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Neural Regeneration Research 2012年第10期7卷 761-765页

作者： Weihui Huang Dawei Zang yi lu Ping jiang Department of Neurology Tianjin First Center Hospital Tianjin Medical University Tianjin 300192 China

This study aimed to investigate the number of amino methyl isoxazole propionic acid （AMPA） receptors and production of endogenous neural stem cells in the SOD1 G93AG1H transgenic mouse model of amyotrophic lateral sclerosis, at postnatal day 60 following administration of basic fibroblast growth factor （FGF-2）. A radioligand binding assay and immunohistochemistry were used to estimate the number of AMPA receptors and endogenous neural stem cells respectively. Results showed that the number of AMPA receptors and endogenous neural stem cells in the brain stem and sensorimotor cortex were significantly increased, while motor function was significantly decreased at postnatal days 90 and 120. After administration of FGF-2 into mice, numbers of endogenous neural stem cells increased, while expression of AMPA receptors decreased, whilst motor functions were recovered. At postnatal day 120, the number of AMPA receptors was negatively correlated with the number of endogenous neural stem cells in model mice and FGF-2-treated mice. Our experimental findings indicate that FGF-2 can inhibit AMPA receptors and increase the number of endogenous neural stem cells, thus repairing neural injury in amyotrophic lateral sclerosis mice.

关键词： amino methyl isoxazole propionic acid receptor amyotrophic lateral sclerosis basic fibroblast growth factor endogenous neural stem cells

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Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane

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World Journal of Gastroenterology 2017年第29期23卷 5333-5344页

作者： Xiao-Feng Yan Pei Zhao Dong-Yan Ma yi-lu jiang Jiao-Jiao luo Liu Liu Xiao-Ling Wang Department of Biology School of Basic Medical Science Shanghai University of Traditional Chinese Medicine Women and Infant Hospital of Zhengzhou Shanghai University of Traditional Chinese Medicine

AIM To investigate the capability of salvianolic acid B(Sal B) to protect hepatocytes from hydrogen peroxide(H_2O_2)/carbon tetrachloride(CCl_4)-induced lysosomal membrane permeabilization. METHODS Cell Counting Kit-8 assay was used to measure cell viability. Apoptosis and death were assayed through flow cytometry. Brd U incorporation was used to detect cell proliferation. Serum alanine aminotransferase activity and liver malondialdehyde(MDA) content were measured. Liver histopathological changes were evaluated using hematoxylin-eosin staining. Lysosomal membrane permeability was detected with Lyso Tracker Green-labeled probes and acridine orange staining. The levels of protein carbonyl content(PCC), cathepsins(Cat)B/D, and lysosome-associated membrane protein 1(LAMP1) were evaluated through western blotting. Cytosol Cat B activity analysis was performed with chemiluminescence detection. The m RNA level ofLAMP1 was evaluated through quantitative real-time polymerase chain reaction. RESULTS Results indicated that H_2O_2 induced cell injury/death. Sal B attenuated H_2O_2-induced cell apoptosis and death, restored the inhibition of proliferation, decreased the amount of PCC, and stabilized the lysosome membrane by increasing the LAMP1 protein level and antagonizing Cat B/D leakage into the cytosol. CCl_4 also triggered hepatocyte death. Furthermore, Sal B effectively rescued hepatocytes by increasing LAMP1 expression and by reducing lysosomal enzyme translocation to the *** Sal B protected mouse embryonic hepatocytes from H_2O_2/CCl_4-induced injury/death by stabilizing the lysosomal membrane.

关键词： Lysosomal membrane permeabilization Injury Salvianolic acid B Hepatocyte

Hybrid Block Diagonalization Precoding for Multi-User Weighted Sum-Rate Maximization

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China Communications 2024年第8期21卷 127-141页

作者： Su Xiaofeng jiang yi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Department of Communication Science and EngineeringFudan UniversityShanghai 200433China

This paper studies large-scale multi-input multi-output(MIMO)orthogonal frequency division multiplexing(OFDM)communications in a broadband frequency-selective channel,where a massive MIMO base station(BS)communicates with multiple users equipped with *** develop a hybrid precoding design to maximize the weighted sum-rate(WSR)of the users by optimizing the digital and the analog precoders *** the digital part,we employ block-diagonalization to eliminate inter-user interference and apply water-filling power allocation to maximize the *** the analog part,the optimization of the PSN is formulated as an unconstrained problem,which can be efficiently solved by a gradient descent *** results show that the proposed block-diagonal hybrid precoding algorithm can outperform the existing works.

