检索结果-南通市图书馆

Application of texture signatures based on multiparameter-magnetic resonance imaging for predicting microvascular invasion in hepatocellular carcinoma:Retrospective study

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1309-1318页

作者： Hai-Yang Nong Yong-yi Cen Mi Qin Wen-Qi Qin You-Xiang xie Lin Li Man-Rong Liu Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology The Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Radiology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Despite continuous changes in treatment methods,the survival rate for advanced hepatocellular carcinoma(HCC)patients remains low,highlighting the importance of diagnostic methods for *** To explore the efficacy of texture analysis based on multi-parametric magnetic resonance(MR)imaging(MRI)in predicting microvascular invasion(MVI)in preoperative *** This study included 105 patients with pathologically confirmed HCC,categorized into MVI-positive and MVI-negative *** employed Original Data Analysis,Principal Component Analysis,Linear Discriminant Analysis(LDA),and Non-LDA(NDA)for texture analysis using multi-parametric MR images to predict preoperative *** effectiveness of texture analysis was determined using the B11 program of the MaZda4.6 software,with results expressed as the misjudgment rate(MCR).RESULTS Texture analysis using multi-parametric MRI,particularly the MI+PA+F dimensionality reduction method combined with NDA discrimination,demonstrated the most effective prediction of MVI in *** accuracy in the pulse and equilibrium phases was 83.81%.MCRs for the combination of T2-weighted imaging(T2WI),arterial phase,portal venous phase,and equilibrium phase were 22.86%,16.19%,20.95%,and 20.95%,*** area under the curve for predicting MVI positivity was 0.844,with a sensitivity of 77.19%and specificity of 91.67%.CONCLUSION Texture analysis of arterial phase images demonstrated superior predictive efficacy for MVI in HCC compared to T2WI,portal venous,and equilibrium *** study provides an objective,non-invasive method for preoperative prediction of MVI,offering a theoretical foundation for the selection of clinical therapy.

关键词： Magnetic resonance imaging Hepatocellular carcinoma Texture analysis Microvascular invasion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reinforced Lewis covalent bond by twinborn nitride heterostructure for lithium-sulfur batteries

引用

Journal of Energy Chemistry 2024年第1期88卷 363-372,I0009页

作者： Yaochen Song Pengkai Tang Yanjie Wang yi Wang Linnan Bi Qi Liang Liang He Qingyu xie yiyong Zhang Peng Dong yingjie Zhang Yao Yao Jiaxuan Liao Sizhe Wang Yangtze Delta Region Institute(QuZhou) University of Electronic Science and Technology of ChinaQinzhou 324000ZhejiangChina School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731SichuanChina National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093YunnanChina School of Materials Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science&TechnologyXi’an 710021ShaanxiChina School of Environmental Science and Engineering North China Electric Power UniversityBaoding 071003HebeiChina

The practical application of lithium-sulfur(Li-S)batteries,as promising next-generation batteries,is hindered by their shuttle effect and the slow redox ***,a tungsten and molybdenum nitride heterostructure functionalized with hollow metal-organic framework-derived carbon(W_(2)N/Mo_(2)N)was proposed as the sulfur *** hollow spherical structure provides storage space for sulfur,enhances electrical conductivity,and inhibits volume *** metal atoms in the nitrides bonded with lithium polysulfides(Li PSs)through Lewis covalent bonds,enhancing the high catalytic activity of the nitrides and effectively reducing the energy barrier of Li PSs redox ***,the high intrinsic conductivity of nitrides and the ability of the heterostructure interface to accelerate electron/ion transport improved the Li+*** leveraging the combined properties of strong adsorption and high catalytic activity,the sulfur host effectively inhibited the shuttle effect and accelerated the redox kinetics of Li ***-efficiency Li+transmission,strong adsorption,and the efficient catalytic conversion activities of Li PSs in the heterostructure were experimentally and theoretically *** results indicate that the W_(2)N/Mo_(2)N cathode provides stable,and long-term cycling(over 2000 cycles)at 3 C with a low attenuation rate of 0.0196%per *** design strategy of a twinborn nitride heterostructure thus provides a functionalized solution for advanced Li-S batteries.

