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Brachiopods from the Silurian “Lower Red Beds” of Wuhan（E. Hubei， South China）: paleoecological and paleogeographical implications

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Journal of Earth Science 2024年

作者： Jia-yi yin yi-long liu Lie-Bin Huang yi-Ming Gong Rui-Wen Zong School of Earth Sciences， China University of Geosciences Faculty of Land and Resources Engineering， Kunming University of Science and Technology State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences

The age and sedimentary environment of the Silurian “Lower Red Beds” (LRBs)， which occur widely in South China， have long been controversial because of the scarcity of index fossils. Recently， these beds have been dated by trilobites as middle-late Aeronian to early Telychian in age. Here， we report abundant brachiopods from the LRBs in Wuhan， Middle Yangtze Region， including atrypides (Meifodia hunanensis， Zygospiraella sp. 1， Zygospiraella sp. 2 and Nalivkinia? sp.)， spiriferides (Striispirifer acuminiplicatus， Striispirifer? sp.)， strophomenides (Eostropheodonta? sp. and Katastrophomena modesta)， and linguliformeans (Anomaloglossa? sp. and Orbiculoidea? sp.). Most of these are common in the Leijiatun， Xiangshuyuan， Shihniulan， Niuchang， Lojoping， and Shamao formations in the Upper Yangtze Region. The discovery of brachiopods from the LRBs in Wuhan not only enrich the biodiversity of the LRBs in the Yangtze Region， where Meifodia， Zygospiraella， Katastrophomena and Eostropheodonta are first found in the LRBs， but also expand the paleogeographical distribution of brachiopods to Middle-Lower Yangtze Region that first radiated after the end-Ordovician extinction. In addition， this brachiopod fauna also provides important implications for the sedimentary environment of LRBs during the Llandovery， which is usually developed in the nearshore shallow-water (BA1-2)， althought this paper extends to the deeper parts of the shallow-marine (BA3-4).

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High-temperature oxidation behavior and degradation mechanism of chromium-coated zirconium alloy cladding: a review

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Tungsten 2025年第1期7卷 50-70页

作者： yi Li Bei-Qi Wang Xin-yin Zhang Shi-Jie Wang Cong-yi Li Hui-long Yang Ran-Ran Su Tong liu School of Mechanical Engineering Shanghai Jiao Tong University College and Graduate School of Arts and Sciences University of Virginia Global Institute of Future Technology Shanghai Jiao Tong University

Accident-tolerant fuels(ATF) have been extensively studied to reduce the production rate and total amount of heat and hydrogen generated from high-temperature steam oxidation during severe ***-coated zirconium alloy cladding has become one of the most promising candidates for ATF because of its excellent corrosion and oxidation *** paper provides a comprehensive overview of the research progress on oxidation behaviors and degradation mechanisms in chromium-coated zirconium alloy cladding under high-temperature *** techniques to strengthen the oxidation resistance are highlighted and ***,challenges and opportunities for various future directions are addressed.

关键词： Accident-tolerant fuel Chromium coating Degradation mechanism High-temperature oxidation behavior Zirconium alloy cladding

Neurological deterioration in the acute phase of minor ischemic stroke is an independent predictor of poor outcomes at 1 year： results from the China National Stroke Registry （CNSR）

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Chinese Medical Journal 2013年第18期126卷 3411-3416页

作者： JU yi ZHAO Xing-quan WANG Chun-xue WANG yi-long liu Gai-fen WANG Yong-jun Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background The risk of clinical deterioration still exists in the acute phase despite the fact that patients with minor stroke may display less severe symptoms. The impact of this clinical deterioration on long-term outcomes is unknown. We characterized the clinical features of neurological deterioration （ND） in the acute phase of minor ischemic stroke （MIS） and investigated its impact on mid- and long-term outcomes. Methods This was a multi-centered, prospective clinical study involving patients with MIS （the National Institutes of Health Stroke Scale, NIHSS ~3） recruited from the China National Stroke Registry. Patients were included who had been hospitalized within 24 hours of stroke onset. Baseline characteristics, complication rates during hospitalization, etiology of stroke, as well as 3-, 6-, and 12-month post-stroke outcomes were compared between patients with and without ND during the acute phase. Results A number of 368 （15.2%） out of 2424 patients included in the study exhibited ND in the acute phase. Compared to patients without ND, patients with ND had longer hospital stay, increased rate of baseline diabetes, and multiple complications. Multivariate Logistic regression indicated that ND in acute phase was an independent factor predictive of increased dependence （adjusted odds ratio = 5.20, 95% CI, 3.51-7.70, P 〈0.001） at 12-month post-stroke. Conclusions The risk of ND in the acute phase is high in patients with MIS. ND in the acute phase is an independent predictor for poor outcomes at 12 months post-stroke onset.

