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Mediated protective effect of electroacupuncture pretreatment by miR-214 on myocardial ischemia/reperfusion injury

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Journal of Geriatric cardiology 2014年第4期11卷 303-310页

作者： Pei-Yu LIU yi TIAN Shi-Yuan XU Department of Anesthesiology ZhuJiang Hospital of Southern Medicine University Guangzhou 510282 Guangdong Province China Department of Anesthesiology Hainan Provincial Corps Hospital of Chinese People's Armed Police Forces Haikou 570203 Hainan Province China Department of Anesthesiology Haikou People's Hospital Haikou 570203 Hainan Province China

Background Electroacupuncture pretreatment plays a protective role in myocardial ischemia/reperfusion （I/R） injury and microRNAs （miRNAs） could act on various facets of cardiac function. However, the role of miRNAs in the cardioprotection by electroacupuncture pre-treatment on myocardial I/R injury remains unknown. The purpose of the study was to examine whether miR-214 was involved in cardio-protection by electroacupuncture. Methods Using rat myocardial I/R model, we examined the role of electroacupuncture pretreatment in myocardial I/R injury and analyzed the changes in the expression of miR-214. In addition, I/R was simulated in vitro by performing oxy-gen-glucose deprivation （OGD） on H9c2 cell cultures, and the effect of electroacupuncture pretreatment on I/R injury as well as expressional level of miR-214 were examined in vitro. Furthermore, the miR-214 mimic was transfected into OGD-treated H9c2 cells, we analyzed the cell apoptosis, lactate dehydrogenase （LDH） and creatine kinase （cK） activities, intracellular free ca2＋concentration （[ca2＋]i） as well as the relative protein levels of sodium/calcium exchanger 1（NcX1）, BcL2-like 11 （BIM）, calmodulin-dependent protein kinase IIδ（caMKIIδ） and cyclophilin D （cypD）. Results The in vivo results revealed that compared with the I/R group, the electroacupuncture pretreatment group showed significant decreased myocardial infarct size, as well as the increased indices of the cardiac function, including heart rate, mean arterial pressure, left ventricular systolic pressure and maximal rate for left ventricular pressure rising and declining （±dp/dt max）. In addition, electroacupuncture pretreatment could inhibit the elevation of LDH and cK activities induced by I/R injury. The quantitative PcR （qPcR） results demonstrated electroacupuncture pretreatment could provide cardioprotection against myocardial I/R injury in rats with miR-214 up-regulation. In the meanwhile, in vitro, electroacupuncture pretreatment protected H9c2 c

关键词： I/R injury miR-214 Electroacupuncture Protective effect

测高卫星联合反演南极冰架厚度长时间序列及其变化特征

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大地测量与地球动力学 2024年

作者：刘甜甜沈强 Shum c K 江利明汪汉胜高凡张旭中国科学院精密测量科学与技术创新研究院中国科学院大学俄亥俄州立大学地球科学学院大地测量科学部

联合IcESat、cryoSat-2和IcESat-2测高卫星数据，估算全南极冰架2003～2022年厚度产品。结果显示，南极冰架整体为减薄趋势，其中Amundsen区域厚度减薄最快，Amery区域减薄最缓慢。

关键词：南极冰架厚度 IcESat cryosat-2 IcESat-2

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中继卫星与用户星双向跟踪关系及策略

西安电子科技大学学报 2007年第1期34卷 6-10页

作者：李于衡孙恩昌易克初西安电子科技大学综合业务网理论及关键技术国家重点实验室陕西西安710071

从跟踪策略和通信链路建立角度出发,利用中继卫星(TDRS)和用户星的空间几何关系,充分考虑用户星体和地球遮挡因素,推导出基于卫星经典轨道根数和姿态的TDRS与用户星的双向跟踪规律以及TDRS对用户星覆盖率计算公式.同时为了克服星体遮挡... 详细信息

从跟踪策略和通信链路建立角度出发,利用中继卫星(TDRS)和用户星的空间几何关系,充分考虑用户星体和地球遮挡因素,推导出基于卫星经典轨道根数和姿态的TDRS与用户星的双向跟踪规律以及TDRS对用户星覆盖率计算公式.同时为了克服星体遮挡,提出用户星天线安装在星体对天面桅杆上的最佳安装策略,确定了桅杆高度与星体长度的关系,它们是TDRS和用户星跟踪部件设计和业务测控的基础.