关键词： Heterostructure Adsorption Redox kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controllable construction of ionic frameworks for multi-site synergetic enhancement of CO_(2) capture

引用

Frontiers of Chemical Science and Engineering 2024年第1期18卷 37-49页

作者： Yuke Zhang Hongxue Xu Haonan Wu Lijuan Shi Jiancheng Wang qun yi State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

CO_(2) capture is one of the key technologies for dealing with the global warming and implementing lowcarbon development *** emergence of ionic metal-organic frameworks(I-MOFs)has diversified the field of porous materials,which have been extensively applied for gas adsorption and *** this work,amino-functionalized imidazolium ionic liquid as organic monodentate ligand was used for one step synthesis microporous Cu based *** tuning of the adsorption properties was obtained by incorporating aromatic anions,such as phenoxy,benzene carboxyl,and benzene sulfonic acid group into the I-MOFs via a facile ion exchange *** new I-MOFs showed high thermal stability and high capacity of 5.4 mmol·g^(-1) under atmospheric conditions for selective adsorption of CO_(2).The active sites of microporous Cu-MOF are the ion basic center and unsaturated metal,and electrostatic attraction and hydroxyl bonding between CO_(2) and modified functional sulfonic groups are responsible for the *** work provides a feasible strategy for the design of I-MOF for functional gas capture.

关键词： carbon dioxide capture micropores ionic liquids multi-site synergism ionic metal-organic frameworks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

引用

Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo Pan Hu Jiayi xie Kefu Tang Shixiu Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu Zhengfang yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioinspired anti-freezing 3D-printable conductive hydrogel microfibers for highly-sensitive and wide-range detection of ultralow and high strains

引用

Green Chemical Engineering 2024年第1期5卷 132-143页

作者： yi-Min Yang Ting-Yuan Hu Haidong Fan Lu Shi Shi-Yuan Zhang Zhuang Liu Xiao-Jie Ju Rui xie Wei Wang Liang-yin Chu School of Chemical Engineering Sichuan UniversityChengdu610065China Department of Mechanics Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China

Soft strain sensors that can transduce stretch stimuli into electrical readouts are promising as sustainable wearable ***,most strain sensors cannot achieve highly-sensitive and wide-range detection of ultralow and high *** by bamboo structures,anti-freezing microfibers made of conductive poly(vinyl alcohol)hydrogel with poly(3,4-ethylenedioxythiphene)-poly(styrenesulfonate)are developed via continuous microfluidic *** microfibers provide unique bamboo-like structures with enhanced local stress to improve both their length change and resistance change upon stretching for efficient signal *** microfibers allow highlysensitive(detection limit:0.05%strain)and wide-range(0%-400%strain)detection of ultralow and high strains,as well as features of good stretchability(485%strain)and anti-freezing property(freezing temperature:-41.1°C),fast response(200 ms),and good *** experimental results,together with theoretical foundation analysis and finite element analysis,prove their enhanced length and resistance changes upon stretching for efficient signal *** integrating microfluidic spinning with 3D-printing technique,the textiles of the microfibers can be flexibly *** microfibers and their 3D-printed textiles enable highperformance monitoring of human motions including finger bending and throat vibrating during *** work provides an efficient and general strategy for developing advanced conductive hydrogel microfibers as highperformance wearable strain sensors.

