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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Population migration across the Qinghai-Tibet Plateau:Spatiotemporal patterns and driving factors

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Journal of Geographical Sciences 2021年第2期31卷 195-214页

作者： WANG nan WANG Huimeng DU Yunyan yi Jiawei liu Zhang TU Wenna State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resource and Environment University of Chinese Academy of SciencesBeijing 100049China

Developing a comprehensive understanding of inter-city interactions is crucial for regional *** therefore examined spatiotemporal patterns of population migration across the Qinghai-Tibet Plateau(QTP)using migration big data from Tencent for the period between 2015 and *** initially used decomposition and breakpoint detection methods to examine time-series migration data and to identify the two seasons with the strongest and weakest population migration levels,between June 18th and August 18th and between October 8th and February 15th,*** migration within the former period was 2.03 times that seen in the *** then used a variety of network analysis methods to examine population flow directions as well as the importance of each individual city in *** two capital cities on the QTP,Lhasa and Xining,form centers for population migration and are also transfer hubs through which migrants from other cities off the plateau enter and leave this *** show that these two cities contribute more than 35%of total population *** majority of migrants tend to move within the province,particularly during the weakest migration *** also utilized interactive relationship force and radiation models to examine the interaction strength and the radiating energy of each individual *** show that Lhasa and Xining exhibit the strongest interactions with other cities and have the largest radiating ***,the radiating energy of the QTP cities correlates with their gross domestic product(GDP)(Pearson correlation coefficient:0.754 in the weakest migration season,WMS versus 0.737 in the strongest migration season,SMS),while changes in radiating energy correlate with the tourism-related revenue(Pearson correlation coefficient:0.685).These outcomes suggest that level of economic development and level of tourism are the two most important factors driving the QTP population *** results of this analysis pro

关键词： Qinghai-Tibet Plateau population migration migration big data flow radiation model spatiotemporal interaction mode

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Intracellular HSP70L1 inhibits human dendritic cell maturation by promoting suppressive H3K27me3 and H2AK119Ub1 histone modifications

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Cellular & Molecular Immunology 2020年第1期17卷 85-94页

作者： Lin yi Zhiqing Li Tianju Hu Juan liu nan Li Xuetao Cao Shuxun liu National Key Laboratory of Medical Immunology&Institute of Immunology Second Military Medical University200433ShanghaiChina Department of Immunology&Center for Immunotherapy Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences100005 BeijingChina

Epigenetic regulation has been attracting increasing attention due to its role in cell differentiation and ***,the epigenetic mechanisms that regulate human dendritic cell(DC)differentiation and development remain poorly *** previous studies show that extracellular heat shock protein 70-like protein(HSP70L1)is a potent adjuvant of Th1 responses via stimulating DCs when released from cells;however,the role of intracellular HSP70L1 in DC differentiation and maturation remains ***,we demonstrate that intracellular HSP70L1 inhibits human DC maturation by suppressing MHC and costimulatory molecule expression,in contrast to the adjuvant activity of extracellular *** stability of intracellular HSP70L1 is dependent on DNAJC2,a known epigenetic ***,intracellular HSP70L1 inhibits the recruitment of Ash1l to and maintains the repressive H3K27me3 and H2AK119Ub1 modifications on the promoter regions of costimulatory,MHC and STAT3 ***,intracellular HSP70L1 is an inhibitor of human DC *** results provide new insights into the epigenetic regulation of cell development by intracellular HSP70L1.

关键词： HSP70L1 DNAJC2 Monocyte-derived dendritic cell Histone modification H3K27me3 H2AK119Ub1 H3K4me3

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利伐沙班在犬和猫临床应用的研究进展

动物医学进展 2025年第1期46卷 97-102页

作者：王炜江蓝路心怡付诗懿刘亦婷韦力煣俞峰刘波中国农业大学动物医学院北京100193 中国农业大学教学动物医院北京100193

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够... 详细信息

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。

关键词：新型口服抗凝药利伐沙班血栓栓塞犬猫

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Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming Zhang Hanyu Wu Qi Chen Jiaxin Yang Bonan liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

A Computational Study of Radio Frequency Atmospheric Pressure Discharge in Nitrogen and Oxygen Mixture Gases

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Chinese Physics Letters 2013年第3期30卷 100-103页

作者： WANG yi-nan liu Yue LIN Guo-Qiang Key Laboratory of Materials Modification by Laser Electronand Ion Beams(Ministry of Education)School of Physics and Optoelectronic TechnologyDalian University of TechnologyDalian 116024

The characteristics of radio frequency atmospheric pressure discharge in nitrogen and oxygen mixture gases are investigated by using a one-dimensional fluid *** model consists of equations of particle continuity,Poisson's equation,and the electron energy *** effect of the concentrations of O_(2) in N_(2) on the discharge characteristics is *** results show that when the concentration of O_(2) in N_(2) is less than 12%,as the amount of O_(2) grows,the electron density and the N4+ion density decrease;the main negative particles are *** the concentration of O_(2) in N_(2) is greater than 12%,the electron density and the N_(4)^(+) ion density increase with the increasing admixture of oxygen;the main negative particle is the O^(-) ***,the O^(-) ion density,the O_(2)^(+) ion density,the electron temperature and the mixture gases electronegativity increase with growth of O_(2) in the range from 4%to 20%and with density of O_(2) in N_(2).

关键词： equation. gases Oxygen

Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia Li Wenwu liu Shiji Da Lingbin Kong Fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

Postoperative Oxygen Therapy vs Prophylactic Noninvasive Positive Pressure Ventilation with Different interfaces in Stanford Type A Aortic Dissection

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中国循环杂志 2016年第Z1期31卷 -页

作者： yi Yang nan liu Yong Yang Center for Cardiac Intensive Care Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases. Beijing China

Evidence fusion theory in healthcare

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Journal of Management Analytics 2018年第4期5卷 276-286页

作者： Jiangnan liu nan Kang yi Man Alliance Manchester Business School The University of ManchesterManchesterUK Antai College of Economics and Management Shanghai Jiaotong UniversityShanghaiPeople’s Republic of China

In the context of popularized healthcare,cloud computing centers are used to collect medical data from the cloud and diagnose *** means a technical framework that can be applied to the medical diagnostic process in popularized healthcare is needed in order to provide technical *** on the evidence fusion theory,this study established a multi-modality image evidence fusion method,which can simulate the doctor’s diagnostic process and use multiple modalities of medical images to diagnose *** study used the evidence fusion method to fuse two different modalities of medical *** accuracy of the diagnosis after fusion was higher than that of diagnosis through two modalities *** fusion method has achieved great results in the process of multi-modality image fusion.

关键词： popularized healthcare artificial intelligence evidence reasoning brain tumor detection