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Forward and backward models for fault diagnosis based on parallel genetic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1420-1425页

作者： yi LIU ying LI yi-jia cao Chuang-xin GUO School of Electrical Engineering Zhejiang University Hangzhou 310027 China

In this paper, a mathematical model consisting of forward and backward models is built on parallel genetic algorithms (PGAs) for fault diagnosis in a transmission power system. A new method to reduce the scale of fault sections is developed in the forward model and the message passing interface (MPI) approach is chosen to parallel the genetic algorithms by global sin-gle-population master-slave method (GPGAs). The proposed approach is applied to a sample system consisting of 28 sections, 84 protective relays and 40 circuit breakers. Simulation results show that the new model based on GPGAs can achieve very fast computation in online applications of large-scale power systems.

关键词： Forward and backward models Fault diagnosis Global single-population master-slave genetic algorithms (GPGAs) Parallel computation

Electrical Conductivity of Eclogite, Amphibolite and Garnet-Quartz-Mica Schist with Implications for the Conductivity in the Qiangtang Terrane of Northern Tibetan Plateau

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Journal of Earth Science 2020年第4期31卷 683-692页

作者： yi cao Xinzhuan Guo Jinxue Du State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China Key Laboratory for High-Temperature and High-Pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China

Understanding the electrical conductivity of high pressure metamorphic rocks is essential to constrain the compositions in the subduction zone and continental crust. In this study, we calculated the electrical conductivity for such rocks sampled from the central Qiangtang metamorphic belt in the northern Tibetan Plateau. The results reveal that, when aqueous fluids are absent, the conductivity of meta-mafic rocks(e.g., eclogite and amphibolite) is strikingly higher than that of meta-felsic rocks(e.g., garnet-quartz-mica schist). The conductivity of eclogite decreases due to the enrichment of amphibole, but this effect is diminished when a critical degree of amphibolization is reached. Our calculated conductivity of eclogite and amphibolite differs greatly from the experimentally derived results for the eclogites from other localities, partly owing to the strong effects of different mineral assemblages and chemical compositions on the conduction mechanisms and efficiencies. However, the disparity of conductivity between our calculated and the previously measured results for a similar amphibole-rich eclogite sampled from the same locality suggests that trails of highly conductive rutile-ilmenite aggregates may contribute to the higher bulk-rock conductivity in the laboratory measurements. Moreover, since the calculated conductivity of eclogite and amphibolite is not high enough at the temperatures relevant to their metamorphic thermal condition, partial melts or aqueous fluids originated from the upwelling asthenosphere are more likely to explain the anomalously high electrical conductivity zones in magnetotelluric images in the Qiangtang terrane in the northern Tibetan Plateau.

关键词： electrical conductivity eclogite amphibolite felsic schist high pressure metamorphic rock

Fatigue-resistant Hydrogels

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Chemical Research in Chinese Universities 2024年第1期40卷 64-77页

作者： LI Luofei LEI Hai cao yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China Department of Physics Zhejiang UniversityHangzhou 310027P.R.China

Hydrogels have been extensively studied for applications in various fields, such as tissue engineering and soft robotics, as determined by their mechanical properties. The mechanical design of hydrogels typically focuses on the modulus, toughness, and deformability. These characteristics play important roles and make great achievements for hydrogel use. In recent years, a growing body of research has concentrated on the fatigue property of hydrogels, which determines their resistance to crack propagation in the networks during cyclic mechanical loads for applications. However, knowledge of hydrogel fatigue behavior remains notably deficient. Here, we present a brief overview of the fatigue behavior of hydrogels, encompassing the general experimental methods to measure the fatigue property and fundamental theoretical calculation models. Then, we highlight multiple strategies to enhance the fatigue resistance of hydrogels. Finally, we present our perspectives on fatigue-resistant hydrogels, outstanding challenges and potential directions for future research.

