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ROS-mediated BNIP3-dependent mitophagy promotes coelomocyte survival in Apostichopus japonicus in response to Vibrio splendidus infection

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Zoological Research 2022年第2期43卷 285-300页

作者： Lian-Lian Sun yi-na shao Mei-Xiang You Cheng-Hua Li State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266071China State-Province Joint Laboratory of Marine Biotechnology and Engineering Ningbo UniversityNingboZhejiang 315211China

Organisms produce high levels of reactive oxygen species(ROS)to kill pathogens or act as signaling molecules to induce immune responses;however,excessive ROS can result in cell *** maintain ROS balance and cell survival,mitophagy selectively eliminates damaged mitochondria via mitophagy receptors in *** marine invertebrates,however,mitophagy and its functions remain largely *** the current study,Vibrio splendidus infection damaged mitochondrial morphology in coelomocytes and reduced mitochondrial membrane potential(ΔΨm)and mitophagosome *** colocalization of mitochondria and lysosomes further confirmed that lipopolysaccharide(LPS)treatment increased mitophagy *** explore the regulatory mechanism of mitophagy,we cloned Bcl2/adenovirus E1 B 19 kDa protein-interacting protein 3(BNIP3),a common mitophagy receptor,from sea cucumber Apostichopus japonicus(Aj BNIP3)and confirmed that Aj BNIP3 was significantly induced and accumulated in mitochondria after *** infection and LPS *** the mitochondrial membrane,Aj BNIP3 interacts with microtubule-associated protein 1 light chain 3(LC3)on phagophore membranes to mediate *** Aj BNIP3 interference,mitophagy flux decreased ***,Aj BNIP3-mediated mitophagy was activated by ROS following the addition of exogenous hydrogen peroxide(H2 O2),ROS scavengers,and ROS ***,inhibition of BNIP3-mediated mitophagy by Aj BNIP3 small interfering Rna(si Rna)or high concentrations of lactate increased apoptosis and decreased coelomocyte *** findings highlight the essential role of Aj BNIP3 in damaged mitochondrial degradation during *** mitophagy activity is required for coelomocyte survival in *** against *** infection.

关键词： Apostichopus japonicus Mitophagy Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3 Reactive oxygen species Microtubule-associated protein 1 light chain 3

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Elliptical encirclement control capable of reinforcing performances for UAVs around a dynamic target

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Defence Technology（防务技术） 2024年第2期32卷 104-119页

作者： Fei Zhang Xingling shao yi Xia Wendong Zhang national Key Laboratory for Electronic Measurement Technology School of Instrument and ElectronicsNorth University of ChinaTaiyuan030051China

Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external ***,elliptical encirclement with a time-varying observation radius,may permit a more flexible and high-efficacy enclosing solution,whilst the non-orthogonal property between axial and tangential speed components,non-ignorable environmental perturbations,and strict assignment requirements empower elliptical encircling control to be more challenging,and the relevant investigations are still *** this line,an appointed-time elliptical encircling control rule capable of reinforcing circumnavigation performances is developed to enable Unmanned Aerial Vehicles(UAVs)to move along a specified elliptical path within a predetermined reaching *** remarkable merits of the designed strategy are that the relative distance controlling error can be guaranteed to evolve within specified regions with a designer-specified convergence ***,wind perturbations can be online counteracted based on an unknown system dynamics estimator(USDE)with only one regulating parameter and high computational *** tool demonstrates that all involved error variables are ultimately limited,and simulations are implemented to confirm the usability of the suggested control algorithm.

