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World Journal of Hepatology 2018年第10期10卷 772-779页

作者： yi-lan lin Department of Radiation Oncology Rinecker Proton Therapy Center

Presented here is the clinical course of a 63-yearold patient with a central, large and unresectable hepatocellular carcinoma(HCC) with liver metastases and tumor invasion of the portal and hepatic veins. After the tumor had been diagnosed, the patient was immediately treated with proton beam therapy(PBT), at a total dose of 60 Gy(relative biological effectiveness) in 20 fractions administered within 4 wk. To manage the respiratory movements, at the Rinecker Proton Therapy Center, apneic oxygenation was given daily, under general anesthesia. The patient tolerated both the PBT and general anesthesia very well, and did now show any signs of acute or late toxicity. The treatment was followed by constant reductions in the tumor marker alpha-fetoprotein and the cholestatic parameters gamma-glutamyltransferase and alkaline phosphatase. The patient commenced an adjuvant treatment with sorafenib, given at 6-wk intervals, after the PBT. Follow-up with regular magnetic resonance imaging has continued for 40 mo so far, demonstrating remarkable shrinkage of the HCC(maximal diameter dropping from approximately 13 cm to 2 cm). To date, the patient remains free of tumor recurrence. PBT served as a safe and effective treatment method for an unresectable HCC with vascular invasion.

关键词： Particle therapy Proton beam therapy Apneic oxygenation Unresectable Vascular invasion Hepatocellular carcinoma Intrahepatic metastasis

Proton beam therapy of periorbital sinonasal squamous cell carcinoma: Two case reports and review of literature

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World Journal of Clinical Oncology 2020年第8期11卷 655-672页

作者： yi-lan lin Department of Radiation Oncology Rinecker Proton Therapy CenterMunich 81371Germany

BACKGROUND Sinonasal malignancies are rare but demanding due to complex anatomy,usually late diagnosis,and inconsistent therapy strategy based on multimodality *** cell carcinoma(SCC)is the most common histology,with poorer *** the setting of orbital invasion,an orbital exenteration may be ***,in case of primary rejection of disfiguring surgery or unresectable disease,proton beam therapy(PBT)should be largely considered,allowing for better sparing of neighboring critical structures and improved outcomes by dose *** SUMMARY A 62-year-old male presented with a recurrent SCC in the nasal septum abutting frontal skull base and bilateral orbits at 7 mo after primary partial nasal *** of refusal of face-deforming surgery and considerable adverse effects of conventional radiotherapy,the patient underwent a PBT by hyperfractionated accelerated scheme,resulting in complete response and moderate *** 2 years,a nasal reconstruction was implemented with satisfactory appearance and recurrence-freedom to *** patient with an initially extended sinonasal SCC,invading right orbit and facial soft tissue,declined an orbital exenteration and was treated with a normofractionated PBT to the gross tumor and elective cervical *** follow-up showed a continuous tumor remission with reasonable late toxicities,such as cataract and telangiectasia on the *** T4a stage and disapproval of concurrent chemotherapy owing to individual choice,both patients still achieved outstanding treatment outcomes with PBT *** PBT enabled orbit preservation and excellent tumor control without severe adverse effects on both presented patients with locally advanced sinonasal SCC.

关键词： Proton beam therapy Intensity modulated proton therapy Sinonasal malignancies Squamous cell carcinoma Orbital exenteration Case report

Reirradiation of recurrent breast cancer with proton beam therapy:A case report and literature review

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World Journal of Clinical Oncology 2019年第7期10卷 256-268页

