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The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel

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Petroleum Science 2024年第1期21卷 1-13页

作者： Zi-Zhi Lin Jun-Qian Li Shuang-Fang Lu qin-hong Hu Peng-Fei Zhang Jun-Jie Wang Qi Zhi hong-Sheng Huang Na yin Yue Wang Tian-Chen Ge National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025HainanChina College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

The occurrence characteristics of shale oil are of great significance to the movability of shale *** this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization *** Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,*** which the silicon-rich shale has the best *** relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 *** the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 *** occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space.

关键词： Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

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Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure

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Journal of Genetics and Genomics 2024年第8期51卷 844-854页

作者： yi Hu Huaming Cao Jie Sheng yizhuo Sun Yuping Zhu qin Lin Na yi Siyu He Luying Peng Li Li State Key Laboratory of Cardiology and Medical Innovation Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Shanghai Arrhythmias Research Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Laboratory of Molecular Genetics and Stem Cell Differentiation Tongji University School of MedicineShanghai 200120China Department of Cardiology Shanghai Shibei HospitalShanghai 200435China Research Units of Origin and Regulation of Heart Rhythm Chinese Academy of Medical SciencesShanghai 200120China

Pathological myocardial hypertrophy is a common early clinical manifestation of heart failure,with noncoding RNAs exerting regulatory ***,the molecular function of circular RNAs(circRNAs)in the progression from cardiac hypertrophy to heart failure remains *** uncover functional circRNAs and identify the core circRNA signaling pathway in heart failure,we construct a global triple network(microRNA,circRNA,and mRNA)based on the competitive endogenous RNA(ceRNA)*** observe that cardiac hypertrophy-related circRNA(circRNA CHRC),within the ceRNA network,is down-regulated in both transverse aortic constriction mice and Ang-II--treated primary mouse *** circRNA CHRC increases cross-sectional cell area,atrial natriuretic peptide,andβ-myosin heavy chain levels in primary mouse *** screening shows that circRNA CHRC targets the miR-431-5p/KLF15 axis implicated in heart failure progression in vivo and in *** with anti-Ago2-RNA confirms the interaction between circRNA CHRC and miR-431-5p,while miR-431-5p mimics reverse Klf15 activation caused by circRNA CHRC *** summary,circRNA CHRC attenuates cardiac hypertrophy via sponging miR-431-5p to maintain the normal level of Klf15 expression.

关键词： circRNA CHRC Heart failure CeRNA miR-431-4p KIf15

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Gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect Science 2024年第1期31卷 119-133页

作者： Jie-Yu Zhang Jing Zhao Keyan Zhu-Salzman qin-qin Ji yi-Ping Jiang Liu-Bin Xiao De-Jin Xu Guang-Chun Xu Lin-Quan Ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic ***,silencing efficacy varies greatly among different insect ***,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA *** disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi ***,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of ***(AldsRNase)was identified and *** alignment indicated that its 6 key amino acid residues and the Mg2+-binding site were similar to those of other insects’*** signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali *** showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole *** purified AldsRNase protein obtained by heterologously expressed can rapidly degrade *** comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is ***,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut *** cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in *** and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression

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A Pricing Model of Airbag Options with Discrete Monitoring

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Acta Mathematicae Applicatae Sinica 2024年

作者： Min HU Shui-yi HU Cong qin Fan ZHOU Center for Financial Engineering Soochow UniversitySuzhou College of Liberal Arts and Sciences University of Connecticut

In this paper, we propose a pricing model of airbag options with discrete monitoring, time-varying barriers, early exercise opportunities, and other popular features simultaneously. We show that the option value is a viscosity solution of a PDE system. In particular, a closed-form solution is obtained in the classic BlackScholes economy with no early exercise opportunities. For the general case, we develop a numerical algorithm and conduct an extensive numerical analysis after calibrating the model to the CSI 500 index in China. Greek letters, dynamic hedging, and assessment of investing in airbag options are also studied.

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Analysis of acupoint massage combined with touch on relieving anxiety and pain in patients with oral implant surgery

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World Journal of Psychiatry 2024年第4期14卷 533-540页

作者： Jin-hong Qu Cheng-Cheng Shou Xin He qin Wang Yue-Xia Fang Department of Stomatology Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Software R&D Hangzhou Broadlink Technology CoLtd.Hangzhou 311300Zhejiang ProvinceChina Department of Stomatology Hangzhou Red Cross HospitalHangzhou 310003Zhejiang ProvinceChina Department of Cardiovascular Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina Department of Traditional Chinese Medicine Development Hangzhou Lin'an Traditional Chinese Medicine HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local *** patients under local anesthesia are conscious during this procedure,compared with general anesthesia-related operations,they are more likely to experience negative emotions,such as anxiety and *** emotional reactions result in shivering and chills in the limbs,leading to poor doctor-patient cooperation and even avoidance of *** traditional Chinese medicine,it is believed that acupoint massage regulates blood and Qi,dredge menstruation,and relieve pain,which is beneficial for patients’emotional adjustment;however,there are few related clinical *** To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch *** One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups,according to a random number table,with 50 patients in each *** control group received routine intervention,and the study group received acupoint massage combined with touch on the basis of the control ***[assessed using the Modified Dental Anxiety Scale(MDAS)],pain severity,blood pressure,heart rate,and satisfaction were compared between the two *** Before intervention,the difference in MDAS score between the two groups was not significant(P>0.05),while after the intervention,the MDAS scores decreased in both groups compared with those before the intervention(P0.05).The systolic and d

关键词： Oral implant Acupoint massage Touch Anxiety Degree of pain

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Doped microspheres for whispering gallery mode microlasing

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Science Bulletin 2024年第13期69卷 2021-2024页

作者： Xiaoxuan Wang Chaoyang Huang Chuansheng Xia Feifei qin Gangyi Zhu Lingfeng Mao yi Ma Zengliang Shi Qiannan Cui Chunxiang Xu State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China School of Electronic Science and Engineering Southeast UniversityNanjing 210096China Peter Grünberg Research Centre College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China

Whispering gallery mode(WGM)optical microcavities,which are capable of light field confinement and manipulation in a relatively small volume,have gained considerable attention from fundamentals in enhanced light-matter interactions to laser applications[1].Undergoing decades of development,the improvement of lasing performance is always a significant issue,including low threshold and high quality(Q)factor[2].Increasing optical gain and reducing the losses are the key aspects towards the realization of a high-quality WGM laser.A perfect cavity structure and a smooth surface are the most crucial determinants to reduce optical losses and enhance light field confined abilities.