关键词： block-diagonal gradient descent hybrid precoding iterative optimization MIMO-OFDM multi-user water-filling power allocation weighted sum-rate maximization

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Dynamic Crosslinked Phosphorescent Poly(vinyl alcohol)-Terpyridine Films with Enhanced Mechanical Properties and Tunable Shape Memory

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Chinese Journal of Polymer Science 2024年第10期42卷 1595-1601,I0015页

作者： Meng Wei Wei-Hao Feng Chen Yu Zhen-yi jiang Guang-Qiang yin Wei lu Tao Chen Key Laboratory of Advanced Marine Materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing100049China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo315211China

Achieving versatile room temperature phosphorescence(RTP)materials,especially with tunable mechanical properties and shape memory is attractive and essential but rarely ***,a strategy was reported to realize multi-functional RTP films with multicolor fluorescence,ultralong afterglow,adjustable mechanical properties,and shape memory through the synergistic dynamic interaction of lanthanide(Ln~Ⅲ)-terpyridine coordination,borate ester bonds,and hydrogen bondings in a poly(vinyl alcohol)(PVA)*** varying the amount of borax,the mechanical properties of the films could be finely controlled due to the change of crosslinking degree of dynamic borate ester bonds in *** assembly and disassembly of borate ester bonds upon the trigger of borax and acid were applied as reversible linkage to achieve programmable shape memory *** addition,the films displayed both fascinating multicolor fluorescence and ultralong afterglow characteristics due to the presence of Ln III doping and confinement of terpyridine in *** study provides a new avenue to impart modulable mechanical strength and shape memory to RTP materials.

关键词： Room temperature phosphorescence materials Dynamic bonds Multicolor fluorescent Tunable mechanical properties Shape memory

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Single-source-precursor synthesis and air-plasma ablation behavior of(Ti,Zr,Hf)C/SiC ceramic nanocomposites at 2200℃

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Journal of Advanced Ceramics 2024年第7期13卷 1043-1059页

作者： Li lu Qingbo Wen Jinrun Hu Tianxing jiang Xiangchao Ren Yalei Wang yi Zeng Xiang Xiong State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

Dense monolithic(Ti,Zr,Hf)C/SiC ceramic nanocomposites with four different molar ratios of metallic elements in the(Ti,Zr,Hf)C phase(i.e.,Ti:Zr:Hf=1:1:1,2:3:5,2:3:3,and 1:2:1)were prepared upon pyrolysis of novel(Ti,Zr,Hf)-containing single-source precursors(SSPs),followed by spark plasma sintering(SPS).A thorough characterization was conducted to elucidate the synthesis of the SSPs,polymer-to-ceramic transformation,chemical/phase compositions,and microstructure of the SiTiZrHfC-based *** results revealed the feasibility of synthesizing nanocomposites with high(Ti,Zr,Hf)C contents using the SSP *** nanocomposites were characterized by a unique microstructure with in situ generated(Ti,Zr,Hf)C@C core-shell nanoparticles homogeneously mixed withβ-*** ablation behavior of the nanocomposites was evaluated on an air-plasma device for 60 ***,the nanocomposites exhibited excellent ablation resistance,and the lowest linear ablation rate reached−0.58μm/s at 2200°***,the ablation resistance can be dramatically improved by precisely tailoring the atomic ratios of metal elements within the(Ti,Zr,Hf)C phase via the molecular design of the *** formation of a multiple-oxide layer with both a high-meltingpoint phase((Ti,Zr,Hf)O_(2))and low-melting-point phases((Zr,Hf)TiO_(4))and glassy SiO_(2),as well as their structure,played a critical role in the enhanced ablation *** uniform distribution of the high-melting-point(Ti,Zr,Hf)O_(2)nano/microparticles throughout the glassy SiO_(2)matrix significantly enhanced the viscosity and stability of the oxide layer by the pinning effect,offering superior protection against the ingress of oxygen atoms and excellent resistance to mechanical erosion.

关键词： ultrahigh-temperature ceramics(UHTCs) multicomponent carbide nanocomposites ablation behavior multiple oxides

Pollution characteristics and quantitative source apportionment of heavy metals within a zinc smelting site by GIS-based PMF and APCS-MLR models

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Journal of Environmental Sciences 2024年第10期144卷 100-112页

作者： Huagang Lv Zhihuang lu Guangxuan Fu Sifang Lv Jun jiang yi Xie Xinghua luo Jiaqing Zeng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Zhuzhou Qingshuitang Technology Co. Ltd.Zhuzhou 412000China New World Environment Protection Group of Hunan Changsha 410083China