关键词： Elliptical encirclement Reinforced performances Wind perturbations UAVs

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Influence of vibration on the lubrication effect of a splash-lubricated gearbox

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第4期25卷 324-339页

作者： yi LIU Kailin ZHANG Shuai shao Hongxu XIANG Zhijian YE State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

In this study,we investigate the effect of rail vibrations on the lubrication and efficiency of a splash-lubricated gearbox;specifically,the gearbox of a rail-transit vehicle.A high-fidelity 3D numerical model of the gearbox in a moving reference system is described,as well as computational fluid dynamics(CFD)simulations of the gearbox with different vibration *** effects of rotational speed,oil-immersion depth,and different oil-injection volume rates on lubrication and efficiency are *** propose a method of evaluating the internal lubrication condition of a splash-lubricated gearbox and quantitatively compare the effects of different operating parameters on lubrication and ***,our experiment to verify the feasibility of the simulation method is *** results show that with vibration,the churning loss and oil supply for the bearings are significantly higher than those under static *** addition,among different vibrational directions,lateral vibration has the greatest influence on the lubrication condition and efficiency of the *** the studied railway-vehicle gearbox,the best lubrication condition is achieved at a rotational speed of 1600 r/min and an oil-immersion depth of two times the tooth height(***).Rotational speed is the operating parameter that has the most significant effect on the lubrication and efficiencyofthegearbox.

关键词： Comprehensive lubrication evaluation Churning loss Moving reference system Splash lubrication Vibrational excitation Gearbox

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Equivalent Impedance Parameter Calculation of Three-phase Symmetrical Loads for Harmonic Source Location

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 251-260页

作者： yi Zhang Bijie Liu Caihua Lin Zhenguo shao Yuncong Xu the Department of Electrical Engineering and Automation Fuzhou UniversityFuzhouChina State Grid Fujian Electric Power Research Institute FuzhouChina

The equivalent impedance parameters of loads have been widely used to identify and locate the harmonic ***,the existing calculation methods suffer from outliers caused by the zero-crossing of the *** outliers can result in inaccuracy and unreliability of harmonic source *** address this issue,this paper proposes an innovative method of equivalent impedance parameter calculation of three-phase symmetrical loads that avoid *** correctness and effectiveness of the proposed method are verified by simulations on Simulink using actual monitoring *** results show that the proposed method is not only simple and easy to implement but also highly accurate.

关键词： abc-αβtransformation equivalent impedance parameters of load harmonic source location nonlinear load power quality

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Enhancement of low-temperature toughness of Fe-Mn-C-Al alloy by rare earth Ce-modified inclusions

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Journal of Iron and Steel Research International 2024年第1期31卷 157-173页

作者： Guang-kai Yang Chang-ling Zhuang yi-zhuang Li Chen Hu shao-bo Li College of Materials and Metallurgy Guizhou UniversityGuiyang550025GuizhouChina Department of Mechanical Engineering University of Hong KongHong Kong999077China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025GuizhouChina

Fe-Mn-C-Al alloys have been recognized as promising materials for certain low-temperature applications due to their exceptional mechanical properties and ***,their limited low-temperature toughness restricts their large-scale applications in specific *** influence of trace amounts of rare earth cerium(Ce)on the low-temperature toughness of Fe-18Mn-0.6C-1.8Al alloys was *** addition of Ce effectively alters the inclu-sions in the alloy,transforming large-sized irregular inclusions into fine ellipsoidal rare earth *** leads to a significant reduction in both the proportion and average size of the inclusions,resulting in their effective dispersion throughout the matrix and improved cryogenic *** presence of Ce-containing inclusions within the matrix reduces stress concentration,thereby inhibiting microcrack formation and improving impact absorption ***-cally,the addition of rare earth Ce alters the fracture behavior of the material at room temperature and low temperature,changing from brittle cleavage fracture to a more ductile failure *** impact toughness of the Fe-Mn-C-Al alloy is significantly improved by the addition of 0.0048 wt.%Ce,particularly at-196℃where the impact toughness reaches 103.6 J/cm^(2),representing an impressive improvement of 87.3%.

关键词： Fe-Mn-C-Al alloy Rare earth Low-temperature toughness Inclusion Fracture

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Siliceous mesocellular foam supported Cu catalysts for promoting non-thermal plasma activated CO_(2) hydrogenation toward methanol synthesis

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 55-65页

作者： yi Chen shaowei Chen Yan shao Cui Quan Ningbo Gao Xiaolei Fan Huanhao Chen State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUK Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China

Electrified non-thermal plasma (NTP) catalytic hydrogenation is the promising alternative to the thermal counterparts, being able to be operated under mild conditions and compatible with green electricity/hydrogen. Rational design of the catalysts for such NTP-catalytic systems is one of the keys to improve the process efficiency. Here, we present the development of siliceous mesocellular foam (MCF) supported Cu catalysts for NTP-catalytic CO_(2) hydrogenation to methanol. The findings show that the pristine MCF support with high specific surface area and large mesopore of 784 m2·g−1 and ~8.5 nm could promote the plasma discharging and the diffusion of species through its framework, outperforming other control porous materials (viz., silicalite-1, SiO_(2), and SBA-15). Compared to the NTP system employing the bare MCF, the inclusion of Cu and Zn in MCF (i.e., Cu1Zn1/MCF) promoted the methanol formation of the NTP-catalytic system with a higher space-time yield of methanol at ~275 μmol·g_(cat)^(−1)·h^(−1) and a lower energy consumption of 26.4 kJ^(−1)·mmol_(CH_(3)OH)^(-1) (conversely, ~225 μmol·g_(cat)^(−1)·h^(−1) and ~71 kJ^(−1)·mmol_(CH_(3)OH)^(-1), respectively, for the bare MCF system at 10.1 kV). The findings suggest that inclusion of active metal sites (especially Zn species) could stabilize the CO_(2)/CO-related intermediates to facilitate the surface reaction toward methanol formation.

关键词： non-thermal plasma(NTP)catalysis Cu catalyst CO_(2)hydrogenation methanol siliceous mesocellular foam(MCF)

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New food sources and production systems:a comparison of international regulations and China’s advancements in novel foods with synthetic biology

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Food Science and Human Wellness 2024年第5期13卷 2519-2542页

作者： Xin Liu Di Wu yi shao Yongning Wu Key Laboratory for Deep Processing of Major Grain and Oil(The Chinese Ministry of Education) College of Food Science and EngineeringWuhan Polytechnic UniversityWuhan 430023China Institute for Global Food Security School of Biological SciencesBelfast B795DLUnited Kingdom NHC Key Laboratory of Food Safety Risk Assessment China National Center for Food Safety Risk AssessmentBeijing 100021China Department of Nutrition and Food Safety Peking Union Medical CollegeResearch Unit of Food SafetyChinese Academy of Medical SciencesBeijing 100021China

The global shift towards sustainable food systems has sparked innovations in food sources and production systems,including cell-based meat,plant-based food products,precision fermentation,and 3D food *** advancements pose regulatory challenges and opportunities,with China emerging as a critical player in adopting and regulating new food *** review explores the international landscape of new food sources and production systems(NFPS),focusing on China’s role and regulatory approaches compared to global *** this comparative analysis,we aim to contribute to the ongoing dialogue on food safety regulation,offering insights and recommendations for policymakers,industry stakeholders,and researchers engaged in the global food system’s *** comprehensive overview underscores the dynamic nature of regulatory frameworks governing NFPS,highlighting the international efforts to ensure food safety,consumer protection,and the sustainable evolution of the food industry.

关键词： New food sources Food production system Food safety International regulation Synthetic biology China

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Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy

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Chinese Chemical Letters 2024年第6期35卷 445-450页

作者： Leichen Wang Anqing Mei na Li Xiaohong Ruan Xu Sun Yu Cai Jinjun shao Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211800China School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou 221116China Center for Rehabilitation Medicine Rehabilitation&Sports Medicine Research Institute of Zhejiang ProvinceDepartment of Rehabilitation MedicineZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China

Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient singlet oxygen(^(1)O_(2))***,bromine or iodine atoms are introduced on the aza-borondipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient~1O_(2) ***,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthesized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor *** to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(Φ_(Δ))of 66% which was superior to similar brominated photosensitizers previously *** encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conversion efficiency(η)of 43.0% under 660 nm *** vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h *** the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.

