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The Relationship between Intrahepatic Distribution of Hepatitis B Virus Core Antigen and Serum ALT, HBV DNA Levels and HBeAg Status

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国际感染病学（电子版） 2012年第2期1卷 84-90页

作者： Qing He Qi-yuan tang Xiao-hua Le De-liang Lv Xiang-mei Zhang Fei-jian Ao yi-min tang Shan Huang John Nunnari Gui-lin Yang Shenzhen Institute of Infectious Diseases Shenzhen Third People’s Hospital Shenzhen Hospital for Chronic Diseases Control and Prevention Department of Neurobiology University of Massachusetts Medical School

Objective The clinical significance of differential distribution of hepatitis B virus(HBV)nucleocapsid antigen in hepatocytes remains *** goal of this study is to determine the relationship between distinct HBV core antigen distribution pattern and alanine transaminase(ALT),liver histological inflammatory activity grades,serum HBeAg status and HBV DNA *** Total of 958 cases with chronic hepatitis B were recruited into this *** function tests,serum HBV DNA level,serological HBV markers and liver immunohistochemistry were examined according to the conventional *** Square tests were performed to analyze the differences among these *** It was found that 552(58%)cases were tested positive for HBV core antigen by immunohistochemical *** hepatitis B core antigen(HBcAg)expression correlated with ALT level and serum HBV DNA and liver inflammatory activity scores,however,nuclear HBcAg expression in hepatocytes was associated with normal ALT level,lower liver inflammatory activity score and higher serum HBV DNA level and rate of HBeAg *** nuclear and cytoplasmic HBcAg expression in hepatocytes associated with a middle ALT level and liver inflammatory activity score,higher rate of serum detectable HBeAg and a higher HBV DNA ***,undetectable core antigen was related to a lower ALT level and histological inflammatory activity grade,lower positive HBeAg rate and HBV DNA *** Undetectable liver HBcAg is associated with HBV clearance,ALT normalization and hepatitis B e antigen(HBeAg)seroconversion,and cytoplasmic HBcAg expression associated with higher hepatic inflammatory ***,nuclear HBcAg expression correlates with immune tolerance characterized with normal ALT and lower liver inflammatory activity,higher HBV replication level and higher rate of HBeAg positivity.

关键词： HBcAg distribution Immunohistochemistry HBV DNA Chronic hepatitis B HBeAg ALT

Quasispecies of Hepatitis B Virus

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国际感染病学（电子版） 2012年第4期1卷 177-182页

Hepatitis B virus(HBV) circulates in blood and replicates in the presence of quasispecies. During HBV replication, HBV DNA polymerase lacks fidelity and proofreading function partly because its exonuclease activity is either absent or deficient. Therefore, HBV genome is mutated with unusually high frequency. And these mutations can affect more than one open reading frame due to overlapping genes. Otherwise, natural substitutions, deletions or insertions involving the Cp/ENⅡ locus in the X gene can significantly alter the extent of viral replication activity. Particular selection pressures such as host immune system and antiviral therapy readily select out escape mutants from this pre-existing quasispecies pool. Antiviral drug resistance in chronic hepatitis B(CHB) can be caused by the viral mutation frequency, the intrinsic mutability of the antiviral target site, the selective pressure exerted by the drug, the magnitude and rate of virus replication, the overall replication fitness of the mutant, the genetic barrier of the compound and the availability of replication space. Potent inhibition of HBV replication could be able to prevent the development of drug resistance because mutagenesis is replication dependent. Viral load may decline to a point where the continued production of quasispecies with the potential to resist new drug treatments no longer occurs, if viral replication can be suppressed for a sufficient length of time.

关键词： Quasispecies Hepatitis B virus Mutation

The Major Problems and Research Ideas of Diaphragm Spring Clutch in Economical Automobile

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机电工程技术 2008年第11期37卷 33-35,44页

作者： LV Jun-cheng MO yi-min tang Chun-qiu Wuhan University of Technology Wuhan430070 China

Through failure investigation and statistical analysis of economical automobile diaphragm spring clutch,educing the major problems of economical automobile diaphragm spring clutch,and also offering a detailed study of... 详细信息

关键词：膜片弹簧离合器汽车行业汽车设计

紫外诱变驯化提高酿酒酵母木糖发酵的抑制物耐受性

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生物技术通报 2017年第9期33卷 191-199页

作者：张译之苟敏汤岳琴四川大学建筑与环境学院成都610065

利用驯化和紫外处理结合驯化的手段对一株木糖发酵工业菌株的抑制物耐受性进行提升。在反复批次培养过程中不断提高含9种抑制物的混合抑制物浓度,使细胞的生长和发酵逐渐适应高浓度抑制物环境,分离突变菌株并进行评价。紫外处理结合驯... 详细信息

