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Effects of endothelial nitric oxide synthase uncoupling on pulmonary endothelial dysfunction in rats with decompression sickness

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Military Medical Research 2015年第3期3卷 166-171页

作者： Hai-Shan Lin Min Ou yi-qun fang Third Clinical Medical School in Southern Medical University Department of VIP Respiratory Navy General Hospital of PLA Navy Medical Research Unit

Background: To investigate the effects of unsafe decompression on rat pulmonary endothelial function and its relevant ***: Sixty male Sprague-Dawley(SD) rats were randomly divided into a control group(n=30) and a decompression sickness(DCS) group(n=30). The DCS model was established by placing the rats in the DCS group in a pressurized cabin where they were exposed to a 600 k Pa compressed air environment for 60 min, and the pressure was then reduced by 100 k Pa/min until it reached atmospheric pressure. After the surviving rats in the DCS group and the rats in the control group were anesthetized, their pulmonary arteries were stripped to test the in vitro pulmonary artery endothelium-dependent vasodilation capacity. Western blotting was used to measure the expression and dissociation of endothelial nitric oxide synthase(e NOS) in pulmonary artery tissues and all protein nitration levels in pulmonary artery tissues; reactive oxygen species(ROS) formation was measured via in vitro pulmonary artery superoxide anion probe dihydroethidium(DHE) ***: After experiencing unsafe decompression, 10 of the 30 rats in the DCS group died. The pulmonary artery endothelium-dependent vasodilation capacity in the surviving rats decreased significantly(P0.05), but the ratio of e NOS monomer/dimer in the DCS group was significantly higher than that in the control group(P<0.05). All protein tyrosine nitration levels in the pulmonary artery tissues of the DCS group were significantly higher than those of the control group(P<0.05). The results of DHE staining showed that the amount of ROS formation in the pulmonary arteries of the DCS group was significantly higher than that of the control group(P<0.05).Conclusion: Unsafe decompression during a simulated submarine escape process can lead to e NOS dimer uncoupling in the pulmonary artery endot

关键词： Decompression sickness Nitric oxide synthase type III Superoxide anion 3-nitrotyrosine

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The research progress of diving medicine in China

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中国应用生理学杂志 2012年第6期28卷 540-547页

作者： yi-qun fang Xiao-chen BAO Ci LI Miao MENG Heng-rong YUAN Jun MA Yan WANG The Naval Medical Research Institute

Diving medicine is one of the branches of military medicine,and plays an important role in naval *** review introduces the progress of researches on undersea and hyperbaric physiology and medicine in the past few years in *** article describes our research achievement in conventional diving and its medical support,researches on saturation diving and its medical support,submarine escape and its medical support,effects of hyperbaric environments and fast buoyancy ascent on immunological and cardiological *** disorders(including decompression sickness and oxygen toxicity) are also introduced.

关键词：军事医学饱和潜水中国研究成果生理学诺贝尔医疗心脏病

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Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi qun yi Yao Liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Complete reconstruction Co-based complex Precatalysts Oxygen evolution reaction

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分阶段研发项目价值实物期权评估的模糊优化

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上海交通大学学报 2009年第4期43卷 583-586页

作者：夏轶群陈俊芳上海交通大学安泰经济与管理学院上海200052

为了改善研发项目价值评估的刚性化,以最大限度地挖掘项目价值,可以将模糊理论的柔性特征结合实物期权评估方法.对于风险高、耗时长的项目,首先寻找一个分阶段的组合期权,然后将其中的各参数根据梯形模糊数原理作模糊化处理,并用模糊算... 详细信息

为了改善研发项目价值评估的刚性化,以最大限度地挖掘项目价值,可以将模糊理论的柔性特征结合实物期权评估方法.对于风险高、耗时长的项目,首先寻找一个分阶段的组合期权,然后将其中的各参数根据梯形模糊数原理作模糊化处理,并用模糊算法修正该组合期权模型.数值算例的结果表明,净现值法评估和不分阶段的模糊期权定价都显然低估了风险价值,而分阶段模糊组合期权定价能够最大限度地发现项目潜在价值.参数模糊化和分阶段组合期权的模糊算法是关键点和创新点.

关键词：研发项目价值评估实物期权模糊优化

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哈莱姆文艺复兴时期美国黑人文学的繁荣及其成因

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衡阳师范学院学报 2017年第2期38卷 111-115页

作者：易群芳上海外国语大学英语学院上海200083

哈莱姆文艺复兴时期美国黑人文学空前繁荣,哈莱姆文学运动兴起并兴盛一时,黑人作家打开了白人主流出版社的大门,与其时的主要白人出版商的关系也有了重大突破。复兴期间黑人文学的繁荣是20世纪初美国社会多种经济、政治、文化因素合力... 详细信息

哈莱姆文艺复兴时期美国黑人文学空前繁荣,哈莱姆文学运动兴起并兴盛一时,黑人作家打开了白人主流出版社的大门,与其时的主要白人出版商的关系也有了重大突破。复兴期间黑人文学的繁荣是20世纪初美国社会多种经济、政治、文化因素合力作用的产物。而老一辈黑人知识分子利用当时主流社会盛行的"黑人时尚"的有利时机全力培育和提携年轻"新黑人"作家,加之年轻黑人作家勇于追求自身文学创作的独立和自由,则是黑人文学在其文学传统的滋养中成长和发展、在复兴时期达到空前繁荣的最直接成因。

关键词：哈莱姆文艺复兴美国黑人文学的繁荣繁荣成因

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-fang Wu yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi Liang Xiaomei Shao Jianqiao fang Junfan fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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淀粉与丙烯酰胺的辐照接枝共聚及其絮凝性能研究

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食品科技 2011年第7期36卷 220-223页

作者：刘军杜先锋程轶群王芳英安徽农业大学茶与食品科技学院合肥230036

研究了淀粉与丙烯酰胺辐照接枝共聚的反应条件。以单因素实验考察了淀粉与丙烯酰胺质量比、淀粉乳浓度和辐照剂量3个因素对接枝率的影响。通过正交实验确定了最佳反应条件为:淀粉与丙烯酰胺质量比1:2,淀粉乳浓度6%,辐照剂量10kGy。通过... 详细信息

研究了淀粉与丙烯酰胺辐照接枝共聚的反应条件。以单因素实验考察了淀粉与丙烯酰胺质量比、淀粉乳浓度和辐照剂量3个因素对接枝率的影响。通过正交实验确定了最佳反应条件为:淀粉与丙烯酰胺质量比1:2,淀粉乳浓度6%,辐照剂量10kGy。通过高岭土悬浊液絮凝实验结果表明:高岭土悬浊液的浊度去除率可达到86.33%。

关键词：淀粉丙烯酰胺辐照接枝共聚絮凝

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基于动态Allan方差的光纤陀螺稳定性分析

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电子设计工程 2018年第6期26卷 161-164页

作者：崔逸群覃方君丰仕林海军工程大学导航工程系湖北武汉430033

针对光纤陀螺实际信号在长时间内,容易受到温度和其他器件物理性能的改变而变化的特点,提出了基于动态Allan方差的光纤陀螺稳定性分析。在不同时段内分别计算光纤陀螺信号的Allan方差,在不同时间维度捕捉信号的非平稳变化,从而确定光纤... 详细信息

针对光纤陀螺实际信号在长时间内,容易受到温度和其他器件物理性能的改变而变化的特点,提出了基于动态Allan方差的光纤陀螺稳定性分析。在不同时段内分别计算光纤陀螺信号的Allan方差,在不同时间维度捕捉信号的非平稳变化,从而确定光纤陀螺信号稳定性随时间变化规律。仿真和实测数据实验均验证了本文方法的可行性与有效性。本文方法可以用于光纤陀螺稳定性分析,能够直观反映光纤陀螺方差随时间变化的规律,光纤陀螺随机信号的稳定性分析将不再局限于Allan方差的二维曲线描述。

关键词：动态Allan方差光纤陀螺稳定性分析信号变化

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紫色丘陵区不同土地利用方式下土壤团粒的分形特征

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土壤通报 2009年第2期40卷 221-225页

作者：季轶群王子芳高明魏朝富李东陈晨陶春西南大学资源环境学院重庆北碚400716

为研究不同土地利用方式对土壤团粒的影响,探索土壤质量、结构的定量化描述,采用湿筛法对重庆市荣昌县吴家镇的旱地(玉米地),水田(望天田),撂荒地(旱地撂荒8年以上,常年为白茅草覆盖)和人工林(柏树,种植年限12年)4种利用方式下土壤的团... 详细信息

为研究不同土地利用方式对土壤团粒的影响,探索土壤质量、结构的定量化描述,采用湿筛法对重庆市荣昌县吴家镇的旱地(玉米地),水田(望天田),撂荒地(旱地撂荒8年以上,常年为白茅草覆盖)和人工林(柏树,种植年限12年)4种利用方式下土壤的团聚体含量进行了测定并对其分形特征进行了研究。结果表明:土壤团聚体总量为人工林地>水田>旱地>撂荒地。且这4种土地利用方式土壤团粒结构分形维数在2.057～2.833之间,表现为团聚体总量越高,其结构的粒径分布的分形维数越高。不同剖面深度表现为:0～5cm团聚体分形维数最高;5～10cm团聚体分形维数最小。分形维数具体表现为林地>水田>旱地>撂荒地,其中分形维数平均为2.832,水田为2.819,旱地为2.658,撂荒地为2.239。土壤颗粒分形维数和有效钾含量呈极显著的正相关;与土壤全氮和速效磷含量呈显著正相关;与全磷、全钾、碱解氮关系不密切。因此,土壤分形维数能客观反映土壤结构性状,是表征土壤结构好坏的一个综合性定量指标。

关键词：土地利用方式团聚体团粒结构分形维数土壤养分

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