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Hidrotic ectodermal dysplasia in a Chinese pedigree:A case report

World Journal of Clinical Cases 2023年第6期11卷 1403-1409页

作者： ming-yi liao Hui Peng Long-Nian Li Tao Yang Shi-yin Xiong Xiao-ying Ye Department of Dermatology First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Dermatology Ganzhou People's HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND We report on a large family of Chinese Han individuals with hidrotic ectodermal dysplasia(HED)with a variation in GJB6(c.31G>A).The patients in the family had a triad of clinical manifestations of varying *** the same variation locus have been reported,the clinical manifestations of this family were difficult to distinguish from those of congenital thick nail disorder,palmoplantar keratosis,and congenital *** SUMMARY This investigation involved a large Chinese family of 46 members across five generations and included 12 patients with *** proband(IV4)was a male patient with normal sweat gland function and dental development,no skeletal dysplasia,no cognitive disability,and no hearing *** parents were not consanguineously *** examination of the proband revealed thinning hair and thickened grayish-yellow nails and toenails with some longit-udinal ridges,in addition to mild bilateral palmoplantar ***6,GJB2,and GJA1 have been reported to be the causative genes of HED;therefore,we subjected the patient’s samples to Sanger sequencing of these three *** this family,the variation locus was at GJB6(c.31G>A,***11Arg).Overex-pression vectors of wild-type GJB6 and its variants were established and transfected into HaCaT cell models,and the related mRNA and protein expression changes were determined using real-time reverse transcriptase-polymerase chain reaction and Western blot,*** We report another HED phenotype associated with GJB6 variations,which can help clinicians to diagnose HED despite its varying presentations.

关键词： Hidrotic ectodermal dysplasia GJB6 Connexin Gene sequencing Cell transfection Case report

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负离子合成POSS端基官能化聚苯乙烯

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高分子学报 2016年第6期26卷 722-727页

作者：廖明义张贺大连海事大学交通运输装备与海洋工程学院大连116026

以苯乙烯为单体、氯丙基七异丁基多面体低聚倍半硅氧烷(chloropropyllsobutyl POSS,POSS-Cl)为封端剂、正丁基锂(n-Bu Li)为引发剂、环己烷为溶剂、四氢呋喃(THF)为结构调节剂,采用阴离子聚合技术,合成了POSS端基官能化聚苯乙烯(PS-POS... 详细信息

以苯乙烯为单体、氯丙基七异丁基多面体低聚倍半硅氧烷(chloropropyllsobutyl POSS,POSS-Cl)为封端剂、正丁基锂(n-Bu Li)为引发剂、环己烷为溶剂、四氢呋喃(THF)为结构调节剂,采用阴离子聚合技术,合成了POSS端基官能化聚苯乙烯(PS-POSS).采用核磁共振仪(1~H-NMR、^(13)C-NMR)和凝胶渗透色谱仪(GPC)对PS-POSS的结构和分子量分布进行了表征,证明了POSS与聚苯环乙烯锂(PSLi)发生了封端反应生成PSPOSS;封端后分子量分布略有加宽,特别是相比传统有机封端剂,没有二聚等副产物生成.考察了引发剂种类、结构调节剂用量、POSS用量、PS分子量、封端反应温度和时间等因素对PS-POSS封端效率的影响.结果表明,在THF/n-BuLi摩尔比大于5、POSS/n-BuLi摩尔比等于1.1、反应温度为60℃、反应时间为30 min时,封端效率最高,达到80%以上;而随着PS数均分子量增加,封端效率逐渐降低.

