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Monte Carlo Simulation of the Temperature-Dependent Resistance for (La_(1-x)Y_(x))_(2/3)Ca_(1/3)MnO_(3) (0≤x≤0.2)

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Chinese Physics Letters 2001年第10期18卷 1392-1394页

作者： LI Zhong-yi YUAN Song-liu PENG Gang TANG Chao-qun Institute of Materials Physics and Department of Physics Huazhong University of Science and TechnologyWuhan 430074

Resistance as a function of temperature for optimally doped manganese perovskites is simulated based on a random resistor network model which is generated through the Monte Carlo method by identifying neighbours in each cubic lattice randomly occupied by ferromagnetic metallic particles. Only one parameter, i.e. the number density of ferromagnetic particles, is used as an adjustable parameter, and it is shown that the model yields excellent agreement with measured resistance data in (La_(1-x)Y_(x))_(2/3)Ca_(1/3)MnO_(3) (0 ≤ x ≤ 0.2) for temperatures covering the whole range from the high-T insulating bebaviour to the low-T metallic state.

关键词： resistance metallic ferromagnetic

Berberine hydrochloride alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying gut microbiome signaling

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Asian Journal of Andrology 2024年第5期26卷 500-509页

作者： yi-qun Tian Xiang Ren Jing Wang Xing Li yi-Sheng yin Zi-Hao Guo Zhen-Liang Qin Xiao-Yong Zeng Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Urology of Hubei Province Wuhan 430000China

Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is highly prevalent worldwide and poses a significant threat to men’s health,particularly affecting young ***,the exact causes and mechanisms behind CP/CPPS remain unclear,leading to challenges in its *** this research,a CP/CPPS rat model was established with complete Freund’s adjuvant(CFA),and berberine hydrochloride was administered through daily gavage to assess its therapeutic *** alterations in the gut microbiome induced by CP/CPPS and berberine hydrochloride were investigated through 16S ribosomal RNA sequencing of cecum content and colonic epithelial *** investigate the impact of the gut microbiome on CP/CPPS,a pseudo germ-free rat model was established,and fecal microbiome transplantation(FMT)was performed on these *** all,berberine hydrochloride demonstrated effective reduction of inflammation and oxidative stress in the prostate,offering significant therapeutic advantages for CP/*** analysis of the gut microbiome using 16S ribosome RNA sequencing,distinct differences were observed between CP/CPPS rats and control rats,and Clostridium butyricum was identified as a key *** germ-free rats that underwent FMT from CP/CPPS rats or rats treated with berberine hydrochloride displayed varying levels of inflammatory cytokine production,oxidative stress,and activity of associated signaling *** conclusion,the therapeutic potential of berberine hydrochloride in addressing CP/CPPS is highly *** gut microbiome has emerged as a critical factor in the development of CP/CPPS and plays a pivotal role in mediating the therapeutic effects of berberine hydrochloride.

关键词： berberine hydrochloride chronic prostatitis/chronic pelvic pain syndrome gut microbiome

MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase Ⅱ gamma

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Neural Regeneration Research 2018年第7期13卷 1216-1224页

作者： Ting Wang qun Cai Wen-Jie Yang Hai-Hua Fan Jian-Feng yi Feng Xu Department of Emergency First Affiliated Hospital of Soochow University Suzhou Jiangsu Province China Department of Emergency Affiliated Hospital of Nantong University Nantong Jiangsu Province China Department of Pediatrics Affiliated Hospital of Nantong University Nantong Jiangsu Province China Medical College of Nantong University Nantong Jiangsu Province China

Septic encephalopathy is a frequent complication of sepsis,but there are few studies examining the role of micro RNAs（mi Rs） in its *** this study,a mi R-219 mimic was transfected into rat hippocampal neurons to model mi R-219 overexpression.A protective effect of mi R-219 was observed for glutamate-induced neurotoxicity of rat hippocampal neurons,and an underlying mechanism involving calmodulin-dependent protein kinase II γ（Ca MKIIγ） was *** R-219 and Ca MKIIγ m RNA expression induced by glutamate in hippocampal neurons was determined by quantitative real-time reverse transcription-polymerase chain reaction（q RT-PCR）.After neurons were transfected with mi R-219 mimic,effects on cell viability and apoptosis were measured by 3-（4,5-dimethylthiazolyl-2）-2,5-diphenyltetrazolium bromide（MTT） assay and flow *** addition,a luciferase reporter gene system was used to confirm Ca MKIIγ as a target gene of mi *** blot assay and rescue experiments were also utilized to detect Ca MKIIγ expression and further verify that mi R-219 in hippocampal neurons exerted its effect through regulation of Ca MKIIγ.MTT assay and q RT-PCR results revealed obvious decreases in cell viability and mi R-219 expression after glutamate stimulation,while Ca MKIIγ m RNA expression was ***,flow cytometry,and caspase-3 activity assays showed that mi R-219 overexpression could elevate glutamate-induced cell viability,and reduce cell apoptosis and caspase-3 ***,luciferase Ca MKIIγ-reporter activity was remarkably decreased by co-transfection with mi R-219 mimic,and the results of a rescue experiment showed that Ca MKIIγ overexpression could reverse the biological effects of mi ***,these findings verify that mi R-219 expression was decreased in glutamate-induced neurons,Ca MKIIγ was a target gene of mi R-219,and mi R-219 alleviated glutamate-induced neuronal excitotoxicity by negatively controlling Ca MKIIγ expression.