作者： yi-lan lin Department of Radiation Oncology Rinecker Proton Therapy Center

BACKGROUND Locoregional recurrence of breast cancer is challenging for clinicians,due to the various former treatments patients have ***,treatment of the recurrence with systemic therapy and subsequent reirradiation of chest wall is accompanied by increased toxicities,particularly radiation-induced cardiovascular *** by proton beam therapy(PBT)enables superior preservation of adjacent organs at risk as well as concurrent dose escalation for delivery to the gross *** technology is expected to improve the overall outcome of recurrent breast *** SUMMARY A 47-year-old female presented with an extensive locoregional recurrence at 10 yr after primary treatment of a luminal A breast *** of tumor progression despite having undergone bilateral ovarectomy and systemic therapy,the patient was treated with PBT BE total dose of 64.40 Gy to each gross tumor and 56.00 Gy to the upper mediastinal and retrosternal lymphatics including the entire sternum in 28 ***-up computed tomography showed a partial remission,without evidence of newly emerging *** 19 mo after the PBT,the patient developed a radiation-induced pericardial disease and pleural effusions with clinical burden of dyspnea,which were successfully treated by drainage and *** analysis of the puncture fluid showed no malignancy,and the subsequent computed tomography scan indicated stable disease as well as significantly decreased pericardial and pleural *** patient remains free of progression to *** PBT was a safe and effective method of reirradiation for locoregionally recurrent breast cancer in our patient.

关键词： Proton beam therapy Recurrent breast cancer Chest wall recurrence Reirradiation Pericarditis Radiation-induced cardiovascular disease Case report

Serum soluble ST2 is a promising prognostic biomarker in HBV-related acute-on-chronic liver failure

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 181-188页

作者： Shao-Wen Jiang Peng Wang Xiao-Gang Xiang Rui-Dong Mo lan-yi lin Shi-San Bao Jie Lu Qing Xie Department of Infectious Diseases Ruijin Hospital Shanghai Jiaotong University School of Medicine Discipline of Pathology School of Medical Sciences and Bosch InstituteUniversity of Sydney

BACKGROUND： The IL-33/ST2 axis is involved in the pathogenesis of many diseases such as autoimmune diseases, cancer,and heart failure. However, studies of the IL-33/ST2 pathway in HBV-related acute-on-chronic liver failure（HBV-ACLF） are lacking. The present study aimed to determine the prognostic role of serum IL-33/soluble ST2（s ST2） in ***： Serum levels of IL-33 and sS T2 in healthy controls（HC, n=18）, chronic hepatitis B（CHB, n=27） and HBV-ACLF（n=51） patients at the 1st and 4th week after enrollment were detected using ELISA, and clinical data were collected. The follow-up of HBV-ACLF patients lasted for 6 months at ***： There was no significant difference of serum IL-33 level among HC, CHB and HBV-ACLF patients at week ***, serum s ST2 level differed significantly among the three groups： highest in the HBV-ACLF group, moderate in the CHB group and lowest in the HC group. There was a reverse correlation between serum s ST2 level and the survival of HBV-ACLF patients. The level of serum s ST2 in HBV-ACLF survivors was significantly declined from week 1 to week 4 following the treatment, whereas that in HBV-ACLF nonsurvivors remained at a high level during the same period. Furthermore, serum sS T2 level was significantly correlated with laboratory parameters and the most updated prognostic scores（CLIF-C OF score, CLIF-C ACLF score and ACLF grades）. Thereceiver operating characteristics curves demonstrated that serum sS T2 level was a good diagnostic marker for predicting the 6-month mortality in HBV-ACLF patients, comparable to the most updated prognostic scores. Serum sS T2 cut-off points for predicting prognosis in HBV-ACLF patients were 76 ng/mL at week 1 or 53 ng/mL at week 4, respectively. HBV-ACLF patients with serum sS T2 level above the cut-off point often had a worse prognosis than those below the cut-off ***： Serum s ST2 may act as a promising biomarker to assess severity and predict prognosis of patients with HBV

关键词： biomarker HBV-related acute-on-chronic liver failure interleukin-33 prognosis soluble ST2

Analysis of CD8^+CD28^-T-suppressor cells in living donor liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 241-246页

作者： yi-Xin lin,lan-lan Wang,Lu-Nan Yan,Pei Cai,Bo Li,Tian-Fu Wen and Yong Zeng Center of Liver Transplantation and Department of Surgery,Division of Clinical Immunology and Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu610041,China Center of Liver Transplantation and Department of Surgery West China Hospital Sichuan University Chengdu China.

