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Potassium iodide catalyzed reductive dehalogenation ofα-halo-ketones using Hantzsch ester diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate as reductant

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Chinese Chemical Letters 2010年第8期21卷 931-934页

作者： Hong Sheng li yi qun li Department of Chemistry Jinan UniversityGuangzhou 510632China

In the presence of diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate（DHP） and a catalytic amount of potassium iodide,severalα-halo ketones were easily reduced to the corresponding ketones in acetone *** procedure presented here showed several merits such as short reaction time,practical experimental and isolated procedure,and excellent yields of products.

关键词： Dehalogenation α-Halo ketones Hantzsch ester 1 4-Dihydro-2 6-dimethylpyridine-3 5-dicarboxylate Potassium iodide

Efficient and Eco-friendly Process for the Synthesis of Bi(indolyl)methanes Catalyzed by Sodium Hydrogensulfate Monohydrate in Ionic liquid n-Butylpyridinium Tetrafluoroborate

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Chinese Chemical Letters 2006年第6期17卷 723-726页

作者： li Ping ZHANG yi qun li Mei Yun ZHOU Department of Chemistry Jinan University Guangzhou 510632

Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.

关键词： Bi(indolyl)methane ionic liquid sodium hydrogen sulfate.

Knoevenagel condensation catalysed by poly(vinyl chloride) supported tetraethylenepentamine (PVC-TEPA)

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Chinese Chemical Letters 2007年第3期18卷 266-268页

作者： Fen Dong yi qun li Rong Feng Dai Department of Chemistry Jinan University Guangzhou 510632 China

Poly（vinyl chloride） supported tetraethylenepentamine （PVC-TEPA） has been found to be an efficient catalyst for the Knoevenagel condensation. A wide range of aromatic aldehydes easily undergo condensations with ethyl cyanoacetate and malononitrile in the commercial 95% ethanol in refluxing using PVC-TEPA as catalyst to afford the desired products of good purity in moderate to excellent yields. A recycling study confirmed that the catalyst could be reused, the yield of the desired condensation product were not reduced. The merits of this protocol are environmentally benign, simple operation, convenient work-up and good yields. Furthermore, the catalyst can easily be recovered and reused at five times with comparable yields.

关键词： Knoevenagel condensation PVC-supported tetraethylenepentamine Catalysis

n-Butyl Pyridinium Nitrate as a Reusable Ionic liquid Medium for Knoevenagel Condensation

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Chinese Chemical Letters 2003年第5期14卷 448-450页

作者： yi qun li Xin Ming XU Mei Yun ZHOU Department of Chemistry Jinan UniversityGuangzhou 510632

The Knoevenagel condensation of carbonyl substrates with active methylene compounds proceeds smoothly with ammonium acetate as catalyst in n-butyl pyridinium nitrate to afford the desired products of good purity in mo... 详细信息

关键词： n-Butyl pyridinium nitrate ionic liquid Knoevenagel condensation.

Synthesis of 9-Arylpolyhydroacridine Promoted by Ionic liquid Under Solvent-free Condition

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Chinese Chemical Letters 2006年第7期17卷 874-876页

作者： Jian Hua WEI yi qun li Xi Zhong liAN Mei Yun ZHOU Department of Chemistry Jinan University Guangzhou 510632

The condensation reactions of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione and ammonium acetate efficiently promoted by several ionic liquids under solvent-free condition to afford corresponding 3, 3, 6, 6-te... 详细信息

关键词： 9-Arylpolyhydroacridine ionic liquid synthesis.

Prokaryotic Expression and Polyclonal Antibody Preparation of PRL3

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Chemical Research in Chinese Universities 2007年第6期23卷 697-700页

作者： SHEN Xing-gui li Wan-nan WANG Jing JIANG yi-qun li Qing-shan FU Xue-qi Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Jilin University Changchun 130021 P. R. China

Phosphatase of regenerating liver 3 （ PRL3 ）, which belongs to the superfamily of protein tyrosine phosphatases （PTPs）, represents a group of low molecular weight PTPs that participate in tumorigenesis and metastasis processes. Presented here are the results of cloning, prokaryotic expression, purification, and polyclonal antibody preparation of PRL3. To obtain a specific polyclonal antibody against PRL3, the authors have prepared GST-PRL3 to immunize rabbits and purify an anti-PRL3 polyclonal antibody by negative selection affinity columns. Western blot analysis shows that the anti-PRL3 polyclonal antibody has a specific binding ability with PRL3 protein. The anti-PRL3 polyclonal antibody provides a good tool to further study the function of PRL3.

关键词： PRL3 Prokaryotic expression Polyclonal antibody

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： yi-qun li Fang-Zhou Sun Chun-Xiao li Hong-Nan Mo Yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

Ultrasound-guided fascia iliaca compartment block combined with general anesthesia for amputation in an acute myocardial infarction patient after percutaneous coronary intervention: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2567-2572页

作者： Chen ling Xing-Qing liu yi-qun li Xian-Jie Wen Xu-Dong Hu Kai Yang Department of Anesthesiology Affiliated Foshan Hospital of Southern Medical University and Second People’s Hospital of Foshan

BACKGROUND Fascia iliaca compartment block is a technique that blocks three nerves,similar to a 3-in-1 nerve *** block provides analgesia for patients undergoing lower limb surgery,and is a simple technique that is easy to ***,we report a case of fascia iliaca compartment block in a patient with myocardial infarction who underwent emergency middle thigh *** SUMMARY A 78-year-old female patient weighing 38 kg with gangrene and occlusive peripheral atherosclerosis of the right leg underwent an emergency middle thigh *** patient had a history of hypertension,coronary heart disease,cerebral infarction,anterior wall myocardial infarction,and had recently undergone percutaneous coronary intervention consisting of coronary angiography and right coronary artery stent *** the patient's condition,an ultrasound-guided fascia iliaca compartment block combined with general anesthesia was implemented for *** fascia iliaca compartment block provided analgesia for the operation,and reduced the dosage of general *** also alleviated adverse cardiovascular effects caused by pain stress,and ensured the safety of the patient during the perioperative *** block also provided postoperative *** patient had a good prognosis,and was subsequently discharged from *** Fascia iliaca compartment block provides surgical *** also alleviates adverse cardiovascular effects,and ensures patient safety during the perioperative period.

关键词： Ultrasound-guided Fascia iliaca compartment block Acute myocardial infarction Case report Percutaneous coronary intervention

Synthesis of novel β-propanamides to inhibit cholesteryl ester transfer protein(CETP)

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Chinese Chemical Letters 2017年第2期28卷 260-263页

作者： Hong-Lei Xie Chun-Chi liu yi-qun li Chang-lin Bai Chen-Zhou Hao Jing Guo Chang-qun Luo Dong-Mei Zhao Mao-Sheng Cheng Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China

A novel series of β-propanamide derivatives as inhibitors of cholesteryl ester transfer protein（CETP）were ***,H3（IC_（50） 2 μmol/L） was observed to inhibit CETP moderately（Xie et ah,2016）.Structural modifications based on H3 led to discovery of the successful CETP inhibitor,known as *** a similar approach,compound Q08 was identified as a highly potent CETP inhibitor with an IC_（50） of 490 nmol/L in vitro.

关键词： CETP inhibitor Cardiovascular disease High-density lipoprotein Low-density lipoprotein In vitro