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Pituitary stalk interruption syndrome and liver changes:From clinical features to mechanisms

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World Journal of Gastroenterology 2020年第44期26卷 6909-6922页

作者： Ze-Yu Wu yi-ling li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Pituitary stalk interruption syndrome(PSIS)is a rare congenital abnormality characterized by thinning or disappearance of the pituitary stalk,hypoplasia of the anterior pituitary and an ectopic posterior *** the etiology of PSIS is still unclear,gene changes and perinatal adverse events such as breech delivery may play important roles in the pathogenesis of *** can cause multiple hormone deficiencies,such as growth hormone,which then cause a series of changes in the human *** the one hand,hormone changes affect growth and development,and on the other hand,they could affect human metabolism and subsequently the liver resulting in nonalcoholic fatty liver disease(NAFLD).Under the synergistic effect of multiple mechanisms,the progression of NAFLD caused by PSIS is faster than that due to other ***,in addition to early identification of PSIS,timely hormone replacement therapy and monitoring of relevant hormone levels,clinicians should routinely assess the liver function while managing PSIS.

关键词： Pituitary stalk interruption syndrome Hormone deficiency Etiology liver change Clinical characteristics Mechanisms

Lunate dislocation with avulsed triquetral fracture: A case report

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World Journal of Clinical Cases 2022年第1期10卷 331-337页

作者： ling-yi li Cheng-Jyh lin Chih-Yuan Ko Department of Orthopedic Surgery China Medical University HospitalTaichung City 40402Taiwan

BACKGROUND Lunate dislocation is an uncommon traumatic wrist injury that require prompt surgical *** or delayed treatment often leads to a poor *** reduction and surgical repair of disrupted ligaments are done in most cases to prevent long-term joint ***,this method has certain limitations that include partial functional improvement,which poses a high risk for degenerative arthritis and wrist *** SUMMARY A 37-year-old man presented to the Emergency Department of our hospital following a motorcycle *** examination revealed swelling and tenderness of the right hand and *** patient was initially misdiagnosed with a wrist contusion by an emergency physician,but was eventually diagnosed with lunate dislocation associated with a triquetral avulsed fracture,indicated for open reduction and ligament *** performed closed reduction and two Kirschner wire fixations following Tavernier’s *** injured hand was protected with a standard short-arm orthosis for one *** patient returned to normal daily work without discomfort at five months ***,there was no lunate necrosis or arthritis in the latest radiologic *** This case provides evidence that the closed reduction technique for addressing such cases can reduce soft tissue destruction.

关键词： Hand trauma Carpal injury Lunate dislocation Triquetral fracture Closed reduction Case report

Synthesis, characterization r）oly [LA-co-（GIc-alt-Lys）] for and biological evaluation of nerve regeneration scaffold

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Frontiers of Materials Science 2014年第1期8卷 95-101页

作者： yi-Xia yiN Ji-ling yi li-Juan XIE Qiong-Jiao YAN Hong-lian DAI Shi-Pu li Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

A novel nerve repairing material poly [LA-co.（GIc-alt-Lys）] （PLGL） was synthesized. The viability and growth of Schwann cells （SCs） co-cultured With poly （D, L- lactic acid）（PDLLA） films （control group） and PLGL films were evaluated by MTT assay and SEM observation. Then, contact angle measurement, histological assessment and enzyme-linked immunosorbent assay （EliSA） testing on inflammatory-related cyto- kines such as IL-10 and TGF-β1 were performed. The results showed that, compared with PDLLA, PLGL films possesses better hydrophilicity, biocompatibility, degradation property and less inflammatory reaction. The present study indicated that PLGL scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.

关键词： Schwann cell (SC) poly [LA-co-(GIc, alt-Lys)] (PLGL) implantation inflammatory factor biocompatibility

Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection

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World Journal of Clinical Cases 2021年第23期9卷 6639-6653页

作者： Xin-He Zhang Die Huang yi-ling li Bing Chang Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