关键词： Unexpected bromination Aza-BODIPY Photodynamic therapy Photothermal therapy Synergetic therapy

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Mg-Al-hydrotalcite with alkaline sites protects Ni/KIT-6 from formation of amorphous coke in glycerol steam reforming via tailoring reaction intermediates

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 25-39页

作者： Yunyu Guo yiran Wang Yuewen shao Shu Zhang yi Wang Song Hu Jun Xiang Xun Hu School of Material Science and Engineering University of JinanJinan 250022China Joint International Research Laboratory of Biomass Energy and Materials College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

During steam reforming,the performance of a catalyst and amount/property of coke are closely related to reaction intermediates reaching surface of a ***,modification of reaction intermediates by placing Mg-Al-hydrotalcite above Ni/KIT-6 catalyst in steam reforming of glycerol was conducted at 300 to 600°*** results revealed that the catalytic activity of Ni/KIT-6 in the lower bed was enhanced with either Mg1-Al5-hydrotalcite(containing more acidic sites)or Mg5-Al1-hydrotalcite(containing more alkaline sites)as upper-layer *** in situ infrared characterization of steam reforming demonstrated that Mg-Al-hydrotalcite catalyzed the deoxygenation of glycerol,facilitating the reforming of the partially deoxygenated intermediates over Ni/***-Al-hydrotalcite as protective catalyst,however,did not protect the Ni/KIT-6 from formation of more ***,this did not lead to further deactivation of Ni/KIT-6 while Mg5-Al1-hydrotalcite even substantially enhanced the catalytic stability,even though the coke was much more significant than that in the use of single Ni/KIT-6(52.7%vs.28.6%).The reason beneath this was change of the property of coke from more aliphatic to more ***5-Al1-hydrotalcite catalyzed dehydration of glycerol,producing dominantly reaction intermediates bearing C=C,which formed the catalytic coke of with carbon nanotube as the main form with smooth outer walls as well as higher aromaticity,C/H ratio,crystallinity,crystal carbon size,thermal stability,and resistivity toward oxidation on Ni/KIT-6 in the lower *** comparison,the abundance of acidic sites on Mg1-Al5-hydrotalcite catalyzed the formation of more oxygen-containing species,leading to the formation of carbon nanotubes of rough surface on Ni/KIT-6.

关键词： steam reforming of glycerol Mg-Alhydrotalcite sacrificial catalyst reaction intermediates property of coke

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Epitaxial growth of borophene on graphene surface towards efficient and broadband photodetector

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nano Research 2024年第4期17卷 3053-3060页

作者： Zenghui Wu Chen Shifan Zitong Wu yi Liu Wei shao Xinchao Liang Chuang Hou Guoan Tai The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

In-situ integration of multiple materials with well-defined interfaces as heterostructures is of great interest due to their unique properties and potential for new device *** of its polymorphism and diverse bonding geometries,borophene is a promising candidate for two-dimensional heterostructures,but suitable synthesis conditions have limited its potential *** this end,we demonstrate the vertical borophene and graphene heterostructures which form by epitaxial growth of borophene onto multilayer graphene on Cu substrates via chemical vapor deposition,where hydrogen and naBH_(4) are respectively used as the carrier gas and the boron *** lattice structure of the as-synthesized borophene well coincides with the predictedα′-boron *** borophene-based photodetector shows an excellent broadband photoresponse from the ultraviolet(255 nm)to the infrared(940 nm)wavelengths,with enhanced responsivity compared to pristine borophene or graphene *** work informs emerging efforts to integrate borophene into nanoelectronic applications for both fundamental investigations and technological applications.

关键词： borophene graphene heterostructure photodetector two-dimensional materials

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