关键词： optical lasing mode

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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang yi-Fu Wang Jie Zheng yi-Ming Lei Zhong-Yuan Chen yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv hong-hong Wang Juan-Juan Xie yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Silicon photonic spectrometer with multiple customized wavelength bands

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Photonics Research 2024年第5期12卷 1016-1023页

作者： LONG ZHANG XIAOLIN yi DAJIAN LIU SHIHAN hong GAOPENG WANG HENGZHEN CAO YAOCHENG SHI DAOXIN DAI State Key Laboratory for Modern Optical Instrumentation Center for Optical&Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityZjingang CampusHangzhou 310058China Intelligent Optics and Photonics Research Center Jiaxing Research InstituteZhejiang UniversityJiaxing 314000China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

A silicon photonic spectrometer with multiple customized wavelength bands is developed by introducing multiple channels of wideband optical filters based on multimode waveguide gratings(MWGs)for pre-filtering and the corresponding thermally tunable narrowband filter for high *** these multiple customized wavelength bands,the central wavelengths,bandwidths,and resolutions are designed flexibly as desired,so that the system is simplified and the footprint is minimized for several practical applications(e.g.,gas sensing).A customized silicon photonic spectrometer is designed and demonstrated experimentally with four wavelength bands centered around1310 nm,1560 nm,1570 nm,and 1930 nm,which is,to the best of our knowledge,the first on-chip spectrometer available for sensing multiple gas components like HF,CO,H_(2)S,and CO_(2).The spectral resolutions of the four wavelength bands are 0.11 nm,0.08 nm,0.08 nm,and 0.37 nm,*** a customized silicon photonic spectrometer shows great potential for various applications,including gas monitors,wearable biosensors,and portable spectral-domain optical coherence tomography.

关键词： waveguide bands multiple

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Design to enhance sensing performance of ZIF-8 crystals

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Progress in Natural Science:Materials International 2024年第2期34卷 240-250页

作者： Ya-Ru Li Xiuxiu Dong Shu-yi Pan Lin Luo hong-Tao Lei Zhen-Lin Xu Guangdong Provincial Key Laboratory of Food Quality and Safety College of Food Science South China Agricultural University Key Laboratory of Modern Agricultural Equipment and Technology (Jiangsu University) Ministry of Education School of Agricultural Engineering Jiangsu University

Metal-organic frameworks（MOFs） are a large class of crystalline porous materials that composed of organic ligands and metal ions,of which zeolitic imidazolate frameworks（ZIFs） are a broad *** most wellknown ZIF-like material is ZIF-8 crystals,which have been the subject of extensive research for ***-8 crystals have been synthesized under various conditions for application in the fields of sensing,drug delivery,and *** paper provides a brief introduction to the preparation methods,formation processes,and formation mechanisms of ZIF-8 crystals in different media,and then explains the effects of different precursor conditions(type of Zn2+,ratio of raw materials,and type of solvent) on ZIF-8 crystals in terms of formation ***,current reports on the application of ZIF-8-based chemiresistive gas sensors,electrochemical,fluorescent and colorimetric sensors are also ***,ZIF-8 crystals with good catalytic properties will be obtained based on rational design for promoting the application in different fields of the sensors.

关键词： Formation mechanism Regulation Sensing performance Synthesis method ZIF-8

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Autoimmune hepatitis-primary biliary cholangitis overlap syndrome complicated by various autoimmune diseases:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1174-1181页

作者： Yu-Jie qin Ting Gao Xing-Nian Zhou Ming-Liang Cheng hong Li Clinical Medicine School of Guizhou Medical University Guiyang 550025Guizhou ProvinceChina Department of Pathology The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Infectious Diseases Guizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina Department of Infectious Diseases Guizhou Provincial People's HospitalGuiyang 550025Guizhou ProvinceChina

BACKGROUND Autoimmune hepatitis(AIH)and primary biliary cholangitis(PBC)are two common clinical autoimmune liver diseases,and some patients have both diseases;this feature is called AIH-PBC overlap *** thyroid disease(AITD)is the most frequently overlapping extrahepatic autoimmune ***(IgG)4-related disease is an autoimmune disease recognized in recent years,characterized by elevated serum IgG4 levels and infiltration of IgG4-positive plasma cells in *** SUMMARY A 68-year-old female patient was admitted with a history of right upper quadrant pain,anorexia,and jaundice on physical *** examination revealed elevated liver enzymes,multiple positive autoantibodies associated with liver and thyroid disease,and imaging and biopsy suggestive of pancreatitis,hepatitis,and PBC.A diagnosis was made of a rare and complex overlap syndrome of AIH,PBC,AITD,and IgG4-related *** features improved on treatment with ursodeoxycholic acid,methylprednisolone,and *** This case highlights the importance of screening patients with autoimmune diseases for related conditions.

关键词： Overlap syndrome Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Autoimmune thyroid disease Case report

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