The abandoned smelters present a substantial pollution threat to the nearby soil and *** this study,63 surface soil samples were collected from a zinc smelter to quantitatively describe the pollution characteristics,ecological risks,and source apportionment of heavy metal(loid)s(HMs).The results revealed that the average contents of Zn,Cd,Pb,As,and Hg were 0.4,12.2,3.3,5.3,and 12.7 times higher than the risk screening values of the construction sites,***,the smelter was accumulated heavily with Cd and Hg,and the contribution of Cd(0.38)and Hg(0.53)to ecological risk was 91.58%.ZZ3 and ZZ7 were the most polluted workshops,accounting for 25.7%and 35.0%of the pollution load and ecological risk,*** influence of soil parent materials on pollution was minor compared to various workshops within the *** with PMF,APCS-MLR and GIS analysis,four sources of HMs were identified:P1(25.5%)and A3(18.4%)were atmospheric deposition from the electric defogging workshop and surface runoff from the smelter;P2(32.7%)and A2(20.9%)were surface runoff of As-Pb foul acid;P3(14.5%)and A4(49.8%)were atmospheric deposition from the leach slag drying workshop;P4(27.3%)and A1(10.8%)were the smelting process of zinc *** paper described the distribution characteristics and specific sources of HMs in different process workshops,providing a new perspective for the precise remediation of the smelter by determining the priority control factors.

关键词： Smelter site Heavy metal(loid)s Source apportionment Positive matrix factorization Absolute principal component score-multiple linear regression

Comparative analysis of DNA-SIP and magnetic-nanoparticle mediated isolation (MMI) on unraveling dimethoate degraders

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 59-69页

作者： luning Lian yi Xing Dayi Zhang Longfei jiang Mengke Song Bo jiang School of Energy and Environmental Engineering University of Science&Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science&Technology BeijingBeijing 100083China National Environmental and Energy Science and Technology International Cooperation Base University of Science&Technology BeijingBeijing 100083China College of New Energy and Environment Jilin UniversityChangchun 130021China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China National Engineering Laboratory for Site Remediation Technologies Beijing 100015China

Microorganisms are crucial in the bioremediation of organophosphorus pesticides. However, most functional microorganisms (> 99%) are yet to be cultivated. This study applied two cultivation-independent approaches, DNA-SIP and magnetic-nanoparticle mediated isolation (MMI), to identify the functional microorganisms in degrading dimethoate in agricultural soils. MMI identified five dimethoate degraders: Pseudomonas, Bacillus, Ramlibacter, Arthrobacter, and Rhodococcus, whereas DNA-SIP identified three dimethoate degraders: Ramlibacter, Arthrobacter, and Rhodococcus. Also, MMI showed higher resolution than DNA-SIP in identifying functional microorganisms. Two organic phosphohydrolase (OPH) genes: ophC2 and ophB, were involved in dimethoate metabolism, as revealed by DNA-SIP and MMI. The degradation products of dimethoate include omethoate, O,O,S-trimethyl thiophosphorothioate, N-methyl-2-sulfanylacetamide, O,O-diethyl S-hydrogen phosphorodithioate, O,O,O-trimethyl thiophosphate, O,O,S-trimethyl thiophosphorodithioate, and O,O,O-trimethyl phosphoric. This study emphasizes the feasibility of using SIP and MMI to explore the functional dimethoate degraders, expanding our knowledge of microbial resources with cultivation-independent approaches.

关键词： Stable isotope probing(SIP) Magnetic-nanoparticle mediated isolation(MMI) Dimethoate Biodegradation Cultivation-independent approach

Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

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Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian jiang Xiujuan LEI yi PAN Chunyan JI Wei jiang College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

A state-of-the-art review of the development of self-healing concrete for resilient infrastructure

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 151-169页

作者： Dong lu Xi jiang Yao ZHANG Shaowei ZHANG Guoyang lu Zhen LENG Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Laboratory of Fire Safety School of Safety Engineering and Emergency ManagementShijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The brittleness of cement composites makes cracks almost inevitable,producing a serious limitation on the lifespan,resilience,and safety of concrete *** address this brittleness,self-healing concrete has been developed for regaining its mechanical and durability properties after becoming cracked,thereby promising sustainable development of concrete *** paper provides a comprehensive review of the latest developments in self-healing *** begins by summarizing the methods used to evaluate the self-healing efficiency of ***,it compares strategies for achieving healing *** then discusses the typical approaches for developing self-healing ***,critical insights are proposed to guide future studies on the development of novel self-healing *** review will be useful for researchers and practitioners interested in the field of self-healing concrete and its potential to improve the durability,resilience,and safety of concrete infrastructure.

关键词： resilient infrastructure sustainable concrete self-healing cracks

Association between Serum Ferritin Levels and Metabolic-associated Fatty Liver Disease in Adults:a Cross-sectional Study Based on the NHANES

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Current Medical Science 2024年第3期44卷 494-502页

作者： jiang-hui LI Xue-yao MA Yun yi lu-rao LI Zhi-yong XU ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective Ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic *** study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of *** A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 *** steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive *** regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver *** The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),Plusion Our study revealed that elevated serum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in *** serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey