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An immunological storm for cancer therapy: 2018 Nobel Prize in Physiology or Medicine

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Science Bulletin 2018年第24期63卷 1608-1610页

作者： Si-Yang Liu yi-long wu Guangdong General Hospital School of MedicineSouth China University of Technology

Immunotherapy with checkpoint inhibitors (CPIs)is a new approach to cancer therapy that harnesses and enhances the innate abilities of the immune system to recognize and fight *** has become a breakthrough in the history of cancer treatment and is of epoch-making significance [1 ]. In the past century,Nobel Prize has been awarded to the advances in immunology for 15 *** year,it won for the 16th *** *** from the University of Texas MD Anderson Cancer Center and Japanese immunologist Tasuku Honjo were awarded the 2018 Nobel Prize in Physiology or Medicine,for their great contributions to the discovery of the CTLA-4 and PD-1 and the development of promising cancer therapy by inhibition of negative immune *** research shows how different strategies to inhibit the brakes on the immune system can be used in the treatment of cancer,which became a landmark in the history of cancer therapy.

关键词： Immunotherapy checkpoint inhibitors cancer

Combined gastroscopic and laparoscopic resection of gastric metastatic adenosquamous carcinoma from lung: A case report

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 3065-3073页

作者： yin Lin yi-long wu Dong-Dong Zou Xiao-long Luo Shi-Yan Zhang Department of Gastroenterology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Proctology Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

BACKGROUND Primary lung cancer is the leading cause of cancer-related death *** metastatic sites include the brain,liver,bones,and adrenal ***,gastric metastases from lung cancer are *** case may be the first report of a combined gastroscopic and laparoscopic resection for gastric metasta-tic adenosquamous carcinoma(ASC).CASE SUMMARY We report a case of gastric metastasis from lung *** patient was a 61-year-old Han Chinese female who first attended our hospital complaining of a per-sistent cough,leading to the diagnosis of advanced-stage lung *** more than four years of chemotherapy,the patient began to experience epi-gastric *** was performed,and pathological examination of biopsy specimens confirmed that the gastric lesion was a metastasis from lung *** lesion was successfully resected by combined gastroscopy and *** examination of the resected gastric specimen revealed *** Gastric metastases from lung cancer are ***,histological and immunohistochemical staining are useful for diagnosing metastatic *** management may provide extended survival in appropriately selected patients.

关键词： Primary lung cancer Gastric metastasis Endoscopic submucosal dissection Laparoscopic surgery Adenosquamous carcinoma Case report

Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1148-1154页

作者： yi-long wu Wei-Jie Ou Ming Zhong Su Lin Yue-Yong Zhu Endoscopy Center the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Hepatol-ogy Hepatology Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Endocri-nology Department Metabolic Diseases Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Fujian Diabetes Research Institute the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Clinical Research Center for Liver and Intestinal Diseases of Fujian Province FuzhouFujianChina

Background and Aims:Acute liver failure(ALF)is as-sociated with high *** D(GSDMD)is the executioner of pyroptosis and is involved in the patho-physiology of immune dysregulation This study investi-gated the role of the GSDMD inhibitor necrosulfonamide(NSA)in ***:An ALF model was established by lipopolysaccharide/D-galactosamine challenge in C57BL/6J *** were divided into four groups:normal controls(control group),ALF group(ALF group),dimethyl sulfoxide group(DMSO group),and NSA intervention group(NSA group).Survival was monitored,liver damage was de-termined by hematoxylin and eosin staining,and serum alanine aminotransferase(ALT).Underlying mechanisms were explored by quantitative real-time PCR,western blot-ting,and enzyme-linked immunosorbent ***:Pyroptosis was activated in ALF model *** treat-ed with GSDMD inhibitor NSA developed less severe liver *** reduced the expression of GSDMD,NLRP3,cleaved caspase-1,cleaved caspase-11,and secretion of interleukin-1 beta in ALF mice ***:Py-roptosis was activated in *** alleviated ALF via the pyroptosis pathway.

关键词： Liver failure Acute Pyroptosis GSDMD GSDMD-NT Necrosul-fonamide

Nedaplatin/Gemcitabine Versus Carboplatin/Gemcitabine in Treatment of Advanced Non-small Cell Lung Cancer: A Randomized Clinical Trial

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Chinese Journal of Cancer Research 2012年第2期24卷 97-102页

作者： Jin-ji Yang Qing Zhou Ri-qiang Liao yi-sheng Huang Chong-rui Xu Zhen Wang Bin-chao Wang Hua-jun Chen yi-long wu Division of Pulmonary Oncology Guangdong Lung Cancer InstituteCancer CenterGuangdong General Hospital&Guangdong Academy of Medical SciencesGuangzhou 510080China