BACKGROUND:Human CD8 + CD28 - T-suppressor(Ts) cells have been considered to indicate a reduced need for immunosuppression in pediatric liver-intestine transplant recipients and recipients of deceased heart-kidney ***,in adult-to-adult living donor liver transplantation(A-A LDLT)little information is available and the clinical significance is still unknown. METHODS:Flow cytometry was used to detect the population of CD8+CD28 -Ts cells present in peripheral blood in A-A LDLT recipients(n=31),patients with end- stage liver disease(n=24)and healthy controls(n=19). Meanwhile,we tested the graft function and trough levels of immunosuppression in *** clinical and follow- up data of 31 transplant recipients were analyzed. RESULTS:Compared with diseased controls(P=0.007) and healthy individuals(P=0.000),a notable expansion of CD8 + CD28 - Ts cells was found in recipients of A-A *** was associated with graft function,levels of immunosuppression and rejection episodes. CONCLUSIONS:To monitor the CD8 + CD28 - Ts cells levels is important to evaluate the immune state of recipients. Meanwhile,it is also important to promote expansion of CD8+CD28 -Ts cells in recipients of A-A LDLT,not only to sustain good graft function and decrease the dosage of immunosuppressants,but also to reduce the occurrence of rejection.

关键词： T-suppressor cells CD8-positive living donor liver transplantation clinical analysis

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen Xu Feng Yuan Shi Xin-lin Li Zheng-Rong Shi Xiang lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

基于微透析技术的花椒挥发油在体经皮促透作用研究

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中国中药杂志 2017年第14期42卷 2676-2682页

作者：兰颐杨琳史大勇王英新吴学萍谢璇吴清山东达因海洋生物制药股份有限公司山东威海264300 北京中医药大学中药学院北京100102

该文拟采用经皮微透析技术测定花椒挥发油对不同脂溶性中药成分皮肤药动学行为的影响,评价其在体经皮促透特征。选择川芎嗪和葛根素作为亲脂性和亲水性模型药物,采用浓差法考察微透析探针体外回收率与传递率,采用反向渗析法测定药物探... 详细信息

该文拟采用经皮微透析技术测定花椒挥发油对不同脂溶性中药成分皮肤药动学行为的影响,评价其在体经皮促透特征。选择川芎嗪和葛根素作为亲脂性和亲水性模型药物,采用浓差法考察微透析探针体外回收率与传递率,采用反向渗析法测定药物探针在体回收率;以常用化学促透剂氮酮为阳性对照,测定不同浓度花椒挥发油对川芎嗪和葛根素的皮肤药动学行力影响。结果显示,2种模型药物探针回收率与传递率相等,药物在渗析膜间无相互作用,川芎嗪和葛根素的在体相对回收率分别为59.17%,19.85%。在体经皮试验表明花椒挥发油对川芎嗪具良好促透效果,且呈浓度依赖性关系,5%花椒挥发油的在体促透倍数(ER)为98.64,比氮酮最佳浓度的促透效果更好(3%氮酮,ER=89.11);同时,花椒挥发油也可显著增加葛根素的在体经皮吸收,也表现出浓度依赖性关系。因此,该研究进一步证实花椒挥发油作为经皮促透剂的良好促透性能,为其在中药外用制剂中的应用提供了数据支持。

关键词：花椒挥发油微透析促透剂在体经皮吸收反向渗析法

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua Wang yi-Xin Liu Lu Xu lin Fu Ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou ying Xiaoli Si Naijia Xue yi Liu Ran Zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

The Minimum Stretch Spanning Tree Problem for Typical Graphs

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 510-522页

作者： lan lin yi-xun lin School of Electronics and Information Engineering Tongji UniversityShanghai 200092China School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China

With applications in communication networks,the minimum stretch spanning tree problem is to find a spanning tree T of a graph G such that the maximum distance in T between two adjacent vertices is *** problem has been proved NP-hard and fixed-parameter polynomial algorithms have been obtained for some special families of *** this paper,we concentrate on the optimality characterizations for typical classes of *** determine the exact formulae for the complete k-partite graphs,split graphs,generalized convex graphs,and several planar grids,including rectangular grids,triangular grids,and triangulated-rectangular grids.

关键词： communication network spanning tree optimization tree spanner max-stretch congestion