关键词： POSS PS 负离子聚合端基官能化封端效率

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随机可变时滞系统的渐近稳定性

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系统工程与电子技术 2005年第4期27卷 700-703页

作者：沈轶江明辉廖晓昕华中科技大学控制科学与工程系湖北武汉430074

讨论了一类随机可变时滞系统解的渐近稳定性。应用It 公式、半鞅收敛定理与多个Lyapunov函数建立了这类随机可变时滞系统渐近稳定性的有效判据,使实际应用中构造Lyapunov函数更为方便。同时也说明了结果包含经典的随机系统稳定性结果为... 详细信息

讨论了一类随机可变时滞系统解的渐近稳定性。应用It 公式、半鞅收敛定理与多个Lyapunov函数建立了这类随机可变时滞系统渐近稳定性的有效判据,使实际应用中构造Lyapunov函数更为方便。同时也说明了结果包含经典的随机系统稳定性结果为其特殊情况。与经典的随机稳定性理论相比,所建立的稳定性结果无须LV负定,充分利用了随机扰动项的作用,并且从理论上解释了一个不稳定的系统有时加入适当随机扰动后反而稳定。最后。

关键词：随机可变时滞系统渐近稳定 Lyapunov函数 Ito公式半鞅收敛定理

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Transvaginal 3D Ultrasound Evaluation of Post-Cesarean Section Uterine Diverticulum

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Open Journal of Obstetrics and Gynecology 2015年第12期5卷 698-702页

作者： Cui-Lan Li Xue-Tang Mo Kai-Xuan Deng Dun-Jin Chen Xing-Cheng Gao Jin-Guo Zhai yi-ming liao Hui-Ru Dai Xiang Cai The Third Affiliated Hospital of Guangzhou Medical University & Key Laboratory for Major Obstetric Diseases of Guangdong Province & Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Guangzhou China Department of Computer Science Hong Kong Baptist University Hong Kong China

Objectives: This study focused on evaluating the value of transvaginal 3D ultrasound for the diagnosis and prognostic assessment of post-cesarean section uterine diverticulum. Materials and Methods: We retrospectively analyzed the data from 32 patients with post-cesarean section uterine diverticulum over three recent years. In all patients, transvaginal 3D ultrasound was used to measure the size of the uterine diverticulum and the thickness of the lower uterine segment (LUS) and myometrium. Patients with a LUS with a myometrial thickness under 4 mm underwent resection and repair surgery;those with a LUS with a myometrial thickness over 4 mm underwent hysteroscopic resection. The postoperative sonograms were compared with preoperative images to evaluate the efficacy of various treatments. Results: The mean length, width and depth of the uterine diverticula were 18.30 ± 2.80 mm, 9.14 ± 3.20 mm and 11.49 ± 2.71 mm, respectively. The average LUS myometrial thickness was 3.40 ± 0.80 mm (with a range of 1.6 mm - 6.3 mm). After surgery, two patients’ sonograms still showed diverticula at the post-cesarean section scar, measuring 6 mm × 7 mm × 6 mm and 6 mm × 8 mm × 4 mm. There were significant differences in the size of uterine diverticula between preoperative and postoperative sonograms (P < 0.05) and the effective rate of surgery was 93.75% (30/32). Conclusions: Transvaginal 3D ultrasound is an accurate method for detecting post-cesarean section uterine diverticulum and is helpful for assessing surgical options and prognosis. The LUS myometrial thickness, which is considered as an optional index of post-cesarean section uterine diverticulum, should be measured routinely.

关键词： Post-Cesarean Section Uterine Diverticulum Transvaginal 3D Ultrasound LUS Myometrial Thickness

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中药刺蒺藜对兔视网膜神经细胞的作用

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国际眼科杂志 2009年第2期9卷 282-283页

作者：廖明怡黄丽娜曾平刘军湖北中医学院中国湖北省武汉市430061 中国广东省深圳市眼科医院 518001

目的:观察中药刺蒺藜对高眼压兔视网膜神经节细胞(RGCs)的作用。方法:将16只健康新西兰兔随机分为正常组(A组)、高眼压组(B组)和高眼压治疗组(C组),以20g/L甲基纤维素前房注射建立B,C组兔慢性高眼压模型,C组予以每日静脉注射刺蒺藜针剂5... 详细信息

