory of Critical Care Medicine Department of Critical Care MedicineZhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsuChina Department of Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhouJiangsuChina

Background The dead space fraction(VD/VT)has proven to be a powerful predictor of higher mortality in acute respiratory distress syndrome(ARDS).However,its measurement relies on expired carbon dioxide,limiting its widespread application in clinical *** estimates employing routine variables have been found to be reliable substitutes for direct measurement of VD/*** this study,we evaluated the prognostic value of these dead space estimates obtained in the first 7 days following the initiation of *** This retrospective observational study was conducted using data from the Chinese database in intensive care(CDIC).Eligible participants were adult ARDS patients receiving invasive mechanical ventilation while in the intensive care unit between 1st January 2014 and 31st March *** collected data during the first 7 days of ventilation to calculate various dead space estimates,including ventilatory ratio(VR),corrected minute ventilation(V_(Ecorr)),VD/VT(Harris–Benedict),VD/VT(Siddiki estimate),and VD/VT(Penn State estimate)longitudinally.A time-dependent Cox model was used to handle these time-varying *** A total of 392 patients(median age 66[interquartile range:55–77]years,median SOFA score 9[interquartile range:7–12])were finally included in our analysis,among whom 132(33.7%)patients died within 28 days of ***(hazard ratio[HR]=1.04 per 0.1 increase,95%confidence interval[CI]:1.01 to 1.06;P=0.013),V_(Ecorr)(HR=1.08 per 1 increase,95%CI:1.04 to 1.12;P1.3,V_(Ecorr)>7.53,a

关键词： Acute respiratory distress syndr ome Mechanical ventilation Dead space 28-day mortality

Generation of millijoule-level sub-5 fs violet laser pulses

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High Power Laser Science and Engineering 2024年第2期12卷 33-40页

作者： Xinhua xie yi Hung Yunpei Deng Adrian L.Cavalieri Andrius Baltuška Steven L.Johnson SwissFEL Paul Scherrer InstituteVilligen PSISwitzerland Photonics Institute Technische Universität WienViennaAustria Institute of Applied Physics University of BernBernSwitzerland Institute for Quantum Electronics Physics DepartmentETH ZurichZurichSwitzerland

We demonstrate the generation,spectral broadening and post-compression of second harmonic pulses using a thin beta barium borate(BBO)crystal on a fused-silica substrate as the nonlinear interaction *** combining second harmonic generation in the BBO crystal with self-phase modulation in the fused-silica substrate,we efficiently generate millijoule-level broadband violet pulses from a single optical *** second harmonic spectrum covers a range from long wave ultraviolet(down to 310 nm)to visible(up to 550 nm)with a bandwidth of 65 ***,we compress the second harmonic beam to a duration of 4.8 fs with a pulse energy of 0.64 mJ(5 fs with a pulse energy of 1.05 mJ)using chirped *** all-solid free-space apparatus is compact,robust and pulse energy scalable,making it highly advantageous for generating intense second harmonic pulses from near-infrared femtosecond lasers in the sub-5 fs regime.

关键词： post-compression second harmonic generation self-phase modulation supercontinuum generation

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加强地球系统内外联动的研究

科学通报 2024年第2期69卷 146-148页

作者：徐义刚谢树成中国科学院广州地球化学研究所同位素地球化学国家重点实验室广州510640 中国地质大学(武汉)生物地质与环境地质国家重点实验室地球科学学院武汉430074

地球科学在经历了19世纪的神创论到进化论、20世纪的固定论到活动论两次转型发展之后,到21世纪迎来了地球系统科学的大发展时代[1],地球科学的研究前沿和发展方向正发生重要变革.地球系统科学的一个关键主题是地球系统的内外联动,它不... 详细信息

地球科学在经历了19世纪的神创论到进化论、20世纪的固定论到活动论两次转型发展之后,到21世纪迎来了地球系统科学的大发展时代[1],地球科学的研究前沿和发展方向正发生重要变革.地球系统科学的一个关键主题是地球系统的内外联动,它不仅涉及地球的物理过程、化学过程和生命过程交织在一起的动力学过程,还直接关系到宜居地球的形成及其发展演化.“十四五”期间科技部启动的“地球系统与全球变化”专项正是这一发展主题的体现.