关键词： Hydrogel Fatigue-resistant Fracture

Reactivity study and kinetic evaluation of CuO-based oxygen carriers modified by three different ores in chemical looping with oxygen uncoupling(CLOU)process

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Chinese Journal of Chemical Engineering 2021年第9期34卷 54-63页

作者： cao Kuang Shuzhong Wang ming Luo Jun Zhao Key Laboratory of Thermo-Fluid Science and Engineering of MOE School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China

In the chemical looping with oxygen uncoupling(CLOU)process,CuO is a promising material due to the high oxygen carrier capacity and exothermic reaction in fuel reactor but limited by the low melting *** combustion rate of carbon is faster than the decoupling rate of oxygen carrier(OC).Hence,high temperature tolerance and rapid oxygen release rate of CuO modified by three different ores were investigated in this *** kinetics analysis of oxygen decoupling with Cu-based oxygen carriers was also *** showed that CuO modified by chrysolite had faster oxygen release rate than that of *** showed obvious positive effect on the oxidization *** selected OCs could keep stable in at least 20 cycles,for about 1200 *** core model(SCM)fitted well for the decoupling process in the temperature range of 1123-1223 *** rate kinetic information may aid in the development of chemical looping with oxygen uncoupling(CLOU)technologies during reactor design and process *** doped copper oxide with chrysolite and limestone could improve the reactivity of CuO in decoupling and coupling process and also improve the high temperature tolerance.

关键词： Reaction kinetics Chemical looping with oxygen uncoupling(CLOU) Sintering Natural ore CO_(2)capture

Mechanistic target of rapamycin kinase(Mtor)is required for spermatogonial proliferation and differentiation in mice

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Asian Journal of Andrology 2020年第2期22卷 169-176页

作者： Jun cao Zuo-Bao Lin ming-Han Tong Yong-Lian Zhang yi-Ping Li Yu-Chuan Zhou State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyCAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Spermatogonial development is a vital prerequisite for spermatogenesis and male ***,the exact mechanisms underlying the behavior of spermatogonia,including spermatogonial stem cell(SSC)self-renewal and spermatogonial proliferation and differentiation,are not fully *** studies demonstrated that the mTOR complex 1(mTORC1)signaling pathway plays a crucial role in spermatogonial development,but whether MTOR itself was also involved in any specific process of spermatogonial development remained *** this study,we specifically deleted Mtor in male germ cells of mice using Stra8-Cre and assessed its effect on the function of *** Mtor knockout(KO)mice exhibited an age-dependent perturbation of testicular development and progressively lost germ cells and fertility with *** age-related phenotypes were likely caused by a delayed initiation of Mtor deletion driven by *** examination revealed a reduction of differentiating spermatogonia in Mtor KO mice,suggesting that spermatogonial differentiation was *** proliferation was also impaired in Mtor KO mice,leading to a diminished spermatogonial pool and total germ cell *** results show that MTOR plays a pivotal role in male fertility and is required for spermatogonial proliferation and differentiation.

关键词： male fertility mice Mtor spermatogenesis spermatogonia testis

TEMPO-Regulated Regio-and Stereoselective Cross-Dihalogenation with Dual Electrophilic X^(+) Reagents

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Chinese Journal of Chemistry 2021年第11期39卷 3004-3010页

作者： yi Kong Tongxiang cao Shifa Zhu Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhouGuangdong510640 China

A TEMPO catalyzed cross-dihalogenation reaction was established via redox-regulation of the otherwise complex system of dual electrophilic X+***,the ICl,BrCl,I_(2) and Br_(2) were generated in-situ,which enabled high regio-or stereoselective access to a myriad of iodochlorination,bromochlorination and homo-dihalogenation products with a wide spectrum of *** its mild conditions and operational simplicity,this method could enable wide applications in organic synthesis,which was exemplified by divergent synthesis of two *** mechanistic investigations via radical clock reaction,pinacol ring expansion and Hammett experiments were conducted,which confirmed the intermediacy of halonium *** addition,a dynamic catalytic model based on the versatile catalytic role of TEMPO was proposed to explain the selective outcomes.

关键词： Halogenation Organocatalysis Electrophilic addition Redox-regulation Alkynes

Prediction of the Charpy V-notch impact energy of low carbon steel using a shallow neural network and deep learning

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International Journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1309-1320页

作者： Si-wei Wu Jian Yang Guang-ming cao State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

The impact energy prediction model of low carbon steel was investigated based on industrial data. A three-layer neural network, extreme learning machine, and deep neural network were compared with different activation functions, structure parameters, and training functions. Bayesian optimization was used to determine the optimal hyper-parameters of the deep neural network. The model with the best performance was applied to investigate the importance of process parameter variables on the impact energy of low carbon steel. The results show that the deep neural network obtains better prediction results than those of a shallow neural network because of the multiple hidden layers improving the learning ability of the model. Among the models, the Bayesian optimization deep neural network achieves the highest correlation coefficient of 0.9536, the lowest mean absolute relative error of 0.0843, and the lowest root mean square error of 17.34 J for predicting the impact energy of low carbon steel. Among the variables, the main factors affecting the impact energy of low carbon steel with a final thickness of7.5 mm are the thickness of the original slab, the thickness of intermediate slab, and the rough rolling exit temperature from the specific hot rolling production line.

关键词： prediction shallow neural network deep neural network impact energy low carbon steel

Visual Object Tracking and Servoing Control of a Nano-Scale Quadrotor:System,Algorithms,and Experiments

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IEEE/CAA Journal of Automatica Sinica 2021年第2期8卷 344-360页

作者： Yuzhen Liu Ziyang Meng Yao Zou ming cao the Department of Precision Instrument Tsinghua UniversityBeijing 100084China the School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing 10083China the Institute of Engineering and Technology University of GroningenGroningen 9747AGThe Netherlands

There are two main trends in the development of unmanned aerial vehicle(UAV)technologies:miniaturization and intellectualization,in which realizing object tracking capabilities for a nano-scale UAV is one of the most challenging *** this paper,we present a visual object tracking and servoing control system utilizing a tailor-made 38 g nano-scale quadrotor.A lightweight visual module is integrated to enable object tracking capabilities,and a micro positioning deck is mounted to provide accurate pose *** order to be robust against object appearance variations,a novel object tracking algorithm,denoted by RMCTer,is proposed,which integrates a powerful short-term tracking module and an efficient long-term processing *** particular,the long-term processing module can provide additional object information and modify the short-term tracking model in a timely ***,a positionbased visual servoing control method is proposed for the quadrotor,where an adaptive tracking controller is designed by leveraging backstepping and adaptive *** and accurate object tracking is achieved even under *** results are presented to demonstrate the high accuracy and stability of the whole tracking system.

关键词： Nano-scale quadrotor nonlinear control positionbased visual servoing visual object tracking

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells and hepatocytes

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Frontiers of Medicine 2016年第2期10卷 204-211页

作者： Jiangnan Liu Bin yi Zhe Zhang yi cao Laboratory of Molecular and Experimental Pathology Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Kunming College of Life Science University of Chinese Academy of Sciences Kunming 650223 China

CD176 （Thomsen-Friedenreich antigen） is a tumor-associated carbohydrate epitope （glycotope） functionally involved in blood spread and fiver metastasis of cancer cells by mediating the adhesion of cancer cells to endothelial cells and hepatocytes, respectively. CD176 could be a promising target for antitumor immunotherapy. We applied B lymphocytes obtained from mice immunized with CD176 antigen and constructed a phage display library. A positive clone of CD176 single-chain variable antibody fragment （scFv） was successfully screened from this library. The CD176 scFv was expressed in Escherichia coli and purified. The purified scFv can bind to the natural CD176 expressed on the surface of cancer cells. Furthermore, the CD176 scFv inhibits the adhesion of CD176＋ cancer cells to endothelial cells and hepatocytes. This CD176 scFv provides a basis for future development of recombinant CD176-specific antibodies that can be used in therapeutic application.

关键词： CD 176 Thomsen-Friedenreich antigen scFv cancer therapy adhesion metastasis