Objective： To evaluate the efficacy and safety of nedaplatin/gemcitabine （NG） and carboplatin/gemcitabine （CG） in the management of untreated advanced non-small cell lung cancer （NSCLC）. Methods： Sixty-two patients with previously untreated advanced NSCLC were recruited between June 2006 and November 2007. Subjects were randomly assigned to the NG arm （n=30） and the CG arm （n=32）. Only patients （24 and 25 in the NG and CG arms, respectively） who completed 〉2 chemotherapy cycles were included in the data analysis. The primary outcome measure was the objective response rate （ORR）. The secondary outcome measures included progression-free survival （PFS）, overall survival （OS） and adverse events. Results： There were no statistically significant differences in the efficacy measures （ORR, P=0.305; median PFS, P=0.298, median OS, P=0.961） or in the major adverse events （grade 3/4 neutropenia, P=0.666; grade 3/4 anemia, P=0.263; grade 3/4 thrombocytopenia, P=0.222） between the two treatment arms. However, there was a trend towards higher ORR （37.5% vs. 24.0%）, longer PFS （6.0 vs. 5.0 months）, and less adverse events in the NG arm. Conclusion： NG regimen seems to be superior over CG regimen for advance NSCLS, but further investigation is needed to validate this superiority.

关键词： Non-small cell lung cancer Chemotherapy Nedaplatin Carboplatin Gemcitabine Squamous cell carcinoma

Establishment and application of a multiplex genetic mutation-detection method of lung cancer based on MassARRAY platform

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Cancer Biology & Medicine 2016年第1期13卷 68-76页

作者： Hong-Xia Tian Xu-Chao Zhang Zhen Wang Jian-Guang Chen Shi-Liang Chen Wei-Bang Guo yi-long wu Medical Research Center Guangdong Lung Cancer Institute Guangdong General Hospital Guangdong Academy of Medical Sciences

Objective: This study aims to establish a method for highly parallel multiplexed detection of genetic mutations in Chinese lung cancer samples through Agena i PLEX chemistry and matrix-assisted laser desorption ionization time-of-flight analysis on Mass ARRAY mass spectrometry ***: We reviewed the related literature and data on lung cancer treatments. We also identified 99 mutation hot spots in 13 target genes closely related to the pathogenesis, drug resistance, and metastasis of lung cancer. A total of 297 primers, composed of99 paired forward and reverse amplification primers and 99 matched extension primers, were designed using Assay Design software. The detection method was established by analyzing eight cell lines and six lung cancer specimens. The proposed method was then validated through comparisons by using a Lung Carta^(TM) kit. The sensitivity and specificity of the proposed method were evaluated by directly sequencing EGFR and KRAS genes in 100 lung cancer ***: The proposed method was able to detect multiplex genetic mutations in lung cancer cell lines. This finding was consistent with the observations on previously reported mutations. The proposed method can also detect such mutations in clinical lung cancer specimens. This result was consistent with the observations with Lung Carta^(TM) kit. However, an FGFR2 mutation was detected only through the proposed method. The measured sensitivity and specificity were 100% and 96.3%, ***: The proposed Mass ARRAY technology-based multiplex method can detect genetic mutations in Chinese lung cancer patients. Therefore, the proposed method can be applied to detect mutations in other cancer tissues.

关键词： Lung neoplasms driver genes mutation multigene testing MassARRAY

Single nucleotide polymorphisms of MAGE-A3 gene and its clinical implications in Chinese patients with non-small cell lung cancer(NSCLC)

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Chinese Journal of Cancer Research 2015年第3期27卷 301-308页

作者： Xue-Ning Yang Ling Huang Yu Chen She-Juan An Xu-Chao Zhang Ri-Qiang Liao Jian Su yi-long wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong General Hospital& Guangdong Academy of Medical Sciences

Background： Available study revealed advanced tumors have a higher expression rate of MAGE-A3 gene which has a lot of single nucleotide polymorphism（SNP） loci with polymorphisms. This study aimed to analyze the allele frequency of SNP loci in MAGE-A3 gene and investigate the relationship between MAGE-A3 gene polymorphisms and clinical ***： Tumor samples of a cohort of 191 NSCLC patients were collected. EGFR m RNA expression were detected by q RT-PCR. SNPs in whole length of MAGE-A3 gene were detected by direct sequencing. Frequencies of the SNPs were correlated to gene expression, mutation status of EGFR and clinical ***： Sequencing analysis confirmed that allele frequencies of genotypes on SNP loci rs5970360, rs5925210, rs5970361, rs5925211 and rs35123853 were CC（0.681）/CT（0.319）, CC（0.660）/CG（0.340）, CC（0.681）/CA（0.319）, AA（0.984）/AT（0.016） and GG（1.000）/GA（0.000）, respectively, which were different from the frequencies and genotypes of MAGE-A3 in SNP database. Chi-square tests showed the EGFR mR NA expression level had significant correlation with the genotypes of SNP loci rs5970360 and rs5925210. But all frequencies of each MAGE-A3 SNPs were not found significantly different between EGFR mutant and wild type patients. MAGE-A3 gene polymorphisms had no significant effects on survival of NSCLC ***： Chinese patients with NSCLC had different SNP patterns of MAGE-A3 in comparison with those in international SNP database. These MAGE-A3 SNP loci might have not prognostic significance. MAGE-A3 SNP loci rs5970360 and rs5925210 might be predictive for EGFR m RNA expression levels and helpful to the selection of patients for epidermal growth factor receptor（EGFR） targeted immunotherapy.