Clonorchis sinensis infection is still a major public health *** is estimated that more than 15 million people worldwide are infected,especially in Northeast China,Taiwan,South Korea,and North *** detection of Clonorchis sinensis eggs in feces and bile is still the only gold standard for the diagnosis of Clonorchis sinensis infection,and new detection methods are needed to improve the detection *** Clonorchis sinensis invades the human body,it mainly parasitizes the hepatobiliary ***,it is closely related to hepatobiliary diseases such as cholangitis,bile duct stones,liver fibrosis,and *** increase in immunoglobulin G4(IgG4)caused by Clonorchis sinensis infection is rare and there are few reports about the relevant *** may be related to the inflammatory factors interleukin(IL)-4,IL-10,and IL-13 produced by human phagocytes,T cells,B cells,and other immune cells in the process of resisting the invasion of Clonorchis ***,this finding still needs further clarification and *** article reviews the epidemiology,clinical manifestations,serology,imaging,pathogenic mechanism,and control measures of Clonorchis sinensis infection to help establish the diagnostic process for Clonorchis *** report novel mechanisms of IgG4 elevation due to Clonorchis sinensis infection to provide more experience and a theoretical basis for clinical diagnosis and treatment of this infection.

关键词： liver damage Bile duct damage Hepatobiliary system destruction Clonorchis sinensis infection Immunoglobulin G4 Clinical manifestations

Eosinophilic pancreatitis:a review of the pathophysiology,diagnosis,and treatment

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Gastroenterology Report 2021年第2期9卷 115-124,I0001页

作者： Yue Sun Dan Pan Kai Kang Ming-Jun Sun yi-ling li li-Xuan Sang Bing Chang Department of Gastroenterology First Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China Department of Geriatrics First Affiliated HospitalChina Medical UniversityShenyangLiaoningP.R.China

Eosinophilic pancreatitis(EP)is an extremely rare disease caused by purely eosinophilic infiltration of the *** is prone to being misdiagnosed as pancreatic cancer,causing unnecessary economic and physical harm to the *** report three cases of EP that were cured by steroids without relapse from 2017 to *** clinical data of the three patients,including clinical manifestations,serological manifestations,imaging(ultrasound,computed tomography,and MRI),pathological diagnosis and treatment,and telephone follow-up of all patients,were retrospectively *** addition,a literature search was conducted on the Web of Science and PubMed databases using key terms related to EP,considering case reports with no restrictions on the date of publication or *** conclusion,we analysed 19 cases and determined the diagnostic criteria for *** diagnostic algorithm for EP can be used to diagnose EP *** hope that our standards and algorithm can reduce the rate of misdiagnosis and contribute to clinical diagnosis and *** addition,we expect to evaluate more EP cases to test our diagnostic criteria and design a systematic diagnostic flow chart.

关键词： eosinophilic pancreatitis rare disease diagnostic criteria mechanism diagram systematic diagnostic flowchart

Two triterpene glycosides from the sea cucumber Bohadschia marmorata Jaeger

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Chinese Chemical Letters 2008年第4期19卷 457-460页

作者： Wei Hua Yuan Yang Hua yi ling li Bao Shu liu Hong Wei Zhang Peng Sun Research Center for Marine Drugs School of PharmacySecond Military.Medical UniversityShanghai 200433PR China

Further studies on the sea cucumber Bohadschia marmorata Jaeger led to the isolation of a new holostan-type triterpene glycoside,Marmoroside C（1）together with a known triterpene glycoside（2）.On the basis of spectroscopic analyses,including two- dimensional NMR techniques,and chemical reactions,the structure of the new triterpene glycoside was elucidated as 3-O-[3-O- methyl-β-D-glucopyranosyl-（1→3）-β-D-glucopyranosyl-（1→4）-β-D-quinovopyranosyl-（1→2）-4-O-sodium-sulfato-β-D-xylo- pyranosyl]-25-acetoxy-22-oxo-9（11）-holostene-3β,12α,17α-triol.

关键词： Sea cucumber Bohadschia marmorata Triterpene glycoside

Indoor monocular mobile robot navigation based on color landmarks

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重庆邮电大学学报（自然科学版） 2009年第2期21卷 162-165页

作者： LUO Yuan ZHANG Bai-sheng ZHANG yi li ling Research Center of Intelligent System and Robotics Chongqing University of Posts and Telecommunications Chongqing 400065 P. R. China

A robot landmark navigation system based on monocular camera was researched theoretically and *** the landmark setting and its data structure in programming was given;then the coordinates of them getting by robot and global localization of the robot was described;finally experiments based on Pioneer III mobile robot show that this system can work well at different topographic situation without lose of signposts.