关键词：地球科学地球系统科学物理过程转型发展固定论神创论内外联动发展演化

Paradoxical herniation associated with hyperbaric oxygen therapy after decompressive craniectomy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1793-1798页

作者： Zhong-Xing Ye Xin-Xin Fu Yang-Zong Wu Ling Lin Liang-Qi xie Yu-Ling Hu yi Zhou Zhu-Gui You Hai Lin Department of Neurosurgery The Second People's Hospital of Fujian Province(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine)Fuzhou 350001Fujian ProvinceChina Department of Neurosurgery The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Neurosurgery Zhangping City HospitalLongyan 364400Fujian ProvinceChina

BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still *** SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after *** was administered 22 d after surgery due to speech *** herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation *** timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up *** Paradoxical herniation is rare and may be caused by ***,the underlying mechanism is unknown,and the understanding of this phenomenon is *** use of mannitol may worsen this *** skull repair can treat paradoxical herniation and prevent serious complications.

关键词： Decompressive craniectomy Hyperbaric oxygen therapy Mannitol Paradoxical herniation Case report

How can we establish animal models of HIV-associated lymphoma?

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Animal Models and Experimental Medicine 2024年第4期7卷 484-496页

作者： Qing Xiao Liuyue Zhai Xiaomei Zhang yi Liu Jun Li Xiaoqing xie Guofa Xu Sanxiu He Huihui Fu yifeng Tang Fujie Zhang Yao Liu Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Department of Hematology-OncologyChongqing University Cancer HospitalChongqingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina

Human immunodeficiency virus(HIV)infection is strongly associated with a height-ened incidence of *** mirror the natural course of human HIV infection,animal models have been *** models serve as valuable tools to inves-tigate disease pathobiology,assess antiretroviral and immunomodulatory drugs,ex-plore viral reservoirs,and develop eradication ***,there are currently no validated in vivo models of HIV-associated lymphoma(HAL),hampering progress in this crucial domain,and scant attention has been given to developing animal models dedicated to studying HAL,despite their pivotal role in advancing *** re-view provides a comprehensive overview of the existing animal models of HAL,which may enhance our understanding of the underlying pathogenesis and approaches for malignancies linked to HIV infection.

关键词： animal model HIV-associated lymphoma(HAL) human immunodeficiency virus(HIV) immunodeficient mice primate model

mA reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation

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Science China Life Sciences 2024年

作者： Chuansheng Chen Guanghua Wang Qicheng Zou Ke Xiong Zhiwen Chen Beihua Shao yi Liu Duanyang xie Yong Ji Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical University State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital School of Medicine Tongji University Department of Pathology and Pathophysiology School of Medicine Tongji University Department of Cardiology School of Medicine Tongji University Shanghai Arrhythmia Research Center Shanghai East Hospital School of Medicine Tongji University

Atrial fibrillation（AF） is the most common arrhythmia, which is tightly associated with the abnormal expression and function of ion channels in the atrial cardiomyocytes. N6-methyladenosine（m6A）, a widespread chemical modification in eukaryotic m RNA, is known to play a significant regulatory role in the pathogenesis of heart disease. However, the significance of m6A regulatory proteins in the onset of AF remains unclear. Here, we demonstrate that the m6A reader protein YTHDF2 regulates atrial electrical remodeling and AF onset by modulating the Cav1.2 expression. Firstly, YTHDF2 expression was selectively upregulated in rat atrial cardiomyocytes with AF. Secondly,YTHDF2 knockout reduced AF susceptibility in mice. Thirdly, the knockout of YTHDF2 increased Cav1.2 protein levels in an m6A-independent manner, ultimately prolonging the atrial myocardial refractory period, a critical electrophysiological substrate for the onset of AF. Fourthly, the N-terminal domain of YTHDF2 was identified as critical for Cacna1c m RNA translation regulation. Overall, our findings unveil that YTHDF2 can alter Cav1.2 protein expression in an m6A-independent manner, thereby facilitating the onset of AF. Our study suggests that YTHDF2 may be a potential intervention target for AF.