关键词： nerve regeneration brain injury septic encephalopathy miR-219 hippocampal neurons glutamate excitotoxicity apoptosis caspase-3 calmodulin-dependent protein kinase Ⅱ γ luciferase reporter gene system neuroprotection neural regeneration

Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits

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Neural Regeneration Research 2021年第8期16卷 1460-1466页

作者： Gao-Jing Xu qun Zhang Si-Yue Li yi-Tong Zhu Ke-Wei Yu Chuan-Jie Wang Hong-Yu Xie yi Wu Department of rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Medicine Jinshan Hospital of Fudan UniversityShanghaiChina

Currently, no specific treatment exists to promote recovery from cognitive impairment after a stroke. Dysfunction of the actin cytoskeleton correlates well with poststroke cognitive declines, and its reorganization requires proper regulation of Rho-associated kinase(ROCK) proteins. Fasudil downregulates ROCK activation and protects neurons against cytoskeleton collapse in the acute phase after stroke. An enriched environment can reduce poststroke cognitive impairment. However, the efficacy of environmental enrichment combined with fasudil treatment remains poorly understood. A photothrombotic stroke model was established in 6-week-old male C57 BL/6 mice. Twenty-four hours after modeling, these animals were intraperitoneally administered fasudil(10 mg/kg) once daily for 14 successive days and/or provided with environmental enrichment for 21 successive days. After exposure to environmental enrichment combined with fasudil treatment, the number of neurons in the hippocampal CA1 region increased significantly, the expression and proportion of p-cofilin in the hippocampus decreased, and the distribution of F-actin in the hippocampal CA1 region increased significantly. Furthermore, the performance of mouse stroke models in the tail suspension test and step-through passive avoidance test improved significantly. These findings suggest that environmental enrichment combined with fasudil treatment can ameliorate memory dysfunction through inhibition of the hippocampal ROCK/cofilin pathway, alteration of the dynamic distribution of F-actin, and inhibition of neuronal death in the hippocampal CA1 region. The efficacy of environmental enrichment combined with fasudil treatment was superior to that of fasudil treatment alone. This study was approved by the Animal Ethics Committee of Fudan University of China(approval No. 2019-Huashan Hospital JS-139) on February 20, 2019.

关键词： cognitive environment hippocampus injury neuroprotection pathway repair stroke

Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第48期18卷 7302-7307页

作者： Qian Zhu Jing Li Jian-Jun Yan Liang Huang Meng-Chao Wu yi-qun Yan Department of Hepatobiliary Surgery Jingmen First People's Hospital First Department of Hepatic Surgery Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM:To determine the risk factors for hepatocellular carcinoma(HCC) rupture,and report the management and long-term survival results of patients with spontaneous rupture of ***:Among 4209 patients with HCC who were diagnosed at Eastern Hepatobiliary Surgery Hospital from April 2002 to November 2006,200(4.8%) patients with ruptured HCC(case group) were studied retrospectively in term of their clinical characteristics and prognostic *** one-stage therapeutic approach to manage ruptured HCC consisted of initial management by conservative treatment,transarterial embolization(TACE) or hepatic *** of various treatments in the case group were evaluated and compared with the control group(202 patients) without ruptured HCC during the same study *** data were expressed as mean ± SD or me-dian(range) where appropriate and compared using the unpaired t *** variables were compared using the Chi-square test with Yates correction or the Fisher exact test where *** overall survival rate in each group was determined using the Kaplan-Meier method and a log-rank ***:Compared with the control group,more patients in the case group had underlying diseases of hypertension(7.5% vs 3.0%,P =0.041) and liver cirrhosis(87.5% vs 56.4%,P 5 cm(83.0% vs 57.4%,P ying diseases of hypertension(P = 0.002) and liver cirrhosis(P 5 cm(P < 0.001),vascular thrombus(P = 0.002) and extrahepatic invasion(P < 0.001) were predictive for spontaneous rupture of *** the 200 patients with spontaneous rupture of HCC,105 patients underwent hepatic resection,33 received TACE,and 62 were managed with conservative *** median survival time(MST) of all patients with spo

关键词： Hepatocellular carcinoma Spontaneous rupture Predictors Hepatectomy Overall survival Disease-free survival

What is the next generation therapeutic strategy for castration-resistant prostate cancer

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Asian Journal of Andrology 2015年第2期17卷 223-224页

作者： Si-Meng Wen Chang-yi Quan Ning Jiang Zhi-qun Shang Yuan-Jie Niu Department of Urology Second Hospital of Tianjin Medical University Tianjin China qanjin Institute of Urology Tianjin Medical University Tianjin China.