关键词： Conductive hydrogel microfibers Microfluidics Sensitive detection Wide detection range Anti-freezing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bioactive peptides alleviating oxidative stress-associated diseases by targeting the Nrf2 signaling pathway

引用

Food Science and Human Wellness 2024年

作者： Dandan Qin Zuomin Hu Shuai Han yi Luo Feiyan Yang Tiantian xie Feijun Luo Hunan Key Laboratory of Grain-oil Deep Process and Quality Control， Hunan Key Laboratory of Forestry Edible Resources Safety and Processing， College of Food Science and Engineering， Central South University of Forestry and Technology Department of Gastroenterology， Xiangya Hospital， Central South University

Oxidative stress is caused by an imbalance of the antioxidant defense system and excessive production of free radicals， which can damage biological macromolecules such as proteins， lipids and nucleic acids， which can cause aging， ischemia-reperfusion injury， inflammatory injury， liver and kidney injury and other diseases. The nuclear factor erytheroid-2-related factor 2 (Nrf2) is a major regulator of redox balance. The Nrf2 pathway also exerts a central function in cell apoptosis， oxidative stress damage and metabolic diseases. Bioactive peptides are small molecular peptides composed of amino acid residues. They have many biological activities and play important physiological roles in human body. Antioxidant peptide is a kind of peptide which can reduce oxidative stress damage. They are safe， non-toxic and easily absorbed. In this review， we summarized the mechanism of bioactive peptides in regulating oxidative stress， especially antioxidant peptides， through regulating the Nrf2 signaling pathway and the expressions of oxidative stress-related genes， to alleviate oxidative stress-induced damage. The paper will provide valuable reference to investigators in the antioxidant peptide field and also promote the applications of antioxidant peptides in the oxidative stress-associated diseases.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于注意力机制融合多特征的东北虎个体自动跟踪方法

引用

生物多样性 2024年第3期32卷 137-150页

作者：许群谢永华东北林业大学计算机与控制工程学院哈尔滨150040

跟踪野生动物可以了解它们的生态习性和种群动态。自动化的、高效准确的目标跟踪算法对于野生动物保护具有重要意义。由于东北虎(Panthera tigris altaica)生存环境复杂,行动方式隐蔽且具有快速运动的特点,拍摄到的图像可能存在运动模... 详细信息

跟踪野生动物可以了解它们的生态习性和种群动态。自动化的、高效准确的目标跟踪算法对于野生动物保护具有重要意义。由于东北虎(Panthera tigris altaica)生存环境复杂,行动方式隐蔽且具有快速运动的特点,拍摄到的图像可能存在运动模糊问题,难以捕获清晰稳定的画面。因此,监测东北虎种群的难点在于实现自动准确地跟踪东北虎个体。在实际环境中,由于光照变化、遮挡、相似性干扰等问题的存在,导致错误跟踪东北虎个体。针对这些问题,本文提出了一种基于注意力特征融合的孪生网络跟踪框架,旨在实现对实际复杂场景中东北虎个体的准确跟踪。基于孪生网络的视觉目标跟踪框架将目标跟踪视为相似性学习问题,本文对传统基于孪生网络的跟踪架构进行改进,将注意力特征融合嵌入主干网络ResNet50中进行特征提取。为了增强模型对跟踪场景中发生极端尺度变化的东北虎个体的关注度,本文在注意力特征融合模块中引入了多尺度通道注意力机制,以适应不同的东北虎个体状态和环境变化。实验结果表明,本文的方法与当前的先进跟踪器相比取得了更优的跟踪性能,跟踪成功率和精确度分别达到了72.5%和93.9%,相比基准跟踪算法分别提高了4.1%和2.3%,证明本文的跟踪方法可以在复杂的实际场景下为自动高效地监测东北虎提供一种有效的方案。

关键词：东北虎单目标跟踪孪生网络特征融合注意力机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nutritional intervention based on curcumin-loaded polysaccharides nanoparticle for synergetic improvement of ulcerative colitis

引用

Food Science and Human Wellness 2024年

作者： Jun Yang Jieqiong Lin yi Luo Xianxiang Chen Mingyue Shen Yuanxing Wang Jianhua xie State Key Laboratory of Food Science and Resources， Nanchang University