关键词：移动机器人导航系统彩色标志室内数据结构全球定位基础里程

Resection with limb salvage in an Asian male adolescent withEwing’s sarcoma: A case report

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World Journal of Clinical Cases 2022年第22期10卷 7960-7967页

作者： Chien-ying Lai Kuan-Ju Chen Tsung-Yu Ho ling-yi li Chien-Chung Kuo Hsien-Te Chen yi-Chin Fong Department of Orthopedic Surgery China Medical University HospitalTaichung 404Taiwan Spine Center China Medical University HospitalTaichung 404Taiwan School of Medicine China Medical UniversityTaichung 404Taiwan

BACKGROUNDEwing’s sarcoma is a highly malignant primary bone tumor that commonly affectschildren. For young patients, multidisciplinary treatment and limb salvage arerecommended, and surgical plans considering the growth potential and boneactivity after tumor resection are *** SUMMARYAn 11-year-old Asian boy had a 1-mo history of a right-sided limping *** revealed a proximal tumor with bone destruction and physealinvolvement over the right femoral neck. He was diagnosed with stage IV(T1N0M1aG3) Ewing’s sarcoma with bilateral lung metastases. Neoadjuvantchemotherapy decreased the tumor size and confined it to the metaphysealregion. The patient underwent four stages of surgery: wide tumor excision plusreconstruction with vascular fibular bone graft plus internal fixation;repeat openreduction and internal fixation;femoral lengthening with orthosis after physealmaturity;and orthosis removal and bone elongation (approximately 6 cm).Following surgery, he could walk without discomfort and had almost equal-sizedbilateral femoral heads, indicating physis preservation. The surgery wassuccessful, and normal femoral head growth was achieved after completeremission. The patient was able to resume normal activities with equal length ofthe bilateral lower *** treatment and reconstruction following resection are important in skeletally immature patients with Ewing’s sarcoma to improve quality of life.

关键词： Ewing’s sarcoma Lower limb discrepancy Orthosis Vascular fibular graft Reconstruction Case report

Success of susceptibility-guided eradication of Helicobacter pylori in a region with high secondary clarithromycin and levofloxacin resistance rates

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World Journal of Gastroenterology 2024年第2期30卷 184-195页

作者： Yan-Meng Wang Mo-Ye Chen Jing Chen Xin-He Zhang Yan Feng Yu-Xi Han yi-ling li Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Key Laboratory of Cancer Etiology and Prevention in liaoning Education Department The First Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Resistance to clarithromycin(CLA)and levofloxacin(LFX)of Helicobacter pylori(***)is increasing in severity,and successful eradication is ***,the eradication success rate has greatly declined,leaving a large number of patients with previous treatment *** To investigate secondary resistance rates,explore risk factors for antibiotic resistance,and assess the efficacy of susceptibility-guided *** We recruited 154 subjects positive for Urea Breath Test who attended The First Affiliated Hospital of China Medical University between July 2022 and April *** underwent a string test after an overnight *** gastric juice was obtained and transferred to vials containing storage ***,DNA extraction and the specific DNA amplification were performed using quantitative polymerase chain reaction(qPCR).Demographic information was also analyzed as part of the *** on these results,the participants were administered susceptibility-guided *** was compared with that of the empiric treatment *** A total of 132 individuals tested positive for the *** ureA gene by qPCR *** resistance rate reached a high level of 82.6%(n=109),LFX resistance rate was 69.7%(n=92)and dual resistance was 62.1%(n=82).Gastric symptoms[odds ratio(OR)=2.782;95%confidence interval(95%CI):1.076-7.194;P=0.035]and rural residence(OR=5.152;95%CI:1.407-18.861;P=0.013)were independent risk factors for secondary resistance to CLA and LFX,respectively.A total of 102 and 100 individuals received susceptibility-guided therapies and empiric treatment,*** antibiotic susceptibility-guided treatment and empiric treatment groups achieved successful eradication rates of 75.5%(77/102)and 59.0%(59/411)by the intention-to-treat(ITT)analysis and 90.6%(77/85)and 70.2%(59/84)by the per-protocol(PP)analysis,*** eradication rates of these two treatment strategies were significantly

关键词： Helicobacter pylori Antibiotic resistance Clarithromycin Levofloxacin String-test Susceptibility-guided therapy Eradication rate