利用驯化和紫外处理结合驯化的手段对一株木糖发酵工业菌株的抑制物耐受性进行提升。在反复批次培养过程中不断提高含9种抑制物的混合抑制物浓度,使细胞的生长和发酵逐渐适应高浓度抑制物环境,分离突变菌株并进行评价。紫外处理结合驯化比直接驯化能更有效的提升细胞对高浓度抑制物的耐受能力;通过突变菌株分离和筛选,获得3株抑制物耐受能力高于出发菌株的突变菌株,它们在抑制物浓度100%MI(甲酸1 g/L,乙酸3.5 g/L,乙酰丙酸1.5 g/L,糠醛1.5 g/L,5-羟甲基糠醛1.5g/L,丁香醛0.1 g/L,香草醛0.1 g/L,松柏醛0.025 g/L,肉桂酸0.025 g/L)条件下的木糖消耗率比出发菌株高出11.3%-23.2%。紫外诱变处理结合驯化过程可以有效提高酿酒酵母对混合抑制物的耐受性。

关键词：酿酒酵母抑制物耐受燃料乙醇木糖利用

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

yi-Qi-Zeng-min-tang,a Chinese medicine,ameliorates insulin resistance in type 2 diabetic rats

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World Journal of Gastroenterology 2011年第8期17卷 987-995页

作者： Zeng Zhang Hong-Li Xue yi Liu Wen-Jian Wang Institute of Chinese Integrative Medicine Huashan Hospital Fudan University Shanghai 200040 China Institute of Chinese Integrative Medicine Huashan Hospital Fudan University Shanghai 200040 China Institute of Integrated Clinical Medicine Shanghai Academy of Traditional Chinese Medicine YueyangIntegrative Medicine Hospital Shanghai Traditional ChineseMedicine University Shanghai 200437 China

AIM:To investigate the effects of the Chinese herbal decoction,yi-Qi-Zeng-min-tang(YQZMT),on insulin resistance in type 2 diabetic ***:Sprague-Dawley rats were divided into two dietary regiments by feeding either normal pellet diet(NPD) or high fat diet(HFD).Four weeks later,the HFD-fed rats were injected intraperitoneally with lowdose streptozotocin(STZ).Rats with non-fasting blood glucose level ≥ 16.67 mmol/L were considered type 2 diabetic and further divided into five subgroups:the type 2 diabetes model group,low-dose,medium-doseand high-dose YQZMT groups,and rosiglitazone ***-matched NPD-fed rats served as *** or rosiglitazone were administered for 8 *** glucose and insulin tolerance tests were performed before and after the treatment to measure the glucose tolerance and insulin *** levels of biochemical parameters,adipocytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),as well as free fatty acids(FFAs),were also ***:There was significant elevation of insulin resistance and serum levels of fasting glucose(12.82 ± 1.08 mmol/L vs 3.60 ± 0.31 mmol/L,P < 0.01),insulin(7197.36 ± 253.89 pg/mL vs 4820.49 ± 326.89 pg/mL,P < 0.01),total cholesterol(TC)(8.40 ± 0.49 mmol/L vs 2.14 ± 0.06 mmol/L,P < 0.01),triglyceride(2.24 ± 0.12 mmol/L vs 0.78 ± 0.05 mmol/L,P < 0.01),low-density lipoprotein cholesterol(LDL-c)(7.84 ± 0.51 mmol/L vs 0.72 ± 0.04 mmol/L,P < 0.01) and decrease in high-density lipoprotein cholesterol(HDL-c)(0.57 ± 0.03 mmol/L vs 1.27 ± 0.03 mmol/L,P < 0.01) in the low-dose STZ and high-fat diet induced type 2 diabetic group when compared with the control *** of YQZMT induced dose-and timedependent changes in insulin resistance,glucose and lipid profile,and reduced levels of FFA,TNF-α and IL-6 in the type 2 diabetic *** the treatment,compared with the diabetic group,the insulin resistance was ameliorated in the high-dose YQZMT(2.82 g/100 g per day) group

关键词： yi-Qi-Zeng-min-tang Insulin resistance Type 2 diabetes Lipids Adipocytokines Free fatty acids

经皮椎间孔镜技术治疗腰椎管狭窄症的早期临床疗效分析

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中国矫形外科杂志 2016年第19期24卷 1745-1748页

作者：赵一民汤玮王振东胡彦彬赵强丁晓琳山东省日照市第二人民医院骨科 276800 泰山医学院附属医院骨科山东省泰安市271000

[目的]探讨经皮椎间孔镜技术治疗腰椎管狭窄症的早期临床疗效及手术技巧。[方法]收集本院2014年11月～2015年9月收治的腰椎管狭窄症患者35例,均为单侧侧隐窝狭窄,均行症状侧侧方椎间孔入路,L4、5节段24例,L5S1节段11例。平均病程23.9个... 详细信息