Prostate cancer （PCa） is one of the most common cancers in the world. Since androgen receptor （AR） signal plays key roles in the PCa progression, targeting androgens via the current androgen deprivation therapy （ADT） is the main therapeutic strategy for advanced PCa. However, most patients who receive ADT, including the second generation anti-androgens enzalutamide （also known as MDV3100） may finally develop the castration （or anti-androgen） resistance after 12-24 months treatment. In the manuscript by Asangani et aL, the authors demonstrated that targeting the amino-terminal bromodomains of BRD4 could preferentially suppress human castration-resistant prostate cancer （CRPC） cell lines. While further studies are required to understand the full impact of their findings, the innovative approach provides a potential novel epigenetic approach for the concerted blockade of oncogenic drivers in CRPC.

关键词： @@

Enhancement Effect of Patterning Resolution Induced by an Aluminum Thermal Conduction Layer with AgInSbTe as a Laser Thermal Lithography Film

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Chinese Physics Letters 2012年第7期29卷 157-159页

作者： LI Hao WANG Rui GENG Yong-You WU yi-qun WEI Jing-Song Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800 Key Lab of Functional Inorganic Material Chemistry(Ministry of Education) Heilongjiang UniversityHarbin 150080

We employ an aluminum (Al) film as a thermal conduction layer under the laser thermal lithography AgInSbTe phase-change film to improve the patterning resolution in laser thermal *** patterns were fabricated by laser writing and *** laser writing was conducted by a setup where the laser wavelength and the numerical aperture of the converging lens were 405nm and 0.90,*** wet-etching was carried out in a 17wt% ammonium sulfide *** results indicate that the patterning resolution enhancement induced by an Al thermal conduction layer is more than 20% compared with that of the samples without an Al thermal conduction *** analysis reveals that the resolution-enhancing effect may be due to the changes of heat diffusion directions induced by the Al thermal conduction layer.

关键词： lithography InSb conduction

基于GARCH族模型的信息冲击对香港同业拆借市场的影响

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统计与信息论坛 2015年第5期30卷 74-80页

作者：杜轶群长安大学经济与管理学院陕西西安710064

香港同业拆借市场为香港商业银行和金融机构提供了短期资金借贷的平台。该市场形成的同业拆借利率HIBOR为存贷款利率的走向提供了重要参考。基于GARCH族模型研究了信息对香港同业拆借市场的冲击并绘制了相应的信息冲击曲线,发现PARCH-t(... 详细信息

香港同业拆借市场为香港商业银行和金融机构提供了短期资金借贷的平台。该市场形成的同业拆借利率HIBOR为存贷款利率的走向提供了重要参考。基于GARCH族模型研究了信息对香港同业拆借市场的冲击并绘制了相应的信息冲击曲线,发现PARCH-t(1,1)模型对数据的拟合度最高,发现信息对该市场的冲击具有明显的非对称性,好消息比坏消息给该市场带来的冲击更大。

关键词： GARCH族模型同业拆借市场信息冲击

Molecular Cloning and Expression of Polyphenoloxidase Genes from the Mushroom, Agaricus bisporus

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Agricultural Sciences in China 2011年第2期10卷 185-194页

作者： LI Nan-yi CAI Wei-ming JIN qun-li QIN Qiao-ping RAN Fu-lai College of Agriculture and Food Science Zhejiang Agricultural and Forestry UniversityHangzhou 311300P.R.China Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhou 310021P.R.China Odessa College University of AveOdessa 79764USA

The polyphenoloxidase（PPO） is the key enzyme considered to be responsible for mushroom *** using homology cloning and rapid amplification of cDNA ends（RACE）,two new PPO genes and the corresponding cDNA were identified from the fruit bodies of Agaricus bisporus（AbPPO3 and AbPPO4,GenBank accession ***936494 and GU936493,respectively）.The genomic DNA sequences of AbPPO3 and AbPPO4 are 2 080 and 2 189 bp in length,respectively,encoding putative polypeptides of approximately 66 and 68 *** deduced amino acid sequences show characteristic features of two copper-binding domains conserved in the type III copper proteins including fungal polyphenol *** comparisons indicate that AbPPO3 and AbPPO4 present 55.3% similarity to each other（48% identity）.We also obtained more than 1.5-kb long sequences upstream of the start codon of the AbPPO3 and AbPPO4 and recognized them as their respective putative *** of the two PPO promoter regions show that they contain abundant cis-acting elements which are probably responsible for anaerobic induction,light,wound,stress,and auxin ***-quantitative RT-PCR results indicate that AbPPO3 and AbPPO4 were highly expressed in the mature fruit bodies and up-regulated after 2-d storage of *** results suggest that AbPPO3 and AbPPO4 may play roles in *** browning and pigmentation during development and postharvest storage and the elements in promoters may act as regulatory elements for the inducible expression of AbPPO3 and *** successful cloning and expression analysis of AbPPO3 and AbPPO4 warrant a further investigation on the structure and function of *** PPO which points to the possible targets for genetic manipulation.

关键词： polyphenoloxidase Agaricus bisporus tyrosinase promoter browning