关键词： schemic stroke minor stroke predictor acute phase outcomes

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan long Jiajia liu Yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna liu yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Identifying the dynamic behaviors in complete reconstruction of Co-based complex precatalysts during electrocatalytic oxygen evolution

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Journal of Energy Chemistry 2025年第1期100卷 226-233页

作者： Jingfang Zhang Danyang Wu Linke Cai Youluan Lu Fanpeng Cheng Lijuan Shi Qun yi Yao liu yi Huang Key Laboratory of Green Chemical Engineering Process of Ministry of Education Engineering Research Center of Phosphorus Resources Development and Utilization of Ministry of Education Hubei Key Laboratory of Novel Reactor and Green Chemical Technology School of Chemical Engineering & Pharmacy Wuhan Institute of Technology Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction of Ministry of Education College of Chemistry Central China Normal University College of Materials Science and Engineering Fuzhou University

Transition metal-based nanomaterials have emerged as promising electrocatalysts for oxygen evolution reaction（OER）. Considerable research efforts have shown that self-reconstruction occurs on these nanomaterials under operating conditions of OER process. However, most of them undergo incomplete reconstruction with limited thickness of reconstruction layer, leading to low component utilization and arduous exploration of real catalytic mechanism. Herein, we identify the dynamic behaviors in complete reconstruction of Co-based complexes during OER. The hollow phytic acid（PA） cross-linked CoFe-based complex nanoboxes with porous nanowalls are designed because of their good electrolyte penetration and mass transport ability, in favor of the fast and complete reconstruction. A series of experiment characterizations demonstrate that the reconstruction process includes the fast substitution of PA by OH-to form Co（Fe）(OH)xand subsequent potential-driven oxidation to Co（Fe）OOH. The obtained CoFeOOH delivers a low overpotential of 290 mV at a current density of 10 mA cm-2and a long-term *** experiment results together with theory calculations reveal that the Fe incorporation can result in the electron rearrangement of reconstructed CoFeOOH and optimization of their electronic structure,accounting for the enhanced OER activity. The work provides new insights into complete reconstruction of metal-based complexes during OER and offers guidelines for rational design of high-performance electrocatalysts.

关键词： Oxygen evolution reaction

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen liu Xuliang Lin Xueqing Qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

Deficiency of integrin Mac-1 suppressed the initiation and progression of intestine polyps in APCmin mice

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Deficiency of integrin Mac-1 suppressed the initiation and p...

广州市城区2000～2004年儿童恶性肿瘤发病和死亡率分析

生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： yi-long liu Qian-Qian Zhang Yan Lei Meng-ying Liao Li-Jing Wang Vascular Biology Research Institute Guangdong Key Laboratory of Pharmaceutical Bioactive SubstancesGuangdong Pharmaceutical University

Accumulating evidence demonstrated that tumor microenvironment plays an important role during *** has been reported that the leukocytes in the tumor microen-vironment can promote tumorigenesis and ***-1,a member ofβ2 integrins family,is expressed in the most of myeloid derived leukocytes and plays an important role in the firm adhesion of leukocytes to vascular ***,whether Mac-1 could affect the tumor growth and metastasis is still *** this

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癌症 2010年第3期29卷 359-362页

作者：曹卡加刘奕龙马国胜华南肿瘤学国家重点实验室广东广州510060 中山大学肿瘤防治中心鼻咽癌科广东广州510060 广州市肿瘤登记处广东广州510060

背景与目的：恶性肿瘤是儿童死亡的主要原因之一。本研究分析广州市儿童肿瘤的发病率,探讨儿童肿瘤的发病规律,为广州市儿童肿瘤的防治研究提供科学依据。方法：收集广州市肿瘤登记处2000-2004年儿童肿瘤的发病资料和死亡资料,统计和分... 详细信息

背景与目的：恶性肿瘤是儿童死亡的主要原因之一。本研究分析广州市儿童肿瘤的发病率,探讨儿童肿瘤的发病规律,为广州市儿童肿瘤的防治研究提供科学依据。方法：收集广州市肿瘤登记处2000-2004年儿童肿瘤的发病资料和死亡资料,统计和分析儿童肿瘤的发病率和死亡率。用卡方检验比较不同年份儿童肿瘤的发病率和各年龄别发病率。结果：2000-2004年,广州市儿童肿瘤的发病率为17.91/10万（其中男性18.92/10万,女性16.70/10万）,死亡率为4.73/10万（其中男性4.65/10万,女性4.83/10万）。儿童肿瘤发病率最高的前3位肿瘤依次为淋巴样白血病、中枢神经系统肿瘤和非霍奇金淋巴瘤。0岁组的发病率为77.52/10万, 1-4岁组为21.49/10万, 5-9岁组为9.66/10万, 10-14岁组为17.11/10万, 4组发病率比较差异有统计学意义（χ^2=307.602,P〈0.001）。结论：淋巴样白血病、中枢神经系统肿瘤和非霍奇金淋巴瘤是广州市儿童最常见的恶性肿瘤。4岁以下的儿童是肿瘤的高发人群。

关键词：恶性肿瘤/流行病学儿童肿瘤发病率死亡率肿瘤登记广州