目的:观察中药刺蒺藜对高眼压兔视网膜神经节细胞(RGCs)的作用。方法:将16只健康新西兰兔随机分为正常组(A组)、高眼压组(B组)和高眼压治疗组(C组),以20g/L甲基纤维素前房注射建立B,C组兔慢性高眼压模型,C组予以每日静脉注射刺蒺藜针剂5mg/kg,连续用药30d后摘取眼球进行RGCs观察及视网膜神经纤维层(RNFL)厚度测量。结果:造模后各组眼压均有升高,HE染色切片中C组RGCs变性程度及RNFL受损程度明显低于B组(P<0.01)。结论:中药刺蒺藜能在一定程度上保护高眼压状态下的视网膜神经节细胞。

关键词：刺蒺藜高眼压视网膜神经节细胞兔

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng yi Haihan Zou Gao Deng ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying Ge Tian Yu-Xuan Xiao yi Lu Si-ming Wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan yi He Pan Chen ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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吻合器痔环切术联合痔核缝扎术治疗出血性重度痔的临床效果

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中国当代医药 2018年第14期25卷 51-53页

作者：陈杏仪廖明梁家基彭小春广东省佛山市南海区第四人民医院肛肠科广东佛山528200

目的探讨吻合器痔环切术(PPH)联合痔核缝扎术治疗出血性重度痔的临床效果。方法选取2015年6月~2017年12月我院收治的100例出血性重度痔患者作为研究对象,按照随机数字表法分为研究组和对照组,每组50例。对照组行单纯PPH术,研究组行PPH... 详细信息

目的探讨吻合器痔环切术(PPH)联合痔核缝扎术治疗出血性重度痔的临床效果。方法选取2015年6月~2017年12月我院收治的100例出血性重度痔患者作为研究对象,按照随机数字表法分为研究组和对照组,每组50例。对照组行单纯PPH术,研究组行PPH联合痔核缝扎术,比较两组患者的手术时间、术中出血量、术后住院时间、疼痛评分(NRS)、术后出血情况、治愈率和并发症等的情况。结果研究组的手术时间长于对照组,术中出血量显著大于对照组,差异有统计学意义(P<0.05);研究组术后出血发生率为0%,显著低于对照组的22%,研究组的治愈率(90%)显著高于对照组(72%),差异均有统计学意义(P<0.05)。研究组肛门狭窄和肛门失禁发生率均为0.0%,低于对照组的20.0%和18.0%,差异有统计学意义(P<0.05)。结论 PPH联合痔核缝扎术治疗出血性重度痔较单纯PPH手术效果更优,适合临床推广。

关键词：痔吻合器痔环切术联合痔核缝扎术疗效

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Dynamic prediction of moving trajectory in pipe jacking: GRU-based deep learning framework

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Frontiers of Structural and Civil Engineering 2023年第7期17卷 994-1010页

作者： yi-Feng YANG Shao-ming liao Meng-Bo LIU Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghai 200092China Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China

The moving trajectory of the pipe-jacking machine(PJM),which primarily determines the end quality of jacked tunnels,must be controlled strictly during the entire jacking *** prediction models to support drivers in performing rectifications in advance can effectively avoid considerable trajectory deviations from the designed jacking ***,a gated recurrent unit(GRU)-based deep learning framework is proposed herein to dynamically predict the moving trajectory of the *** this framework,operational data are first extracted from a data acquisition system;subsequently,they are preprocessed and used to establish GRU-based multivariate multistep-ahead direct prediction *** verify the performance of the proposed framework,a case study of a large pipe-jacking project in Shanghai and comparisons with other conventional models(i.e.,long short-term memory(LSTM)network and recurrent neural network(RNN))are *** addition,the effects of the activation function and input time-step length on the prediction performance of the proposed framework are investigated and *** results show that the proposed framework can dynamically and precisely predict the PJM moving trajectory during the pipe-jacking process,with a minimum mean absolute error and root mean squared error(RMSE)of 0.1904 and 0.5011 mm,*** RMSE of the GRU-based models is lower than those of the LSTM-and RNN-based models by 21.46%and 46.40%at the maximum,*** proposed framework is expected to provide an effective decision support for moving trajectory control and serve as a foundation for the application of deep learning in the automatic control of pipe jacking.

关键词： dynamic prediction moving trajectory pipe jacking GRU deep learning

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