关键词： MAGE-A3 epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) single nucleotide polymorphism (SNP)

Genomic Evolution of Lung Cancer Metastasis:Current Status and Perspectives

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Cancer Communications 2021年第12期41卷 1252-1256页

作者： Wen-Fang Tang Rui Fu yi Liang Jie-Shan Lin Zhen-Bin Qiu yi-long wu Wen-Zhao Zhong Department of Cardiothoracic Surgery Zhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital&Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080P.R.China Department of Nephrology Blood Purification CenterZhongshan City People’s HospitalZhongshanGuangdong 528403P.R.China Southern Medical University GuangzhouGuangdong 510515P.R.China

INTRODUCTION Lung cancer is one of the cancers with the highest morbidity and mortality *** the two past decades,although the treatment of non-small cell lung cancer(NSCLC)has been revolutionized by the use of tyrosine kinase inhibitor(TKI)and immune treatments,metastatic disease remains largely incurable and presents a 5-year survival rate of approximately 10%[1].

关键词： Lung mortality lung

Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer

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四川生理科学杂志 2021年第1期43卷 158-158页

作者： yi-long wu From the Guangdong Lung Cancer Institute Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences Guangzhou (Y.-L.W.) the Thoracic Surgery Department National Cancer Center–National Clinical Research Center for Cancer–Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing (J.H.) and the Lung Cancer Center Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai (S.L.) — all in China the Department of Thoracic Surgery and Oncology National Cancer Center Hospital East Kashiwa (M.T.) and the Department of Thoracic Oncology Kanagawa Cancer Center Yokohama (T.K.) — both in Japan the Department of Medical Oncology Austin Health Melbourne VIC Australia (T.J.) the Department of Respiratory Diseases Evangelische Lungenklinik Berlin (C.G.) the Department of Medical Oncology Hospital de la Santa Creu i Sant Pau Barcelona (M.M.) and the Department of Oncology Hospital Universitario Fundación Jiménez Díaz Madrid (M.D.) the David Geffen School of Medicine at the University of California Los Angeles Los Angeles (J.W.G.) the Center of Innovative Technologies and Oncology N.N. Blokhin Russian Cancer Center Russian Academy of Medical Sciences Moscow (K.L.) the Department of Oncology Asan Medical Center University of Ulsan College of Medicine (S.-W.K.) and the Precision Medicine Lung Cancer Center Konkuk University Medical Center (K.-Y.L.) — both in Seoul South Korea the Department of Thoracic Surgery Cho Ray Hospital Ho Chi Minh City Vietnam (H.-V.V.) the Division of Medical Oncology Faculty of Medicine Siriraj Hospital Bangkok Thailand (C.A.) the Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan (C.-J.Y.) the Division of Thoracic Oncology European Institute of Oncology IRCCS Milan (F.M.) and Medical Oncology 2 Istituto Oncologico Veneto IRCCS Padua (L.B.) — both in Italy the Department of Medical Oncology and Hematology Univers

Background:Osimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor(EGFR)mutation-positive advanced non-small-cell lung cancer(NSCLC).The efficacy and safety of osimertinib as adjuvant therapy are ***:In this double-blind,phase 3 trial,we randomly assigned patients with completely resected EGFR mutation-positive NSCLC in a 1:1 ratio to receive either osimertinib(80 mg once daily)or placebo for 3 *** primary end point was disease-free survival among patients with stage Ⅱ to ⅢA disease(according to investigator assessment).

关键词： Lung NSCLC lung

The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge

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Science Bulletin 2019年第8期64卷 499-503页

作者： yi-Chen Zhang Qing Zhou Zhi-Hong Chen Ming-Feng Zhang Jin-Ji Yang Hai-Yan Tu Xu-Chao Zhang Chong-Rui Xu Hong-Hong Yan Xiao-Xiao Peng Xiao-Yan Bai Shao-Kun Chuai Jun-yi Ye yi-long wu The Second School of Clinical Medicine Southern Medical University Guangdong Lung Cancer Institute Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Burning Rock Biotech

Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated impressive activity in EGFR T790M-positive non-small cell lung cancer (NSCLC) progressed from prior EGFR-TKI... 详细信息

关键词： cis The spatiotemporal evolution of EGFR C797S mutation in EGFR-mutant non-small cell lung cancer:opportunities for third-generation EGFR inhibitors re-challenge