关键词：中继卫星用户星覆盖计算天线安装

Fabrication and application of hierarchical mesoporous MoO2/Mo2c/c microspheres

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Journal of energy chemistry 2018年第3期27卷 940-948页

作者： Xiaoyan Li Qinggui xiao Hongling Zhang Hongbin Xu yi Zhang Key Laboratory of Green Process and engineering Chinese Academy of SciencesBeijing 100190China National engineering Laboratory for Hydrometallurgical cleaner Production Technology Institute of Process Engineering.Chinese Academy of Sciences.Beijing 100190China University of chinese Academy ofSc.ences Beijing 100049China

Hierarchical mesoporous MoO2/Mo2c/c microspheres,which are composed of primary nanoparticles with a size of about 30 nm,have been designed and synthesized through polymer regulation and subsequent carbonization *** as-synthesized microspheres were characterized by XRD,Raman,SEM,TEM,XPS measurements and so *** was found that polyethylene glycol acted as a structure-directing agent,mild reducing agent and carbon source in the formation of these hierarchical mesoporous Mo O2/Mo2c/c ***,the electrochemical property of the microspheres was also investigated in this *** as an anode material for lithium ion batteries,the hierarchical mesoporous Mo O2/Mo2c/c electrode delivered the discharge specific capacities of 665 and 588 m Ah/g after 100 cycles at current densities of 100 and 200 m A/g,*** satisfactory cycling performance and controllable process facilitate the practical applications of the hierarchical mesoporous Mo O2/Mo2c/c as a potential anode material in high-energy density lithium-ion batteries.

关键词： Lithium ion batteries Anode materials MoO2/Mo2c/c Mesoporous Polymer regulation

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新型磺酸盐聚氨酯表面活性剂的制备及性能

华南理工大学学报（自然科学版） 2011年第3期39卷 32-36页

作者：林东恩胡守印张逸伟华南理工大学化学与化工学院广东广州510640

以甲苯二异氰酸酯(TDI)、聚醚二醇(PEG1000,PEG2000,PEG6000,PE6200)以及自制的新型磺酸盐二胺扩链剂为原料,采用丙酮法经预聚和扩链合成了4种新型水溶性磺酸盐聚氨酯高分子表面活性剂(PUS),采用FT-IR对产物的结构进行了分析,并对产物... 详细信息

以甲苯二异氰酸酯(TDI)、聚醚二醇(PEG1000,PEG2000,PEG6000,PE6200)以及自制的新型磺酸盐二胺扩链剂为原料,采用丙酮法经预聚和扩链合成了4种新型水溶性磺酸盐聚氨酯高分子表面活性剂(PUS),采用FT-IR对产物的结构进行了分析,并对产物的表面张力、临界胶束浓度(cMc)、乳化性能、发泡性能进行了研究.结果表明:以聚乙二醇为底物所得到的表面活性剂的临界胶束浓度约为20 g/L,在此浓度下水溶液表面张力为41.6mN/m;以嵌段聚醚为底物所得到的表面活性剂的临界胶束浓度则小于1g/L,在此浓度下水溶液的表面张力为32mN/m.另外,该类表面活性剂都具有一定的触变性和乳化力,以及较低的发泡性和泡沫稳定性.

关键词：聚氨酯磺酸盐表面活性剂临界胶束浓度乳化性发泡性

Evaluation of a Wireless Solar Powered Personal Weather Station

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Agricultural Sc.ences 2024年第1期15卷 36-53页

作者： Robert J. Lascano Timothy S. Goebel Dennis c. Gitz III John E. Stout cropping Systems Research Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We are evaluating dryland cotton production in Martin county, Texas, measuring cotton lint yield per unit of rainfall. Our goal is to collect rainfall data per 250 - 400 ha. Upon selection of a rainfall gauge, we realized that the cost of using, for example, a tipping bucket-type rain gauge would be too expensive and thus searched for an alternative method. We selected an all-in-one commercially available weather station;hereafter, referred to as a Personal Weather Station (PWS) that is both wireless and solar powered. Our objective was to evaluate average measurements of rainfall obtained with the PWS and to compare these to measurements obtained with an automatic weather station (AWS). For this purpose, we installed four PWS deployed within 20 m of the Plant Stress and Water conservation Meteorological Tower that was used as our AWS, located at USDA-ARS cropping Systems Research Laboratory, Lubbock, TX. In addition, we measured and compared hourly average values of short-wave irradiance (Rg), air temperature (Tair) and relative humidity (RH), and wind speed (WS), and calculated values of dewpoint temperature (Tdew). This comparison was done over a 242-day period (1 October 2022-31 May 2023) and results indicated that there was no statistical difference in measurements of rainfall between the PWS and AWS. Hourly average values of Rg measured with the PWS and AWS agreed on clear days, but PWS measurements were higher on cloudy days. There was no statistical difference between PWS and AWS hourly average measurements of Tair, RH, and calculated Tdew. Hourly average measurements of Rg and WS were more variable. We concluded that the PWS we selected will provide adequate values of rainfall and other weather variables to meet our goal of evaluating dryland cotton lint yield per unit rainfall.

关键词： Automation Sensors citizen Weather Station Mesonet Rainfall Weather Variables

补阳还五汤调控自噬稳定斑块抗动脉粥样硬化机制研究

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四川中医 2024年第9期42卷 56-61页

作者：范增光刘怡雯袁野鸡西市人民医院医疗集团黑龙江鸡西158100 黑龙江中医药大学黑龙江哈尔滨150040 江西中医药大学附属医院江西南昌330006 江西中医药大学江西南昌330004

基于自噬探讨补阳还五汤通过稳定动脉斑块,发挥抗动脉粥样硬化的作用。选取ApoE^(-/-)小鼠进行模型复制,模型复制成功后分为模型组、补阳还五汤(低、高剂量)及阿托伐他汀组;c57BL/6J背景的ApoE^(-/-)小鼠设为空白组,连续灌胃4周。Masso... 详细信息

基于自噬探讨补阳还五汤通过稳定动脉斑块,发挥抗动脉粥样硬化的作用。选取ApoE^(-/-)小鼠进行模型复制,模型复制成功后分为模型组、补阳还五汤(低、高剂量)及阿托伐他汀组;c57BL/6J背景的ApoE^(-/-)小鼠设为空白组,连续灌胃4周。Masson染色观察小鼠主动脉窦斑块纤维化程度;生化分析仪测定血脂表达水平;ELISA法检测氧化物酶体增殖物激活受体γ(PPARγ)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)表达水平;Western Blot法检测被泛素结合蛋白62(p62)、微管相关蛋白1轻链3(Lc3)蛋白表达水平。结果显示,与模型比较,补阳还五汤能够减轻小鼠主动脉窦补胶原纤维面积;升高小鼠血清中高密度脂蛋白胆固醇(HDL-c)表达水平(Pc)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-c)表达水平(Pc3Ⅱ/Lc3Ⅰ蛋白表达(P<0.05)。提示补阳还五汤发挥稳定动脉粥样硬化斑块的作用,可能与促进自噬有关。

关键词：动脉粥样硬化补阳还五汤自噬动脉斑块

13例侵袭性肺曲霉菌病继发机化性肺炎的临床特征分析

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重庆医学 2024年第5期53卷 745-747,753页

作者：赵顺鑫王楠叶立群王红民郑州大学第一附属医院呼吸内科郑州450052 郑州市中医院医院感染管理科郑州450007

目的分析侵袭性肺曲霉菌病继发机化性肺炎的临床特点。方法收集郑州大学第一附属医院呼吸内科2019年1月至2021年1月经病理确诊的13例侵袭性肺曲霉菌病继发机化性肺炎患者的临床资料,回顾性分析患者的临床特征、实验室检查、影像特征... 详细信息

目的分析侵袭性肺曲霉菌病继发机化性肺炎的临床特点。方法收集郑州大学第一附属医院呼吸内科2019年1月至2021年1月经病理确诊的13例侵袭性肺曲霉菌病继发机化性肺炎患者的临床资料,回顾性分析患者的临床特征、实验室检查、影像特征、治疗及转归。结果大部分患者在侵袭性肺曲霉菌病确诊2~3周发病,均有咳嗽、咳痰、发热,伴c反应蛋白和红细胞沉降率升高;胸部cT显示为原感染灶周围出现斑片状阴影,多伴实变、晕征、支气管充气征,可伴空洞、胸腔积液;继发双肺多叶段受累,多为小斑片状阴影、结节影、树芽征;接受糖皮质激素治疗后,1周内症状均得到控制,疗程3~6个月。结论侵袭性肺曲霉菌病继发机化性肺炎的临床特征与隐源性机化性肺炎有一定相似性,预后更好。

关键词：侵袭性肺曲霉菌病机化性肺炎糖皮质激素

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鄂尔多斯盆地东缘太原组风暴沉积特征及环境模式

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沉积学报 2024年第4期42卷 1370-1383页

作者：宋慧波张彬于振锋金毅胡斌牛永斌张立军河南理工大学资源环境学院河南焦作454000 山西蓝焰煤层气工程研究有限责任公司山西晋城048000 河南省煤系非常规资源成藏与开发重点实验室河南焦作454000

【目的】鄂尔多斯盆地东缘乡宁地区甘草山一带下二叠统太原组灰岩中发育多层风暴沉积,主要分布在L2、L3、L4和L5灰岩层中。【方法】基于岩性、沉积构造、遗迹化石和沉积序列研究,对该区碳酸盐岩风暴事件沉积序列中的侵蚀基底构造与生物... 详细信息

【目的】鄂尔多斯盆地东缘乡宁地区甘草山一带下二叠统太原组灰岩中发育多层风暴沉积,主要分布在L2、L3、L4和L5灰岩层中。【方法】基于岩性、沉积构造、遗迹化石和沉积序列研究,对该区碳酸盐岩风暴事件沉积序列中的侵蚀基底构造与生物碎屑滞积层、粒序层、纹理层、生物成因构造(遗迹化石)和泥灰岩或灰质泥岩层的主要特征进行了较详细论述。【结果】根据不同灰岩层中风暴沉积序列的垂向组成特点,识别出5种风暴沉积类型:类型A沉积序列由波状侵蚀基底和粒序层两个沉积单元构成,发育于近岸正常天气浪基面之上的滨岸带;类型B沉积序列以波状侵蚀基底、粒序层和纹理层(丘状—洼状交错层理)三个层段为特征,产生于潮下带、正常天气浪基面与风暴浪基面之间的上部沉积环境;类型c由波状侵蚀基底、粒序层、纹理层(丘状—洼状交错层理及缓波状层理)和顶部泥灰岩层等4个沉积单元组成,形成于正常天气浪基面与风暴浪基面之间的下部沉积环境;类型D沉积序列由基底侵蚀及生物碎屑滞积层、粒序层、生物扰动层和泥灰岩层组成,出现于风暴浪基面附近的沉积环境;类型E则以微波状侵蚀基底、薄层粒序层、遗迹化石层和泥灰岩层构成为特点,发生在风暴浪基面附近及之下的浅海沉积环境。【结论】该研究不仅对鄂尔多斯盆地下二叠统太原组碳酸盐岩及其沉积环境提出了新的认识,而且可以对该地层中的油气资源勘探与开发提供沉积环境分析和古地理重建方面的事件沉积佐证。

关键词：太原组风暴沉积沉积环境下二叠统鄂尔多斯盆地