[目的]探讨经皮椎间孔镜技术治疗腰椎管狭窄症的早期临床疗效及手术技巧。[方法]收集本院2014年11月～2015年9月收治的腰椎管狭窄症患者35例,均为单侧侧隐窝狭窄,均行症状侧侧方椎间孔入路,L4、5节段24例,L5S1节段11例。平均病程23.9个月,平均随访时间6.5个月。分别于术前及术后1 d、3个月和末次随访时行视觉疼痛模拟评分（visual analogue scale,VAS）、Oswestry功能障碍指数（Oswestry disability index,ODI）和改良Mac Nab疗效评定标准对临床疗效进行分析评估,对患者术前和末次随访时X线片、CT和MRI影像学资料进行对比分析。并统计手术时间、术中出血量、术后并发症、住院时间等临床资料。[结果]腰痛VAS评分从术前（7.21±0.22）降至术后1 d、3个月、末次随访时的（1.97±0.19）分、（1.35±0.24）分、（1.13±0.25）分;腿痛VAS评分从术前（8.54±0.22）分降至术后1 d、3个月、末次随访时的（2.08±0.28）分、（1.11±0.16）分、（1.06±0.33）分,较术前均有明显改善;ODI评分分别从术前（75.89±2.61）分降至（23.22±3.09）分、（15.17±1.42）分、（13.85±1.26）分。末次随访时,依据改良的Mac Nab标准评估,优良率达91.4%。[结论]经皮椎间孔镜技术在早期可有效治疗腰椎管狭窄症,使神经根在侧隐窝处得到及时彻底减压及松解,临床效果显著。

关键词：腰椎管狭窄症侧隐窝经皮椎间孔镜椎间孔入路

Modeling and Prediction of Fatigue Properties of Additively Manufactured Metals

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Acta Mechanica Solida Sinica 2023年第2期36卷 181-213页

作者： Wei tang Ziming tang Wenjun Lu Shuai Wang min yi State Key Lab of Mechanics and Control of Mechanical Structures&Institute for Frontier Science&Key Lab for Intelligent Nano Materials and Devices of ministry of Education&College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics(NUAA)Nanjing 210016China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China

Additive manufacturing(AM)has emerged as an advanced technique for the fabrication of complex near-net shaped and lightweight metallic parts with acceptable mechanical *** strength of AM metals has been confirmed comparable or even superior to that of metals manufactured by conventional processes,but the fatigue performance is still a knotty issue that may hinder the substitution of currently used metallic components by AM counterparts when the cyclic loading and thus fatigue failure *** essential complements to high-cost and time-consuming experimental fatigue tests of AM metals,models for fatigue performance prediction are highly *** this review,different models for predicting the fatigue properties of AM metals are summarized in terms of fatigue life,fatigue limit and fatigue crack growth,with a focus on the incorporation of AM characteristics such as AM defect and processing parameters into the *** predicting the fatigue life of AM metals,empirical models and theoretical models(including local characteristic model,continuum damage mechanics model and probabilistic method)are *** terms of fatigue limit,the introduced models involve the Kitagawa–Takahashi model,the Murakami model,the El-Haddad model,*** modeling the fatigue crack growth of AM metals,the summarized methodologies include the Paris equation,the Hartman-Schijve equation,the NASGRO equation,the small-crack growth model,and numerical *** of these models for AM metals are similar to those for conventionally processed materials,but are modified and pay more attention to the AM ***,an outlook for possible directions of the modeling and prediction of fatigue properties of AM metals is provided.

关键词： Additive manufacturing Fatigue properties Metals Modeling and prediction Microstructure

Theoretical study on magnetocaloric effect and its electric-field regulation in CrI_(3)/metal heterostructure

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 134-141页

作者： Weiwei He Ziming tang Qihua Gong min yi Wanlin Guo State Key Laboratory of Mechanics and Control for Aerospace Structures Key Laboratory for Intelligent Nano Materials and Devices of Ministry of EducationInstitute for Frontier ScienceNanjing University of Aeronautics and AstronauticsNanjing 210016China MIIT Key Laboratory of Aerospace Information Materials and Physics College of PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China

The extraordinary properties of a heterostructure by stacking atom-thick van der Waals(vdW)magnets have been extensively ***,the magnetocaloric effect(MCE)of heterostructures that are based on monolayer magnets remains to be ***,we deliberate MCE of vd W heterostructure composed of a monolayer CrI_(3)and metal atomic layers(Ag,Hf,Au,and Pb).It is revealed that heterostructure engineering by introducing metal substrate can improve MCE of CrI_(3),particularly boosting relative cooling power to 471.72μJ m^(-2)and adiabatic temperature change to 2.1 K at 5 T for CrI_(3)/*** improved MCE is ascribed to the enhancement of magnetic moment and intralayer exchange coupling in CrI_(3)due to the CrI_(3)/metal heterointerface induced charge *** field is further found to tune MCE of CrI_(3)in heterostructures and could shift the peak temperature by around 10 K in CrI_(3)/Hf,thus manipulating the working temperature window of *** theoretical results could enrich the research on low-dimensional magnetocaloric materials.

关键词： magnetocaloric effect heterostructure metal substrate

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