The prevalence of ulcerative colitis (UC) is increasing annually， while current non-targeted drugs for UC have limited effectiveness， easily relapsed， and serious side effects. Herein， curcumin (Cur)-loaded nanoparticle with conlon-targeted property based on Mesona chinensis polysaccharides was developed for the synergistic and targeted improvement of UC. Results show that ZmNPs have good encapsulation of Cur， targeted delivery of Cur to the colon， and prolonged its retention time. In vivo safety assessments have shown that ZmNPs have good safety and biocompatibility. As expected， Cur-ZmNPs effectively alleviated the symptoms of DSS-induced UC by decreasing colonic inflammation by inhibiting the TLR4/MAPK pathway， regulating the levels of oxidative stress and immune homeostasis of UC mice. Oral administration of Cur-ZmNPs can reduce apoptosis of intestinal epithelial cells， alleviate colonic mucosal damage and repair intestinal barrier function. Cur-ZmNPs also had a positive effect on improving gut microbiota disorders and promoting the production of SCFAs. This study provides a novel strategy for synergistic alleviation of UC by MCP-based NPs loaded with food bioactives.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chromosome-scale genome assembly-assisted identification of Brassica napus BnDCPA1 for improvement of plant architecture and yield heterosis

引用

Plant Communications 2024年第7期5卷 1-4页

作者： Chuanji Zhao Xiaobo Cui Meili xie yi Zhang Lingyi Zeng Yueying Liu Junyan Huang Xiong Zhang Chaobo Tong Qiong Hu Lijiang Liu Shengyi Liu Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhanChina These authors contributed equally to this article

Plant architecture can act as a pivotal determinant of crop yield by maximizing photosynthate accumulation in grains,but no *** rapeseed ideotype has yet been ***,semi-dwarf and compact(SDC)rapeseed plant types with the capacity to maximize silique number per hectare and seed weight per silique are expected to optimize plant architecture for groundbreaking seed yield,avoiding lodging and promoting mechanical harvest(Liu et al.,2022).In this study,we report the mutant dc1,which exhibits DC plant architecture with significantly increased silique number in the main inflorescence compared with currently cultivated high and loose(HL)plant types like those of elite cultivars(Figure 1A and Supplemental Figure 1).

关键词： elite cultivar dwarf

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma

引用

International Journal of Oral Science 2024年第2期16卷 251-264页

作者： Gan Xiong Nan xie Min Nie Rongsong Ling Bokai Yun Jiaxiang xie Linlin Ren Yaqi Huang Wenjin Wang Chen yi Ming Zhang Xiuyun Xu Caihua Zhang Bin Zou Leitao Zhang Xiqiang Liu Hongzhang Huang Demeng Chen Wei Cao Cheng Wang Hospital of Stomatology Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Stomatology Sun Yat-sen UniversityGuangzhouChina Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhouChina Department of Periodontics Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhouChina Institute for Advanced Study Shenzhen UniversityShenzhenChina Center for Translational Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouChina Department of Oral and Maxillofacial Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Oral and Maxillofacial&Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina National Center for Stomatology National Clinical Research Center for Oral diseasesShanghai Key Laboratory of StomatologyShanghaiChina

Ameloblastoma is a benign tumor characterized by locally invasive phenotypes,leading to facial bone destruction and a high recurrence ***,the mechanisms governing tumor initiation and recurrence are poorly ***,we uncovered cellular landscapes and mechanisms that underlie tumor recurrence in ameloblastoma at single-cell *** results revealed that ameloblastoma exhibits five tumor subpopulations varying with respect to immune response(IR),bone remodeling(BR),tooth development(TD),epithelial development(ED),and cell cycle(CC)*** note,we found that CC ameloblastoma cells were endowed with stemness and contributed to tumor recurrence,which was dominated by the EZH2-mediated *** EZH2 effectively eliminated CC ameloblastoma cells and inhibited tumor growth in ameloblastoma patient-derived *** data described the tumor subpopulation and clarified the identity,function,and regulatory mechanism of CC ameloblastoma cells,providing a potential therapeutic target for ameloblastoma.

关键词： inhibited cycling eliminated

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：