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Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway

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Asian Journal of Andrology 2024年第2期26卷 195-204页

作者： Zhao Yang Jia-Qi Chen Tian-Jie Liu Yu-Le Chen Zhen-Kun Ma yi-Zeng Fan Zi-Xi Wang Shan Xu Ke Wang Xin-Yang Wang Lei Li Hong-Jun xie Department of Urology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China

Tumor-derived exosomes have been shown to play a key role in organ-specific metastasis,and the androgen receptor regulates prostate cancer(PCa)*** is unclear whether the androgen receptor regulates the recruitment of prostate cancer cells to the bone microenvironment,even bone metastases,through ***,we found that exosomes isolated from PCa cells after knocking down androgen receptor(AR)or enzalutamide treatment can facilitate the migration of prostate cancer cells to *** addition,AR silencing or treatment with the AR antagonist enzalutamide may increase the expression of circular RNA-deoxyhypusine synthase(circ-DHPS)in PCa cells,which can be transported to osteoblasts by ***-DHPS acts as a competitive endogenous RNA(ceRNA)against endogenous miR-214-3p to promote C-C chemokine ligand 5(CCL5)levels in *** the level of CCL5 in osteoblasts could recruit more PCa cells into the bone ***,blocking the circ-DHPS/miR-214-3p/CCL5 signal may decrease exosome-mediated migration of prostate cancer cells to osteoblasts.

关键词： androgen receptor circRNA exosome prostate cancer

Helicobacter pylori and immunotherapy for gastrointestinal cancer

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The Innovation 2024年第2期5卷 51-60页

作者： Keren Jia Yang Chen yi xie Xicheng Wang Yajie Hu Yu Sun Yanshuo Cao Liyan Zhang Yakun Wang Zhenghang Wang Zhihao Lu Jian Li Xiaotian Zhang Lin Shen Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China

Helicobacter pylori infection is associated with the risk of gastrointestinal(GI)cancers;however,its impact on immunotherapy for GI cancers remains *** this study,we included 10,122 patients who underwent ^(13)C-urea breath *** 636 patients with Epstein-Barr virus–negative microsatellite-stable gastric cancer(GC)who were treated with anti-PD-1/PD-L1 therapy,***–positive patients exhibited significantly longer immune-related progression-free survival(irPFS)compared with ***–negative patients(6.97 months versus 5.03 months,p<0.001,hazard ratio[HR]0.76,95%confidence interval[CI]0.62–0.95,p=0.015).Moreover,the ***–positive group demonstrated a trend of 4 months longer median immune-related overall survival(irOS)than the ***–negative ***–positive GC displayed higher densities of PD-L1+cells and nonexhausted CD8+T cells,indicative of a“hot”tumor *** analysis revealed that ***–positive GC shared molecular characteristics similar to those of immunotherapy-sensitive ***,***–positive patients with DNA mismatch repair–deficient(dMMR)/microsatellite instability–high(MSI-H)colorectal adenocarcinoma and esophageal squamous cell carcinoma(ESCC)had shorter irPFS compared with ***–negative patients(16.13 months versus not reached,p=0.042,HR 2.26,95%CI 1.13–4.50,p=0.021 and 5.57 months versus 6.97 months,p=0.029,HR 1.59,95%CI 1.14–2.23,p=0.006,respectively).The difference in irOS between ***–positive and–negative patients had the same trend as that between dMMR/MSI-H colorectal adenocarcinoma and ESCC *** also identified a trend of shorter irPFS and irOS in ***–positive liver cancer and pancreatic cancer *** summary,our findings supported that *** infection is a beneficial factor for GC immunotherapy by shaping hot tumor ***,in dMMR/MSI-H colorectal adenocarcinoma and ESCC patients,*** adversely affects the efficacy of immunothera

关键词： immunotherapy gastrointestinal pylori